Table 2 Analgesic effects of crude alkaloids and standard drugs using tail flick method

Control (2 % Tween 80)

0.78 ± 1.30

0.88 ± 1.21

0.98 ± 1.021

0.86 ± 1.025

0.92 ± 1.401

Wf Cr.A 50 mg

1.01 ± 1.12* (22.70 %)

1.38 ± 1.112* (36.23 %)

1.68 ± 1.131** (41.66 %)

2.41 ± 1.163*** (64.31 %)

2.15 ± 1.138*** (57.20 %)

Av Cr.A 50 mg

0.92 ± 1.20 (15.21 %)

1.14 ± 1.411* (22.52 %)

1.41 ± 1.161** (30.49 %)

1.65 ± 1.206*** (47.87 %)

1.57 ± 1.282*** (41.40 %)

Ca Cr.A 50 mg

0.89 ± 1.30 (12.35 %)

1.09 ± 1.411* (19.85 %)

1.35 ± 1.161** (27.40 %)

1.53 ± 1.226*** (43.79 %)

1.49 ± 1.218*** (38.25 %)

Vn Cr.A 50 mg

0.90 ± 1.10 (13.81 %)

1.12 ± 1.521* (21.75 %)

1.38 ± 1.611** (28.98 %)

1.55 ± 1.261*** (44.69 %)

1.51 ± 1.618*** (39.27 %)

Ph Cr.A 50 mg

0.97 ± 0.82 (19.58 %)*

1.23 ± 1.135* (28.45 %)

1.70 ± 1.141** (42.35 %)

2.33 ± 1.133** (63.09 %)

2.04 ± 1.123** (54.90 %)

Bp Cr.A 50 mg

0.90 ± 0.97 (13.81 %)

1.11 ± 1.411* (20.42 %)

1.37 ± 1.261** (28.46 %)

1.57 ± 1.237*** (45.22 %)

1.53 ± 1.218*** (39.90 %)

Standard (Morphine 5 mg)

1.54 ± 1.24** (49.35 %)

2.11 ± 1.066** (58.29 %)

4.52 ± 1.038*** (78.31 %)

4.98 ± 1.309*** (82.70 %)

4.74 ± 1.074*** (80.59 %)

Wf Cr.A (50 mg) + Naloxone (2 mg)

0.82 ± 0.83

0.81 ± 1.165

0.93 ± 1.049

0.87 ± 1.029

0.83 ± 1.461

Av Cr.A (50 mg) + Naloxone (2 mg)

0.96 ± 0.91

0.86 ± 1.036

0.88 ± 1.131

0.89 ± 1.381

0.84 ± 1.069

Ca Cr.A (50 mg) + Naloxone (2 mg)

0.84 ± 1.08

0.91 ± 1.044

0.84 ± 1.045

0.94 ± 1.263

0.78 ± 1.422

Vn Cr.A (50 mg) + Naloxone (2 mg)

0.94 ± 1.03

0.88 ± 1.051

0.81 ± 1.521

0.86 ± 1.061

0.87 ± 1.356

Ph Cr.A (50 mg) + Naloxone (2 mg)

0.81 ± 0.69

0.96 ± 1.031

1.05 ± 1.271

0.91 ± 1.251

0.93 ± 1.034

Bp Cr.A 50 mg + Naloxone (2 mg)

0.88 ± 1.124

0.81 ± 0.89

0.94 ± 1.034

0.93 ± 1.304

0.94 ± 1.263

Morphine (5 mg) + Naloxone (2 mg)

0.76 ± 0.82

0.87 ± 1.336

0.96 ± 1.204

0.89 ± 1.035

0.97 ± 1.432