|  | Time Intervals | |||||
Tissue | Series | 24 h | 48 h | 72 h | 7 d | 15 d | 30 d |
ALT activity (μM/mg protein/min) | |||||||
Liver | Â | Â | Â | Â | Â | Â | Â |
 | Dw | 0.244 ± 0.073 | 0.293 ± 0.034 | 0.318 ± 0.030 | 0.339 ± 0.085 | 0.328 ± 0.067 | 0.321 ± 0.065 |
 | As | 0.280 ± 0.053 | 0.299 ± 0.048 | 0.344 ± 0.051 | 0.640 ± 0.024b | 0.689 ± 0.065b | 0.643 ± 0.063b |
 | As+Ars Alb-30 | 0.328 ± 0.077 | 0.217 ± 0.044 | 0.319 ± 0.084 | 0.466 ± 0.039b | 0.473 ± 0.067a | 0.322 ± 0.080a |
 | As+Ars Alb-200 | 0.257 ± 0.093 | 0.264 ± 0.044 | 0.327 ± 0.068 | 0.518 ± 0.062 | 0.306 ± 0.056b | 0.277 ± 0.050a |
 | As+A-30 | 0.653 ± 0.113 | 0.318 ± 0.060 | 0.399 ± 0.042 | 0.599 ± 0.109b | 0.644 ± 0.100 | 0.650 ± 0.091 |
 | As+A-200 | 0.511 ± 0.079 | 0.345 ± 0.045 | 0.396 ± 0.064 | 0.610 ± 0.078 | 0.660 ± 0.074 | 0.767 ± 0.096 |
Blood | Dw | 0.715 ± 0.032 | 0.740 ± 0.093 | 0.987 ± 0.081 | 0.766 ± 0.062 | 0.639 ± 0.034 | 0.736 ± 0.066 |
 | As | 0.651 ± 0.097 | 0.910 ± 0.065 | 1.311 ± 0.109a | 1.004 ± 0.076a | 0.950 ± 0.079b | 1.003 ± 0.059a |
 | As+Ars Alb-30 | 0.741 ± 0.069 | 0.630 ± 0.019 | 0.852 ± 0.094a | 0.878 ± 0.088 | 0.307 ± 0.044c | 0.273 ± 0.044c |
 | As+Ars Alb-200 | 0.538 ± 0.066 | 0.521 ± 0.050 | 1.049 ± 0.093 | 0.875 ± 0.070 | 0.571 ± 0.082a | 0.409 ± 0.061c |
 | As+A-30 | 1.209 ± 0.133 | 0.938 ± 0.098 | 1.617 ± 0.097 | 0.939 ± 0.063b | 1.253 ± 0.106 | 0.902 ± 0.063 |
 | As+A-200 | 0.564 ± 0.034 | 1.002 ± 0.103 | 1.522 ± 0.097 | 0.928 ± 0.107 | 1.106 ± 0.194 | 1.212 ± 0.121 |
AST activity (μM/mg protein/min) | |||||||
Liver | Â | Â | Â | Â | Â | Â | Â |
 | Dw | 0.288 ± 0.038 | 0.214 ± 0.033 | 0.233 ± 0.042 | 0.259 ± 0.039 | 0.272 ± 0.016 | 0.257 ± 0.018 |
 | As | 0.289 ± 0.024 | 0.282 ± 0.026 | 0.236 ± 0.018 | 0.433 ± 0.043a | 0.341 ± 0.024a | 0.319 ± 0.019a |
 | As+Ars Alb-30 | 0.241 ± 0.023 | 0.224 ± 0.037 | 0.215 ± 0.022 | 0.222 ± 0.018b | 0.308 ± 0.045 | 0.216 ± 0.044 |
 | As+Ars Alb-200 | 0.250 ± 0.043 | 0.278 ± 0.046 | 0.213 ± 0.037 | 0.241 ± 0.011b | 0.194 ± 0.031b | 0.088 ± 0.009c |
 | As+A-30 | 0.255 ± 0.037 | 0.301 ± 0.033 | 0.276 ± 0.045 | 0.327 ± 0.023a | 0.372 ± 0.047a | 0.239 ± 0.058 |
 | As+A-200 | 0.333 ± 0.062 | 0.285 ± 0.026 | 0.243 ± 0.034 | 0.363 ± 0.041 | 0.339 ± 0.040 | 0.298 ± 0.036 |
Blood | Â | Â | Â | Â | Â | Â | Â |
 | Dw | 0.199 ± 0.023 | 0.221 ± 0.016 | 0.241 ± 0.014 | 0.239 ± 0.016 | 0.243 ± 0.016 | 0.243 ± 0.009 |
 | As | 0.309 ± 0.018b | 0.282 ± 0.020a | 0.424 ± 0.021c | 0.294 ± 0.013a | 0.530 ± 0.053c | 0.383 ± 0.018c |
 | As+Ars Alb-30 | 0.247 ± 0.025 | 0.204 ± 0.015a | 0.204 ± 0.004c | 0.194 ± 0.026b | 0.304 ± 0.029b | 0.287 ± 0.026a |
 | As+Ars Alb-200 | 0.263 ± 0.015 | 0.210 ± 0.009a | 0.249 ± 0.020c | 0.200 ± 0.015a | 0.268 ± 0.027b | 0.229 ± 0.018c |
 | As+A-30 | 0.385 ± 0.026a | 0.311 ± 0.041 | 0.426 ± 0.037 | 0.387 ± 0.031 | 0.549 ± 0.047 | 0.498 ± 0.036a |
 | As+A-200 | 0.389 ± 0.021a | 0.319 ± 0.028 | 0.478 ± 0.041 | 0.293 ± 0.031 | 0.542 ± 0.061 | 0.460 ± 0.033 |
GSH Content (μM/mg of Liver) | |||||||
Liver | Â | Â | Â | Â | Â | Â | Â |
 | Dw | 1.383 ± 0.064 | 1.240 ± 0.051 | 1.162 ± 0.072 | 1.359 ± 0.072 | 1.376 ± 0.111 | 1.238 ± 0.110 |
 | As | 1.447 ± 0.066 | 1.061 ± 0.035a | 0.978 ± 0.073 | 0.757 ± 0.033c | 0.782 ± 0.092b | 0.615 ± 0.098b |
 | As+Ars Alb-30 | 1.483 ± 0.086 | 1.377 ± 0.065b | 1.344 ± 0.066b | 1.207 ± 0.122b | 1.196 ± 0.109a | 1.055 ± 0.045b |
 | As+Ars Alb-200 | 1.580 ± 0.105 | 1.145 ± 0.084 | 1.230 ± 0.093 | 1.173 ± 0.108b | 1.265 ± 0.084b | 1.187 ± 0.077b |
 | As+A-30 | 1.360 ± 0.119 | 0.817 ± 0.082a | 0.818 ± 0.048 | 0.832 ± 0.115b | 0.697 ± 0.116 | 0.474 ± 0.045 |
 | As+A-200 | 1.436 ± 0.109 | 0.924 ± 0.117 | 0.937 ± 0.100 | 0.758 ± 0.074 | 0.718 ± 0.091 | 0.692 ± 0.035 |
GSH Content (nM/ml of Blood) | |||||||
Blood | Â | Â | Â | Â | Â | Â | Â |
 | Dw | 296.779 ± 6.948 | 274.076 ± 9.037 | 284.093 ± 6.839 | 275.882 ± 8.284 | 274.503 ± 7.090 | 241.913 ± 12.136 |
 | As | 275.882 ± 11.433 | 245.502 ± 7.214a | 265.208 ± 11.621 | 237.456 ± 7.442b | 142.375 ± 16.466c | 110.200 ± 7.47c |
 | As+Ars Alb-30 | 303.881 ± 9.855 | 300.925 ± 14.232b | 286.556 ± 16.079 | 236.388 ± 15.958 | 284.011 ± 18.742c | 182.191 ± 14.149c |
 | As+Ars Alb-200 | 281.630 ± 11.363 | 226.324 ± 13.620 | 274.651 ± 14.291 | 299.037 ± 17.341a | 313.898 ± 12.932c | 286.967 ± 7.691b |
 | As+A-30 | 240.248 ± 17.659 | 236.635 ± 3.915 | 235.239 ± 10.893 | 102.569 ± 6.585b | 104.811 ± 6.347 | 87.281 ± 9.834 |
 | As+A-200 | 259.953 ± 8.857 | 274.856 ± 14.680 | 181.869 ± 12.780c | 153.213 ± 17.617b | 146.809 ± 13.915 | 106.740 ± 6.259 |