Figure 5

The core microRNA target genes in multiple pathways regulated by SST. (A) Nodes with high relative betweenness centrality were selected as the core microRNA targets in multiple pathways enriched in (A) the temporal up-pattern genes and (B) the temporal down-pattern genes. Each circle represents an individual gene node and each arrow represents its regulatory edge type. Out-going edges reflect nodes that act as regulators, whereas in-going edges reflect nodes that are subject to intermolecular regulations. The orange circles indicate the core nodes with a relative betweenness centrality greater than 0.01. The pathways, including core nodes genes, are also indicated schematically.