Figure 3

Effects of PA on the activities of histone demethylases. (A) Effects of PA, apocynin or 2,4-PDCA on histone demethylase JMJD2A activity. IC₅₀ values are mean ± SEM of three separate experiments. (B) Effects of PA, apocynin or 2,4-PDCA on histone demethylase JMJD2B activity. IC₅₀ values are mean ± SEM of three separate experiments. (C) Effects of PA, apocynin or 2,4-PDCA on histone demethylase JMJD2C activity. IC₅₀ values are mean ± SEM of three separate experiments. (D) Effects of PA or apocynin on the activities of lysine-specific demethylase LSD1, histone deacetylase HDAC1 and HDAC8. Values are mean ± SEM (n = 4). Data are expressed as a percentage of the control value in each experiment.