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Table 2 Absolute & relative organ weights in rats orally treated with HZJW

From: Gastroprotective and anti-Helicobacter pylori potential of herbal formula HZJW: safety and efficacy assessment

Parameter Sex Dose (mg/kg)
0 mg/kg 1000 mg/kg 2500 mg/kg 5000 mg/kg
13 wk 26 wk Recovery 13 wk 26 wk Recovery 13 wk 26 wk Recovery 13wk 26 wk Recovery
Body weight Male 486.2 ± 16.4 604.4 ± 70.0 641.3 ± 95.7 516.3 ± 101.3 634.6 ± 60.1 670.7 ± 65.7 482.3 ± 44.4 628.1 ± 67.7 660.4 ± 39.7 481.8 ± 39.5 637.8 ± 82.5 691.7 ± 63.8
Female 291.3 ± 16.8 331.8 ± 27.2 338.9 ± 35.6 280.9 ± 17.0 333.4 ± 32.2 329.7 ± 34.7 266.0 ± 9.3 308.3 ± 25.7 318.4 ± 15.2 269.0 ± 36.4 322.2 ± 31.9 336.6 ± 29.5
Brain Male 2.096 ± 0.064 2.240 ± 0.124 2.163 ± 0.103 2.214 ± 0.115 2.221 ± 0.095 2.191 ± 0.090 2.080 ± 0.117 2.281 ± 0.079 2.224 ± 0.092 2.092 ± 0.183 2.238 ± 0.089 2.261 ± 0.049
Female 1.996 ± 0.066 2.021 ± 0.064 2.088 ± 0.096 1.947 ± 0.040 2.011 ± 0.064 2.028 ± 0.043 2.006 ± 0.046 2.008 ± 0.105 2.003 ± 0.063 1.985 ± 0.029 2.040 ± 0.060 2.029 ± 0.039
% to body weight Male 0.431 ± .016 0.376 ± 0.054 0.344 ± 0.055 0.439 ± 0.067 0.352 ± 0.033 0.329 ± 0.034 0.434 ± 0.039 0.366 ± 0.036 0.338 ± 0.027 0.436 ± 0.043 0.356 ± 0.046 0.329 ± 0.030
Female 0.687 ± 0.041 0.612 ± 0.041 0.621 ± 0.066 0.695 ± 0.045 0.608 ± 0.060 0.620 ± 0.065 0.754 ± 0.023* 0.655 ± 0.057 0.630 ± 0.019 0.747 ± 0.082 0.638 ± 0.065 0.606 ± 0.051
Thymus Male 0.297 ± 0.097 0.270 ± 0.069 0.262 ± 0.063 0.351 ± 0.170 0.219 ± 0.106 0.250 ± 0.092 0.313 ± 0.043 0.223 ± 0.084 0.200 ± 0.038 0.270 ± 0.048 0.262 ± 0.056 0.224 ± 0.059
Female 0.367 ± 0.057 0.245 ± 0.073 0.187 ± 0.057 0.325 ± 0.041 0.232 ± 0.038 0.225 ± 0.045 0.283 ± 0.053 0.226 ± 0.061 0.214 ± 0.071 0.304 ± 0.091 0.231 ± 0.063 0.218 ± 0.023
% to body weight Male 0.061 ± 0.018 0.044 ± 0.009 0.041 ± 0.008 0.065 ± 0.019 0.034 ± 0.013* 0.037 ± 0.013 0.065 ± 0.011 0.035 ± 0.012 0.030 ± 0.005* 0.056 ± 0.008 0.041 ± 0.008 0.032 ± 0.006
Female 0.126 ± 0.017 0.074 ± 0.023 0.055 ± 0.014 0.116 ± 0.015 0.070 ± 0.010 0.069 ± 0.015 0.106 ± 0.018 0.073 ± 0.017 0.067 ± 0.021 0.112 ± 0.026 0.071 ± 0.014 0.065 ± 0.009
Heart Male 1.381 ± 0.111 1.625 ± 0.204 1.653 ± 0.259 1.494 ± 0.193 1.710 ± 0.229 1.613 ± 0.225 1.408 ± 0.156 1.702 ± 0.169 1.749 ± 0.138 1.467 ± 0.093 1.699 ± 0.182 1.912 ± 0.182
Female 0.832 ± 0.042 1.100 ± 0.101 1.046 ± 0.138 0.917 ± 0.094 1.089 ± 0.109 1.013 ± 0.091 0.905 ± 0.066 1.024 ± 0.091 0.986 ± 0.069 0.969 ± 0.102 1.098 ± 0.136 1.014 ± 0.068
% to body weight Male 0.284 ± 0.014 0.270 ± 0.029 0.258 ± 0.004 0.294 ± 0.037 0.271 ± 0.039 0.240 ± 0.015* 0.292 ± 0.021 0.272 ± 0.021 0.265 ± 0.020 0.306 ± 0.028 0.268 ± 0.016 0.277 ± 0.016
Female 0.286 ± 0.012 0.333 ± 0.034 0.308 ± 0.010 0.326 ± 0.023* 0.328 ± 0.027 0.308 ± 0.016 0.341 ± 0.036* 0.334 ± 0.044 0.310 ± 0.016 0.362 ± 0.025** 0.341 ± 0.032 0.302 ± 0.018
Lung Male 1.782 ± 0.201 1.831 ± 0.271 1.845 ± 0.237 1.862 ± 0.779 1.876 ± 0.246 1.910 ± 0.094 1.528 ± 0.103* 1.930 ± 0.088 1.916 ± 0.052 1.516 ± 0.066* 1.898 ± 0.127 2.099 ± 0.322
Female 1.210 ± 0.061 1.434 ± 0.110 1.409 ± 0.098 1.506 ± 0.538 1.449 ± 0.168 1.28 ± 0.062* 1.210 ± 0.072 1.438 ± 0.166 1.419 ± 0.048 1.204 ± 0.192 1.443 ± 0.138 1.503 ± 0.152
% to body weight Male 0.366 ± 0.038 0.304 ± 0.041 0.289 ± 0.025 0.354 ± 0.087 0.296 ± 0.034 0.287 ± 0.033 0.318 ± 0.021* 0.310 ± 0.029 0.291 ± 0.016 0.316 ± 0.026 0.300 ± 0.028 0.303 ± 0.035
Female 0.416 ± 0.024 0.434 ± 0.036 0.418 ± 0.043 0.537 ± 0.189 0.438 ± 0.064 0.394 ± 0.041 0.456 ± 0.037 0.466 ± 0.036 0.446 ± 0.025 0.447 ± 0.021 0.450 ± 0.048 0.448 ± 0.041
Liver Male 11.492 ± 1.894 12.852 ± 1.753 14.019 ± 2.841 12.564 ± 3.570 13.450 ± 1.903 14.001 ± 1.859 11.882 ± 1.267 14.860 ± 2.256* 15.212 ± 1.286 11.380 ± 0.892 16.043 ± 3.106* 16.306 ± 1.798
Female 6.885 ± 0.495 8.213 ± 1.184 7.582 ± 0.862 7.057 ± 0.719 8.522 ± 0.984 7.761 ± 1.048 6.920 ± 0.305 8.136 ± 0.742 7.659 ± 0.794 7.356 ± 1.218 8.733 ± 0.742 7.594 ± 0.724
% to body weight Male 2.356 ± 0.312 2.125 ± 0.125 2.180 ± 0.190 2.407 ± 0.256 2.117 ± 0.187 2.084 ± 0.143 2.461 ± 0.062 2.363 ± 0.209** 2.301 ± 0.061 2.366 ± 0.123 2.498 ± 0.193** 2.357 ± 0.164
Female 2.369 ± 0.223 2.481 ± 0.355 2.239 ± 0.151 2.510 ± 0.189 2.561 ± 0.237 2.351 ± 0.132 2.605 ± 0.169 2.644 ± 0.205 2.402 ± 0.171 2.728 ± 0.105* 2.728 ± 0.300 2.258 ± 0.159
Spleen Male 0.614 ± 0.042 0.799 ± 0.116 0.833 ± 0.115 0.639 ± 0.105 0.849 ± 0.110 0.795 ± 0.096 0.708 ± 0.166 0.810 ± 0.115 0.868 ± 0.133 0.673 ± 0.073 0.916 ± 0.101* 0.859 ± 0.104
Female 0.431 ± 0.023 0.618 ± 0.149 0.582 ± 0.108 0.460 ± 0.054 0.544 ± 0.074 0.553 ± 0.060 0.478 ± 0.035 0.574 ± 0.115 0.545 ± 0.035 0.446 ± 0.081 0.518 ± 0.080 0.543 ± 0.057
% to body weight Male 0.126 ± 0.006 0.133 ± 0.022 0.130 ± 0.009 0.126 ± 0.021 0.134 ± 0.009 0.118 ± 0.007 0.147 ± 0.030 0.129 ± 0.009 0.131 ± 0.018 0.140 ± 0.015 0.145 ± 0.015 0.124 ± 0.009
Female 0.148 ± 0.009 0.187 ± 0.046 0.172 ± 0.026 0.164 ± 0.020 0.164 ± 0.021 0.168 ± 0.013 0.180 ± 0.016** 0.186 ± 0.033 0.171 ± 0.006 0.167 ± 0.028 0.162 ± 0.026 0.162 ± 0.018
Kidney Male 2.832 ± 0.228 3.343 ± 0.322 3.406 ± 0.309 2.943 ± 0.433 3.421 ± 0.481 3.449 ± 0.451 2.766 ± 0.141 3.519 ± 0.316 3.856 ± 0.456 3.013 ± 0.428 3.622 ± 0.410 4.178 ± 0.503*
Female 1.655 ± 0.139 1.896 ± 0.164 1.868 ± 0.199 1.568 ± 0.152 1.932 ± 0.175 1.914 ± 0.255 1.605 ± 0.045 1.978 ± 0.175 1.892 ± 0.111 1.626 ± 0.192 2.025 ± 0.164 1.857 ± 0.167
% to body weight Male 0.582 ± 0.031 0.557 ± 0.056 0.537 ± 0.060 0.577 ± 0.070 0.540 ± 0.072 0.513 ± 0.029 0.577 ± 0.058 0.563 ± 0.048 0.584 ± 0.062 0.624 ± 0.059 0.572 ± 0.059 0.603 ± 0.026
Female 0.569 ± 0.052 0.574 ± 0.058 0.552 ± 0.031 0.558 ± 0.048 0.582 ± 0.054 0.581 ± 0.049 0.604 ± 0.027 0.643 ± 0.049** 0.594 ± 0.024* 0.606 ± 0.029* 0.632 ± 0.056 0.552 ± 0.034
Adrenal grand Male 0.068 ± 0.012 0.050 ± 0.006 0.062 ± 0.009 0.059 ± 0.013 0.056 ± 0.007 0.051 ± 0.005* 0.062 ± 0.012 0.055 ± 0.009 0.057 ± 0.005 0.053 ± 0.009* 0.056 ± 0.008 0.065 ± 0.010
Female 0.066 ± 0.007 0.063 ± 0.009 0.067 ± 0.009 0.061 ± 0.009 0.063 ± 0.008 0.055 ± 0.006* 0.066 ± 0.006 0.065 ± 0.012 0.064 ± 0.011 0.061 ± 0.008 0.069 ± 0.009 0.057 ± 0.010
% to body weight Male 0.014 ± 0.002 0.008 ± 0.002 0.010 ± 0.001 0.012 ± 0.004 0.009 ± 0.001 0.008 ± 0.001* 0.013 ± 0.003 0.009 ± 0.002 0.009 ± 0.001 0.011 ± 0.002 0.009 ± 0.002 0.009 ± 0.001
Female 0.023 ± 0.002 0.019 ± 0.003 0.020 ± 0.002 0.022 ± 0.003 0.019 ± 0.003 0.017 ± 0.001* 0.025 ± 0.003 0.021 ± 0.004 0.020 ± 0.004 0.023 ± 0.004 0.022 ± 0.003 0.017 ± 0.003
Testis(Rt.)/ Ovary (Lt.) Male 3.391 ± 0.243 3.669 ± 0.398 3.767 ± 0.306 3.607 ± 0.142 3.606 ± 0.788 3.666 ± 0.315 3.324 ± 0.689 3.831 ± 0.472 3.822 ± 0.331 3.594 ± 0.362 3.632 ± 0.851 4.047 ± 0.343
Female 3.594 ± 0.362 0.146 ± 0.030 0.164 ± 0.049 0.145 ± 0.017 0.157 ± 0.038 0.157 ± 0.047 0.149 ± 0.017 0.156 ± 0.022 0.152 ± 0.016 0.148 ± 0.018 0.166 ± 0.036 0.164 ± 0.017
% to body weight Male 0.698 ± 0.052 0.610 ± 0.054 0.593 ± 0.050 0.716 ± 0.109 0.567 ± 0.109 0.548 ± 0.033 0.684 ± 0.095 0.613 ± 0.079 0.579 ± 0.032 0.751 ± 0.114 0.571 ± 0.128 0.587 ± 0.046
Female 0.046 ± 0.007 0.044 ± 0.010 0.048 ± 0.014 0.051 ± 0.005* 0.048 ± 0.013 0.049 ± 0.015 0.056 ± 0.007* 0.051 ± 0.006 0.048 ± 0.006 0.055 ± 0.002 0.052 ± 0.010 0.049 ± 0.006
Epididymis (Lt.)/Uterus Male 1.264 ± 0.099 1.542 ± 0.205 1.555 ± 0.142 1.440 ± 0.207 1.547 ± 0.329 1.562 ± 0.403 1.322 ± 0.170 1.550 ± 0.306 1.575 ± 0.170 1.431 ± 0.080* 1.511 ± 0.271 1.669 ± 0.262
Female 0.649 ± 0.173 0.803 ± 0.289 0.883 ± 0.114 0.879 ± 0.283 0.991 ± 0.340 0.970 ± 0.274 0.715 ± 0.195 0.907 ± 0.213 0.691 ± 0.152 0.752 ± 0.338 0.770 ± 0.264 0.893 ± 0.365
% to body weight Male 0.260 ± 0.021 0.260 ± 0.054 0.245 ± 0.026 0.285 ± 0.050 0.244 ± 0.047 0.231 ± 0.043 0.273 ± 0.015 0.248 ± 0.050 0.239 ± 0.032 0.299 ± 0.035 0.240 ± 0.053 0.241 ± 0.029
  Female 0.225 ± 0.070 0.245 ± 0.092 0.264 ± 0.048 0.315 ± 0.108 0.299 ± 0.102 0.296 ± 0.084 0.269 ± 0.074 0.298 ± 0.082 0.217 ± 0.044 0.272 ± 0.084 0.240 ± 0.082 0.271 ± 0.125
  1. Note: Data represents body weights right before necropsy, after fasting; Values are mean ± S.D. (n = 5 (4 weeks or recovery), 10 (26 weeks), recovery (30 weeks)/sex/dose). * P < 0.05 & ** P < 0.01 compared with normal group.