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Table 2 Effect of test materials and propanolol on systolic (sBP) and diastolic (dBP) blood pressure of rats

From: Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models

Group Dose (mg/kg bw.) Blood Pressure (mmHg)
   Before induction of hypertension After induction of hypertension After treatment of hypertension
   sBP dBP sBP dBP sBP dBP
Normal - 118 ± 0.4 81 ± 0.3 120 ± 0.3 82 ± 0.4 120 ± 0.3* 81 ± 0.4*
Untreated control - 119 ± 0.5 80 ± 0.4 178 ± 0.4 128 ± 0.4 181 ± 0.6 137* ± 0.4
Propanolol-treated 10 120 ± 0.6 81 ± 0.3 177 ± 0.4 131 ± 0.5 135 ± 0.4* 95 ± 0.4*
CUR 1000 119 ± 0.5 82 ± 0.3 178 ± 0.3 130 ± 0.4 164 ± 0.4 126 ± 0.3
  3000 119 ± 0.4 79 ± 0.4 180 ± 0.4 131 ± 0.5 152 ± 0.3 121 ± 0.4
  5000 118 ± 0.4 78 ± 0.3 179 ± 0.4 130 ± 0.4 136 ± 0.4* 101 ± 0.4*
ZO 1000 119 ± 0.5 81 ± 0.3 178 ± 0.5 130 ± 0.5 168 ± 0.3 119 ± 0.3
  3000 120 ± 0.5 80 ± 0.3 180 ± 0.4 129 ± 0.5 163 ± 0.5 120 ± 0.5
  5000 120 ± 0.4 81 ± 0.4 181 ± 0.5 128 ± 0.4 162 ± 0.4 119 ± 0.4
AL 1000 121 ± 0.5 79 ± 0.4 180 ± 0.4 131 ± 0.5 155 ± 0.3 109 ± 0.4
  3000 118 ± 0.4 82 ± 0.4 179 ± 0.5 126 ± 0.5 156 ± 0.4 105 ± 0.5
  5000 119 ± 0.3 81 ± 0.3 177 ± 0.4 169 ± 0.4 134 ± 0.4* 98 ± 0.3*
PC 100 117 ± 0.3 79 ± 0.4 180 ± 0.4 127 ± 0.5 180 ± 0.5 126 ± 0.4
  500 118 ± 0.4 81 ± 0.3 177 ± 0.3 129 ± 0.4 170 ± 0.4 122 ± 0.4
  1000 120 ± 0.5 80 ± 0.4 179 ± 0.4 128 ± 0.4 139 ± 0.3* 113 ± 0.4*
PPF 1000 119 ± 0.4 82 ± 0.4 179 ± 0.4 131 ± 0.4 169 ± 0.5 117 ± 0.3
  3000 120 ± 0.5 79 ± 0.4 180 ± 0.5 130 ± 3.3 162 ± 0.4 121 ± 0.4
  4000 119 ± 0.4 80 ± 0.3 181 ± 0.5 128 ± 0.5 162 ± 0.4 120 ± 0.5
  1. Data are presented as mean ± SEM values
  2. *Statistically significant difference with baseline by paired t-test:
  3. sBP and dBP of CUR-treated group at high dose level (p < 0.001)
  4. sBP and dBP of AL-treated group at high dose level (p < 0.001)
  5. sBP and dBP of PC-treated group at high dose level (p < 0.001)
  6. sBP and dBP of propanolol-treated group at high dose level (p < 0.001)