Table 1 Effect of ethanolic extract of CA ( Centella asiatica ) on insulin secretion from isolated rat islets

Group	Insulin secretion (ng/mg islet protein)
Group	Glucose: 3 mM	Glucose: 11 mM
Control	2.99 (2.65-4.27)	5.41 (4.91-9.27)*
CA 20 μg/ml	2.78 (2.19-3.56)	5.03 (4.24-8.54)
CA 40 μg/ml	3.09 (2.43-3.82)	5.11 (4.39-7.98)
CA 80 μg/ml	2.85 (2.07-3.69)	5.24 (4.78-8.61)
Glibenclamide (10 μg/l)	5.89 (4.34-6.95)*	8.92 (7.67-9.86)*

Isolated rat islets were incubated for 60 min with ethanol extract of Centella asiatica (10, 20, and 30 mg/ml) in the presence of 3 or 11 mM glucose. Data are presented as median (range), n=5. Mann–Whitney U-test was used to evaluate statistical significance. *p < 0.05 compared with control (3 mM glucose without extract).

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