From: Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves
Model | Treatment | Dose, (mg/kg) | Gastric juice | Gastric wall mucus | |||
---|---|---|---|---|---|---|---|
Volume (ml) | pH | Total acidity (meq/l) | Free acidity (meq/l) | Alcian blueμg/g wet tissue | |||
Pylorus ligation | 10% DMSO | - | 5.83 ± 1.01 | 1.50 ± 0.09 | 5427.00 ± 380.40 | 4367.00 ± 573.30 | 85.68 ± 13.76 |
Ranitidine | 100 | 1.63 ± 0.30a | 4.41 ± 0.76b | 1433.00 ± 92.15c | 1500.00 ± 235.20d | 241.30 ± 14.11* | |
MEMM | 50 | 6.50 ± 0.52 | 1.82 ± 0.12 | 3100.00 ± 392.30c | 2420.00 ± 438.80d | 151.26 ± 32. 17* | |
250 | 2.58 ± 0.61a | 2.43 ± 0.22b | 3107.00 ± 458.00c | 2040.00 ± 327.60d | 354.24 ± 38.71* | ||
500 | 1.95 ± 0.16a | 3.55 ± 0.63b | 3105.00 ± 435.2c | 933.30 ± 291.90d | 422.08 ± 67.73* | ||
Quercitrin | 50 | 4.31 ± 0.74a | 2.38 ± 0.23b | 4648.00 ± 223.50c | 3211.00 ± 261.60d | 258.63 ± 17.48* | |
250 | 4.72 ± 0.38a | 4.43 ± 0.16b | 3519.00 ± 380.40c | 2367.00 ± 382.80d | 407.42 ± 21.76* |