Table 1 Sub-acute toxicity effects of methanol and aqueous extracts of Croton macrostachyus
Extract | Dose | Parameters | Day 0 | Day 4 | P-Value |
|---|---|---|---|---|---|
Methanol | 500 mg | Body weight(gm) | 33.00 ± 2.59 | 32.34 ± 2.91 | 0.628 |
PCV (%) | 54.60 ± 1.29 | 54.20 ± 1.62 | 0.840 | ||
WBC (mm3) | 7360 ± 1591.34 | 10300 ± 250.49 | 0.114 | ||
Hb | not determined | not determined | |||
750 mg | Body weight (gm) | 34.66 ± 2.29 | 35.92 ± 2.13 | 0.085 | |
PCV (%) | 51.60 ± 0.93 | 50.20 ± 0.66 | 0.404 | ||
WBC (mm3) | 5180.00 ± 908.93 | 7470.00 ± 314.88 | 0.720 | ||
Hb | not determined | not determined | |||
1000 mg | Body weight(gm) | 36.56 ± 1.10 | 33.14 ± 1.76 | 0.124 | |
PCV (%) | 52.20 ± 1.96 | 52.20 ± 0.86 | 0.852 | ||
WBC (mm3) | 9420.00 ± 489.03 | 9840.00 ± 1259.41 | 0.647 | ||
Hb | not determined | not determined | |||
NC | Body weight (gm) | 35.86 ± 0.56 | 40.12 ± 0.97 | 0.007 | |
PCV (%) | 52.00 ± 0.89 | 52.40 ± 0.60 | 0.587 | ||
WBC (mm3) | 9700 ± 921.95 | 5500 ± 916.79 | 0.004 | ||
Hb | not determined | not determined | |||
Aqueous | 500 mg | Body weight (gm) | 31.34 ± 0.56 | 33.58 ± 0.72 | 0.002 |
PCV (%) | 55.4 ± 1.50 | 50.80 ± 2.33 | 0.079 | ||
WBC (mm3) | 5530.00 ± 501.65 | 8870.00 ± 1750.90 | 0.152 | ||
Hb | not determined | not determined | |||
750 mg | Body weight (gm) | 31.94 ± 1.09 | 29.12 ± 2.02 | 0.072 | |
PCV (%) | 55.00 ± 1.18 | 53.60 ± 0 .87 | 0.245 | ||
WBC (mm3) | 9760.0 ± 932.12 | 13610 ± 1581.41 | 0.72 | ||
Hb | not determined | not determined | |||
1000 mg | Body weight (gm) | 30.20 ± 1.49 | 25.90 ± 2.38 | 0.018 | |
PCV (%) | 55.40 ± 2.14 | 57.60 ± 1.12 | 0.282 | ||
WBC (mm3) | 4700.00 ± 470.11 | 9730.00 ± 1503.46 | 0.53 | ||
Hb | not determined | not determined | |||
NC | Body weight (gm) | 26.54 ± 1.16 | 29.36 ± 1.52 | 0.021 | |
PCV (%) | 54.60 ± 0.75 | 47.40 ± 0.81 | 0.007 | ||
WBC (mm3) | 9630 ± 1260.22 | 8000 ± 1832.01 | 0.54 | ||
Hb | not determined | not determined |