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  1. Therapeutic vaccines against cervical cancer remain ineffective. Previously, we demonstrated that blocking the signalling of a cytokine, interleukin 10, at the time of immunisation elicited significantly highe...

    Authors: Xuan Pan, Bowei Ma, Xinchao You, Shu Chen, Jialing Wu, Tianfang Wang, Shelley F. Walton, Jianwei Yuan, Xiaolian Wu, Guoqiang Chen, Yuejian Wang, Guoying Ni and Xiaosong Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:163

    Content type: Research article

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  2. Baltic amber teething necklaces have been popularized as a safe and natural alternative to conventional or pharmacological medicines for the management of teething pain. However, claims made by retailers regar...

    Authors: Michael D. Nissen, Esther T. L. Lau, Peter J. Cabot and Kathryn J. Steadman

    Citation: BMC Complementary and Alternative Medicine 2019 19:162

    Content type: Research article

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  3. Cervical cancer is the second most prevalent cancer worldwide. Portulaca oleracea L. polysaccharide (POL-P3b) has been found to have enhancing immune and anti-cervical cancer activity by oral administration. Dend...

    Authors: Rui Zhao, Xingyue Shao, Guiyan Jia, Yulan Huang, Zhe Liu, Bocui Song and Jinzuo Hou

    Citation: BMC Complementary and Alternative Medicine 2019 19:161

    Content type: Research article

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  4. Delayed gastric emptying play an important role in the pathology of functional dyspepsia. Owing to their functional attributes in alleviating the gastrointestinal disorders, single or polyherbal formulations h...

    Authors: Ramanaiah Illuri, Sudeep Heggar Venkataramana, David Daguet and Shyamprasad Kodimule

    Citation: BMC Complementary and Alternative Medicine 2019 19:159

    Content type: Research article

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  5. Wumei Pill (WMP), a famous herbal formula, has been widely used to treat digestive system diseases in clinical practice in China for centuries. We have found a correlation between the indications of WMP and th...

    Authors: Yuxiang Wan, Lin Xu, Zeyu Liu, Ming Yang, Xin Jiang, Qiaoli Zhang and Jinchang Huang

    Citation: BMC Complementary and Alternative Medicine 2019 19:158

    Content type: Research article

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  6. Cucurbitacin B is the major bioactive constituent in Trichosanthes cucumerina L. fruits, which the pharmacological properties have been studied for decades particularly an anti-tumor activity. The pharmacokinetic...

    Authors: Natthaphon Hunsakunachai, Nitra Nuengchamnong, Weena Jiratchariyakul, Tanawan Kummalue and Phisit Khemawoot

    Citation: BMC Complementary and Alternative Medicine 2019 19:157

    Content type: Research article

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  7. The traditional Chinese medicine prescription, Qianggan formula have been confirmed to be effective on non-alcoholic steatohepatitis (NASH), however, the underlying molecular mechanisms remain obscure.

    Authors: Mingzhe Zhu, Meng Li, Wenjun Zhou, Yang Yang, Fenghua Li, Li Zhang and Guang Ji

    Citation: BMC Complementary and Alternative Medicine 2019 19:156

    Content type: Research article

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  8. Osteochondral defects mostly occur as a result of trauma or articular degeneration. The poor regenerative ability of articular cartilage remains osteochondral defects are a tricky problem to deal with. The mod...

    Authors: Juntao Zhang, Donglin Zhang, Chaochao Wu, Aifeng Liu, Chao Zhang, Jianjie Jiao and Man Shang

    Citation: BMC Complementary and Alternative Medicine 2019 19:155

    Content type: Research article

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  9. Of over 35 Saudi plants traditionally used to treat liver disorders, majority still lack scientific validations. We therefore, evaluated the anti-oxidative, anti-apoptotic and hepatoprotective potential of Solanu...

    Authors: Mohammad K. Parvez, Mohammed S. Al-Dosari, Ahmed H. Arbab, Perwez Alam, Mansour S. Alsaid and Azmat A. Khan

    Citation: BMC Complementary and Alternative Medicine 2019 19:154

    Content type: Research article

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  10. Rhus trilobata Nutt. (Anacardiaceae) (RHTR) is a plant of Mexico that is traditionally used as an alternative treatment for several types of cancer. However, the phytochemical composition and potential toxicity o...

    Authors: Luis Varela-Rodríguez, Blanca Sánchez-Ramírez, Ivette Stephanie Rodríguez-Reyna, José Juan Ordaz-Ortiz, David Chávez-Flores, Erika Salas-Muñoz, Juan Carlos Osorio-Trujillo, Ernesto Ramos-Martínez and Patricia Talamás-Rohana

    Citation: BMC Complementary and Alternative Medicine 2019 19:153

    Content type: Research article

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  11. The leaves of Gongronema latifolium Benth. have long been recognized traditionally as a remedy for a variety of ailments in Africa. This study was conducted to evaluate the safety profile of the ethanolic extract...

    Authors: Bassel Al-Hindi, Nor Adlin Yusoff, Mariam Ahmad, Item Justin Atangwho, Mohd Zaini Asmawi, Majed Ahmed Al-Mansoub, Yasser Mahfooth Tabana, Idris Bello and Mun Fei Yam

    Citation: BMC Complementary and Alternative Medicine 2019 19:152

    Content type: Research article

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  12. Costunolide, a sesquiterpene lactone extracted from Radix Aucklandiae, has the activity against multiple cancers. However, the effect of costunolide on gastric cancer (GC) have remained to be ambiguous. In this s...

    Authors: Zhanpeng Yan, Tingting Xu, Zhentao An, Ying Hu, Wanzhen Chen, Jinxia Ma, Changle Shao and Fangshi Zhu

    Citation: BMC Complementary and Alternative Medicine 2019 19:151

    Content type: Research article

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  13. Traditional medicine remedies are commonly used for treatment of diverse ailments including bacterial infections. The activity against resistant bacteria and safety of some remedies sold as anti-infective trea...

    Authors: Moses Njutain Ngemenya, Ghogo Gail Rinda Djeukem, Kennedy Dohjinga Nyongbela, Petuel Ndip Ndip Bate, Smith Borakaeyabe Babiaka, Elvis Monya and Rudolf Khundou Kanso

    Citation: BMC Complementary and Alternative Medicine 2019 19:150

    Content type: Research article

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  14. The kidney is an essential organ required by the body to perform several important functions. Nephrotoxicity is one of the most prevailing kidney complications that result from exposure to an extrinsic or intr...

    Authors: Marwa M. Abu-Serie, Noha H. Habashy and Adham M. Maher

    Citation: BMC Complementary and Alternative Medicine 2019 19:149

    Content type: Research article

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  15. Sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson, SBT) is a valuable plant because of its medical and therapeutic potential. Different bioactive compounds in SBT berries are of special interest to various resea...

    Authors: Bartosz Skalski, Bogdan Kontek, Bernadetta Lis, Beata Olas, Łukasz Grabarczyk, Anna Stochmal and Jerzy Żuchowski

    Citation: BMC Complementary and Alternative Medicine 2019 19:148

    Content type: Research article

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  16. Ethanol withdrawal (EtOHW) anxiety is a crucial risk factor for alcoholic relapse. The neuropeptide nociceptin/orphanin FQ (N/OFQ) acts upon its receptor (NOP) to antagonize corticotropin-releasing factor (CRF...

    Authors: Li Bo Li, Young Woo Kim, Yu Hua Wang, Li Bai, Xiao Dong Zhu, Zheng Lin Zhao, Chul Won Lee, Yu Jiao, Tong Wu, Zhen Zhen Cai, Sang Chan Kim, Won G. An, Chae Ha Yang, Guang Cheng Cui and Rong Jie Zhao

    Citation: BMC Complementary and Alternative Medicine 2019 19:147

    Content type: Research article

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  17. There is increasing interest in the pharmaceutical and food industries to substitute synthetic chemicals with naturally occurring compounds possessing bioactive properties. Plants are valuable sources of bioac...

    Authors: Maria Rezzoug, Boulanouar Bakchiche, Abdelaziz Gherib, Ascrizzi Roberta, FlaminiGuido, Özge Kilinçarslan, Ramazan Mammadov and Sanaa K. Bardaweel

    Citation: BMC Complementary and Alternative Medicine 2019 19:146

    Content type: Research article

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  18. Previous research findings support an antimicrobial effect of polyphenols against a variety of pathogens, but there is no evidence of this effect against periodontal pathogens in complex biofilms. The purpose ...

    Authors: María C. Sánchez, Honorato Ribeiro-Vidal, Adelaida Esteban-Fernández, Begoña Bartolomé, Elena Figuero, María V. Moreno-Arribas, Mariano Sanz and David Herrera

    Citation: BMC Complementary and Alternative Medicine 2019 19:145

    Content type: Research article

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  19. Moringa oleifera, also known as horseradish tree or drumstick tree, has strong antioxidant properties. In the present study, we investigated the potential effect of Moringa oleifera stem extract (MOSE) on catarac...

    Authors: Lei Qi, Yu Zhou, Weijie Li, Mali Zheng, Ruisheng Zhong, Xin Jin and Yuan Lin

    Citation: BMC Complementary and Alternative Medicine 2019 19:144

    Content type: Research article

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  20. Constipation, a common health problem, causes discomfort and affects the quality of life. This study intended to evaluate the potential laxative effect of triple fermented barley (Hordeum vulgare L.) extract (FBe...

    Authors: Jong-Min Lim, Young Dae Kim, Chang-Hyun Song, Su-Jin Park, Dong-Chan Park, Hyung-Rae Cho, Go-Woon Jung, Khawaja Muhammad Imran Bashir, Sae Kwang Ku and Jae-Suk Choi

    Citation: BMC Complementary and Alternative Medicine 2019 19:143

    Content type: Research article

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  21. Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptati...

    Authors: Luke Esau, Guishan Zhang, Sunil Sagar, Ulrich Stingl, Vladimir B. Bajic and Mandeep Kaur

    Citation: BMC Complementary and Alternative Medicine 2019 19:142

    Content type: Research article

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  22. Antimicrobial resistance (AMR) remains an important global health issue but the gap between AMR and development of new antimicrobials is increasing. Plant extracts may have good activity per se or may be sourc...

    Authors: Ibukun M. Famuyide, Abimbola O. Aro, Folorunso O. Fasina, Jacobus N. Eloff and Lyndy J. McGaw

    Citation: BMC Complementary and Alternative Medicine 2019 19:141

    Content type: Research article

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  23. Cholera is one of the most deadly diarrheal diseases that require new treatments. We investigated the neutralization of cholera toxin by five plant extracts obtained from the Rosaceae family that have been tra...

    Authors: Magdalena Komiazyk, Malgorzata Palczewska, Izabela Sitkiewicz, Slawomir Pikula and Patrick Groves

    Citation: BMC Complementary and Alternative Medicine 2019 19:140

    Content type: Research article

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  24. Several studies have found that caffeic acid (CA), a well-known phytochemical, displays important antioxidant and anti-cancer activities. However, no evidence exists on the protective effect and its mechanisms...

    Authors: Sung-Yong Yang, Min Cheol Pyo, Mi-Hyun Nam and Kwang-Won Lee

    Citation: BMC Complementary and Alternative Medicine 2019 19:139

    Content type: Research article

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  25. Oxymatrine (OM), a quinolizidine alkaloid extracted from a herb Sophorae Flavescentis Radix, has been used to treat liver fibrotic diseases. However, the mechanism of its anti-fibrosis effects is still unclear. T...

    Authors: Li-Ying Song, Yu-Tao Ma, Wei-Jin Fang, Yang He, Jia-Li Wu, Shan-Ru Zuo, Zhen-Zhen Deng, Sheng-Feng Wang and Shi-Kun Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:138

    Content type: Research article

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  26. The Cree of Eeyou Istchee (James Bay area of northern Quebec) suffer from a high rate of diabetes and its complications partly due to the introduction of the western lifestyle within their culture.

    Authors: Ashleigh D. Downing, Hoda M. Eid, Andrew Tang, Fida Ahmed, Cory S. Harris, Pierre S. Haddad, Timothy Johns, John T. Arnason, Steffany A. L. Bennett and Alain Cuerrier

    Citation: BMC Complementary and Alternative Medicine 2019 19:137

    Content type: Research article

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  27. Tomato fruit (Lycopersicon esculentum Mill.) has been suggested to be useful for the prevention of diabetes. Esculeoside A is the main saponin compounds in tomatoes. This study investigated the hypoglycemic effec...

    Authors: Ziming Yang, Li Zhang, Jinglei Liu, Fenglai Lu, Lei Wang, Yueyuan Chen and Dianpeng Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:136

    Content type: Research article

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  28. Sexual problems are widespread and adversely affect the interpersonal relationships and the quality of life. Currently, synthetic drugs improving sexual function are available, but expenditures for such agents...

    Authors: Yi Zhang, Feixian Zhou and Fahuan Ge

    Citation: BMC Complementary and Alternative Medicine 2019 19:135

    Content type: Research article

    Published on:

  29. Calotropis gigantea (CG) is a tall and waxy flower that is used as a traditional remedy for fever, indigestion, rheumatism, leprosy, and leukoderma. However, the precise mechanisms of its anticancer effects have ...

    Authors: Jiyon Lee, Hui-Ju Jang, Hyunwoo Chun, Thu-Huyen Pham, Yesol Bak, Jong-Woon Shin, Hang Jin, Yong-In Kim, Hyung Won Ryu, Sei Ryang Oh and Do-Young Yoon

    Citation: BMC Complementary and Alternative Medicine 2019 19:134

    Content type: Research article

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  30. Nigerian Cannabis sativa (hemp) causes male gonadotoxicity by inducing hyperprolactinemia, down-regulation of hypothalamic-pituitary-testicular axis, and oxidative stress. Benin republic hemp has been preferred b...

    Authors: Abdullateef Isiaka Alagbonsi, Luqman Aribidesi Olayaki, Halimat Amin Abdulrahim, Thomson Sijuade Adetona and Gbemileke Tobiloba Akinyemi

    Citation: BMC Complementary and Alternative Medicine 2019 19:132

    Content type: Research article

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  31. The effects of acupuncture on in vitro fertilization (IVF) outcomes remain controversial. And the variation in participant, interventions, outcomes studied, and trial design may relate to the efficacy of adjuv...

    Authors: Zheng-yun Xie, Zhi-hang Peng, Bing Yao, Li Chen, Yan-yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-yan Yang and You-bing Xia

    Citation: BMC Complementary and Alternative Medicine 2019 19:131

    Content type: Research article

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  32. Angoroside C, cinnamic acid, and harpagoside are bioactive constituents in Scrophularia ningpoensis. Currently, an infrared-assisted extraction (IRAE) method coupled with high-performance liquid chromatography wi...

    Authors: Lina Su, Yinghui Deng, Nianzu Chen, Xiuwen Zhang and Taomin Huang

    Citation: BMC Complementary and Alternative Medicine 2019 19:130

    Content type: Research article

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  33. Green tea has polyphenols like flavonoids and catechins; mainly epigallocatechin-3-gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC) and epicatechin (EC), out of which EGCG is of higher abundan...

    Authors: Ashlesha P. Pandit, Shreyas R. Joshi, Preeti S. Dalal and Vinita C. Patole

    Citation: BMC Complementary and Alternative Medicine 2019 19:129

    Content type: Research article

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  34. Salvia officinalis has been used successfully for the treatment of hot flushes and excessive sweating during menopause. However, modes of actions have not been elucidated conclusively. We explored its pharmacolog...

    Authors: Carsten Tober and Roland Schoop

    Citation: BMC Complementary and Alternative Medicine 2019 19:128

    Content type: Research article

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  35. Xin-Ji-Er-Kang (XJEK) is a Chinese herbal formula, which has been reported to exert effective protection against cardiovascular diseases, including hypertension and myocarditis.

    Authors: Ling Ding, Pan Cheng, Li Wang, Juan Hu, Yong-xue Zhang, Guo-wei Cai, Guang-yao Huang and Shan Gao

    Citation: BMC Complementary and Alternative Medicine 2019 19:127

    Content type: Research article

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  36. Gut microbiota plays a crucial role in the treatment of gastrointestinal (GI) diseases such as chemotherapy-induced diarrhea (CID). Shenzhu Capsule (SZC) is a Chinese herbal formula, which is composed of Rensh...

    Authors: Jing Wang, Wuwen Feng, Shiyang Zhang, Lu Chen, Fei Tang, Yongcheng Sheng, Hui Ao and Cheng Peng

    Citation: BMC Complementary and Alternative Medicine 2019 19:126

    Content type: Research article

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  37. Mind-body practices are frequently used by people living with HIV to reduce symptoms and improve wellbeing. These include Tai Chi, Qigong, yoga, meditation, and all types of relaxation. Although there is subst...

    Authors: Maria Pilar Ramirez-Garcia, Marie-Pier Gagnon, Sébastien Colson, José Côté, Jorge Flores-Aranda and Myriam Dupont

    Citation: BMC Complementary and Alternative Medicine 2019 19:125

    Content type: Research article

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  38. Troxerutin (TRX), a naturally occurring flavonoid in various fruits, has been reported to exhibit numerous pharmacological and biological activities in vitro and in vivo. However, the molecular mechanisms unde...

    Authors: Ying Li, Pan Ma, Jin Fu, Jingjing Wu and Xue Wu

    Citation: BMC Complementary and Alternative Medicine 2019 19:124

    Content type: Research article

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  39. Infectious diseases, particularly those due to multi-drug resistant bacterial strains are almost impossible to cure globally. In this study we investigated the inhibitory effects of Azadirachta indica A. Juss sec...

    Authors: Sunday O. Okoh, Omobola O. Okoh and Anthony I. Okoh

    Citation: BMC Complementary and Alternative Medicine 2019 19:123

    Content type: Research article

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  40. The regenerative capacity of the liver is crucial for the host to survive after serious hepatic injuries, tumor resection, or living donor liver transplantation. Panax notoginseng saponins (PNS) have been reporte...

    Authors: Hua Zhong, Hao Wu, He Bai, Menghao Wang, Jian Wen, Jianping Gong, Mingyong Miao and Fangchao Yuan

    Citation: BMC Complementary and Alternative Medicine 2019 19:122

    Content type: Research article

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  41. Myeloproliferative neoplasm (MPN) patients suffer from significant symptoms, inflammation and reduced quality of life. Yoga improves these outcomes in other cancers, but this hasn’t been demonstrated in MPNs. ...

    Authors: Jennifer Huberty, Ryan Eckert, Amylou Dueck, Heidi Kosiorek, Linda Larkey, Krisstina Gowin and Ruben Mesa

    Citation: BMC Complementary and Alternative Medicine 2019 19:121

    Content type: Research article

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  42. Albizia adianthifolia (Schum.) is medicinally used in Cameroon to manage bronchitis and skin diseases. Our previous study documented the antibacterial potential of its roots’ methanol extract. In this study, meth...

    Authors: Cedric F. Tchinda, Gaiëlle Sonfack, Ingrid K. Simo, İlhami Çelik, Igor K. Voukeng, Blaise K. Nganou, Gabin T. M. Bitchagno, Sultan Funda Ekti, Mathieu Tene, Pierre Tane, Veronique P. Beng and Victor Kuete

    Citation: BMC Complementary and Alternative Medicine 2019 19:120

    Content type: Research article

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  43. Staphylococcus aureus is a notorious pathogen which often causes nosocomial and community attained infections. These infections steadily increased after evolving the resistance due to indecorous practice of antib...

    Authors: Neelam Kumari, Snehlata Singh, Vandana Kumari, Siddhartha Kumar, Vinay Kumar and Antresh Kumar

    Citation: BMC Complementary and Alternative Medicine 2019 19:119

    Content type: Research article

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  44. Hirudin, an extract from Hirudo spp., is an anticoagulant used to treat a variety of renal diseases, including diabetic nephropathy (DN). Currently, hirudin has to be used at high dosages to treat DN because it p...

    Authors: Hongwu Wang, Huantian Cui, Lan Lin, Yue Ji, Qing Ni, Junchen Li, Jianli Pang, Gongyan Bing and Yuhong Bian

    Citation: BMC Complementary and Alternative Medicine 2019 19:118

    Content type: Research article

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  45. Glossogyne tenuifolia (GT) is a traditional herbal tea in Penghu Island, Taiwan. Its extract is traditionally been used as an antipyretic, hepatoprotective and anti-inflammatory remedy in folk medicine among loca...

    Authors: Shibu Marthandam Asokan, Ruoh-Yuh Wang, Tsu-Han Hung and Wan-Teng Lin

    Citation: BMC Complementary and Alternative Medicine 2019 19:117

    Content type: Research article

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  46. Allium species are magnificently nutritious and are commonly used as a part of the diet in Iran. They have health enhancing benefits including anticancer properties due to the presence of numerous bioactive co...

    Authors: Kosar Vafaee, Soudeh Dehghani, Raheleh Tahmasvand, Farzaneh Saeed Abadi, Saeed Irian and Mona Salimi

    Citation: BMC Complementary and Alternative Medicine 2019 19:116

    Content type: Research article

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  47. Skin burn wound is a notable medical burden worldwide. Rapid and effective treatment of burnt skin is vital to fasten wound closure and healing properly. Amniotic graft and Aloe vera are widely used as wound mana...

    Authors: Md Shaifur Rahman, Rashedul Islam, Md Masud Rana, Lucas-Sebastian Spitzhorn, Mohammad Shahedur Rahman, James Adjaye and Sikder M. Asaduzzaman

    Citation: BMC Complementary and Alternative Medicine 2019 19:115

    Content type: Research article

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  48. Embryonic neural stem cells (eNSCs) are immature precursors of the central nervous system (CNS), with self-renewal and multipotential differentiation capacities. These are regulated by endogenous and exogenous...

    Authors: Reza Mahmoudi, Majid Ghareghani, Kazem Zibara, Maryam Tajali Ardakani, Yahya Jand, Hassan Azari, Jafar Nikbakht and Amir Ghanbari

    Citation: BMC Complementary and Alternative Medicine 2019 19:113

    Content type: Research article

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