Compounds | Absorption | Distribution | Metabolism | Excretion | Toxicity | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Caco-2-Perm | Pgp-inhibitor | Pgp-substrate | HIA | PPB (%) | VD | BBB-Penetration | Inhibitor | Substrate | CL | hERG-Blockers | H-HT | Carcin | |
Rutin | -6.47 | 0.005 | 0.997 | 0.876 | 87.1 | 0.701 | 0.041 | CYP3A4, CYP1A2, CYP2C19, CYP2D6, CYP2C9 | CYP2C9, CYP1A2, CYP2C1,9, CYP3A4, CYP2D6, | 1.50 | 0.227 | 0.083 | 0.055 |
Quercetin | -5.20 |  < 0.100 |  < 0.100 |  < 0.100 | 95.5 | 0.580 |  < 0.100 | CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4 | CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 | 8.28 |  < 0.100 |  < 0.100 |  < 0.100 |