Evaluation of antimalarial activity of leaves of Acokanthera schimperi and Croton macrostachyus against Plasmodium berghei in Swiss albino mice

Table 7 Parasitaemia suppressive effect of methanol extract of Acokanthera schimperi and mean survival time

Group	Dose (mg/kg)	Antimalarial activities on Day-4 post infection		Mean survival time in days
Group	Dose (mg/kg)	% Parasitaemia ± SEM	% Suppression	Mean survival time in days
1	Distilled water (1 mL)	52.80 ± 4.24	0.00	6.2 ± 0.20
2	200	40.80 ± 3.67	22.7	7.00 ± 1.73^b
3	400	36.00 ± 4.74	31.8	7.20 ± 1.3^b
4	600	34.40 ± 2.87	34.8	10.60 ± 0.51*
5	Chloroquine (25)	0.00	100.0	14.2 ± 1.30*

% parasitaemia and mean survival time results presented as mean ± SD; n = 5; values with superscript b are not significantly different from that of the negative control (P > 0.05).*Values are significantly different as compared to that of negative controls (P < 0.05).

ISSN: 2662-7671