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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Content type: Research article

    Natural products obtained from plants can be potent sources for developing a variety of pharmaceutical products. Allium species have been widely studied for their anti-cancer effects and presented promising resul...

    Authors: Ovgu Isbilen, Nahit Rizaner and Ender Volkan

    Citation: BMC Complementary and Alternative Medicine 2018 18:30

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  2. Content type: Research article

    Oxidative stress as well as bacterial and fungal infections are common source of diseases while plants are source of medication for curative or protective purposes. Hence, aim of study was to compare the pharm...

    Authors: Iram Fatima, Sobia Kanwal and Tariq Mahmood

    Citation: BMC Complementary and Alternative Medicine 2018 18:27

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  3. Content type: Research article

    Cupressus macrocarpa Hartw and Corymbia citriodora (Hook.) K.D. Hill & L.A.S. Johnson, widely grown in many subtropical areas, are used for commercial purposes, such as in perfumery, cosmetics, and room freshener...

    Authors: Mohamed Z. M. Salem, Hosam O. Elansary, Hayssam M. Ali, Ahmed A. El-Settawy, Mohamed S. Elshikh, Eslam M. Abdel-Salam and Krystyna Skalicka-Woźniak

    Citation: BMC Complementary and Alternative Medicine 2018 18:23

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  4. Content type: Research article

    Pelargonium sidoides (PS) and Coptis chinensis root (CR) have traditionally been used to treat various diseases, including respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders. The pre...

    Authors: Sang Mi Park, Byung-Gu Min, Ji Yun Jung, Kyung Hwan Jegal, Chul Won Lee, Kwang Youn Kim, Young Woo Kim, Youn-Woong Choi, Il Je Cho, Sae Kwang Ku and Sang Chan Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:20

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  5. Content type: Research article

    Based on clinical medications and related studies, we established a Yang-Gan Jie-Du Sang-Jie (YGJDSJ) herbal formula for hepatocarcinoma treatment. In present study, we evaluated the anti-cancer potential of Y...

    Authors: Bing Hu, Tong Zhang, Hong-Mei An, Jia-Lu Zheng, Xia Yan and Xiao-Wei Huang

    Citation: BMC Complementary and Alternative Medicine 2018 18:17

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  6. Content type: Research article

    Nutmeg is the seed kernel inside the fruit of Myristica fragrans Houtt. (Myristicaceae). It possesses various pharmacological activities but is used in Cameroon only for its flavor in making cakes. The present st...

    Authors: Joachim K. Dzotam, Ingrid Konga Simo, Gabin Bitchagno, Ilhami Celik, Louis P. Sandjo, Pierre Tane and Victor Kuete

    Citation: BMC Complementary and Alternative Medicine 2018 18:15

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  7. Content type: Research article

    Fructose-mediated protein glycation (fructation) has been linked to an increase in diabetic and cardiovascular complications due to over consumption of high-fructose containing diets in recent times. The objec...

    Authors: Hardik Ghelani, Valentina Razmovski-Naumovski, Rajeswara Rao Pragada and Srinivas Nammi

    Citation: BMC Complementary and Alternative Medicine 2018 18:13

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  8. Content type: Research article

    Inflammation has been implicated in many disorders, including cancer and available therapies elicit adverse effects. Plants of the family Rubiaceae have shown potency against inflammation. The anti-inflammator...

    Authors: Oluwayinka Olufunmilayo Owolabi, Dorcas Bolanle James, Ibrahim Sani, Binda T. Andongma, Opeoluwa O. Fasanya and Barnabas Kure

    Citation: BMC Complementary and Alternative Medicine 2018 18:12

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  9. Content type: Research article

    The highbush blueberry (Vaccinium corymbosum) has a beneficial effect on several aspects of human health. The present study investigated the effects of highbush blueberry proanthocyanidins (PACs) on the virulence...

    Authors: Amel Ben Lagha, Geneviève LeBel and Daniel Grenier

    Citation: BMC Complementary and Alternative Medicine 2018 18:10

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  10. Content type: Research article

    Costus speciosus, Cymbopogon citratus, and Tabernaemontana coronaria are herbal plants traditionally used as remedies for symptoms of tuberculosis (TB) including cough. The aims of the present study were to evalu...

    Authors: Suriyati Mohamad, Nur Najihah Ismail, Thaigarajan Parumasivam, Pazilah Ibrahim, Hasnah Osman and Habibah A. Wahab

    Citation: BMC Complementary and Alternative Medicine 2018 18:5

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  11. Content type: Research article

    An impaired leukocytes function is the factor causing the susceptibility of patients with diabetes mellitus to infections. The outmost importance for the understanding of the immunological processes involved i...

    Authors: Mariia Nagalievska, Mariya Sabadashka, Halyna Hachkova and Nataliia Sybirna

    Citation: BMC Complementary and Alternative Medicine 2018 18:4

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  12. Content type: Research article

    The medicinal importance of a novel plant Olax nana Wall. ex Benth. (family: Olacaceae) was revealed for the first time via HPLC-DAD finger printing, qualitative phytochemical analysis, antioxidant, cholinesteras...

    Authors: Muhammad Ovais, Muhammad Ayaz, Ali Talha Khalil, Sayed Afzal Shah, Muhammad Saeed Jan, Abida Raza, Muhammad Shahid and Zabta Khan Shinwari

    Citation: BMC Complementary and Alternative Medicine 2018 18:1

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  13. Content type: Research article

    Basophilic granulocytes (BGs) not only initiate the induction of Th2 cell differentiation, but also amplify the ongoing Th2 response. Shuang-Huang-Lian (SHL) is clinically used for relieving type I hypersensit...

    Authors: Qiaoling Fei, Yixin Han, Ruijuan Qi, Yuan Gao, Lei Fang, Rui Hou, Runlan Cai and Yun Qi

    Citation: BMC Complementary and Alternative Medicine 2018 18:2

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  14. Content type: Research article

    The use of doxorubicin (DOX) an anthracycline antineoplastic agent is withdrawn due to its cardio-toxic side effects. Oxidative stress has been recognized as the primary cause of DOX induced cardiotoxicity. We...

    Authors: Tayyaba Afsar, Suhail Razak, Khalid Mujasam Batoo and Muhammad Rashid Khan

    Citation: BMC Complementary and Alternative Medicine 2017 17:554

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  15. Content type: Research article

    The conversion of the epithelial phenotype of cancer cells into cells with a mesenchymal phenotype-so-called epithelial–mesenchymal transition (EMT)-has been shown to enhance the capacity of the cells to disse...

    Authors: Nareerat Petpiroon, Boonchoo Sritularak and Pithi Chanvorachote

    Citation: BMC Complementary and Alternative Medicine 2017 17:553

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  16. Content type: Research article

    Danshen is a common traditional Chinese medicine used to treat neoplastic and chronic inflammatory diseases in China. However, the effects of Danshen on human oral cancer cells remain relatively unknown. This ...

    Authors: Cheng-Yu Yang, Cheng-Chih Hsieh, Chih-Kung Lin, Chun-Shu Lin, Bo Peng, Gu-Jiun Lin, Huey-Kang Sytwu, Wen-Liang Chang and Yuan-Wu Chen

    Citation: BMC Complementary and Alternative Medicine 2017 17:555

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  17. Content type: Research article

    Although such local herb as Streblus asper (family Moraceae) has long been recognized for traditional folk medicines and important ingredient of traditional longevity formula, its anti-neurodegeneration or anti-a...

    Authors: Anchalee Prasansuklab, Krai Meemon, Prasert Sobhon and Tewin Tencomnao

    Citation: BMC Complementary and Alternative Medicine 2017 17:551

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  18. Content type: Research article

    Mood disorder accounts for 13 % of global disease burden. And while therapeutic agents are available, usually orally administered, most have unwanted side effects, and thus making the inhalation of essential o...

    Authors: Myra O. Villareal, Ayumi Ikeya, Kazunori Sasaki, Abdelkarim Ben Arfa, Mohamed Neffati and Hiroko Isoda

    Citation: BMC Complementary and Alternative Medicine 2017 17:549

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  19. Content type: Research article

    Extracts from Salvia miltiorrhiza Bunge have been used in traditional Asian medicine to treat coronary heart disease, chronic renal failure, atherosclerosis, myocardial infraction, angina pectoris, myocardial isc...

    Authors: Bongkyun Park, Hae Seong Song, Jeong Eun Kwon, Se Min Cho, Seon-A Jang, Mi Yeon Kim and Se Chan Kang

    Citation: BMC Complementary and Alternative Medicine 2017 17:545

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  20. Content type: Research article

    Acute kidney injury (AKI) is an initial factor in many kidney disorders. Pre- and intra-renal AKI biomarkers have recently been reported. Recovery from AKI by herbal medicine has rarely been reported. Thus, th...

    Authors: Sung-Man Oh, Gunhyuk Park, Seung Hoon Lee, Chang-Seob Seo, Hyeun-Kyoo Shin and Dal-Seok Oh

    Citation: BMC Complementary and Alternative Medicine 2017 17:544

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