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Table 1 Effect of VBME at 100, 200 and 300mg/kg i.p. in yeast induced pyrexia

From: Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant

Treatment Dosemg/kg Rectal temperature (°C)
After administration of drug
Normal (A) after 24h (B) 1h (C1) 2h (C2) 3h (C3) 4h (C4) 5h (C5)
Saline 10mL 36.66 ± 0.11 38.92 ± 0.34 38.82 ± 0.21 38.78 ± 0.11 38.68 ± 0.20 38. 68 ± 0.20 38.72 ± 0.15
Paracetamol 150mg 37.08 ± 0.08 39.46 ± 0.04 38.20** ± 0.01 37.80** ± 0.03 37.30** ± 0.02 37.35 ** ± 0.28 37.38** ± 0.04
VBME 100mg 37.06 ± 0.02 39.70 ± 0.43 39.44 ± 0.22 38.98* ± 0.22 38.04** ± 0.11 38.16** ± 0.12 38.22** ± 0.11
  200 37.00 ± 0.14 39.00 ± 0.11 38.68 ± 0.02 38.40*s ± 0.25 37.72** ± 0.45 37.80** ± 0.11 37.85 ± 0.41
  300 37.02 ± 0.12 39.84 ± 0.20 39.30 ± 0.31 38.70* ± 0.12 37.64** ± 0.44 37.74** ± 0.10 37.80** ± 0.23
  1. Data are reported as mean ± S.E.M. for group of six animals. The data was analyzed by ANOVA followed by Dunnett’s test. Asterisks indicated statistically significant values from control. *P < 0.05, **P < 0.01.