Fig. 6

CK inhibited the growth of tumors in nude mice, and CK regulated ferroptosis in tumor tissues by p-FOXO1. (A) The tumor growth inhibition rate (%) of nude mice in the indicated groups; (B) The tumor volume (cm³) of nude mice; (C) The weight of tumors (g) in nude mice; (D) Immunohistochemical staining was used to detect the effects of CK (5, 10, 20 mg/kg) on GPX4 and SLC7A11 protein expression in tumors derived from nude mice inoculated with HepG2 cells (400×); (E) Western blot analysis of tumors from the indicated groups. ^**P < 0.01, ^***P < 0.001, compared with the vehicle group. Pairwise comparison between groups was performed by t-test