Figure 1

Reduction of radiation-induced intestinal injury in tumor-bearing mice by genistein: treatment schedule. (A) The mouse CT26 colon cancer cells were injected subcutaneously into the flanks of BALB/c mice. After 7 d of xenograft implantation, when the tumors had reached ~ 5 mm in diameter, the mice were randomly divided into 6 groups and abdominal site exposed to 5 or 10 Gy irradiation in mice. The mice were euthanized 12 h after irradiation, mice tumors were weighed and evaluated the intestinal apoptotic change. For histopathological examination, the mice were euthanized in each group 3.5 day after irradiation, mice tumors were weighed and evaluated intestinal histological change. After 7 d irradiation exposure, mice were euthanized in each group and mice tumors were weighed. (B) Abdominal site exposed to irradiation in mice. Arrow is the cancer xenograft lesion.