Fig. 8

Comparative growth curves representing the drugs augmenting efficacy of punicalagin against S. typhi. A Time kill curves of S. typhi for Aztreonam with and without punicalagin. Blue: Growth control, no aztreonam/punicalagin; Red: punicalagin (30 μg/mL); Grey: Sub-inhibitory concentration of aztreonam (3.75 μg/mL); Yellow: Sub-inhibitory concentration of ATM (3.75 μg/mL) with punicalagin (30 μg/mL), (B) Time kill curves of S. typhi for amoxicillin clavulanic acid with and without punicalagin. Blue: Growth control, no amoxicillin clavulanic acid/punicalagin; Red; punicalagin (30 μg/mL); Grey: Sub-inhibitory concentration of amoxicillin clavulanic a (1.8 μg/mL); Yellow: sub-inhibitory concentration of amoxicillin clavulanic acid (1.8 μg/mL) with punicalagin (30 μg/mL), (C) Time kill curves of S. typhi for ampicillin with and without punicalagin. Blue: Growth control, no ampicillin/punicalagin; Red: punicalagin (100 μg/mL); Grey: Sub-inhibitory concentration of ampicillin (0.3 μg/mL); Yellow: sub-inhibitory concentration of ampicillin (0.3 μg/mL) with punicalagin (100 μg/mL), (D) Time kill curves of S. typhi for ceftriaxone with and without punicalagin. Blue: Growth control, no ceftriaxone/punicalagin; Red: punicalagin (500 μg/mL); Grey: Sub-inhibitory concentration of ceftriaxone (3.75 μg/mL); Yellow: sub-inhibitory concentration of ceftriaxone (3.75 μg/mL) with punicalagin (500 μg/mL)