Table 4 Effect of Nuna kadugu on body weight gain in experimental rats - repeated oral toxicity study
From: Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats
Treatment | Sex |  |  |      (g) |  |  | ||
|---|---|---|---|---|---|---|---|---|
1stWeek | 2stWeek | 3stWeek | 4stWeek | 5thWeek | 6thWeek | |||
Control (0.5% CMC) | M(n=5) | 156.20±6.78 | 171.60±12.41 | 183.80±15.09 | 187.60±14.26 |  |  | |
F (n=5) | 155.4±10.3 | 157±7.75 | 166.6±4.80 | 169.6±4.54 | ||||
MF(n=10) | 155.8±5.82 | 164.3±7.32 | 175.2±8.00 | 178.6±7.67 | ||||
NK | (300 mg/kg p.o/day) | M(n=5) | 159.2±6.64 | 178.6±10.67 | 189.4±14.7 | 193.6±13.92 | ||
F (n=5) | 143.0±2.16 | 148.4±3.64 | 157.4±3.45 | 160.0±3.49 | ||||
MF(n=10) | 151.10±4.26 | 163.50±7.32 | 173.40±8.90 | 176.80±8.78 | ||||
(600 mg/kg p.o/day) | M(n=5) | 144.0±10.46 | 163.2±9.52 | 166.6±10.29 | 177.00±14.90 | |||
F (n=5) | 142.40±10.27 | 159.40±11.85 | 163.00±10.13 | 177.80±11.06 | ||||
MF(n=10) | 143.20±6.89 | 161.30±7.19 | 164.80±6.83 | 177.40±8.74 | ||||
(900 mg/kg p.o/day) | M(n=5) | 149.00±8.91 | 168.60±10.34 | 190.00±12.12 | 195.20±12.24 | |||
F (n=5) | 139.60±5.23 | 146.80±4.67 | 157.20±6.86 | 161.60±6.99 | ||||
MF(n=10) | 144.3±5.11 | 157.7±6.46 | 173.6±8.54 | 178.40±8.68 | ||||
Satellite group | ||||||||
Control (0.5% CMC) | M(n=5) | 141.00±12.54 | 164.80±16.47 | 169.80±17.46 | 174.60±17.57 | 178.40±20.52 | 185.00±18.43 | |
F (n=5) | 139.80±3.63 | 147.80±4.91 | 147.80±4.30 | 148.60±4.17 | 155.80±2.70 | 160.40±2.78 | ||
MF(n=10) | 140.4±6.15 | 156.3±8.66 | 158.8±9.23 | 161.6±9.55 | 167.1±10.46 | 172.7±9.69 | ||
NK (900 mg/kg p.o/day) | M(n=5) | 152.6±11.56 | 170.2±12.50 | 181.2±8.25 | 179.6±13.95 | 182.2±12.85 | 188.2±9.68 | |
F (n=5) | 149.60±8.46 | 164.80±8.35 | 173.00±11.18 | 176.00±10.78 | 179.00±9.55 | 178.60±12.75 | ||
MF(n=10) | 151.1±6.77 | 167.5±7.14 | 177.1±6.69 | 177.8±8.33 | 180.6±7.56 | 183.4±7.77 | ||