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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Page 7 of 34

  1. Content type: Research article

    Rhazya stricta Decne. is a medicinal plant that is widespread in Saudi Arabia and desert areas of the Arabian Peninsula. Its extract contains alkaloids, tannins, and flavonoids that ar...

    Authors: Faisal S. Alagrafi, Abdullah O. Alawad, Nael M. Abutaha, Fahd A. Nasr, Othman A. Alhazzaa, Sultan N. Alharbi, Mohammad N. Alkhrayef, Mohamed Hammad, Ziyad A. Alhamdan, Abdullah D. Alenazi and Mohammad A. Wadaan

    Citation: BMC Complementary and Alternative Medicine 2017 17:342

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  2. Content type: Research article

    The Thai traditional herbal formula–Mathurameha, consisting of 26 medicinal plants, has been used as an alternative and complementary medicine for diabetes treatment in Wangnamyen Hospital, Thailand. To provid...

    Authors: Kullacha Chayarop, Penchom Peungvicha, Rungravi Temsiririrkkul, Yuvadee Wongkrajang, Wongsatit Chuakul and Piyanuch Rojsanga

    Citation: BMC Complementary and Alternative Medicine 2017 17:343

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  3. Content type: Research article

    Jaun-ointment (JO), also known as Shiunko in Japan, is one of the most popular medicinal formulae used in Korean traditional medicine for the external treatment of skin wound and inflammatory skin conditions. ...

    Authors: Jeong-Hae Choi, Yeon-Suk Song, Hae-June Lee, Gyoo-Cheon Kim and Jin-Woo Hong

    Citation: BMC Complementary and Alternative Medicine 2017 17:340

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  4. Content type: Research article

    To investigate beneficial effects of Pomegranate seeds oil (PSO), leaves (PL), juice (PJ) and (PP) on brain cholinesterase activity, brain oxidative stress and lipid profile in high-fat-high fructose diet (HFD...

    Authors: Zahra Amri, Asma Ghorbel, Mouna Turki, Férièle Messadi Akrout, Fatma Ayadi, Abdelfateh Elfeki and Mohamed Hammami

    Citation: BMC Complementary and Alternative Medicine 2017 17:339

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  5. Content type: Research article

    Myocardial infarction (MI) is a major risk factor responsible for morbidity and mortality. Xinji′erkang (XJEK) has been clinically used as an effective medication in the treatment of coronary heart disease and...

    Authors: Juan Hu, Yong-xue Zhang, Li Wang, Ling Ding, Guang-yao Huang, Guo-wei Cai and Shan Gao

    Citation: BMC Complementary and Alternative Medicine 2017 17:338

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  6. Content type: Research article

    Infectious diseases are the most common causes of morbidity and mortality in developing countries. Wound and wound infections are also major health problem. Nowadays, medicinal plants play a major role in trea...

    Authors: Berhan Begashaw, Bharat Mishra, Asegedech Tsegaw and Zewdneh Shewamene

    Citation: BMC Complementary and Alternative Medicine 2017 17:337

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  7. Content type: Research article

    Our present study was conducted to characterize the phytoconstituents present in the aqueous extract of Momordica charantia and evaluate the antimicrobial efficacy of silver-extract nanoparticles (Ag-Extract-NPs)...

    Authors: Md. Mamun Or Rashid, Kazi Nahid Akhter, Jakir Ahmed Chowdhury, Foysal Hossen, Md. Saddam Hussain and Md. Tanvir Hossain

    Citation: BMC Complementary and Alternative Medicine 2017 17:336

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  8. Content type: Research article

    Ginger is a popular spice and food preservative. The rhizomes of the common ginger have been used as traditional medicine to treat various ailments. 6-Shogaol, a pungent compound isolated from the rhizomes of jah...

    Authors: Syntyche Ling Sing Seow, Sok Lai Hong, Guan Serm Lee, Sri Nurestri Abd Malek and Vikineswary Sabaratnam

    Citation: BMC Complementary and Alternative Medicine 2017 17:334

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  9. Content type: Research article

    Alzheimer’s disease is a neurodegenerative disease, characterized by progressive decline in memory and cognitive functions, that results from loss of neurons in the brain. Amyloid beta (Aβ) protein and oxidati...

    Authors: Alona Telerman, Rivka Ofir, Yoel Kashman and Anat Elmann

    Citation: BMC Complementary and Alternative Medicine 2017 17:332

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  10. Content type: Research article

    Xiao Yao San (XYS) is an herbal prescription which is used in the treatment of depression for thousands of years from Song dynasty in China (960–1127 A...

    Authors: Xiu-Fang Ding, Yue-Hua Li, Jia-Xu Chen, Long-Ji Sun, Hai-Yan Jiao, Xin-Xin Wang and Yan Zhou

    Citation: BMC Complementary and Alternative Medicine 2017 17:326

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  11. Content type: Research article

    Diabetes mellitus (DM) is associated with hyperglycemia, inflammatory disorders and abnormal lipid profiles, currently the extracts from leaves of cynara scolymus has been discovered to treat metabolic disorders ...

    Authors: Maryem Ben Salem, Rihab Ben Abdallah Kolsi, Raouia Dhouibi, Kamilia Ksouda, Slim Charfi, Mahdi Yaich, Serria Hammami, Zouheir Sahnoun, Khaled Mounir Zeghal, Kamel Jamoussi and Hanen Affes

    Citation: BMC Complementary and Alternative Medicine 2017 17:328

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  12. Content type: Research article

    XuefuZhuyu decoction (XFZY) is a well-known traditional Chinese herbal medicine for the treatment of various cardiovascular diseases, such as unstable angina pectoris and myocardial ischemia-reperfusion injury...

    Authors: Xiaowen Shi, Haiyan Zhu, Yuanyuan Zhang, Mingmei Zhou, Danli Tang and Huamin Zhang

    Citation: BMC Complementary and Alternative Medicine 2017 17:325

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  13. Content type: Research article

    Tuberculosis is a world-wide problem affecting humans and animals. There is increasing development of resistance of the pathogens to current antimycobacterial agents. Many authors have investigated activities ...

    Authors: Ishaku L. Elisha, Francien S. Botha, Balungile Madikizela, Lyndy J. McGaw and Jacobus N. Eloff

    Citation: BMC Complementary and Alternative Medicine 2017 17:327

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  14. Content type: Research article

    Hypercholesterolemia is a serious diseases associated with type-2 diabetes, atherosclerosis, cardiovascular disorders and liver diseases. Humans seek for safe herbal medication such as karela (Momordica charan...

    Authors: Dalia Yossri Saad, Mohamed Mohamed Soliman, Ahmed A. Baiomy, Magdy Hassan Yassin and Hanan Basiouni El-Sawy

    Citation: BMC Complementary and Alternative Medicine 2017 17:319

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  15. Content type: Research article

    The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylv...

    Authors: Yan Jiang, Yan Lin, Yi-Juan Hu, Xiao-Jun Song, Hong-Hua Pan and Hong-Jian Zhang

    Citation: BMC Complementary and Alternative Medicine 2017 17:320

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  16. Content type: Research article

    Antacids, anticholinergic drugs, histamine H2- receptor antagonists and irreversible proton pump inhibitors have been used for the treatment of gastric ulcers. However, prolonged use of these drugs may lead to...

    Authors: Ramani Karunakaran, M. Ira Thabrew, G. Mayuri Thammitiyagodage, B. Prasanna Galhena and L.D.A. Menuka Arawwawala

    Citation: BMC Complementary and Alternative Medicine 2017 17:312

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  17. Content type: Research article

    Apoptosis plays a critical role in the progression of diabetic cardiomyopathy (DC). Astragalus polysaccharides (APS), an extract of astragalus membranaceus (AM), is an effective cardioprotectant. Currently, littl...

    Authors: Shuqin Sun, Shuo Yang, Min Dai, Xiujuan Jia, Qiyan Wang, Zheng Zhang and Yongjun Mao

    Citation: BMC Complementary and Alternative Medicine 2017 17:310

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  18. Content type: Research article

    Since long, natural sources have been explored for possible managements of various diseases. In this context, the study is designed to evaluate Isodon rugosus Wall. ex Benth for biological potentials including an...

    Authors: Anwar Zeb, Farhat Ullah, Muhammad Ayaz, Sajjad Ahmad and Abdul Sadiq

    Citation: BMC Complementary and Alternative Medicine 2017 17:284

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  19. Content type: Research article

    Cancer still constitutes one of the major health concerns globally, causing serious threats on patients, their families, and the healthcare system.

    Authors: Victor Kuete, Fabrice W. Fokou, Oğuzhan Karaosmanoğlu, Veronique P. Beng and Hülya Sivas

    Citation: BMC Complementary and Alternative Medicine 2017 17:280

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  20. Content type: Research article

    Several lichen species are reported to be used tradiationally in many theraupatic practices. Many lichen species are reported as sources of several bioactive natural compounds. Several lichen species of Nepal ...

    Authors: Baidya Nath Jha, Mitesh Shrestha, Durga Prasad Pandey, Tribikram Bhattarai, Hari Datta Bhattarai and Babita Paudel

    Citation: BMC Complementary and Alternative Medicine 2017 17:282

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  21. Content type: Research article

    Recinodindron heudelotii (Euphorbiaceae) is a plant used in Africa, particularly in Cameroon to treat various ailments including bacterial infections. In this study, we evaluated the e...

    Authors: Aimé Gabriel Fankam, Jules-Roger Kuiate and Victor Kuete

    Citation: BMC Complementary and Alternative Medicine 2017 17:168

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  22. Content type: Research article

    Sophorae Flos (SF) is a composite of flowers and buds of Styphnolobium japonicum (L.) Schott and has been used in traditional Korean and Chinese medicine for the treatment of hemostasis and inflammation. Previous...

    Authors: Jeong-Mi Kim, Jung-Han Lee, Guem-San Lee, Eun-mi Noh, Hyun-Kyung Song, Dong Ryun Gu, Seong-Cheol Kim, Seoung Hoon Lee, Kang-Beom Kwon and Young-Rae Lee

    Citation: BMC Complementary and Alternative Medicine 2017 17:164

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    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2017 17:235

  23. Content type: Research article

    Polygonum chinense Linn. is a common medicinal plant in Southeast Asia and has been used in traditional medicine in Vietnam. The plant contains phytochemicals with various biological p...

    Authors: Thu Thi Tran, Meehyein Kim, Yejin Jang, Hye Won Lee, Hoa Thi Nguyen, Thanh Ngoc Nguyen, Hae Woong Park, Quang Le Dang and Jin-Cheol Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:162

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  24. Content type: Research article

    Tuberculosis (TB) is a global health problem complicated by drug resistance and human immunodeficiency virus that has dramatically increased active TB. Several medicinal plants are used traditionally to treat ...

    Authors: Wubayehu Kahaliw, Abraham Aseffa, Markos Abebe, Mekonen Teferi and Ephrem Engidawork

    Citation: BMC Complementary and Alternative Medicine 2017 17:143

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  25. Content type: Research article

    In acupuncture practice, the most important step is to confirm the location of a sensitized acupoint which reflects a diagnosis and can be stimulated with a specialized needle to treat the disease. Abnormal sy...

    Authors: Wei He, Xiao-Yu Wang, Hong Shi, Wan-Zhu Bai, Bin Cheng, Yang-Shuai Su, Xiao-Chun Yu, Xiang-Hong Jing and Bing Zhu

    Citation: BMC Complementary and Alternative Medicine 2017 17:141

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  26. Content type: Research article

    Currently, food supplements to improve age-related dementia are required. Therefore, we aimed to determine the effect of the combined extract of Cyperus rotundus and Zingiber officinale (CP1) on the improvement o...

    Authors: Chatchada Sutalangka and Jintanaporn Wattanathorn

    Citation: BMC Complementary and Alternative Medicine 2017 17:135

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  27. Content type: Research article

    Modified Lingguizhugan Decoction (MLD) came from famous Chinese medicine Linggui Zhugan Decoction. The MLD is used for the treatment of metabolic syndrome in the clinical setting. Our study focuses on the comp...

    Authors: Limei Yao, Jingjing Wei, Si Shi, Kunbin Guo, Xiangyu Wang, Qi Wang, Dingsheng Chen and Weirong Li

    Citation: BMC Complementary and Alternative Medicine 2017 17:132

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  28. Content type: Research article

    Lianhuaqingwen Capsule (LH-C) is a traditional Chinese medicine (TCM) formula used to treat respiratory tract infectious diseases in Chinese. The aim of this study was to determine the antiviral activity of LH...

    Authors: Yuewen Ding, Lijuan Zeng, Runfeng Li, Qiaoyan Chen, Beixian Zhou, Qiaolian Chen, Pui leng Cheng, Wang Yutao, Jingping Zheng, Zifeng Yang and Fengxue Zhang

    Citation: BMC Complementary and Alternative Medicine 2017 17:130

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  29. Content type: Research article

    Hypercholesterolaemia (HC) is a major risk factor for ischemic heart disease and is also known to be a risk factor for erectile dysfunction (ED). ED caused by HC is thought to be related to HC-induced oxidativ...

    Authors: Hoon Jang, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, Seung Mo Yuk, Dong Seok Han, Chang Shik Youn, Eun Bi Kwon, Sung Yeoun Hwang and Sae Woong Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:129

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  30. Content type: Research article

    Current tuberculosis regimens have failed to combat the issue of drug resistance and ethno medicines may represent a possible source of antimycobacterial agents. Combretum species are well known in African tra...

    Authors: Tafadzwa Nyambuya, Ruvimbo Mautsa and Stanley Mukanganyama

    Citation: BMC Complementary and Alternative Medicine 2017 17:124

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  31. Content type: Research article

    Allium hookeri (AH) is widely consumed as a vegetable and herbal medicine in southeastern Asia. AH has been reported antioxidant, antimicrobial, improvement of bone health and antidiab...

    Authors: Ja-Young Jang, Min-Jung Lee, Bo-Ram You, Jong-Sik Jin, Sung-Hyen Lee, Ye-Rang Yun and Hyun Ju Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:126

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    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2017 17:176

  32. Content type: Research article

    Obesity is a major health concern both in developed and developing countries. The use of herbal medicines became the subject of interest for the management of obesity due to its natural origin, cost effectiven...

    Authors: Hafeedza Abdul Rahman, Najla Gooda Sahib, Nazamid Saari, Faridah Abas, Amin Ismail, Muhammad Waseem Mumtaz and Azizah Abdul Hamid

    Citation: BMC Complementary and Alternative Medicine 2017 17:122

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  33. Content type: Research article

    Many plants of boreal forest of Quebec have been used by Native Americans to treat a variety of microbial infections. However, the antiviral activities of these plants have been seldom evaluated on cellular mo...

    Authors: Serge Lavoie, Isabelle Côté, André Pichette, Charles Gauthier, Michaël Ouellet, Francine Nagau-Lavoie, Vakhtang Mshvildadze and Jean Legault

    Citation: BMC Complementary and Alternative Medicine 2017 17:123

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  34. Content type: Research article

    Activation of macrophage is involved in many inflammation diseases. Lipopolysaccharide (LPS) is a powerful inflammatory signal contributing to monocytes/macrophages activation associated with increased proinfl...

    Authors: Haijian Sun, Weiwei Cai, Xu Wang, Yanling Liu, Bao Hou, Xuexue Zhu and Liying Qiu

    Citation: BMC Complementary and Alternative Medicine 2017 17:120

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  35. Content type: Research article

    This study explored Bacopa monnieri, a medicinal Ayurvedic herb, as a cardioprotectant against ischemia/reperfusion injury using cardiac function and coronary flow as end-points.

    Authors: Sirintorn Srimachai, Sylvie Devaux, Celine Demougeot, Sarawut Kumphune, Nina D. Ullrich, Ernst Niggli, Kornkanok Ingkaninan, Natakorn Kamkaew, C. Norman Scholfield, Sompol Tapechum and Krongkarn Chootip

    Citation: BMC Complementary and Alternative Medicine 2017 17:117

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  36. Content type: Research article

    Zuo-Jin-Wan (ZJW), a two-herb formula consisting of Coptis chinensis (CC) and Evodia rutaecarpa (ER), is commonly used in traditional Chinese medicine for the treatment of cancers. However, the efficacies and mec...

    Authors: Shun-Ting Chou, Chien-Yun Hsiang, Hsin-Yi Lo, Hui-Fen Huang, Ming-Tsung Lai, Ching-Liang Hsieh, Su-Yin Chiang and Tin-Yun Ho

    Citation: BMC Complementary and Alternative Medicine 2017 17:121

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  37. Content type: Research article

    The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been...

    Authors: Jongsung Lee, Youn Hwa Nho, Seok Kyun Yun and Young Sun Hwang

    Citation: BMC Complementary and Alternative Medicine 2017 17:113

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  38. Content type: Research article

    The prevalence of obesity is surging in an alarming rate all over the world. Pharmaceutical drugs are considered potential adjunctive therapy to lifestyle modification. However, for most, besides being too exp...

    Authors: Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Jeong-Bum Nam, Mi-Ran Kim and Qi Jia

    Citation: BMC Complementary and Alternative Medicine 2017 17:114

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  39. Content type: Research article

    Development of new and effective therapeutics for sexually transmitted herpes simplex virus-2 (HSV-2) infection is important from public health perspective. With an aim to identify natural products from medici...

    Authors: Ajay Kesharwani, Suja Kizhiyedath Polachira, Reshmi Nair, Aakanksha Agarwal, Nripendra Nath Mishra and Satish Kumar Gupta

    Citation: BMC Complementary and Alternative Medicine 2017 17:110

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  40. Content type: Research article

    Liver cancer is a high incidence and fatal disease, the fifth most frequent cancer worldwide that is usually diagnosed at an advanced stage. The number of deaths from liver cancer has not declined even followi...

    Authors: S. Khazaei, R. Abdul Hamid, N. Mohd Esa, V. Ramachandran, Ghomi Tabatabaee F. Aalam, A. Etemad and P. Ismail

    Citation: BMC Complementary and Alternative Medicine 2017 17:104

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  41. Content type: Research article

    Arsenic trioxide (ATO) is approved for treating terminal-stage liver cancer in China. Cryptotanshinone (CT), a STAT3 inhibitor, has exhibited certain anti-tumor potency; however, the use of CT enhanced ATO for...

    Authors: Li Shen, Guangshun Zhang, Zhaohuan Lou, Guanhua Xu and Guangji Zhang

    Citation: BMC Complementary and Alternative Medicine 2017 17:106

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  42. Content type: Research article

    There is growing interest in the use of plants for the treatment and prevention of cancer. Medicinal plants are currently being evaluated as source of promising anticancer agents. In this paper, we have invest...

    Authors: Jaya Bhandari, BushraTaj Muhammad, Pratiksha Thapa and Bhupal Govinda Shrestha

    Citation: BMC Complementary and Alternative Medicine 2017 17:102

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  43. Content type: Research article

    Atopic dermatitis (AD) is an inflammatory, chronically relapsing, and intensively pruritic skin disease that affect 10–30% of the global population. Angelicae dahuricae Radix (ADR) has been reported to be anti-in...

    Authors: Jin Mo Ku, Se Hyang Hong, Hyo In Kim, Hye Sook Seo, Yong Cheol Shin and Seong-Gyu Ko

    Citation: BMC Complementary and Alternative Medicine 2017 17:98

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  44. Content type: Research article

    Rind of Punica granatum is traditionally used in treatment of abdominal cramps and various GIT disorders. So far spasmolytic activity of rind of Punica granatum has been reported using in vitro model. However, it...

    Authors: Niaz Ali, Ayesha Jamil, Syed Wadood Ali Shah, Ismail Shah and Ghayour Ahmed

    Citation: BMC Complementary and Alternative Medicine 2017 17:97

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  45. Content type: Research article

    To contribute to the development of novel anti-influenza drugs, we investigated the anti-influenza activity of crude extracts from 118 medicinal plants collected in Myanmar. We discovered that extract from the...

    Authors: Masaki Shoji, So-Yeun Woo, Aki Masuda, Nwet Nwet Win, Hla Ngwe, Etsuhisa Takahashi, Hiroshi Kido, Hiroyuki Morita, Takuya Ito and Takashi Kuzuhara

    Citation: BMC Complementary and Alternative Medicine 2017 17:96

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  46. Content type: Research article

    In our previous work, the dichloromethane-methanol (1:1 v/v) extract, fractions and isolated compounds from Polyscias fulva stem bark showed interesting antifungal activity. As a continuity of that work, this stu...

    Authors: Guy Sedar Singor Njateng, Zhizhi Du, Donatien Gatsing, Raymond Simplice Mouokeu, Yaping Liu, Hong-Xia Zang, Jianlong Gu, Xiaodong Luo and Jules-Roger Kuiate

    Citation: BMC Complementary and Alternative Medicine 2017 17:99

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  47. Content type: Research article

    Agastache rugosa is well-known as a common traditional Chinese medicine, which have relieving summer-heat, analgesic and antipyretic effects, have long been used as folkloristic remedy...

    Authors: Haiyan Gong, Shaoyu Li, Lijuan He and Rena Kasimu

    Citation: BMC Complementary and Alternative Medicine 2017 17:95

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  48. Content type: Research article

    In the Chinese traditional medicine, plant of Agastache rugosa (Fisch. & C.A. Mey.) Kuntze (A. rugosa) has been used to treat nausea, vomiting and dispel damp. However, currently, few reports about the chemical c...

    Authors: Pengran Cao, Pingyao Xie, Xuebiao Wang, Jinmei Wang, Jinfeng Wei and Wen-yi Kang

    Citation: BMC Complementary and Alternative Medicine 2017 17:93

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  49. Content type: Research article

    Tuberculosis (TB) is still a global health problem mainly due to development of resistance and co-infection with the Human immune Virus (HIV). Treatment of multi and extensively drug resistant TB requires use ...

    Authors: Lydia Bunalema, Ghislain Wabo Fotso, Paul Waako, John Tabuti and Samuel O. Yeboah

    Citation: BMC Complementary and Alternative Medicine 2017 17:89

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