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Table 3 Effect of the essential oil of Foeniculum vulgare and reference compounds on the behavior of mice in the open field model

From: Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice

Treatment

Time spent in central squares (sec)

Number of squared crossed

  

Center

Periphery

Total

Vehicle

2.17 ± 1.33

2.00 ± 1.26

85.17 ± 19.37

87.16 ± 19.31

FV50

3.33 ± 5.92 c*

3.67 ± 7.12 d*

80.83 ± 25.34

84.50 ± 25.99

FV100

10.67 ± 4.32 (a, b)*

9.00 ± 7.54

79.33 ± 10.32 f**

88.33 ± 17.81 f**

FV200

10.50 ± 4.04 a*

14.50 ± 3.27 (a,b,e)*

87.50 ± 19.67 (e, f)*

102.00 ± 21.87 e*

FV400

4.50 ± 5.92

3.34 ± 4.55 d*

53.00 ± 4.94 (a ,d)*

56.33 ± 7.76 d*

Diazepam

9.33 ± 5.32 a*

12.83 ± 10.66 a*

122.67 ± 31.6(a, d)*.c**

133.83 ± 34.93(a, c)**

  1. The data are mean ± S.E.M, n = 6, aagainst control, bagainst 50 mg/kg, cagainst 100 mg/kg, dagainst 200 mg/kg, eagainst 400 mg/kg, fagainst diazepam, *P < 0.05 and **P < 0.01. FV = Foeniculum vulgare essential oil.