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  1. Content type: Research article

    Nigerian Cannabis sativa (hemp) causes male gonadotoxicity by inducing hyperprolactinemia, down-regulation of hypothalamic-pituitary-testicular axis, and oxidative stress. Benin republic hemp has been preferred b...

    Authors: Abdullateef Isiaka Alagbonsi, Luqman Aribidesi Olayaki, Halimat Amin Abdulrahim, Thomson Sijuade Adetona and Gbemileke Tobiloba Akinyemi

    Citation: BMC Complementary and Alternative Medicine 2019 19:132

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  2. Content type: Research article

    The effects of acupuncture on in vitro fertilization (IVF) outcomes remain controversial. And the variation in participant, interventions, outcomes studied, and trial design may relate to the efficacy of adjuv...

    Authors: Zheng-yun Xie, Zhi-hang Peng, Bing Yao, Li Chen, Yan-yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-yan Yang and You-bing Xia

    Citation: BMC Complementary and Alternative Medicine 2019 19:131

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  3. Content type: Research article

    Angoroside C, cinnamic acid, and harpagoside are bioactive constituents in Scrophularia ningpoensis. Currently, an infrared-assisted extraction (IRAE) method coupled with high-performance liquid chromatography wi...

    Authors: Lina Su, Yinghui Deng, Nianzu Chen, Xiuwen Zhang and Taomin Huang

    Citation: BMC Complementary and Alternative Medicine 2019 19:130

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  4. Content type: Research article

    Green tea has polyphenols like flavonoids and catechins; mainly epigallocatechin-3-gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC) and epicatechin (EC), out of which EGCG is of higher abundan...

    Authors: Ashlesha P. Pandit, Shreyas R. Joshi, Preeti S. Dalal and Vinita C. Patole

    Citation: BMC Complementary and Alternative Medicine 2019 19:129

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  5. Content type: Research article

    Salvia officinalis has been used successfully for the treatment of hot flushes and excessive sweating during menopause. However, modes of actions have not been elucidated conclusively. We explored its pharmacolog...

    Authors: Carsten Tober and Roland Schoop

    Citation: BMC Complementary and Alternative Medicine 2019 19:128

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  6. Content type: Research article

    Xin-Ji-Er-Kang (XJEK) is a Chinese herbal formula, which has been reported to exert effective protection against cardiovascular diseases, including hypertension and myocarditis.

    Authors: Ling Ding, Pan Cheng, Li Wang, Juan Hu, Yong-xue Zhang, Guo-wei Cai, Guang-yao Huang and Shan Gao

    Citation: BMC Complementary and Alternative Medicine 2019 19:127

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  7. Content type: Research article

    Gut microbiota plays a crucial role in the treatment of gastrointestinal (GI) diseases such as chemotherapy-induced diarrhea (CID). Shenzhu Capsule (SZC) is a Chinese herbal formula, which is composed of Rensh...

    Authors: Jing Wang, Wuwen Feng, Shiyang Zhang, Lu Chen, Fei Tang, Yongcheng Sheng, Hui Ao and Cheng Peng

    Citation: BMC Complementary and Alternative Medicine 2019 19:126

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  8. Content type: Research article

    Mind-body practices are frequently used by people living with HIV to reduce symptoms and improve wellbeing. These include Tai Chi, Qigong, yoga, meditation, and all types of relaxation. Although there is subst...

    Authors: Maria Pilar Ramirez-Garcia, Marie-Pier Gagnon, Sébastien Colson, José Côté, Jorge Flores-Aranda and Myriam Dupont

    Citation: BMC Complementary and Alternative Medicine 2019 19:125

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  9. Content type: Research article

    Troxerutin (TRX), a naturally occurring flavonoid in various fruits, has been reported to exhibit numerous pharmacological and biological activities in vitro and in vivo. However, the molecular mechanisms unde...

    Authors: Ying Li, Pan Ma, Jin Fu, Jingjing Wu and Xue Wu

    Citation: BMC Complementary and Alternative Medicine 2019 19:124

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  10. Content type: Research article

    Infectious diseases, particularly those due to multi-drug resistant bacterial strains are almost impossible to cure globally. In this study we investigated the inhibitory effects of Azadirachta indica A. Juss sec...

    Authors: Sunday O. Okoh, Omobola O. Okoh and Anthony I. Okoh

    Citation: BMC Complementary and Alternative Medicine 2019 19:123

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  11. Content type: Research article

    The regenerative capacity of the liver is crucial for the host to survive after serious hepatic injuries, tumor resection, or living donor liver transplantation. Panax notoginseng saponins (PNS) have been reporte...

    Authors: Hua Zhong, Hao Wu, He Bai, Menghao Wang, Jian Wen, Jianping Gong, Mingyong Miao and Fangchao Yuan

    Citation: BMC Complementary and Alternative Medicine 2019 19:122

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  12. Content type: Research article

    Myeloproliferative neoplasm (MPN) patients suffer from significant symptoms, inflammation and reduced quality of life. Yoga improves these outcomes in other cancers, but this hasn’t been demonstrated in MPNs. ...

    Authors: Jennifer Huberty, Ryan Eckert, Amylou Dueck, Heidi Kosiorek, Linda Larkey, Krisstina Gowin and Ruben Mesa

    Citation: BMC Complementary and Alternative Medicine 2019 19:121

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  13. Content type: Research article

    Albizia adianthifolia (Schum.) is medicinally used in Cameroon to manage bronchitis and skin diseases. Our previous study documented the antibacterial potential of its roots’ methanol extract. In this study, meth...

    Authors: Cedric F. Tchinda, Gaiëlle Sonfack, Ingrid K. Simo, İlhami Çelik, Igor K. Voukeng, Blaise K. Nganou, Gabin T. M. Bitchagno, Sultan Funda Ekti, Mathieu Tene, Pierre Tane, Veronique P. Beng and Victor Kuete

    Citation: BMC Complementary and Alternative Medicine 2019 19:120

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  14. Content type: Research article

    Staphylococcus aureus is a notorious pathogen which often causes nosocomial and community attained infections. These infections steadily increased after evolving the resistance due to indecorous practice of antib...

    Authors: Neelam Kumari, Snehlata Singh, Vandana Kumari, Siddhartha Kumar, Vinay Kumar and Antresh Kumar

    Citation: BMC Complementary and Alternative Medicine 2019 19:119

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  15. Content type: Research article

    Hirudin, an extract from Hirudo spp., is an anticoagulant used to treat a variety of renal diseases, including diabetic nephropathy (DN). Currently, hirudin has to be used at high dosages to treat DN because it p...

    Authors: Hongwu Wang, Huantian Cui, Lan Lin, Yue Ji, Qing Ni, Junchen Li, Jianli Pang, Gongyan Bing and Yuhong Bian

    Citation: BMC Complementary and Alternative Medicine 2019 19:118

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  16. Content type: Research article

    Glossogyne tenuifolia (GT) is a traditional herbal tea in Penghu Island, Taiwan. Its extract is traditionally been used as an antipyretic, hepatoprotective and anti-inflammatory remedy in folk medicine among loca...

    Authors: Shibu Marthandam Asokan, Ruoh-Yuh Wang, Tsu-Han Hung and Wan-Teng Lin

    Citation: BMC Complementary and Alternative Medicine 2019 19:117

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  17. Content type: Research article

    Allium species are magnificently nutritious and are commonly used as a part of the diet in Iran. They have health enhancing benefits including anticancer properties due to the presence of numerous bioactive co...

    Authors: Kosar Vafaee, Soudeh Dehghani, Raheleh Tahmasvand, Farzaneh Saeed Abadi, Saeed Irian and Mona Salimi

    Citation: BMC Complementary and Alternative Medicine 2019 19:116

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  18. Content type: Research article

    Skin burn wound is a notable medical burden worldwide. Rapid and effective treatment of burnt skin is vital to fasten wound closure and healing properly. Amniotic graft and Aloe vera are widely used as wound mana...

    Authors: Md Shaifur Rahman, Rashedul Islam, Md Masud Rana, Lucas-Sebastian Spitzhorn, Mohammad Shahedur Rahman, James Adjaye and Sikder M. Asaduzzaman

    Citation: BMC Complementary and Alternative Medicine 2019 19:115

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  19. Content type: Research article

    Lactobacillus plantarum, a major species of Lactic Acid Bacteria (LAB), are capable of producing postbiotic metabolites (PM) with prominent probiotic effects that have been documented extensively for rats, poultr...

    Authors: Li-Oon Chuah, Hooi Ling Foo, Teck Chwen Loh, Noorjahan Banu Mohammed Alitheen, Swee Keong Yeap, Nur Elina Abdul Mutalib, Raha Abdul Rahim and Khatijah Yusoff

    Citation: BMC Complementary and Alternative Medicine 2019 19:114

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  20. Content type: Research article

    Embryonic neural stem cells (eNSCs) are immature precursors of the central nervous system (CNS), with self-renewal and multipotential differentiation capacities. These are regulated by endogenous and exogenous...

    Authors: Reza Mahmoudi, Majid Ghareghani, Kazem Zibara, Maryam Tajali Ardakani, Yahya Jand, Hassan Azari, Jafar Nikbakht and Amir Ghanbari

    Citation: BMC Complementary and Alternative Medicine 2019 19:113

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  21. Content type: Research article

    The plant Holarrhena floribunda (H. floribunda; G. Don) is indigenous to sub-Saharan Africa and is traditionally used to treat several ailments. The present study was carried out to isolate and characterize bioac...

    Authors: J. A. Badmus, O. E. Ekpo, A. A. Hussein, M. Meyer and D. C. Hiss

    Citation: BMC Complementary and Alternative Medicine 2019 19:112

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  22. Content type: Research article

    Atherosclerosis is a condition with the vascular accumulation of lipid plaques, and its main major contributing factor is endothelial injury induced by oxidized low-density lipoprotein (ox-LDL). Salidroside (S...

    Authors: Zhongsheng Zhu, Jinyu Li and Xiaorong Zhang

    Citation: BMC Complementary and Alternative Medicine 2019 19:111

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  23. Content type: Research article

    Many studies on the effect of saponin-rich Codonopsis lanceolata as a bioactive source for improving physical health have been performed. C. lanceolata contains triterpenoid saponins, including lancemasides. Thes...

    Authors: Young Seok Lee, HeeEun Kim, Jinhye Kim, Geun Hee Seol and Kwang-Won Lee

    Citation: BMC Complementary and Alternative Medicine 2019 19:110

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  24. Content type: Research article

    Berberine is an isoquinoline alkaloid extracted from various Berberis species which is widely used in East Asia for a wide range of symptoms. Recently, neuroprotective effects of berberine in Alzheimer’s disease ...

    Authors: Ning-Ning Yuan, Cui-Zan Cai, Ming-Yue Wu, Huan-Xing Su, Min Li and Jia-Hong Lu

    Citation: BMC Complementary and Alternative Medicine 2019 19:109

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  25. Content type: Research article

    Tuberculosis is a deadly disease caused by Mycobacterium species. The use of medicinal plants is an ancient global practice for the treatment and prevention of diverse ailments including tuberculosis. The aim of ...

    Authors: Abimbola O. Aro, Jean P. Dzoyem, Maurice D. Awouafack, Mamoalosi A. Selepe, Jacobus N. Eloff and Lyndy J. McGaw

    Citation: BMC Complementary and Alternative Medicine 2019 19:108

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  26. Content type: Research article

    Excessive activation of NLRP3 inflammasome and down-regulation of Sirt1/Smad3 deacetylation pathway play a significant role in the evolution of renal fibrosis. In China, it has been well known that Chinese her...

    Authors: Meng Wang, Liuyi Yang, Jing Yang and Chen Wang

    Citation: BMC Complementary and Alternative Medicine 2019 19:107

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  27. Content type: Research article

    The therapeutic use of Helleborus niger L. is manifold due to its specific phytochemical composition. Two compound groups, the ranunculin derivates including protoanemonin and the steroidal saponins, are also ass...

    Authors: Jennifer E. Felenda, Claudia Turek, Nora Mörbt, Anja Herrick, Margit B. Müller and Florian C. Stintzing

    Citation: BMC Complementary and Alternative Medicine 2019 19:105

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  28. Content type: Research article

    Despite advances in medical treatments, the proportion of the population suffering from alopecia is increasing, creating a need for new treatments to control hair loss and prevent balding. Treatments based on ...

    Authors: Gun-He Nam, Kyung-Jo Jo, Ye-Seul Park, Hye Won Kawk, Je-Geun Yoo, Jin Dong Jang, Sang Moon Kang, Sang-Yong Kim and Young-Min Kim

    Citation: BMC Complementary and Alternative Medicine 2019 19:104

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  29. Content type: Research article

    Chinese herbal bath therapy (CHBT) is a traditional external therapy that has been used for the treatment of uremic pruritus (UP) in China. We conducted a meta-analysis to evaluate the efficacy and safety of C...

    Authors: Wenxuan Xue, Yanhua Zhao, Mengyun Yuan and Zhiqiang Zhao

    Citation: BMC Complementary and Alternative Medicine 2019 19:103

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  30. Content type: Research article

    Calothamnus quadrifidus R.Br has many traditional uses and there are few reports about its chemical and biological activities. So our aim is to isolate the triterpenoidal compounds from dichloromethane fraction (...

    Authors: H. A. Ibrahim, M. R. Elgindi, R. R. Ibrahim and D. G. El-Hosari

    Citation: BMC Complementary and Alternative Medicine 2019 19:102

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  31. Content type: Research article

    Physalin A isolated from Physalis alkekengi var. franchetii has been known to have many pharmacological properties. However, its effect through the Nrf2 pathway has not yet been elucidated. In the present study, ...

    Authors: Ji Min Shin, Kyung-Mi Lee, Hee Ju Lee, Ji Ho Yun and Chu Won Nho

    Citation: BMC Complementary and Alternative Medicine 2019 19:101

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  32. Content type: Research article

    Obesity is a risk factor for many diseases including diabetes, cancer, arthritis, and cardiovascular diseases. Angiogenesis nourishes adipose tissues and contributes to obesity; it can be prevented by suppress...

    Authors: Muhammad Imran Khan, Jin Hyuk Shin and Jong Deog Kim

    Citation: BMC Complementary and Alternative Medicine 2019 19:100

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  33. Content type: Research article

    Type 2 diabetes (T2D) is a global pandemic, and contributes significantly to the increasing incidence of conditions such as cardiovascular disease (CVD). Postprandial plasma glucose measured 2-h after the star...

    Authors: Ratheesh Mohan, Svenia Jose, Johannah Mulakkal, Darla Karpinsky-Semper, Andrew G. Swick and I. M. Krishnakumar

    Citation: BMC Complementary and Alternative Medicine 2019 19:99

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  34. Content type: Research article

    Current therapeutic approaches to treat metastatic breast cancer, although effective, have shown many inadvertent side effects such as genotoxicity due to a lack of selectivity. Thus, these treatment plans are...

    Authors: Christopher Nguyen, Kiruthika Baskaran, Alaina Pupulin, Ivan Ruvinov, Ola Zaitoon, Sahibjot Grewal, Benjamin Scaria, Ali Mehaidli, Caleb Vegh and Siyaram Pandey

    Citation: BMC Complementary and Alternative Medicine 2019 19:98

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  35. Content type: Research article

    Endothelial dysfunction (ED) has been observed in individuals with metabolic syndrome (MetS) and contributes to the initiation and progression of atherosclerosis. The primary management of MetS involves lifest...

    Authors: Pingali Usharani, Padma Latha Merugu and Chandrasekhar Nutalapati

    Citation: BMC Complementary and Alternative Medicine 2019 19:97

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  36. Content type: Research article

    The purpose of this pilot study was to determine if a definitive clinical trial of thiamine supplementation was warranted in patients with acute heart failure. We hypothesized that thiamine, when added to stan...

    Authors: Howard A. Smithline, Michael Donnino, Fidela S. J. Blank, Richard Barus, Ryan A. Coute, Alexander B. Knee and Paul Visintainer

    Citation: BMC Complementary and Alternative Medicine 2019 19:96

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  37. Content type: Research article

    Traditional medicine has always been Pakistan’s cultural heritage, providing health care to a large part of its population. Thus, we aimed to assess and compare the knowledge, attitude, and perception about co...

    Authors: Mariam Ashraf, Hamid Saeed, Zikria Saleem, Hassaan Anwer Rathore, Fawad Rasool, Eman Tahir, Tooba Bhatti, Javeria Khalid, Iqra Bhatti and Ayesha Tariq

    Citation: BMC Complementary and Alternative Medicine 2019 19:95

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  38. Content type: Research article

    The brain is susceptible to methylmercury toxicity, which causes irreversible damage to neurons and glia and the leaf extract Dendropanax morbifera Léveille (DML) has various biological functions in the nervous s...

    Authors: Woosuk Kim, Dae Young Yoo, Hyo Young Jung, Jong Whi Kim, Kyu Ri Hahn, Hyun Jung Kwon, Miyoung Yoo, Sanghee Lee, Sung Min Nam, Yeo Sung Yoon, Dae Won Kim and In Koo Hwang

    Citation: BMC Complementary and Alternative Medicine 2019 19:94

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  39. Content type: Research article

    Complementary and alternative medicine (CAM) is a rather novel issue within public healthcare and health policy-making. CAM use in Europe is widespread, patient-initiated, and patient-evaluated, and the regula...

    Authors: Anita Salamonsen and Solveig Wiesener

    Citation: BMC Complementary and Alternative Medicine 2019 19:93

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  40. Content type: Research article

    To investigate the effects of the Alisma and Rhizoma decoction on nonalcoholic steatohepatitis (NASH) and to further shed light on the underlying mechanisms of the actions of the Alisma and Rhizoma decoction.

    Authors: Lijun Xu, Menghui Jing, Lijuan Yang, Lei Jin, Peiqiang Gong, Juan Lu, Hui Lin, Jinping Wang, Qin Cao and Yuanye Jiang

    Citation: BMC Complementary and Alternative Medicine 2019 19:92

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  41. Content type: Research article

    The extract of Celastrus orbiculatus (COE) have been studied for anti-Helicobacter pylori (H. pylori) activity and anti-cancer effects in vitro and in vivo. However, the molecular mechanism by which COE inhibits

    Authors: Yaodong Zhu, Lei Liu, Lei Hu, Wenqing Dong, Mei Zhang, Yanqing Liu and Ping Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:91

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  42. Content type: Research article

    Papaver nudicaule belongs to the Papaveraceae family, which is planted as an annual herbaceous species generally for ornamental purpose. Papaver rhoeas in the same family has been reported to have various pharmac...

    Authors: Jae-Hyeon Oh, Miyong Yun, Dain Park, In Jin Ha, Chang-Kug Kim, Do-Wan Kim, Eun-Ok Kim and Seok-Geun Lee

    Citation: BMC Complementary and Alternative Medicine 2019 19:90

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  43. Content type: Research article

    Rubus coreanus fruit (RF) has been used as a traditional medicine formulation to treat various diseases including diarrhea, asthma, and cancer in East Asia (Korea, China, and Japan). RF, which is native to Korea,...

    Authors: Kyung Hye Seo, Ji Yeon Lee, Jeong-Yong Park, Gwi Yeong Jang, Hyung Don Kim, Young- Seob Lee and Dong Hwi Kim

    Citation: BMC Complementary and Alternative Medicine 2019 19:89

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  44. Content type: Research article

    Stevia rebaudiana Bertoni has various pharmacological actions, which includes antidiabetic, antioxidant, anti-inflammatory activities. The superoxide and consequently NADPH oxidase (Nox) are relevant targets invo...

    Authors: A. S. Isoyan, K. V. Simonyan, R. M. Simonyan, M. A. Babayan, G. M. Simonyan, V. A. Chavushyan and M. A. Simonyan

    Citation: BMC Complementary and Alternative Medicine 2019 19:88

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  45. Content type: Research article

    Whole-body electrical myostimulation (WB-EMS) is a relatively recent training methodology that has been extraordinarily used in recent years. However, there is a lack of consensus on the effectiveness of WB-EM...

    Authors: Alvaro Pano-Rodriguez, Jose Vicente Beltran-Garrido, Vicenç Hernández-González and Joaquim Reverter-Masia

    Citation: BMC Complementary and Alternative Medicine 2019 19:87

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  46. Content type: Research article

    The modified Si-Jun-Zi Decoction (SJZ), a Chinese medicine formula, is clinically used against multiple malignancies including colorectal cancer (CRC). This study aims to evaluate the effect of modified SJZ on...

    Authors: Jin-Yong Zhou, Min Chen, Cun-En Wu, Yu-Wen Zhuang, Yu-Gen Chen and Shen-Lin Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:86

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  47. Content type: Research article

    In 2011 there was a strengthening of European Union (EU) legislation on the licencing of herbal products which, in the UK, resulted in the introduction of the Traditional Herbal Registration (THR) scheme. This...

    Authors: R. Dickinson, M. C. Kennedy, D. K. Raynor, P. Knapp, M. Thomas and E. Adami

    Citation: BMC Complementary and Alternative Medicine 2019 19:85

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  48. Content type: Case report

    Fructus Psoraleae is the seed of Psoralea corylifolia Linn. Fructus Psoraleae has been shown to be effective in treating some skin diseases, such as vitiligo. As a main ingredient in five types of herbs in the Qu...

    Authors: Ang Li, Minhong Gao, Na Zhao, Ping Li, Jinguo Zhu and Wenfei Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:84

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  49. Content type: Research article

    Integrative and complementary health approaches (ICHA) are often pursued by patients facing chronic illnesses. Most of the studies that investigated the factors associated with ICHA consumption have considered...

    Authors: Fabrice Berna, Anja S. Göritz, Amaury Mengin, Renaud Evrard, Jacques Kopferschmitt and Steffen Moritz

    Citation: BMC Complementary and Alternative Medicine 2019 19:83

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