Table 1 Naranjo ADR probability scale score for the association of Catharanthus roseus and its intoxication
From: Catharanthus roseus intoxication mimicking acute cholangitis
Question | Â | Yes | No | Do Not Know | Score |
|---|---|---|---|---|---|
1. Are there previous conclusive reports on this reaction? |  | + 1 | 0 | 0 | + 1 |
2. Did the adverse event appear after the suspected drug was administered? |  | + 2 | -1 | 0 | + 2 |
3. Did the adverse event improve when the drug was discontinued or a specific antagonist was administered? |  | + 1 | 0 | 0 | + 1 |
4. Did the adverse event reappear when the drug was readministered? |  | + 2 | -1 | 0 | 0 |
5. Are there alternative causes that could on their own have caused the reaction? |  | -1 | + 2 | 0 | + 2 |
6. Did the reaction reappear when a placebo was given? |  | -1 | + 1 | 0 | 0 |
7. Was the drug detected in blood or other fluids in concentrations known to be toxic? |  | + 1 | 0 | 0 | 0 |
8. Was the reaction more severe when the dose was increased or less severe when the dose was decreased? |  | + 1 | 0 | 0 | 0 |
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure? |  | + 1 | 0 | 0 | 0 |
10. Was the adverse event confirmed by any objective evidence? |  | + 1 | 0 | 0 | 0 |
| Â | Â | Total Score: 6 | |||