From: A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats
Treatment | Dose(mg/kg) | Reversibility study | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ā | Ā | Creatinine (Ī¼mol/L) | Urea (mmol/L) | Albumin (g/L) | Protein (g/L) | TC (mmol/L) | HDL (mmol/L) | LDL (mmol/L) | TG (mmol/L) | Glucose (mmol/L) | Uric acid (Ī¼mol/L) | ALP (u/L) | AST (u/L) | ALT (u/L) | TB (Ī¼mol/L) | DB (Ī¼mol/L) |
Distilled water | (10 ml/kg) | 58.75āĀ±ā2.95 | 7.68āĀ±ā0.38 | 39.5āĀ±ā1.68 | 83.13āĀ±ā3.14 | 2.4āĀ± 0.25 | 1.59āĀ±ā0.15 | 0.50āĀ±ā0.18 | 0.65āĀ±ā0.10 | 1.93āĀ± 0.36 | 93.74āĀ±ā8.50 | 28.23āĀ± 5.48 | 65.88āĀ±ā7.87 | 31.75āĀ±ā3.08 | 5.75āĀ±ā0.31 | 1.50āĀ± 0.27 |
DAS-77 | 80 | 60.11āĀ±ā2.67 | 7.72āĀ±ā0.36 | 40.89āĀ±ā1.35 | 84.11 Ā±ā3.25 | 2.18āĀ±ā0.15 | 1.61āĀ± 0.15 | 0.24āĀ±ā0.04 | 0.70āĀ± 0.08 | 2.36āĀ±ā0.34 | 85.33 Ā±ā5.54 | 20.11āĀ±ā2.57 | 58.56 Ā±ā5.26 | 26.67āĀ±ā1.62 | 5.22āĀ±ā0.15 | 1.44āĀ±ā0.18 |
DAS-77 | 400 | 54.50āĀ±ā1.05 | 7.41āĀ±ā0.52 | 39.00āĀ±ā1.60 | 85.38āĀ±ā3.69 | 2.25āĀ±ā0.33 | 1.61āĀ±ā0.32 | 0.70āĀ± 0.16 | 0.68āĀ±ā0.13 | 1.84āĀ±ā0.28 | 97.75āĀ±ā10.75 | 25.69 Ā±ā3.09 | 51.50āĀ±ā4.05 | 33.63āĀ±ā2.06 | 5.38āĀ±ā0.26 | 1.50āĀ±ā0.38 |
DAS-77 | 2000 | 55.50āĀ±ā2.05 | 7.12āĀ±ā0.31 | 38.50āĀ±ā1.34 | 84.67 Ā±ā6.04 | 1.90 Ā±ā0.24 | 1.10āĀ± 0.18 | 0.47āĀ±ā0.09 | 0.70āĀ± 0.10 | 2.03āĀ±ā0.48 | 111.20āĀ±ā13.20 | 29.50 Ā±ā3.47 | 74.50āĀ± 11.22 | 35.33āĀ±ā4.55 | 5.17āĀ±ā0.17 | 1.00āĀ±ā.00 |