Figure 1
Airway responsiveness methods. Pulmonary airflow resistance (R L ) was measured in response to increasing doses of intravenous methacholine (Mch). Using the resulting RL-Mch dose-response curve, indices of airway reactivity (Slope RL), airway sensitivity, the lowest dose producing bronchoconstriction (Break RL) and the maximal degree of bronchoconstriction (Max RL) were measured (repeated measures ANOVA with a Mauchly post-hoc test, sensitized vs. unsensitized; **P < 0.01).