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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Page 5 of 34

  1. Content type: Research article

    Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. In an at...

    Authors: Siti Zawanah Halim, Zainul Amiruddin Zakaria, Maizatul Hasyima Omar, Norhafizah Mohtarrudin, Ikarastika Rahayu Abdul Wahab and Muhammad Nazrul Hakim Abdullah

    Citation: BMC Complementary and Alternative Medicine 2017 17:488

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  2. Content type: Research article

    Coix lacryma-jobi var. ma-yuen (Rom.Caill.) Stapf has been used in China as an herbal medicine. Many studies of this plant have reported anti-proliferative and apoptotic activities on ...

    Authors: Eun Suk Son, Young Ock Kim, Chun Geon Park, Kyung Hun Park, Sung Hwan Jeong, Jeong-Woong Park and Se-Hee Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:486

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  3. Content type: Research article

    During ischemic stroke (IS), adenosine 5′-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors si...

    Authors: Jia Huang, Xiaofang You, Weilin Liu, Changming Song, Xiaomin Lin, Xiufeng Zhang, Jing Tao and Lidian Chen

    Citation: BMC Complementary and Alternative Medicine 2017 17:480

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  4. Content type: Research article

    Essential hypertension is mainly caused by endothelial dysfunction which results from nitric oxide (NO) deficiency. The present study was design to evaluate the protective effect of Bidens pilosa ethylene acetate...

    Authors: Danielle Claude Bilanda, Paul Désiré D. Dzeufiet, Léontine Kouakep, Bibi Farouck O. Aboubakar, Léonard Tedong, Pierre Kamtchouing and Théophile Dimo

    Citation: BMC Complementary and Alternative Medicine 2017 17:479

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  5. Content type: Research article

    Oxidative stress has a pivotal role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complications of diabetes mellitus. There is accumulating evide...

    Authors: Davood Nasiry, Ali Reza khalatbary, Hassan Ahmadvand, Fereshteh Talebpour Amiri and Esmaeil Akbari

    Citation: BMC Complementary and Alternative Medicine 2017 17:476

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  6. Content type: Research article

    Hypertension is one of the most important risk factors for cardiovascular disease (CVD) and a worldwide problem. Despite increases in the development of synthetic drugs for hypertension treatment, the rate of ...

    Authors: Bumjung Kim, Youngki Kwon, Somin Lee, Kyungjin Lee, Inhye Ham and Ho-Young Choi

    Citation: BMC Complementary and Alternative Medicine 2017 17:474

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  7. Content type: Research article

    Many people still experience pain and inflammation regardless of the available drugs for treatments. In addition, the available drugs have many side effects, which necessitated a quest for new drugs from sever...

    Authors: Yohannes Tamrat, Teshome Nedi, Solomon Assefa, Tilahun Teklehaymanot and Workineh Shibeshi

    Citation: BMC Complementary and Alternative Medicine 2017 17:473

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  8. Content type: Research article

    Cisplatin is widely used chemotherapeutic agent for cancer treatment with limited uses due to its neurotoxic side effect. The aim of this study was to determine the potential preventive effects of rutin on the...

    Authors: Mashal M. Almutairi, Wael A. Alanazi, Musaad A. Alshammari, Moureq Rashed Alotaibi, Ali R. Alhoshani, Salim Salah Al-Rejaie, Mohamed M. Hafez and Othman A. Al-Shabanah

    Citation: BMC Complementary and Alternative Medicine 2017 17:472

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  9. Content type: Research article

    Cerebral edema, erupting simultaneously with severe ischemic stroke, might lead to increased intracranial pressure, cerebral herniation, and ultimately death. Studies conducted previously by our team have demo...

    Authors: Nannan Yu, Zhenguo Wang, Yucen Chen, Juntao Yang, Xuan Lu, Yi Guo, Zelin Chen and Zhifang Xu

    Citation: BMC Complementary and Alternative Medicine 2017 17:470

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  10. Content type: Research article

    Propolis and its major constituent – caffeic acid phenethyl ester (CAPE) have good abilities on antitumor and anti-inflammation. However, little is known about the actions of propolis and CAPE on tumor in infl...

    Authors: Huasong Chang, Yuehua Wang, Xusheng Yin, Xinying Liu and Hongzhuan Xuan

    Citation: BMC Complementary and Alternative Medicine 2017 17:471

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  11. Content type: Research article

    Mango mistletoes Dendrophthoe pentandra (MMDP) extract has attracted interest due to its pharmacological properties, including gastro protective effects. The aim of this study was to investigate whether MMDP extr...

    Authors: Agustina Tri Endharti and Sofy Permana

    Citation: BMC Complementary and Alternative Medicine 2017 17:468

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  12. Content type: Research article

    Extracts of plants have been considered as sources of natural antioxidant agents. In this study, we aimed to explore the antioxidant capacity of the aqueous root extract of Asparagus cochinchinensis (Lour.) Merr.

    Authors: Linghua Lei, Yanhua Chen, Lijun Ou, Yinglong Xu and Xiaoying Yu

    Citation: BMC Complementary and Alternative Medicine 2017 17:469

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  13. Content type: Research article

    The emergence of multidrug-resistant bacteria is a worldwide concern and in order to find an alternative to this problem, the occurrence of antimicrobial compounds in Plectranthus amboinicus essential oil was inv...

    Authors: Sara Edwirgens Costa Benício Vasconcelos, Hider Machado Melo, Theodora Thays Arruda Cavalcante, Francisco Eduardo Aragão Catunda Júnior, Mário Geraldo de Carvalho, Francisca Gleire Rodrigues Menezes, Oscarina Viana de Sousa and Renata Albuquerque Costa

    Citation: BMC Complementary and Alternative Medicine 2017 17:462

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  14. Content type: Research article

    Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were act...

    Authors: Sabrina M. Noritake, Jenny Liu, Sierra Kanetake, Carol E. Levin, Christina Tam, Luisa W. Cheng, Kirkwood M. Land and Mendel Friedman

    Citation: BMC Complementary and Alternative Medicine 2017 17:461

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  15. Content type: Research article

    Alkaloids have been considered as the most promising bioactive ingredients in plant species from the genus Zanthoxylum. This study reports on the compositions and contents of the Zanthoxylum alkaloids (ZAs) from ...

    Authors: Yongqiang Tian, Chunyun Zhang and Mingquan Guo

    Citation: BMC Complementary and Alternative Medicine 2017 17:460

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  16. Content type: Research article

    Tinospora cordifolia (Guduchi or Amrita) is an important drug of Ayurvedic System of Medicine and found mention in various classical texts for the treatment of diseases such as jaundic...

    Authors: Picheswara Rao Polu, Udupa Nayanbhirama, Saleemulla Khan and Rajlexmi Maheswari

    Citation: BMC Complementary and Alternative Medicine 2017 17:457

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  17. Content type: Research article

    So-ochim-tang-gamibang (SOCG) is a decoction formula which has been used to improve mental activity in traditional Korean medicine. The present study was performed to evaluate whether ...

    Authors: Hwa Chul Shin, Jae Ho Lee, Ki Joong Kim, Hyun Jin Shin, Jeong June Choi, Chan Yong Lee, Uk Namgung and In Chul Jung

    Citation: BMC Complementary and Alternative Medicine 2017 17:456

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  18. Content type: Research article

    Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of tau...

    Authors: Wenhua Zhu, Siwen Chen, Ronggui Chen, Zhiqing Peng, Jun Wan and Benyan Wu

    Citation: BMC Complementary and Alternative Medicine 2017 17:455

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  19. Content type: Research article

    Radix puerariae (RP) is a herbal medicines for diabetes, mainly because of anti-oxidative, insulin resistance and hypoglycemic effect. Fructus crataegi (FC) also possesses strong antioxidant activity in vitro....

    Authors: Zhengyue Chen, Yanyan Yuan, Xinrong Zou, Mengqi Hong, Ming Zhao, Yu Zhao, Yuanping Liu, Guofu Li, Yabin Zhu, Lin Luo, Beiyan Bao and Shizhong Bu

    Citation: BMC Complementary and Alternative Medicine 2017 17:454

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  20. Content type: Research article

    Foodstuffs of both plant and animal origin contain a wide range of bioactive compounds. Although human intervention studies are mandatory to assess the health effects of bioactives, the in vitro approach is of...

    Authors: Mattia Di Nunzio, Veronica Valli, Lidia Tomás-Cobos, Teresa Tomás-Chisbert, Lucía Murgui-Bosch, Francesca Danesi and Alessandra Bordoni

    Citation: BMC Complementary and Alternative Medicine 2017 17:453

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  21. Content type: Research article

    Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders that are mediated by pathogenic Th1 and Th17 cells. Previous studies have demonstrated that taheebo water extract (TWE) derived from Tabebuia ...

    Authors: Hyun Jung Park, Sung Won Lee, Dong-Joo Kwon, Seong-Il Heo, Se-Ho Park, Sun Young Kim and Seokmann Hong

    Citation: BMC Complementary and Alternative Medicine 2017 17:448

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  22. Content type: Research article

    Previous studies have revealed that gypenosides (GPS) improve the symptoms of anxiety disorders in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned rat model of Parkinson’s disease (PD). The pres...

    Authors: Ting Ting Zhao, Kyung Sook Kim, Keon Sung Shin, Hyun Jin Park, Hyun Jeong Kim, Kyung Eun Lee and Myung Koo Lee

    Citation: BMC Complementary and Alternative Medicine 2017 17:449

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  23. Content type: Research article

    Mutations play a major role in the pathogenesis and development of several chronic degenerative diseases including cancer. It follows, therefore that antimutagenic compound may inhibit the pathological process...

    Authors: Tshepiso Jan Makhafola, Esameldin Elzein Elgorashi, Lyndy Joy McGaw, Maurice Ducret Awouafack, Luc Verschaeve and Jacobus Nicolaas Eloff

    Citation: BMC Complementary and Alternative Medicine 2017 17:446

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  24. Content type: Research article

    “Jiedu Huayu” (JDHY) granules are traditional Chinese herbal compounds that have been used to treat severe liver injury for many years. The purpose of the current study is to evaluate the safety of JDHY granules.

    Authors: Minggang Wang, Hua Qiu, Rongzhen Zhang, Fuli Long and Dewen Mao

    Citation: BMC Complementary and Alternative Medicine 2017 17:450

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  25. Content type: Research article

    The concept of botanical therapeutics has revitalized due to wide importance of plant derived pharmaceuticals. Therefore, the ameliorative characteristics of Ajuga bracteosa were studied.

    Authors: Syeda Saniya Zahra, Madiha Ahmed, Muhammad Qasim, Bilquees Gul, Muhammad Zia, Bushra Mirza and Ihsan-ul Haq

    Citation: BMC Complementary and Alternative Medicine 2017 17:443

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  26. Content type: Research article

    Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail. In this study, we elucidated anti-cancer activ...

    Authors: Su Bin Park, Gwang Hun Park, Hun Min Song, Ho-Jun Son, Yurry Um, Hyun-Seok Kim and Jin Boo Jeong

    Citation: BMC Complementary and Alternative Medicine 2017 17:445

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  27. Content type: Research article

    Agrimonia pilosa Ledeb. is a medicinal plant with physiological activities such as anti-cancer, antioxidant, anti-inflammatory activities and in vitro anti-diabetic activity. However, ...

    Authors: Hwan Hee Jang, Song Yee Nam, Mi Ju Kim, Jung Bong Kim, Jeong Sook Choi, Haeng Ran Kim and Young Min Lee

    Citation: BMC Complementary and Alternative Medicine 2017 17:442

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  28. Content type: Research article

    A variety of plants in Acanthaceae have long been used in traditional Thai ailment and commercialised with significant economic value. Nowadays medicinal plants are sold in processed forms and thus morphologic...

    Authors: Tanakorn Suesatpanit, Kitisak Osathanunkul, Panagiotis Madesis and Maslin Osathanunkul

    Citation: BMC Complementary and Alternative Medicine 2017 17:437

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  29. Content type: Research article

    Tetracera indica Merr. (Family: Dilleniaceae), known to the Malay as ‘Mempelas paya’, is one of the medicinal plants used in the treatment of diabetes in Malaysia. However, no proper s...

    Authors: Md. Mahmudul Hasan, Qamar Uddin Ahmed, Siti Zaiton Mat Soad, Jalifah Latip, Muhammad Taher, Tengku Muhamad Faris Syafiq, Murni Nazira Sarian, Alhassan Muhammad Alhassan and Zainul Amiruddin Zakaria

    Citation: BMC Complementary and Alternative Medicine 2017 17:431

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  30. Content type: Research article

    Recent reports have demonstrated that impaired barrier function and local microinflammation in the duodenal mucosa contribute to the pathogeneses of functional dyspepsia (FD). Thus, restoring normal barrier in...

    Authors: Xiongfei Chang, Luqing Zhao, Jiajia Wang, Xiaofang Lu and Shengsheng Zhang

    Citation: BMC Complementary and Alternative Medicine 2017 17:432

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  31. Content type: Research article

    P-113 (AKRHHGYKRKFH-NH2) is a 12-amino-acid histidine-rich peptide derived from histatin 5 that is highly degradable in high salt concentrations and biological fluids such as serum, plasma and saliva. Nal-P-11...

    Authors: Hong-yan Wang, Li Lin, Wei Fu, Hui-Yuan Yu, Ning Yu, Li-si Tan, Jya-wei Cheng and Ya-ping Pan

    Citation: BMC Complementary and Alternative Medicine 2017 17:426

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  32. Content type: Research article

    GS-E3D is a newly developed pectin lyase-modified red ginseng extract. The purpose of this study was to investigate the therapeutic effects of GS-E3D on diabetes-related renal dysfunction in streptozotocin-ind...

    Authors: Chan-Sik Kim, Kyuhyung Jo, Jin Sook Kim, Mi-Kyung Pyo and Junghyun Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:430

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  33. Content type: Research article

    In immunocompromised patients, human cytomegalovirus (HCMV) infection can lead to severe, life-threatening diseases, such as pneumonitis, hepatitis, gastrointestinal tract disease, and retinitis. We previously...

    Authors: Sohee Bae, Se Chan Kang and Yoon-Jae Song

    Citation: BMC Complementary and Alternative Medicine 2017 17:428

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  34. Content type: Research article

    Various studies have suggested the effectiveness of Chinese medicine in the treatment of diabetic peripheral neuropathy (DPN). There are several principles and methods in Chinese medicine for the treatment of ...

    Authors: Sharad Panthi, Xirun Jing, Chenghan Gao and Tianshu Gao

    Citation: BMC Complementary and Alternative Medicine 2017 17:424

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  35. Content type: Research article

    Euphorbia hirta linn., is a species of Euphorbiaceae family. They are known as asthma plant, barokhervi. The plant E. hirta is famous for its medicinal importance among the tribal popu...

    Authors: Riazul Haque Tuhin, Mst. Marium Begum, Md. Sohanur Rahman, Rubaba Karim, Taslima Begum, Siraj Uddin Ahmed, Ronia Mostofa, Amir Hossain, Mohamed Abdel-Daim and Rayhana Begum

    Citation: BMC Complementary and Alternative Medicine 2017 17:423

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  36. Content type: Research article

    Hepatocellular carcinoma (HCC) accounts for major cancer-related deaths despite current advanced therapies. Treatment and prognosis of HCC is better in patients with preserved liver function. Many natural prod...

    Authors: Fazal Khan, Tariq Jamal Khan, Gauthaman Kalamegam, Peter Natesan Pushparaj, Adeel Chaudhary, Adel Abuzenadah, Taha Kumosani, Elie Barbour and Mohammed Al-Qahtani

    Citation: BMC Complementary and Alternative Medicine 2017 17:418

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  37. Content type: Research article

    Acorus gramineus has been reported to exhibit various pharmacological effects including inhibition of cholesterol synthesis, enhancement of lipid metabolism, prevention of dementia and...

    Authors: Joo-Myung Moon, Hae-Mi Sung, Hyun-Jung Jung, Jae-Won Seo and Ji-Hyang Wee

    Citation: BMC Complementary and Alternative Medicine 2017 17:414

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  38. Content type: Research article

    This study evaluated the in vitro activity of essential oil extracted from the leaves of Myracrodruon urundeuva.

    Authors: Ítalo Diego Rebouças de Araújo, Nayara Coriolano de Aquino, Andreza Conceição Véras de Aguiar Guerra, Renato Ferreira de Almeida Júnior, Renata Mendonça Araújo, Raimundo Fernandes de Araújo Júnior, Kléber Juvenal Silva Farias, José Veríssimo Fernandes and Vânia Sousa Andrade

    Citation: BMC Complementary and Alternative Medicine 2017 17:419

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  39. Content type: Research article

    Torch ginger (Etlingera elatior, EE) is a ginger plant that found in Southeast Asia. Previous study showed its flowers and leaves composed of several flavonoids with anti-cancer activity. This study aims to inves...

    Authors: Aungkana Krajarng, Malin Chulasiri and Ramida Watanapokasin

    Citation: BMC Complementary and Alternative Medicine 2017 17:415

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  40. Content type: Research article

    Kangfuxin (KFX) is the ethanol extract of Periplaneta americana L, which has been widely used in the Traditional Chinese Medicine for the repair and regeneration of injured organ and tissues with long history. Th...

    Authors: Yan-Fen Huang, Long-Jian Li, Si-Qian Gao, Yang Chu, Jie Niu, Fu-Neng Geng, Yong-Mei Shen and Li-Hua Peng

    Citation: BMC Complementary and Alternative Medicine 2017 17:413

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  41. Content type: Research article

    Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is widely used in Southeast Asia, China and India in food preparation and for medicinal purposes. Meanwhile, the neuroprotective ...

    Authors: Xin-Shi Wang, Zeng-Rui Zhang, Man-Man Zhang, Miao-Xuan Sun, Wen-Wen Wang and Cheng-Long Xie

    Citation: BMC Complementary and Alternative Medicine 2017 17:412

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  42. Content type: Research article

    The increase in demand and consumption of single clove garlic or ‘Solo garlic’ (Allium sativum) has resulted in an increase in research on its therapeutic properties. The present study aims to evaluate the antiox...

    Authors: Khalid Mohammed Naji, Elham Shukri Al-Shaibani, Fatima A. Alhadi, Safa’a Abdulrzaq Al-Soudi and Myrene R. D’souza

    Citation: BMC Complementary and Alternative Medicine 2017 17:411

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  43. Content type: Research article

    Electroacupuncture (EA) has been applied to treat and prevent diseases for years. However, molecular events happened in both the acupunctured site and the internal organs after EA stimulation have not been cla...

    Authors: Jing-Shan Wu, Hsin-Yi Lo, Chia-Cheng Li, Feng-Yuan Chen, Chien-Yun Hsiang and Tin-Yun Ho

    Citation: BMC Complementary and Alternative Medicine 2017 17:406

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  44. Content type: Research article

    Trema orientalis (T. orientalis Linn) has been used in the management of malaria in the western part of Nigeria and despite its application in ethnomedicine, there is dearth of scienti...

    Authors: John Oludele Olanlokun, Oluwole Moses David and Anthony Jide Afolayan

    Citation: BMC Complementary and Alternative Medicine 2017 17:407

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  45. Content type: Research article

    Onchocerciasis is one of the tropical neglected diseases (NTDs) caused by the nematode Onchocerca volvulus. Control strategies currently in use rely on mass administration of ivermectin, which has marked activity...

    Authors: Justin Kalmobé, Dieudonné Ndjonka, Djafsia Boursou, Jacqueline Dikti Vildina and Eva Liebau

    Citation: BMC Complementary and Alternative Medicine 2017 17:404

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  46. Content type: Research article

    Hyperlipidaemia is the major risk factor contributing to the development and progression of atherosclerosis, fatty liver and cerebrovascular disease. Pleurotus eryngii (P. eryngii) is rich in biologically active ...

    Authors: Chen Zhang, Juan Li, Jing Wang, Xingling Song, Jianjun Zhang, Shang Wu, Chunlong Hu, Zhiyuan Gong and Le Jia

    Citation: BMC Complementary and Alternative Medicine 2017 17:403

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  47. Content type: Research article

    Holarrhena antidysenterica has been employed as an ethnobotanical plant for the treatment of dysentery, diarrhoea, fever, and bacterial infections. Biological activities of the princip...

    Authors: Thanyaluck Siriyong, Potjanee Srimanote, Sasitorn Chusri, Boon-ek Yingyongnarongkul, Channarong Suaisom, Varomyalin Tipmanee and Supayang Piyawan Voravuthikunchai

    Citation: BMC Complementary and Alternative Medicine 2017 17:405

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  48. Content type: Research article

    Studies of the effects of electromagnetic fields (EMFs) on cartilaginous cells show a broad range of outcomes. However EMFs are not yet clinically applied as standard treatment of osteoarthritis, as EMF effect...

    Authors: Julia Isabelle Redeker, Bärbel Schmitt, Nele Pascale Grigull, Christian Braun, Andreas Büttner, Volkmar Jansson and Susanne Mayer-Wagner

    Citation: BMC Complementary and Alternative Medicine 2017 17:402

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