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  1. Research article

    Thymoquinone (TQ) inhibits the replication of intracellular Mycobacterium tuberculosis in macrophages and modulates nitric oxide production

    Human tuberculosis, which is caused by the pathogen Mycobacterium tuberculosis, remains a major public health concern. Increasing drug resistance poses a threat of disease resurgence and continues to cause consid...

    Hafij Al Mahmud, Hoonhee Seo, Sukyung Kim, Md Imtiazul Islam, Kung-Woo Nam, Hyun-Deuk Cho and Ho-Yeon Song

    BMC Complementary and Alternative Medicine 2017 17:279

    Published on: 25 May 2017

  2. Research article

    Investigation of antioxidant, antimicrobial and toxicity activities of lichens from high altitude regions of Nepal

    Several lichen species are reported to be used tradiationally in many theraupatic practices. Many lichen species are reported as sources of several bioactive natural compounds. Several lichen species of Nepal ...

    Baidya Nath Jha, Mitesh Shrestha, Durga Prasad Pandey, Tribikram Bhattarai, Hari Datta Bhattarai and Babita Paudel

    BMC Complementary and Alternative Medicine 2017 17:282

    Published on: 25 May 2017

  3. Research article

    Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells

    Cancer still constitutes one of the major health concerns globally, causing serious threats on patients, their families, and the healthcare system.

    Victor Kuete, Fabrice W. Fokou, Oğuzhan Karaosmanoğlu, Veronique P. Beng and Hülya Sivas

    BMC Complementary and Alternative Medicine 2017 17:280

    Published on: 25 May 2017

  4. Research article

    Urinary metabolomics study on the protective role of Orthosiphon stamineus in Streptozotocin induced diabetes mellitus in rats via 1H NMR spectroscopy

    Orthosiphon stamineus (OS) is a herb known in ethnomedicine for treating diabetes mellitus (DM). In this study, a 1H NMR based urine metabolomics tool has been used for the first time ...

    Amalina Ahmad Azam, Raghunath Pariyani, Intan Safinar Ismail, Amin Ismail, Alfi Khatib, Faridah Abas and Khozirah Shaari

    BMC Complementary and Alternative Medicine 2017 17:278

    Published on: 25 May 2017

  5. Research article

    What intrinsic factors influence responsiveness to acupuncture in pain?: a review of pre-clinical studies that used responder analysis

    Not many studies have investigated individual sensitivity to acupuncture. To explore the intrinsic factors related to individual responses to acupuncture, we reviewed published pre-clinical studies using respo...

    Yu-Kang Kim, Ji-Yeun Park, Seung-Nam Kim, Mijung Yeom, Seungmin Lee, Ju-Young Oh, Hyangsook Lee, Younbyoung Chae, Dae-Hyun Hahm and Hi-Joon Park

    BMC Complementary and Alternative Medicine 2017 17:281

    Published on: 25 May 2017

  6. Research article

    Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell

    Ovarian cancer is one of the major causes of death among females in worldwide. Cisplatin is a primary anti-cancer drug against ovarian cancer, but the recurrent tumors after treatment frequently show acquired ...

    Bo Yoon Choi, Jong Cheon Joo, Yeon Kyu Lee, Ik-Soon Jang, Soo Jung Park and Yoon Jung Park

    BMC Complementary and Alternative Medicine 2017 17:277

    Published on: 25 May 2017

  7. Research article

    A multi-target therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory and analgesic properties.

    Phytotherapeutics exhibit diverse pharmacological effects that are based on the combined action of a mixture of phytoconstituents. In this study, Prunus domestica gum-loaded, stabilized gold and silver nanopartic...

    Nazar Ul Islam, Raza Amin, Muhammad Shahid, Muhammad Amin, Sumera Zaib and Jamshed Iqbal

    BMC Complementary and Alternative Medicine 2017 17:276

    Published on: 23 May 2017

  8. Research article

    In vivo effect of Commiphora swynnertonii ethanolic extracts on Trypanosoma congolense and selected immunological components in mice

    The search for alternative trypanocidal compounds which can be available at affordable price is of paramount importance for control of trypanosomosis in human and animals. The current study evaluates the in vi...

    Yakob P. Nagagi, Richard S. Silayo, Claudius Luziga and Eliningaya J. Kweka

    BMC Complementary and Alternative Medicine 2017 17:275

    Published on: 23 May 2017

  9. Research article

    Hemodynamic changes caused by acupuncture in healthy volunteers: a prospective, single-arm exploratory clinical study

    Radial pressure pulse wave (RPPW) examination has been a key diagnostic component of traditional Chinese medicine. The objective of this study was to investigate the changes in RPPW along with various hemodyna...

    Tae-Hun Kim, Boncho Ku, Jang-Han Bae, Jae-Young Shin, Min-Ho Jun, Jung Won Kang, Junghwan Kim, Jun-Hwan Lee and Jaeuk U. Kim

    BMC Complementary and Alternative Medicine 2017 17:274

    Published on: 22 May 2017

  10. Research article

    Antiviral activity of phenanthrenes from the medicinal plant Bletilla striata against influenza A virus

    Influenza represents a serious public health concern. The emergence of resistance to anti-influenza drugs underlines the need to develop new drugs. This study aimed to evaluate the anti-influenza viral activit...

    Ya Shi, Bing Zhang, Yiyu Lu, Chaodong Qian, Yan Feng, Liwei Fang, Zhishan Ding and Dongqing Cheng

    BMC Complementary and Alternative Medicine 2017 17:273

    Published on: 22 May 2017

  11. Research article

    Patient needs and preferences for herb-drug-disease interaction alerts: a structured interview study

    While complementary and alternative medicine (CAM) is commonly used in the United States and elsewhere, and hazardous interactions with prescription drugs can occur, patients do not regularly communicate with ...

    Carrie M. Christensen, Rebecca S. Morris, Seraphine Chepkemoi Kapsandoy, Melissa Archer, Jinqiu Kuang, Laura Shane-McWhorter, Bruce E. Bray and Qing Zeng-Treitler

    BMC Complementary and Alternative Medicine 2017 17:272

    Published on: 19 May 2017

  12. Research article

    Methanol extract of Dicranopteris linearis L. leaves impedes acetaminophen-induced liver intoxication partly by enhancing the endogenous antioxidant system

    The present study investigated the potential of methanolic extract of Dicranopteris linearis (MEDL) leaves to attenuate liver intoxication induced by acetaminophen (APAP) in rats.

    Zainul Amiruddin Zakaria, Farah Hidayah Kamisan, Maizatul Hasyima Omar, Nur Diyana Mahmood, Fezah Othman, Siti Selina Abdul Hamid and Muhammad Nazrul Hakim Abdullah

    BMC Complementary and Alternative Medicine 2017 17:271

    Published on: 18 May 2017

  13. Research article

    Practitioners’ perspectives on evaluating treatment outcomes in traditional Chinese medicine

    There are no generally accepted standards for evaluation of treatment outcomes in traditional Chinese medicine (TCM). Pattern differentiation and individual treatments are recognized as the most distinguishing...

    Yan-Hong Zhang, Jing Lv, Wei Gao, Jun Li, Ji-Qian Fang, Li-Yun He and Bao-Yan Liu

    BMC Complementary and Alternative Medicine 2017 17:269

    Published on: 18 May 2017

  14. Research article

    Antioxidant activity, acetylcholinesterase inhibitory potential and phytochemical analysis of Sarcocephalus latifolius Sm. bark used in traditional medicine in Sudan

    Sarcocephalus latifolius is used as a traditional medicine for curing many diseases in Sudan. The main objective of the current study was to determine the antioxidant activity and acet...

    Alsiddig Osama, Sufyan Awadelkarim and Amna Ali

    BMC Complementary and Alternative Medicine 2017 17:270

    Published on: 18 May 2017

  15. Research article

    Membrane of Candida albicans as a target of berberine

    We investigated the mechanisms of anti-Candida action of isoquinoline alkaloid berberine, active constituent of medically important plants of Barberry species.

    Nataša Zorić, Ivan Kosalec, Siniša Tomić, Ivan Bobnjarić, Mario Jug, Toni Vlainić and Josipa Vlainić

    BMC Complementary and Alternative Medicine 2017 17:268

    Published on: 17 May 2017

  16. Research article

    A new, easy-to-make pectin-honey hydrogel enhances wound healing in rats

    Honey, alone or in combination, has been used for wound healing since ancient times and has reemerged as a topic of interest in the last decade. Pectin has recently been investigated for its use in various bio...

    Gessica Giusto, Cristina Vercelli, Francesco Comino, Vittorio Caramello, Massimiliano Tursi and Marco Gandini

    BMC Complementary and Alternative Medicine 2017 17:266

    Published on: 16 May 2017

  17. Research article

    Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L. (Euphorbiaceae) leaves in experimental rats

    The medicinal plants signify a massive basin of potential phytoconstituents that could be valuable as a substitute to allopathic drugs or considered as an analogue in drug development. Phyllanthus niruri L. (Euph...

    Ronia Mostofa, Shanta Ahmed, Mst. Marium Begum, Md. Sohanur Rahman, Taslima Begum, Siraj Uddin Ahmed, Riazul Haque Tuhin, Munny Das, Amir Hossain, Manju Sharma and Rayhana Begum

    BMC Complementary and Alternative Medicine 2017 17:267

    Published on: 16 May 2017

  18. Research article

    Chinese herbal Pulian ointment in treating psoriasis vulgaris of blood-heat syndrome: a multi-center, double-blind, randomized, placebo-controlled trial

    Traditional Chinese medicine (TCM) has a long history in the treatment of psoriasis vulgaris. We aimed to evaluate the clinical efficacy and safety of Chinese herbal Pulian ointment in treating psoriasis vulga...

    Nuo Li, Wenbin Zhao, Jianmin Xing, Jianping Liu, Guangzhong Zhang, Yunbi Zhang, Yuanwen Li, Wali Liu, Fei Shi and Yanping Bai

    BMC Complementary and Alternative Medicine 2017 17:264

    Published on: 15 May 2017

  19. Research article

    Detection of antibacterial activities of Miswak, Kalonji and Aloe vera against oral pathogens & anti-proliferative activity against cancer cell line

    Emerging drug resistance and hindrance of treatment is provoking scientists to search new, less expensive medicinally active compounds. Dental diseases caused by oral pathogens are very frequent chronic infect...

    Sameen Amjed, Kashaf Junaid, Junaid Jafar, Tuaha Amjad, Waqas Maqsood, Nadia Mukhtar, Kanza Tariq, Musarrat Sharif, Sana Javaid Awan and Farheen Ansari

    BMC Complementary and Alternative Medicine 2017 17:265

    Published on: 15 May 2017

  20. Research article

    The effectiveness of long-needle acupuncture at acupoints BL30 and BL35 for CP/CPPS: a randomized controlled pilot study

    The chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the commonest chronic inflammatory diseases in adult men, for which acupuncture has been used to relieve related symptoms. The present s...

    Minjie Zhou, Mingyue Yang, Lei Chen, Chao Yu, Wei Zhang, Jun Ji, Chi Chen, Xueyong Shen and Jian Ying

    BMC Complementary and Alternative Medicine 2017 17:263

    Published on: 12 May 2017

  21. Research article

    Direct and indirect risk associated with the use of dietary supplements among persons with dementia in a Norwegian memory clinic

    The use of dietary supplements (DS) is common among persons with dementia. Direct risks associated with DS use include adverse events and DS-drug interactions. A direct risk is a risk caused by the treatment i...

    Hilde Risvoll, Trude Giverhaug, Kjell H. Halvorsen, Marit Waaseth and Frauke Musial

    BMC Complementary and Alternative Medicine 2017 17:261

    Published on: 12 May 2017

  22. Research article

    "Placebo effect is probably what we refer to as patient healing power": A qualitative pilot study examining how Norwegian complementary therapists reflect on their practice

    Complementary therapists spend considerable time with their patients, especially in the first consultation. The communication between patients and their therapists is important for raising consciousness and ac...

    Trine Stub, Nina Foss and Ingrid Liodden

    BMC Complementary and Alternative Medicine 2017 17:262

    Published on: 12 May 2017

  23. Research article

    Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

    Valproic acid (VPA) is used as a first-line antiepileptic agent and is undergoing clinical trials for use as a treatment for many disorders. Mothers undergoing VPA treatment during early pregnancy reportedly s...

    Maha Al-Askar, Ramesa Shafi Bhat, Manar Selim, Laila Al-Ayadhi and Afaf El-Ansary

    BMC Complementary and Alternative Medicine 2017 17:259

    Published on: 10 May 2017

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