Table 11 Effect of Nuna kadugu on relative organ weight of experimental Sprague Dawley rats in repeated oral toxicity study
From: Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats
Treatment | Sex | Relative organ weight (g %) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Brain | Heart | Liver | Spleen | Kidney | Adrenal | Sex organs | ||||
Testis | Ovaries | |||||||||
Control (0.5% CMC) | M (n=5) | 0.99±0.06 | 0.38±0.02 | 3.53±0.22 | 0.47±0.03 | 0.88±0.03 | 0.03±0.00 | 1.07±0.15 | - | |
F (n=5) | 1.05±0.04 | 0.42±0.43 | 4.21±0.35 | 0.49±0.02 | 0.79±0.08 | 0.02±0.00 | - | 0.05±0.01 | ||
MF (n=10) | 1.02±0.03 | 0.40±0.02 | 3.87±0.23 | 0.48±0.02 | 0.84±0.04 | 0.02±0.00 | - | - | ||
NK | (300 mg/kg p.o/day) | M (n=5) | 0.97±0.08 | 0.41±0.01 | 3.70±0.14 | 0.54±0.11 | 0.93±0.06 | 0.02±0.00 | 1.12±0.15 | - |
F (n=5) | 1.10±0.05 | 0.40±0.02 | 3.79±0.28 | 0.42±0.04 | 0.85±0.03 | 0.03±0.00 | - | 0.07±0.01 | ||
MF (n=10) | 1.04±0.05 | 0.40±0.01 | 3.74±0.15 | 0.48±0.06 | 0.89±0.03 | 0.03±0.00 | - | - | ||
(600 mg/kg p.o/day) | M (n=5) | 1.06±0.12 | 0.40±0.03 | 3.99±0.75 | 0.43±0.06 | 0.96±0.15 | 0.02±0.00 | 1.16±0.20 | - | |
F (n=5) | 1.00±0.04 | 0.39±0.03 | 3.45±0.12 | 0.38±0.03 | 0.77±0.03 | 0.02±0.00 | - | 0.05±0.01 | ||
MF (n=10) | 1.03±0.06 | 0.40±0.02 | 3.72±0.37 | 0.40±0.03 | 0.86±0.08 | 0.02±0.00 | - | - | ||
(900mg/kg p.o/day) | M (n=5) | 0.97±0.06 | 0.38±0.02 | 3.63±0.41 | 0.48±0.04 | 0.84±0.03 | 0.02±0.00 | 1.11±0.16 | - | |
F (n=5) | 1.14±0.04 | 0.40±0.01 | 3.90±0.19 | 0.52±0.06 | 0.85±0.02 | 0.03±0.00 | - | 0.06±0.01 | ||
MF (n=10) | 1.05±0.05 | 0.39±0.01 | 3.76±0.22 | 0.50±0.03 | 0.84±0.02 | 0.03±0.00 | - | - | ||
Satellite group | ||||||||||
Control (0.5% CMC) | M (n=5) | 1.03±0.10 | 0.41±0.02 | 3.93±0.26 | 0.41±0.03 | 0.83±0.05 | 0.03±0.00 | 1.07±0.19 | - | |
F (n=5) | 1.08±0.04 | 0.36±0.01 | 3.91±0.25 | 0.46±0.05 | 0.84±0.04 | 0.03±0.00 | - | 0.07±0.01 | ||
MF (n=10) | 1.05±0.05 | 0.39±0.01 | 3.92±0.17 | 0.44±0.03 | 0.83±0.03 | 0.03±0.00 | - | - | ||
NK (900 mg/kg p.o/day) | M (n=5) | 0.99±0.04 | 0.41±0.04 | 4.06±0.27 | 0.49±0.03 | 0.89±0.04 | 0.03±0.00 | 1.07±0.12 | - | |
F (n=5) | 1.02±0.03 | 0.39±0.04 | 3.41±0.44 | 0.39±0.04 | 0.77±0.07 | 0.03±0.00 | - | 0.07±0.01 | ||
MF (n=10) | 1.02±0.02 | 0.40±0.03 | 3.74±0.27 | 0.44±0.03 | 0.83±0.04 | 0.03±0.00 | - | - | ||