Dose (mg/kg/day) | 0 | 500 | 1000 | 2000 |
---|---|---|---|---|
Males | ||||
Brain | 0.54 ± 0.04 a | 0.58 ± 0.05 | 0.54 ± 0.03 | 0.59 ± 0.01 |
Pituitary gland | 0.003 ± 0.0003 | 0.003 ± 0.0006 | 0.003 ± 0.0003 | 0.002 ± 0.0005 |
Liver | 3.25 ± 0.12 | 3.15 ± 0.21 | 3.06 ± 0.15 | 3.05 ± 0.15 |
Spleen | 0.19 ± 0.01 | 0.19 ± 0.03 | 0.20 ± 0.03 | 0.18 ± 0.03 |
Heart | 0.33 ± 0.02 | 0.34 ± 0.02 | 0.34 ± 0.02 | 0.34 ± 0.02 |
Thymus | 0.14 ± 0.03 | 0.16 ± 0.05 | 0.15 ± 0.03 | 0.11 ± 0.01 |
Salivary glands | 0.17 ± 0.01 | 0.17 ± 0.02 | 0.17 ± 0.01 | 0.19 ± 0.02 |
Seminal vesicle | 0.36 ± 0.08 | 0.41 ± 0.11 | 0.33 ± 0.06 | 0.38 ± 0.04 |
Prostate | 0.13 ± 0.02 | 0.13 ± 0.01 | 0.13 ± 0.02 | 0.12 ± 0.02 |
Kidneys | 0.85 ± 0.06 | 0.82 ± 0.03 | 0.83 ± 0.05 | 0.83 ± 0.05 |
Adrenal glands | 0.017 ± 0.002 | 0.015 ± 0.002 | 0.016 ± 0.002 | 0.017 ± 0.003 |
Testes | 0.89 ± 0.04 | 0.88 ± 0.13 | 0.88 ± 0.14 | 0.87 ± 0.05 |
Epididymides | 0.27 ± 0.03 | 0.27 ± 0.05 | 0.27 ± 0.02 | 0.26 ± 0.02 |
lung | 0.41 ± 0.03 | 0.40 ± 0.04 | 0.39 ± 0.02 | 0.38 ± 0.03 |
Thyroid/Parathyroid | 0.006 ± 0.001 | 0.005 ± 0.001 | 0.006 ± 0.001 | 0.005 ± 0.001 |
Females | ||||
Brain | 0.90 ± 0.05 | 0.85 ± 0.10 | 0.87 ± 0.03 | 0.87 ± 0.02 |
Pituitary gland | 0.006 ± 0.0009 | 0.005 ± 0.0005 | 0.006 ± 0.0010 | 0.005 ± 0.0009 |
Liver | 3.25 ± 0.16 | 3.23 ± 0.13 | 3.25 ± 0.26 | 3.36 ± 0.10 |
Spleen | 0.22 ± 0.04 | 0.21 ± 0.02 | 0.23 ± 0.03 | 0.24 ± 0.02 |
Heart | 0.36 ± 0.02 | 0.35 ± 0.01 | 0.37 ± 0.02 | 0.37 ± 0.02 |
Thymus | 0.19 ± 0.02 | 0.18 ± 0.03 | 0.21 ± 0.04 | 0.21 ± 0.04 |
Salivary glands | 0.19 ± 0.02 | 0.19 ± 0.01 | 0.19 ± 0.01 | 0.21 ± 0.02 |
Kidneys | 0.85 ± 0.04 | 0.85 ± 0.02 | 0.85 ± 0.08 | 0.94 ± 0.07 |
Adrenal glands | 0.034 ± 0.004 | 0.029 ± 0.001 | 0.032 ± 0.005 | 0.034 ± 0.004 |
Ovaries | 0.042 ± 0.004 | 0.040 ± 0.005 | 0.041 ± 0.009 | 0.040 ± 0.005 |
Lung | 0.53 ± 0.02 | 0.51 ± 0.03 | 0.51 ± 0.05 | 0.50 ± 0.04 |
Thyroid/parathyroid | 0.007 ± 0.002 | 0.006 ± 0.001 | 0.007 ± 0.001 | 0.008 ± 0.001 |
Uterus/cervix | 0.23 ± 0.03 | 0.26 ± 0.12 | 0.23 ± 0.07 | 0.32 ± 0.11 |