Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice

Table 1 Survival of untreated diabetic mice and diabetic mice treated with WSDP or EEP

Experimental group	Range of survival (days)	Median ± SD	ILS%^c	T/C%^c	Long-term survivors (LTS)^f
Diabetic mice^a	15-45	38.5 ± 13.12	-	-	3
Diabetic mice + (0.5% EtOH)	22-45	42 ± 9.68	-	-	4
Diabetic mice + WSDP^b	45	45*	30.43	130.43	8
Diabetic mice + EEP^b	45	45*	20,67	120,67	8

^aDiabetic mice; injected iv with alloxan in a single dose of 75 mg kg^-1 body weight and served as untreated diabetic group. Untreated diabetic mice received 0.5 mL physiological solution or 0.5% ethanolic solution intraperitonealy (ip) for 7 consecutive days starting starting 2 days after aloxan injection.
^bDiabetic mice treated with WSDP or EEP ip in a daily dose of 50 mg kg^-1 for 7 days starting 2 days after alloxan injection.
^cILS% (increased life span%) = (T-C)/Cx100. T, mean survival time of treated diabetic group; C, mean survival time of untreated diabetic group.
^dT/C treated diabetic animals versus untreated diabetic animals.
^eLTS- Long-term survivors; mice surviving more than 45 days after alloxan treatment.
Results are expressed as the means of each group (n = 8) of and are representative of two independent experiments.
*Statistically significant difference between WSDP or EEP treated diabetic mice and untreated diabetic animals (*P <0.05; Log-Rank test).

ISSN: 2662-7671