Table 3 Baseline of included studies

Immunomodulation

 CD3+ T cells

0.07 [−0.30, 0.44 ]

I ² = 67%

Z = 0.35 (P = 0.72)

 CD4+ T cells

−0.04 [−0.31, 0.24]

I ² = 52%

Z = 0.27 (P = 0.79)

 CD8+ T cells

−0.01 [−0.19, 0.18]

I ² = 0%

Z = 0.08 (P = 0.94)

 Natural killer cells

−0.38 [−1.39, 0.62]

I ² = 79%

Z = 0.75 (P = 0.45)

 IL-2

0.05 [−0.21, 0.32]

I ² = 0%

Z = 0.39 (P = 0.70)

Bone marrow suppression

 Hemoglobin

0.04 [−0.19, 0.27]

I ² = 0%

Z = 0.37 (P = 0.71)

 Platelets

0.06 [−0.17, 0.29]

I ² = 0%

Z = 0.53 (P = 0.60)

 White blood cells

0.07 [−0.11, 0.24 ]

I ² = 0%

Z = 0.75 (P = 0.45)

Clinical efficacy

 Karnofsky performance score

−0.08 [−0.25, 0.09]

I ² = 0%

Z = 0.93 (P = 0.35)