Table 9 Effect of Nuna kadugu on serum electrolytes of experimental Sprague Dawley rats in repeated oral toxicity study
From: Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats
Treatment | Sex | Serum electrolytes (mmol/l) | |||||
|---|---|---|---|---|---|---|---|
Sodium | Potassium | Chloride | Total Calcium | pH | |||
Control (0.5% CMC) | M(n=5) | 136.46±0.59 | 4.68±0.19 | 99.48±1.32 | 2.38±0.02 | 7.35±0.09 | |
F (n=5) | 140.09±0.86 | 4.06±0.10 | 100.94±1.95 | 2.45±0.02 | 7.42±0.13 | ||
MF(n=10) | 138.28±0.78 | 4.37±0.14 | 100.21±1.14 | 2.42±0.02 | 7.39±0.08 | ||
NK | (300 mg/kg p.o/day) | M(n=5) | 139.03±0.73 | 4.40±0.15 | 99.49±1.14 | 2.33±0.08 | 7.41±0.09 |
F (n=5) | 137.76±0.31 | 4.02±0.08 | 99.20±0.49 | 2.47±0.02 | 7.40±0.06 | ||
MF(n=10) | 138.39±0.43 | 4.21±0.10 | 99.34±0.59 | 2.40±0.05 | 7.40±0.05 | ||
(600 mg/kg p.o/day) | M(n=5) | 138.12±0.70 | 4.35±0.12 | 99.53±0.33 | 2.47±0.01 | 7.38±0.11 | |
F (n=5) | 138.03±1.04 | 4.08±0.12 | 100.27±0.53 | 2.38±0.03 | 7.39±0.05 | ||
MF(n=10) | 138.07±0.59 | 4.21±0.09 | 99.90±0.32 | 2.42±0.02 | 7.39±0.06 | ||
(900mg/kg p.o/day) | M(n=5) | 142.58±1.20 | 4.23±0.13 | 102.82±1.09 | 2.41±0.02 | 7.40±0.09 | |
F (n=5) | 134.75±2.47 | 4.19±0.12 | 98.15±1.03 | 2.41±0.05 | 7.36±0.10 | ||
MF(n=10) | 138.67±1.84 | 4.21±0.08 | 100.49±1.05 | 2.41±0.03 | 7.38±0.06 | ||
Satellite group | |||||||
Control (0.5% CMC) | M(n=5) | 147.40±1.68 | 4.25±0.04 | 100.43±1.62 | 2.36±0.07 | 7.39±0.09 | |
F (n=5) | 132.23±6.90 | 4.19±0.05 | 101.02±1.62 | 2.44±0.07 | 7.39±0.04 | ||
MF(n=10) | 139.82±4.19 | 4.22±0.03 | 100.73±1.09 | 2.40±0.05 | 7.39±0.04 | ||
NK (900 mg/kg p.o/day) | M(n=5) | 140.23±1.15 | 4.25±0.07 | 102.02±1.83 | 2.35±0.09 | 7.40±0.13 | |
F (n=5) | 139.57±0.98 | 4.20±0.08 | 99.79±3.32 | 2.42±0.07 | 7.40±0.15 | ||
MF(n=10) | 139.90 ± 0.72 | 4.23± 0.05 | 100.90 ± 1.82 | 2.39± 0.05 | 7.40 ± 0.09 | ||