Effects of Astragalus polysaccharides on P-glycoprotein efflux pump function and protein expression in H22 hepatoma cells in vitro

Table 1 Impact of APS on H22/ADM cell proliferation (n = 6)

Agents	Concentration (mg/L)	OD Value (mean ± SD)	Inhibition Rate (%)	IC50 (mg/L)	IC50 95%CI (mg/L)
APS	0.8	0.71 ± 0.15	1.11
	4	0.67 ± 0.12	6.69
	20	0.61 ± 0.09	15.04	251.77^★	1.6 × 10–1.2 × 10³
	100	0.47 ± 0.04	34.54
	500	0.27 ± 0.14	62.40
DDP	0.1	0.29 ± 0.02	59.61
	1.0	0.21 ± 0.04	70.75	0.04	1.7 × 10^-3–0.74
	10	0.06 ± 0.03	91.64
NS		1.018 ± 1.06	ND
DMSO	0.1	0.918 ± 0.134	ND

^★ P < 0.05, vs. DDP; ND: Not calculated; SD: Standard deviation; NS: normal saline.

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