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Table 1 The dose-dependent effect of BB on AST and ALT level in CCl 4 -induced acute liver toxicity in mice (n = 8, x ¯ ± s )

From: A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats

Group N Dose(mg/kg) AST(U/I) ALT(U/I)
normal 8 99.0 ± 15.8 44.6 ± 10.6
CCl4 8 271.3 ± 142.0 209.5 ± 153.9
Silymarin 8 100 133.8 ± 49.9 ** 80.4 ± 40.5 *
BB 8 10 202.5 ± 205.5 237.8 ± 383.2
BB 8 30 123.8 ± 17.7 ** 63.9 ± 49.6 **
BB 8 90 119.0 ± 58.6 * 63.9 ± 37.3 **
BB 8 270 123.8 ± 22.0** 45.5 ± 12.0**
BB 8 810 127.3 ± 56.4 ** 59.3 ± 25.3 **
  1. p < 0.05 when compared with normal group; p < 0.01 when compared with normal group; *p < 0.05 when compared with model group; **p < 0.01 when compared with model group.