Normal rats | STZ-diabetic rats | |||
---|---|---|---|---|
Vehicle | Vehicle | PSLR 200 | PSLR 300 | |
Body weight (BW) (g/rat) | 370.39 ± 13.58d | 240.99 ± 16.24b | 264.25 ± 15.11b,c | 307.72 ± 14.72a,c |
Kidney weight (KW) (g) | 1.29 ± 0.23c | 2.43 ± 0.17a | 1.85 ± 0.24a | 1.52 ± 0.16 |
KW/BW ratio × 1000 | 3.48 ± 0.19d | 10.08 ± 0.17b | 7.00 ± 0.12b,c | 4.94 ± 0.11b,c |
Plasma glucose (mg/dl) | 92.68 ± 8.59d | 425.73 ± 18.07b | 336.25 ± 14.92b,c | 306.92 ± 15.31b,c |
HbAlc (%) | 4.79 ± 1.03d | 14.31 ± 1.26b | 11.75 ± 1.18b | 10.91 ± 1.21b |
Urine volume (ml/day) | 9.26 ± 2.43d | 28.16 ± 9.13 b | 18.21 ± 6.28b,c | 15.84 ± 7.31b,c |
Urine protein (mg/day) | 6.95 ± 2.84d | 34.83 ± 5.29b | 16.41 ± 4.13a,c | 12.27 ± 5.21d |
Plasma Cr (μmol/l) | 38.50 ± 6.34d | 96.29 ± 8.73b | 84.10 ± 8.31b | 67.92 ± 7.32b,c |
BUN (mmol/l) | 7.21 ± 1.58c | 16.29 ± 2.80a | 13.16 ± 2.11a | 11.45 ± 2.21a,c |
Ccr (ml/min) | 3.88 ± 0.89d | 1.65 ± 0.54b | 2.37 ± 0.68a,c | 2.77 ± 0.34d |
Plasma AST (U/l) | 125.85 ± 10.47d | 374.68 ± 17.34b | 219.88 ± 18.26b,c | 159.57 ± 17.53d |
Plasma ALT (U/l) | 57.67 ± 7.92d | 218.67 ± 17.12b | 145.14 ± 15.78b,c | 103.42 ± 13.24a,d |
Renal IL-6 (pg/mg protein) | 54.06 ± 8.46d | 159.34 ± 11.38b | 126.34 ± 10.28b,c | 105.89 ± 10.94b,c |
Renal TNF-α (pg/mg protein) | 69.19 ± 9.34d | 172.91 ± 10.11b | 137.12 ± 9.13b,c | 109.45 ± 7.51b,c |
Renal IL-10 (pg/mg protein) | 64.77 ± 4.17d | 28.43 ± 4.25b | 36.49 ± 3.91b,c | 44.64 ± 3.77b,c |