Figure 2From: The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1β Production of IGF-1 from human cartilage explants as measured by media IGF-1 levels. RNI 249 produced a dose-dependent increase in media IGF-1 levels, as determined by ELISA. Only the 50 μg/ml concentration of RNI 249 produced a significant increase over basal, untreated explants (* P < 0.05, n = 6 for all groups).Back to article page