Single and combined treatment with chemotherapeutic drugs and MF | SW1116 | ||
IC50 (M)a | Sensitization ratiob | Pc values | |
CPT (128× 10−11- 1× 10−4 M) | 2.0 × 10−5 | - | |
CPT (128× 10−11 - 1× 10−4 M) + MF (1.5 mM) | 21 × 10−8 | 95.0 | 0.025 |
5FU (89.6× 10−10- 0.7× 10−3 M) | 8.83 × 10−6 | - | |
5FU (89.6× 10−10- 0.7× 10−3 M) + MF (1.5 mM) | 84 × 10−10 | 1051 | 0.025 |
DOX (110× 10−12 - 0.86× 10−5 M) | 0.43 × 10−4 | - | |
DOX (110× 10−12 - 0.86× 10−5) + MF (1.5 mM) | 3.44 × 10−7 | 125 | 0.081 |
TAX (94× 10−11- 1.47× 10−4 M) | 1.47 × 10−4 | - | |
TAX (94× 10−11- 1.47× 10−4 M) + MF (1.5 mM) | 5.72 × 10−6 | 26 | 0.183 |
VBL (3.84× 10−11 - 0.03× 10−4 M) | 0.22 × 10−8 | - | |
VBL (3.84× 10−11 - 0.03× 10−4 M) + MF (1.5 mM) | 3.52 × 10−11 | 62.55 | 0.326 |
VCR (3.84× 10−11 - 0.03× 10−4 M) | 0.4 × 10−8 | - | |
VCR (3.84× 10−11 - 0.03× 10−4 M) + MF (1.5 mM) | 3.15 × 10−11 | 254 | 0.079 |
ETP (5.12× 10−10 - 0.04× 10−3M) | 1.19 × 10−6 | - | |
ETP (5.12× 10−10 - 0.04× 10−3M) + MF (1.5 mM) | 5.4 × 10−10 | 2204 | 0.026 |
ELP (2.56× 10−10 - 0.02× 10−3M) | 0.06 × 10−4 | - | |
ELP (2.56× 10−10 - 0.02× 10−3M) + MF (1.5 mM) | 1.3 × 10−9 | 4615 | 0.001 |
AMS (1.28× 10−10- 0.01× 10−3M) | 0.013 × 10−3 | - | |
AMS (1.28× 10−10- 0.01× 10−3M) + MF (1.5 mM) | 0.2 × 10−7 | 650 | 0.001 |
HHG (25.6× 10−12 – 0.2× 10−5M) | 2.0 × 10−7 | - | |
HHG (25.6× 10−12 – 0.2× 10−5M) + MF (1.5 mM) | 3 × 10−9 | 67 | 0.010 |
Single and combined treatment with chemotherapeutic drugs and MF | SW837 | ||
IC50 (M)a | Sensitization ratiob | Pc values | |
CPT (128× 10−11- 1× 10−4 M) | 5 × 10−5 | - | |
CPT (128 × 10−11- 1× 10−4 M) + MF (1.5 mM) | 4 × 10−6 | 12.5 | 0.012 |
5FU (89.6× 10−10- 0.7× 10−3 M) | 0.7 × 10−3 | - | |
5FU (89.6× 10−10- 0.7× 10−3 M) + MF (1.5 mM) | 2.6 × 10−5 | 269 | 0.001 |
DOX (110× 10−12 - 0.86× 10−5 M) | 3.44 × 10−6 | - | |
DOX (110× 10−12 - 0.86× 10−5) + MF (1.5 mM) | 27.5 × 10−8 | 12.5 | 0.005 |
TAX (94× 10−11- 1.47× 10−4 M) | 1.47 × 10−4 | - | |
TAX (94× 10−11- 1.47× 10−4 M) + MF (1.5 mM) | 5.86 × 10−6 | 25 | 0.045 |
VBL (3.84× 10−11 - 0.03× 10−4 M) | 0.11 × 10−6 | - | |
VBL (3.84× 10−11 - 0.03× 10−4 M) + MF (1.5 mM) | 0.44 × 10−8 | 25 | 0.060 |
VCR (3.84× 10−11 - 0.03× 10−4 M) | 0.2 × 10−7 | - | |
VCR (3.84× 10−11 - 0.03× 10−4 M) + MF (1.5 mM) | 2.4 × 10−9 | 8.33 | 0.119 |
ETP (5.12× 10−10 - 0.04× 10−3M | 0.18 × 10−4 | - | |
ETP (5.12× 10−10 - 0.04× 10−3M) + MF (1.5 mM) | 0.51 × 10−6 | 35 | 0.003 |
ELP (2.56× 10−10 - 0.02× 10−3M) | 0.02 × 10−3 | - | |
ELP (2.56× 10−10 - 0.02× 10−3M) + MF (1.5 mM) | 0.32 × 10−7 | 625 | 0.001 |
HHG (25.6× 10−12 – 0.2× 10−5M) | 0.6 × 10−6 | - | |
HHG (25.6× 10−12 – 0.2× 10−5M) + MF (1.5 mM) | 2.25 × 10−8 | 27 | 0.012 |