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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Page 6 of 34

  1. Content type: Research article

    Electroacupuncture (EA) has been applied to treat and prevent diseases for years. However, molecular events happened in both the acupunctured site and the internal organs after EA stimulation have not been cla...

    Authors: Jing-Shan Wu, Hsin-Yi Lo, Chia-Cheng Li, Feng-Yuan Chen, Chien-Yun Hsiang and Tin-Yun Ho

    Citation: BMC Complementary and Alternative Medicine 2017 17:406

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  2. Content type: Research article

    Trema orientalis (T. orientalis Linn) has been used in the management of malaria in the western part of Nigeria and despite its application in ethnomedicine, there is dearth of scienti...

    Authors: John Oludele Olanlokun, Oluwole Moses David and Anthony Jide Afolayan

    Citation: BMC Complementary and Alternative Medicine 2017 17:407

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  3. Content type: Research article

    Onchocerciasis is one of the tropical neglected diseases (NTDs) caused by the nematode Onchocerca volvulus. Control strategies currently in use rely on mass administration of ivermectin, which has marked activity...

    Authors: Justin Kalmobé, Dieudonné Ndjonka, Djafsia Boursou, Jacqueline Dikti Vildina and Eva Liebau

    Citation: BMC Complementary and Alternative Medicine 2017 17:404

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  4. Content type: Research article

    Hyperlipidaemia is the major risk factor contributing to the development and progression of atherosclerosis, fatty liver and cerebrovascular disease. Pleurotus eryngii (P. eryngii) is rich in biologically active ...

    Authors: Chen Zhang, Juan Li, Jing Wang, Xingling Song, Jianjun Zhang, Shang Wu, Chunlong Hu, Zhiyuan Gong and Le Jia

    Citation: BMC Complementary and Alternative Medicine 2017 17:403

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  5. Content type: Research article

    Holarrhena antidysenterica has been employed as an ethnobotanical plant for the treatment of dysentery, diarrhoea, fever, and bacterial infections. Biological activities of the princip...

    Authors: Thanyaluck Siriyong, Potjanee Srimanote, Sasitorn Chusri, Boon-ek Yingyongnarongkul, Channarong Suaisom, Varomyalin Tipmanee and Supayang Piyawan Voravuthikunchai

    Citation: BMC Complementary and Alternative Medicine 2017 17:405

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  6. Content type: Research article

    Studies of the effects of electromagnetic fields (EMFs) on cartilaginous cells show a broad range of outcomes. However EMFs are not yet clinically applied as standard treatment of osteoarthritis, as EMF effect...

    Authors: Julia Isabelle Redeker, Bärbel Schmitt, Nele Pascale Grigull, Christian Braun, Andreas Büttner, Volkmar Jansson and Susanne Mayer-Wagner

    Citation: BMC Complementary and Alternative Medicine 2017 17:402

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  7. Content type: Research article

    Our previous study demonstrated that an up-regulation of the Brain-Derived Neurotrophic Factor (BDNF) signaling pathway is involved the mechanism causing the recurrence of triple negative breast cancer. The ai...

    Authors: Jen-Hwey Chiu, Fang-Pey Chen, Yi-Fang Tsai, Man-Ting Lin, Ling-Ming Tseng and Yi-Ming Shyr

    Citation: BMC Complementary and Alternative Medicine 2017 17:401

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  8. Content type: Research article

    The resistance of some medico-veterinary parasite strains as well as the unavailability and toxicity of synthetic anthelminthics on humans, animals and the impacts of their residues in the environment have pus...

    Authors: Sergine Errole Ngouateu Teufack, Gertrude NMbogning Tayo, Marc Ngangout Alidou, Jeannette Yondo, Amely Frankline Djiomene, Josué Wabo Poné and Faùily Mpoame Mbida

    Citation: BMC Complementary and Alternative Medicine 2017 17:400

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  9. Content type: Research article

    Cardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC...

    Authors: Min Li, Xue Xu, Xinyu Yang, Joey S. W. Kwong and Hongcai Shang

    Citation: BMC Complementary and Alternative Medicine 2017 17:398

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  10. Content type: Research article

    Chronic stress contributes to the development of brain disorders, such as neurodegenerative and psychiatric diseases. Oxidative damage is well known as a causative factor for pathogenic process in brain tissue...

    Authors: Hyun-Yong Lee, Jin-Seok Lee, Hyeong-Geug Kim, Won-Yong Kim, Seung-Bae Lee, Yung-Hyun Choi and Chang-Gue Son

    Citation: BMC Complementary and Alternative Medicine 2017 17:397

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  11. Content type: Research article

    Arachidonic acid metabolism by cyclooxygenase (COX) is a major pathway for blood platelets’ activation, which is associated with pro-thrombotic platelet activity and the production of pro-inflammatory mediator...

    Authors: Michal Bijak and Joanna Saluk-Bijak

    Citation: BMC Complementary and Alternative Medicine 2017 17:396

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  12. Content type: Research article

    The common usage of chewing sticks prepared from Neem tree (Azadirachta indica) in India suggests its potential efficacy in periodontal diseases. The objective of this study is to explore the antibacterial effect...

    Authors: Leali Heyman, Yael Houri-Haddad, Samuel N. Heyman, Isaac Ginsburg, Yossi Gleitman and Osnat Feuerstein

    Citation: BMC Complementary and Alternative Medicine 2017 17:399

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  13. Content type: Research article

    A variety of anticancer chemotherapeutics induce adverse side effects including myelotoxicity. Dried roots of Phragmites communis Trinius, Phragmitis rhizoma, have been clinically used in traditional folk medicin...

    Authors: Jinhee Kim, You Jin Lee, Young Ah Kim, Eun-Sang Cho, Eunna Huh, Ok-Sun Bang and No Soo Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:393

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  14. Content type: Research article

    [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db ...

    Authors: Mehdi Bin Samad, Md. Nurul Absar Bin Mohsin, Bodiul Alam Razu, Mohammad Tashnim Hossain, Sinayat Mahzabeen, Naziat Unnoor, Ishrat Aklima Muna, Farjana Akhter, Ashraf Ul Kabir and J. M. A. Hannan

    Citation: BMC Complementary and Alternative Medicine 2017 17:395

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  15. Content type: Research article

    It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting acti...

    Authors: Chi-Chung Peng, Hui-Tzu Sun, I-Ping Lin, Ping-Chung Kuo and Jen-Chieh Li

    Citation: BMC Complementary and Alternative Medicine 2017 17:392

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  16. Content type: Research article

    The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereot...

    Authors: Patrick Amoateng, Samuel Adjei, Dorcas Osei-safo, Kennedy K. E. Kukuia, Emelia Oppong Bekoe, Thomas K. Karikari and Samuel B. Kombian

    Citation: BMC Complementary and Alternative Medicine 2017 17:389

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  17. Content type: Research article

    Plants are an efficient source of natural antioxidant against free radicals causing kidney damages. Sida cordata ethyl acetate fraction has been reported for strong in vitro antioxidant potency, previously. In th...

    Authors: Naseer Ali Shah, Muhammad Rashid Khan and Dereje Nigussie

    Citation: BMC Complementary and Alternative Medicine 2017 17:388

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  18. Content type: Research article

    Herbology is the prevailing system among the nationally-accepted alternative or complementary systems of medicine. The system is due to its general and patient-oriented methodology, is widely used in the gener...

    Authors: Saiqa Ishtiaq, Maida Akram, Sairah Hafeez Kamran, Uzma Hanif, Muhammad Shaharyar Khan Afridi, Sajid-ur-Rehman, Atika Afzal, Ayesha Asif, Muhammad Younus and Shehla Akbar

    Citation: BMC Complementary and Alternative Medicine 2017 17:387

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  19. Content type: Research article

    Benign prostatic hyperplasia (BPH) is non-cancerous condition of enlargement of the prostate, a common occurrence in older men. The immature fruits of Poncirus trifoliata (L.) Rafinesque (Rutaceae), Ponciri Fruct...

    Authors: Woo-Young Jeon, Ohn Soon Kim, Chang-Seob Seo, Seong Eun Jin, Jung-Ae Kim, Hyeun-Kyoo Shin, Yong-ung Kim and Mee-Young Lee

    Citation: BMC Complementary and Alternative Medicine 2017 17:384

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  20. Content type: Research article

    As per the recent statistical reports of World Health Organisation (WHO), 13% of total global population is obese. Orlistat remains to be the only drug approved for the long term treatment of obesity. Recent f...

    Authors: M. Katoch, A. Paul, G. Singh and S. N. C. Sridhar

    Citation: BMC Complementary and Alternative Medicine 2017 17:385

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  21. Content type: Research article

    Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present study was aimed to appraise the polarity directed antioxidant, c...

    Authors: Madiha Ahmed, Humaira Fatima, Muhammad Qasim, Bilquees Gul and Ihsan-ul-Haq

    Citation: BMC Complementary and Alternative Medicine 2017 17:386

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  22. Content type: Research article

    Epidemiological and experimental evidences have shown cancer as a leading cause of death worldwide. Although the folklore use of plants as a reliable source of health-restoring principles is well-documented, t...

    Authors: Jeremiah Olorunjuwon Olugbami, Robert Damoiseaux, Bryan France, Esther Modupe Onibiyo, Michael Adedapo Gbadegesin, Shivani Sharma, James Kazimierz Gimzewski and Oyeronke Adunni Odunola

    Citation: BMC Complementary and Alternative Medicine 2017 17:381

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  23. Content type: Research article

    Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarin...

    Authors: Stéphane Zingue, Thomas Michel, Chantal Beatrice Magne Nde, Amstrong Nang Njuh, Julia Cisilotto, Derek Tantoh Ndinteh, Colin Clyne, Xavier Fernandez, Tânia Beatriz Creczynski-Pasa and Dieudonné Njamen

    Citation: BMC Complementary and Alternative Medicine 2017 17:383

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  24. Content type: Research article

    The ethnic population of Arunachal Pradesh uses a number of orchids as such, or in decoction for various ailments. Three untapped orchids namely, Rhynchostylis retusa, Tropidia curculioides and Satyrium nepalense...

    Authors: Manisha Bhatnagar, Nandan Sarkar, Nigam Gandharv, Ona Apang, Sarman Singh and Sabari Ghosal

    Citation: BMC Complementary and Alternative Medicine 2017 17:379

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  25. Content type: Research article

    Asthma is characterized by chronic airway inflammation, leading to structura1 changes in the airway, collectively termed airway remodeling. Airway remodeling is thought to contribute to airway hyper responsive...

    Authors: Xiufeng Tang, Honglei Nian, Xiaoxi Li, Yan Yang, Xiujuan Wang, Liping Xu, Haotian Shi, Xinwei Yang and Renhui Liu

    Citation: BMC Complementary and Alternative Medicine 2017 17:380

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  26. Content type: Research article

    Cancer cachexia is associated with increased pro-inflammatory cytokine levels. Centella asiatica (C. asiatica) possesses antioxidant, anti-inflammatory and anti-tumour potential. We investigated the modulation of...

    Authors: Dhaneshree Bestinee Naidoo, Anil Amichund Chuturgoon, Alisa Phulukdaree, Kanive Parashiva Guruprasad, Kapaettu Satyamoorthy and Vikash Sewram

    Citation: BMC Complementary and Alternative Medicine 2017 17:377

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  27. Content type: Research article

    Prostate cancer is the most common cancer in men in the United States. Fucoidan is a bioactive polysaccharide extracted mainly from algae. The aim of this study was to investigate anti-tumor and anti-angiogeni...

    Authors: Xin Rui, Hua-Feng Pan, Si-Liang Shao and Xiao-Ming Xu

    Citation: BMC Complementary and Alternative Medicine 2017 17:378

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  28. Content type: Research article

    In northeastern Brazil, grape pomace has become a potential alternative byproduct because of the recover phenolic compounds from the vinification process. Comparative analyses were performed between lyophilize...

    Authors: José George F. Albuquerque, Valéria L. Assis, Arthur J. P. O. Almeida, Ionaldo J. L. D. Basílio, Melissa N. Luciano, Bruno R. L. A. Meireles, Ângela M. T. M. Cordeiro, Islânia G. A. Araújo, Robson C. Veras, Thaís P. Ribeiro and Isac A. Medeiros

    Citation: BMC Complementary and Alternative Medicine 2017 17:376

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  29. Content type: Research article

    SC-E1 is a novel herbal formula consisting of five oriental medicinal herbs used frequently in traditional herbal medicine for the treatment of inflammatory diseases in Korea. This study examined the effects o...

    Authors: Ju-Yeon Park, Young-Won Kwon, Soo Chil Lee, Sun-Dong Park and Ju-Hee Lee

    Citation: BMC Complementary and Alternative Medicine 2017 17:374

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  30. Content type: Research article

    Chebulic acid (CA) isolated from T. chebula, which has been reported for treating asthma, as a potent anti-oxidant resources. Exposure to ambient urban particulate matter (UPM) considered as a risk for cardiopulm...

    Authors: Kyung-Won Lee, Mi-Hyun Nam, Hee-Ra Lee, Chung-Oui Hong and Kwang-Won Lee

    Citation: BMC Complementary and Alternative Medicine 2017 17:373

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  31. Content type: Research article

    Solanum nigrum, herbal plant that commonly grows in temperate climate zone, has been used as a traditional folk medicine whose ripen fruits were proven to exhibit anti-tumor properties...

    Authors: Sankar Jagadeeshan, Diana David, S. Jisha, S. Manjula and S. Asha Nair

    Citation: BMC Complementary and Alternative Medicine 2017 17:370

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  32. Content type: Research article

    The roots and stem bark of Berberis orthobotrys (Berberidaceae) have long been used traditionally to treat joint pain. Though, it has not been pharmacologically assessed for rheumatoid arthritis. The current stud...

    Authors: Alamgeer, Ambreen Malik Uttra and Umme Habiba Hasan

    Citation: BMC Complementary and Alternative Medicine 2017 17:371

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  33. Content type: Research article

    The emergence of drug resistant malaria is threatening our ability to treat and control malaria in the Southeast Asian region. There is an urgent need to develop novel and chemically diverse antimalarial drugs...

    Authors: Muhammad Bilal Sadiq, Pattamon Tharaphan, Kesinee Chotivanich, Joel Tarning and Anil Kumar Anal

    Citation: BMC Complementary and Alternative Medicine 2017 17:372

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  34. Content type: Research article

    Beta-mangostin (BM) is a xanthone-type of natural compound isolated from Cratoxylum arborescens. This study aimed to examine the apoptosis mechanisms induced by BM in a murine monomyelocytic cell line (WEHI-3) in...

    Authors: Fatima Abdelmutaal Ahmed Omer, Najihah Mohd Hashim, Mohamed Yousif Ibrahim, Abdulmannan F. Aldoubi, Pouya Hassandarvish, Firouzeh Dehghan, Noraziah Nordin, Hamed Karimian, Landa Zeenelabdin Ali Salim, Mahmood Ameen Abdulla, Karim Al-Jashamy and Syam Mohan

    Citation: BMC Complementary and Alternative Medicine 2017 17:366

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  35. Content type: Research article

    In this study, Aloe vera samples were collected from different climatic regions of India. Quantitative HPTLC (high performance thin layer chromatography) analysis of important anthraquinones aloin and aloe-emodin...

    Authors: Sandeep Kumar, Manila Yadav, Amita Yadav, Pooja Rohilla and Jaya Parkash Yadav

    Citation: BMC Complementary and Alternative Medicine 2017 17:369

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  36. Content type: Research article

    Curcuma longa L. is a well-known medicinal plant that has been used for its anti-cancer, neuroprotective, and hepatoprotective effects. However, the neuroprotective effect of fermented...

    Authors: Cheong-Su Eun, Jong-Soon Lim, Jihye Lee, Sam-Pin Lee and Seun-Ah Yang

    Citation: BMC Complementary and Alternative Medicine 2017 17:367

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  37. Content type: Research article

    Zanthoxylum armatum DC has been an important traditional plant known for its medicinal properties. It is well known for its antimicrobial, larvicidal and cytotoxic activities.

    Authors: Fiaz Alam, Qazi Najum us Saqib and Abdul Waheed

    Citation: BMC Complementary and Alternative Medicine 2017 17:368

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  38. Content type: Research article

    Several lines of evidence suggest the consume of natural products for cancer prevention or treatment. In particular, isothiocyanates (ITCs) exerting anti-cancer properties, have received great interest as pote...

    Authors: Sabrina Giacoppo, Renato Iori, Patrick Rollin, Placido Bramanti and Emanuela Mazzon

    Citation: BMC Complementary and Alternative Medicine 2017 17:362

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  39. Content type: Research article

    Retinal ischemia-related eye diseases result in visual dysfunction. This study investigates the protective effects and mechanisms of Xue-Fu-Zhu-Yu decoction (XFZYD) with respect to retinal ischemia.

    Authors: Shu-Qiu Tan, Xue Geng, Jorn-Hon Liu, Wynn Hwai-Tzong Pan, Li-Xiang Wang, Hui-Kang Liu, Lei Hu and Hsiao-Ming Chao

    Citation: BMC Complementary and Alternative Medicine 2017 17:365

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  40. Content type: Research article

    Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by continuous hyperglycemia associated with insulin resistance and /or reduced insulin secretion. There is an emerging trend regarding the ...

    Authors: Mizher Hezam AL-Zuaidy, Muhammad Waseem Mumtaz, Azizah Abdul Hamid, Amin Ismail, Suhaila Mohamed and Ahmad Faizal Abdul Razis

    Citation: BMC Complementary and Alternative Medicine 2017 17:359

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  41. Content type: Research article

    Sarcopoterium spinosum (S. spinosum) is used by Bedouin medicinal practitioners for the treatment of diabetes. While the anti-diabetic activity of S. spinosum root extract was validate...

    Authors: Uriel Elyasiyan, Adi Nudel, Nir Skalka, Konstantin Rozenberg, Elyashiv Drori, Rachela Oppenheimer, Zohar Kerem and Tovit Rosenzweig

    Citation: BMC Complementary and Alternative Medicine 2017 17:356

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  42. Content type: Research article

    Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease, and the prevalence has increased significantly in recent decades to epidemic proportions in China. Individually, fenugreek (Trigo...

    Authors: Juntao Kan, Rodney A. Velliquette, Kerry Grann, Charlie R. Burns, Jeff Scholten, Feng Tian, Qi Zhang and Min Gui

    Citation: BMC Complementary and Alternative Medicine 2017 17:352

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  43. Content type: Research article

    Tagetes minuta has a long record of human use for the treatment of stomach and intestinal diseases. Most drugs used for diseases treatment are less efficacious with side effects and th...

    Authors: Aboi Igwaran, Benson Chucks Iweriebor, Sunday Ofuzim Okoh, Uchechukwu Uchechukwu Nwodo, Larry Chikwelu Obi and Anthony Ifeanyi Okoh

    Citation: BMC Complementary and Alternative Medicine 2017 17:351

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  44. Content type: Research article

    Colitis is a well-known subtype of inflammatory bowel disease and is caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory and anti-allergic effects on various diseases....

    Authors: Dong-Gun Kim, Mi-Ra Lee, Jae-Myung Yoo, Kwang-Il Park and Jin-Yeul Ma

    Citation: BMC Complementary and Alternative Medicine 2017 17:354

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  45. Content type: Research article

    Bone defects caused by trauma, infection or tumor resection are common in orthopedic clinic and depending on the extent of the fracture; the vast majority require treatment with bone substitutes. Among the bon...

    Authors: Vicente F. Pinheiro Neto, Rachel M. Ribeiro, Camila S. Morais, Matheus B. Campos, Denilson A. Vieira, Porfírio C. Guerra, Ana L. Abreu-Silva, José R. Silva Junior, Flavia Raquel F. Nascimento, Marilene O. R. Borges and Antonio C.R. Borges

    Citation: BMC Complementary and Alternative Medicine 2017 17:350

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  46. Content type: Research article

    A. cordifolia is a plant widely used in Africa to solve many health problems. In Cameroon, it is used in the treatment of urogenital infections. As a continuation of our search for pha...

    Authors: Merline Namekong Djimeli, Siméon Pierre Chegaing Fodouop, Guy Sedar Singor Njateng, Charles Fokunang, Donald Sedric Tala, Fabrice Kengni and Donatien Gatsing

    Citation: BMC Complementary and Alternative Medicine 2017 17:349

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  47. Content type: Research article

    Axon growth inhibitory factors NogoA/Nogo receptor (NgR) and its signaling pathways RhoA/Rho kinase (ROCK) play a critical role in the repair of nerve damage in multiple sclerosis (MS). Bu Shen Yi Sui Capsule ...

    Authors: Ling Fang, Yongqiang Wang, Qi Zheng, Tao Yang, Peiyuan Zhao, Hui Zhao, Qiuxia Zhang, Yuanyuan Zhao, Fang Qi, Kangning Li, Zhenzhen Chen, Junling Li, Nan Zhang, Yongping Fan and Lei Wang

    Citation: BMC Complementary and Alternative Medicine 2017 17:346

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  48. Content type: Research article

    Xeniji, produced by fermenting various types of foods with lactic acid bacteria and yeast, has been commonly consumed as functional food. However, nutrition value, bioactivities and safety of different ferment...

    Authors: Noraisyah Zulkawi, Kam Heng Ng, Rizi Zamberi, Swee Keong Yeap, Dilan Satharasinghe, Indu Bala Jaganath, Anisah Binti Jamaluddin, Sheau Wei Tan, Wan Yong Ho, Noorjahan Banu Alitheen and Kamariah Long

    Citation: BMC Complementary and Alternative Medicine 2017 17:344

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  49. Content type: Research article

    Black ginseng (Panax ginseng C. A. Meyer), three to nine times-steamed and dried ginseng, has biological and pharmacological activities. In this study, the anti-diabetic effects of the black ginseng ethanol extra...

    Authors: Ok-Hwa Kang, Mi-Yae Shon, Ryong Kong, Yun-Soo Seo, Tian Zhou, Do-Yeon Kim, Yeong-Soo Kim and Dong-Yeul Kwon

    Citation: BMC Complementary and Alternative Medicine 2017 17:341

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