Fig. 4
From: KOTMIN13, a Korean herbal medicine alleviates allergic inflammation in vivo and in vitro
Effect of KOTMIN13 on β-hex release, LTC4 production, and PCA. BMMC were sensitized with anti-DNP IgE, treated with KOTMIN13, and then challenged with DNP-HSA. a β-hex and b LTC4 released into the supernatant were determined. c In PCA test, mice were sensitized by intradermal injection of IgE (80 ng) into mouse ears and intravenously challenged with DNP-HSA (60 μg) containing Evans blue after oral administration of KOTMIN13 for 1 h. Ears were removed for measuring the amount of dye extravasation. Values represent mean ± SEM. ##P < 0.01 compared with the negative control (NC, anti-DNP IgE); *P < 0.05, **P < 0.01, and ***P < 0.001 compared with the positive control (PC, anti-DNP IgE/DNP-HSA)