Index | Body weight (g) | Water drinking (mL per rat) | feeding (g per rat) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Group | dose mg/kg | n | D35 | D42 | D49 | D56 | D35 | D42 | D49 | D56 | D35 | D42 | D49 | D56 |
Normal | — | 7 | 399 ± 24.8 | 391 ± 27.6 | 435 ± 15.4 | 440 ± 13.9 | 33.8 ± 8.84 | 48.1 ± 0.88 | 42.5 ± 8.84 | 44.1 ± 0.18 | 24.5 ± 2.81 | 30.6 ± 7.78 | 27.2 ± 2.83 | 28.5 ± 2.76 |
Model | — | 7 | 296 ± 33.6△△ | 272 ± 30.1△△ | 293 ± 33.8△△ | 326 ± 49.4△△ | 39.3 ± 5.48 | 37.0 ± 8.31 | 37.4 ± 4.40 | 35.8 ± 15.8 | 21.8 ± 3.87 | 17.7 ± 6.74 | 16.3 ± 6.07 | 21.7 ± 5.34 |
Silymarin | 150 | 7 | 321 ± 33.3 | 317 ± 47.9** | 357 ± 45.4** | 378 ± 43.1** | 41.3 ± 17.7 | 49.2 ± 13.0* | 55.3 ± 0.47** | 56.0 ± 6.66* | 24.2 ± 6.08 | 13.8 ± 8.22 | 23.4 ± 1.61 | 25.0 ± 0.08 |
Berberine | 120 | 7 | 278 ± 27.1 | 281 ± 30.7 | 296 ± 31.3 | 304 ± 35.8 | 31.2 ± 5.07 | 42.5 ± 15.2 | 34.1 ± 2.79 | 29.8 ± 3.06 | 18.0 ± 6.28 | 14.6 ± 2.31 | 19.0 ± 6.15 | 18.1 ± 3.20 |
CRAE | 600 | 7 | 287 ± 18.9 | 280 ± 28.3 | 303 ± 30.5 | 316 ± 42.8 | 36.6 ± 2.88 | 40.9 ± 7.1 | 33.4 ± 15.16 | 37.3 ± 15.8 | 21.6 ± 3.53 | 14.9 ± 4.33 | 16.6 ± 6.61 | 24.2 ± 18.98 |
Bear bile | 200 | 7 | 279 ± 28.0 | 263 ± 28.3 | 279 ± 35.4 | 302 ± 44.8 | 29.6 ± 6.07 | 41.5 ± 12.4 | 31.4 ± 11.20 | 35.9 ± 11.0 | 18.6 ± 5.49 | 21.1 ± 13.6 | 17.2 ± 5.74 | 21.4 ± 4.96 |
TUDCA | 20 | 7 | 308 ± 48.2 | 291 ± 56.7 | 324 ± 30.6 | 362 ± 30.5 | 32.5 ± 0.35 | 42.5 ± 15.9 | 40.5 ± 7.42 | 37.0 ± 4.24 | 19.8 ± 3.32 | 24.3 ± 11.8 | 22.3 ± 3.59 | 20.6 ± 1.31 |