- Poster presentation
- Open Access
P02.34. Therapeutic effects of traditional Chinese medicine in cancer patients undergoing chemotherapy or radiotherapy: randomized, double-blind controlled trial
© Lo et al; licensee BioMed Central Ltd. 2012
- Published: 12 June 2012
- Intervention Group
- Cancer Patient
- Placebo Group
- Brain Metastasis
Cancer is one of the most major health issues worldwide. An increasing number of cancer patients received surgery, chemotherapy and radiotherapy. However, there usually exists some side-effects. Traditional Chinese Medicine (TCM) is one of the most common complementary therapies used in Taiwan. We designed a randomized, double-blind and placebo-controlled clinical trial to evaluate the role of TCM on patients with cancer.
Inclusion criteria were being diagnosed as cancer patients within 3 years and received chemotherapy (CT) or radiotherapy (RT), age above 18 years old. Exclusion criteria were pregnancy, brain metastasis, or receiving drugs for other clinical trials. These patients were separated to an intervention group (Sheng-Mai-san) and a placebo group for 4 weeks using a randomized, double-blind principle. EORTC QOL-C30 was used to evaluate quality of life. General data, CBC, GOT, GPT, BUN, creatinine, and CEA were also recorded. These data were collected at baseline and one month after using drugs. Enrolled patients were prescribed sealed granules, which contain therapeutic drugs or placebo. We used paired-t tests for statistical analysis.
Forty patients were recruited in this study. Twenty-nine completed the EORTC QOL C30 questionnaire and laboratory data. There were fourteen patients in the intervention group including twelve females and two males. Fifteen patients were in the placebo group, including nine females and six males. Patient characteristics of the two groups were similar. We compared the total scales of EORTC-C30 pretreatment and post treatment and there were significant differences in insomnia, constipation and financial difficulties in intervention group (p<0.05). Besides, we also noted significant decreases in WBC in the placebo group (p=0.01). But neutrophils increased significantly (p<0.05 ) and average WBC increased (still within normal limits) in the intervention group.
TCM (Sheng-Mai-san) improved several symptoms in cancer patients undergoing CR or RT and prevented decreases of WBC. TCM may be a complementary therapy for cancer patients undergoing CT/RT.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.