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Table 2 Genotoxicity induced by extracts from D. gnidium leaves

From: Antioxidant, genotoxic and antigenotoxic activities of daphne gnidium leaf extracts

Extracts Dose (μg/assay) β-gal (UE) PA (UE) IF
Nitrofurantoin 5 42,18 ± 0,092 11,19 ± 0,0021 23,56
NC 0 2,28 ± 0,031 11,27 ± 0,017 1
Petroleum ether extract 50 2,26 ± 0,043 13,95 ± 0,017 0,81
  250 1,96 ± 0,002 14,35 ± 0 0,68
  500 2,13 ± 0,012 13,51 ± 0,01 0,79
Chloroform extract 50 1,27 ± 0,004 8,13 ± 0,016 0,62
  250 1,52 ± 0,002 8,73 ± 0,007 0,69
  500 3,28 ± 0,015 11,27 ± 0 1,16
Ethyl acetate extract 5 0,83 ± 0,001 5,11 ± 0,002 0,73
  15 0,80 ± 0 6,05 ± 0,017 0,60
  30 1,37 ± 0,002 8,15 ± 0,026 0,76
Methanol extract 50 0,71 ± 0,041 5,45 ± 0,003 0,59
  100 0,88 ± 0,004 5,92 ± 0,009 0,68
  200 1,31 ± 0,003 6,58 ± 0,017 0,90
TOF extract 5 1,88 ± 0 5,89 ± 0,003 2
  15 1,81 ± 0,002 7,98 ± 0,024 1,4
  30 1,35 ± 0,004 6,58 ± 0,024 1,28
  1. β-gal: units of β-galactosidase; AP: units of phosphatase alkaline; IF: induction factor.
  2. Positive control of genotoxicity (nitrofurantoin); NC: negative control (non-treated cells).