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Table 9 Semi-quantitative histological analysis on effect of drug intervention against liver fibrosis induced by CCl 4 in rats(n = 7, x ¯ ± s )

From: A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats

Group Hepatocyte death Inflammatory cell infiltration Fibrosis Combined score
Normal 0.8 ± 0.3 0.3 ± 0.2 0.3 ± 0.2 0.5 ± 0.1
Model 5.6 ± 0.9 3.9 ± 0.4 3.3 ± 0.6 4.8 ± 0.7
Sylimarin 3.9 ± 0.2* 2.8 ± 0.6* 2.3 ± 0.6 3.0 ± 0.9*
Berberine 3.5 ± 0.4* 3.1 ± 0.4 2.0 ± 0.5* 3.0 ± 0.6*
CRAE 3.8 ± 0.4* 3.0 ± 0.3* 2.1 ± 0.4* 3.2 ± 0.5*
Bear Bile 3.1 ± 0.3** 2.7 ± 0.7* 2.4 ± 0.5 2.8 ± 0.5**
TUDCA 4.3 ± 0.7 3.5 ± 0.4 2.8 ± 0.2 4.1 ± 0.4
  1. p < 0.05 when compared with normal group; p < 0.01 when compared with normal group; *p < 0.05 when compared with model group; **p < 0.01 when compared with model group.