Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects

Table 1 Effect of Acorus calamus on tissue biomarker changes

Groups	Reduction of NBT (pmol/min/mg of protein)	Total Calcium (ppm/mg of protein)	MPO activity level (U/min/mg of protein)
Normal	3.38 ± 1.18	3.92 ± 1.12	10.12 ± 1.04
Sham	3.42 ± 1.45	3.35 ± 0.73	12.37 ± 1.83
CCI	21.56 ± 1.26 ^a	33.43 ± 1.51 ^a	165.24 ± 3.89 ^a
CCI + vehicle	22.88 ±1.69 ^a	37.36 ± 1.38 ^a	159.63 ± 4.01 ^a
AC (200) per se	3.40 ± 1.19	3.57 ± 0.64	11.94 ± 1.09
Pregabalin (10) per se	3.38 ± 1.23	3.25 ± 1.17	12.08 ± 0.92
CCI + AC (100)	7.49 ± 1.18 ^b	11.26 ± 1.61 ^b	47.36 ± 4.13 ^b
CCI + AC (200)	5.84 ± 1.07 ^b	8.59 ± 1.34 ^b	38.65 ± 3.36 ^b
CCI + Pregabalin (10)	3.27 ± 0.19 ^b	4.43 ± 1.91 ^b	13.14 ± 1.21 ^b

Digits in parentheses indicate the dose of Acorus calamus and pregabalin in mg/kg.
Data expressed as mean ± standard error of mean (SEM), each group consist of six (n = 6) Wistar rat.
^a p < 0.05 vs sham control group.
^b p < 0.05 vs CCI control group.

ISSN: 2662-7671