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Table 4 Impact of drug intervention on the animal daily behavior in alcohol fed-induced liver fibrotic rats (n = 7, x ¯ ± s )

From: A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats

Index Body weight (g) Water drinking (mL per rat) feeding (g per rat)
Group dose mg/kg n D35 D42 D49 D56 D35 D42 D49 D56 D35 D42 D49 D56
Normal 7 399 ± 24.8 391 ± 27.6 435 ± 15.4 440 ± 13.9 33.8 ± 8.84 48.1 ± 0.88 42.5 ± 8.84 44.1 ± 0.18 24.5 ± 2.81 30.6 ± 7.78 27.2 ± 2.83 28.5 ± 2.76
Model 7 296 ± 33.6 272 ± 30.1 293 ± 33.8 326 ± 49.4 39.3 ± 5.48 37.0 ± 8.31 37.4 ± 4.40 35.8 ± 15.8 21.8 ± 3.87 17.7 ± 6.74 16.3 ± 6.07 21.7 ± 5.34
Silymarin 150 7 321 ± 33.3 317 ± 47.9** 357 ± 45.4** 378 ± 43.1** 41.3 ± 17.7 49.2 ± 13.0* 55.3 ± 0.47** 56.0 ± 6.66* 24.2 ± 6.08 13.8 ± 8.22 23.4 ± 1.61 25.0 ± 0.08
Berberine 120 7 278 ± 27.1 281 ± 30.7 296 ± 31.3 304 ± 35.8 31.2 ± 5.07 42.5 ± 15.2 34.1 ± 2.79 29.8 ± 3.06 18.0 ± 6.28 14.6 ± 2.31 19.0 ± 6.15 18.1 ± 3.20
CRAE 600 7 287 ± 18.9 280 ± 28.3 303 ± 30.5 316 ± 42.8 36.6 ± 2.88 40.9 ± 7.1 33.4 ± 15.16 37.3 ± 15.8 21.6 ± 3.53 14.9 ± 4.33 16.6 ± 6.61 24.2 ± 18.98
Bear bile 200 7 279 ± 28.0 263 ± 28.3 279 ± 35.4 302 ± 44.8 29.6 ± 6.07 41.5 ± 12.4 31.4 ± 11.20 35.9 ± 11.0 18.6 ± 5.49 21.1 ± 13.6 17.2 ± 5.74 21.4 ± 4.96
TUDCA 20 7 308 ± 48.2 291 ± 56.7 324 ± 30.6 362 ± 30.5 32.5 ± 0.35 42.5 ± 15.9 40.5 ± 7.42 37.0 ± 4.24 19.8 ± 3.32 24.3 ± 11.8 22.3 ± 3.59 20.6 ± 1.31
  1. p < 0.05 when compared with normal group; p < 0.01 when compared with normal group; *p < 0.05 when compared with model group; **p < 0.01 when compared with model group.