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Table 1 Impact of APS on H22/ADM cell proliferation (n = 6)

From: Effects of Astragalus polysaccharides on P-glycoprotein efflux pump function and protein expression in H22 hepatoma cells in vitro

Agents Concentration (mg/L) OD Value (mean ± SD) Inhibition Rate (%) IC50 (mg/L) IC50 95%CI (mg/L)
APS 0.8 0.71 ± 0.15 1.11   
  4 0.67 ± 0.12 6.69   
  20 0.61 ± 0.09 15.04 251.77 1.6 × 10–1.2 × 103
  100 0.47 ± 0.04 34.54   
  500 0.27 ± 0.14 62.40   
DDP 0.1 0.29 ± 0.02 59.61   
  1.0 0.21 ± 0.04 70.75 0.04 1.7 × 10-3–0.74
  10 0.06 ± 0.03 91.64   
NS   1.018 ± 1.06 ND   
DMSO 0.1 0.918 ± 0.134 ND   
  1. P < 0.05, vs. DDP; ND: Not calculated; SD: Standard deviation; NS: normal saline.