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Table 2 Natural extracts and synthetic compounds that promote survival of S. aureus -infected nematodes

From: Discovery of potential anti-infectives against Staphylococcus aureus using a Caenorhabditis elegans infection model

No.

Extract/compound ID

Plant/animal species

Extraction solvent

Mean % of survival

Fold change survival vs. untreateda

1

UE-01-1

Nypa fruticans husks

Methanol

76.7

3.3

2

UE-01-2

N. fruticans leaves

Hexane

78.4

3.4

3

UE-01-4

N. fruticans roots

Butanol

84.2

3.7

4

UE-01-6

N. fruticans roots

Chloroform

67.3

2.9

5

UE-01-7

N. fruticans leaves

Chloroform

83.3

3.6

6

UE-02-4

Faunus ater

Methanol

63.3

2.8

7

UE-03-3

Swietenia macrophylla seeds

Methanol

70.0

3

8

UE-03-5

S. macrophylla seeds

Ethyl acetate

65.0

2.8

9

UE-03-6

S. macrophylla seeds

Butanol

96.7

4.2

10

UE-08

Curcuma longa

Water

93.3

4

11

UE-11

Eurycoma longifolia roots

Water

73.0

3.2

12

UE-12

Orthosiphon stamineus leaves

Water

71.8

3.1

13

UE-15

Curcumin

-

100.0

4.3

14

UE-18

Silybum eburneum seeds

Water

100.0

4.3

15

UC-01

-

-

90.0

4.5

16

UC-02

-

-

86.7

4.3

17

UC-03

-

-

80.0

4

18

UC-06

-

-

80.0

4

19

UC-07

-

-

90.0

4.5

20

UC-08

-

-

90.0

4.5

21

UC-09

-

-

96.7

4.8

22

UC-10

-

-

86.7

4.3

23

UC-11

-

-

96.7

4.8

24

UC-12

-

-

96.3

4.8

25

UC-15

-

-

100.0

5

26

UC-16

-

-

100.0

5

27

UC-27

-

-

100.0

5

28

UC-28

-

-

100.0

5

  1. aNote that ~20% of the untreated worms survived 72 hours post-infection. The mean percentage of survival from one representative biological replicate out of three independent assays is presented.