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Table 3 Effect of test materials and propanolol (reference control) on heart rate of rats

From: Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models

Group Dose (mg/kg bw.) Heart rate (beat/min)
   Before induction of hypertension After induction of hypertension After treatment of hypertension
Normal - 412 ± 4.3 415 ± 4.1 409 ± 4.5
Untreated control - 399 ± 4.1 535 ± 5.4 570 ± 5.8
Propanolol-treated 10 410 ± 4.4 520 ± 5.5 405 ± 4.4
CUR 1000 411 ± 4.5 530 ± 5.5 530 ± 5.5
  3000 401 ± 4.2 528 ± 5.3 518 ± 5.6
  5000 390 ± 3.9 523 ± 5.4 471 ± 4.3
ZO 1000 420 ± 4.2 526 ± 4.9 499 ± 5.1
  3000 418 ± 4.9 531 ± 5.7 474 ± 5.2
  5000 415 ± 4.6 530 ± 5.5 416 ± 4.1*
AL 1000 403 ± 4.1 544 ± 5.4 431 ± 4.4*
  3000 407 ± 4.3 540 ± 5.6 416 ± 4.3*
  5000 398 ± 3.6 528 ± 5.3 410 ± 4.5*
PC 100 409 ± 4.0 537 ± 5.2 540 ± 5.6
  500 410 ± 4.2 519 ± 5.3 427 ± 4.1*
  1000 420 ± 4.5 509 ± 5.3 419 ± 4.6*
PPF 1000 412 ± 4.5 519 ± 5.2 559 ± 5.8
  2000 398 ± 4.7 534 ± 5.6 544 ± 5.7
  4000 405 ± 4.4 526 ± 5.5 536 ± 5.4
  1. Data are presented as mean ± SEM values
  2. *Statistically significant difference with baseline by paired t-test:
  3. sBP and dBP of ZO-treated group at high dose level (p < 0.001)
  4. sBP and dBP of AL-treated group at all dose levels (p < 0.001)
  5. sBP and dBP of PC-treated group at medium and high dose levels (p < 0.001)