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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Page 5 of 35

  1. Content type: Research article

    According to only a handful of historical sources, Osmunda regalis, the royal fern, has been used already in the middle age as an anti-cancer remedy. To examine this ancient cancer cure, an ethanolic extract of t...

    Authors: Marianne Schmidt, Josef Skaf, Georgiana Gavril, Christine Polednik, Jeanette Roller, Michael Kessler and Ulrike Holzgrabe

    Citation: BMC Complementary and Alternative Medicine 2017 17:518

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  2. Content type: Research article

    European mistletoe (Viscum album) products used in cancer therapy are frequently combined with other anti-cancer-drugs. Hence, potential herb-drug interactions have become a major safety concern in mistletoe ther...

    Authors: Michael Schink and Oliver Dehus

    Citation: BMC Complementary and Alternative Medicine 2017 17:521

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  3. Content type: Research article

    Compound Muniziqi granule (MNZQ) is a multi-component herbal preparation and a popular traditional Uighur medicine used in China for treating endocrine...

    Authors: Nan Zou, Yue Wei, Fenghua Li, Yang Yang, Xuemei Cheng and Changhong Wang

    Citation: BMC Complementary and Alternative Medicine 2017 17:517

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  4. Content type: Research article

    Galetin 3,6-dimethyl ether (FGAL) is a flavonoid isolated from aerial parts of Piptadenia stipulacea. Previously, FGAL was shown to inhibit both carbachol- and oxytocin-induced phasic contractions in the rat uter...

    Authors: Juliana da Nóbrega Carreiro, Iara Leão Luna de Souza, Joedna Cavalcante Pereira, Luiz Henrique César Vasconcelos, Rafael de Almeida Travassos, Barbara Viviana de Oliveira Santos and Bagnólia Araújo da Silva

    Citation: BMC Complementary and Alternative Medicine 2017 17:514

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  5. Content type: Research article

    Conventional scientific studies had supported the use of polysaccharides and β-glucans from a number of fungi, including Ganoderma lucidum for the treatment of recurrent oral ulceration (ROU). Our aim of the p...

    Authors: Ling Xie, Xiaohong Zhong, Dongbo Liu, Lin Liu and Zhilan Xia

    Citation: BMC Complementary and Alternative Medicine 2017 17:511

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  6. Content type: Research article

    Jia-Wei-Jiao-Tai-Wan (JWJTW), composed of Jiao-Tai-Wan (Cinnamomum cassia and Rhizoma coptidis) and other antidiabetic herbs, including Astragalus membranaceus, Herba Gynostemmatis, Radix Puerariae Lobatae, Foliu...

    Authors: Guang Chen, Xueping Yang, Xiaoyu Yang, Lingli Li, Jinlong Luo, Hui Dong, Lijun Xu, Ping Yi, Kaifu Wang, Xin Zou and Fuer Lu

    Citation: BMC Complementary and Alternative Medicine 2017 17:507

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  7. Content type: Research article

    Atherosclerosis is a chronic vascular inflammatory disease. Since even low-level endotoxemia constitutes a powerful and independent risk factor for the development of atherosclerosis, it is important to find t...

    Authors: Daun Jeon, Seok Joong Kim and Hong Seok Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:508

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  8. Content type: Research article

    Paclitaxel (taxol) is a potent anticancer drug that is used in the treatment of a wide variety of cancerous. In the present study, we identified a taxol derivative named 7-epi-10-deacetyltaxol (EDT) from the cult...

    Authors: Kamalraj Subban, Satpal Singh, Ramesh Subramani, Muthumary Johnpaul and Jayabaskaran Chelliah

    Citation: BMC Complementary and Alternative Medicine 2017 17:504

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  9. Content type: Research article

    In vitro and in vivo studies have shown that Zuo Jin Wan (ZJW), a herbal formula of traditional Chinese medicine (TCM), possessed anticancer properties. However, the underlying mechanism for the action of ZJW ...

    Authors: Jielu Pan, Yangxian Xu, Haiyan Song, Xiqiu Zhou, Zemin Yao and Guang Ji

    Citation: BMC Complementary and Alternative Medicine 2017 17:506

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  10. Content type: Research article

    Stress, regardless of its nature is nowadays recognized as one of the major risk factors for neuropsychiatric diseases, such as mood and anxiety disorders. The brain compared with other organs is more vulnerab...

    Authors: Harquin Simplice Foyet, Serge Tchinda Deffo, Pascaline Koagne Yewo, Iulia Antioch, Stéphane Zingue, Emmanuel Acha Asongalem, Pierre Kamtchouing and Alin Ciobica

    Citation: BMC Complementary and Alternative Medicine 2017 17:502

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    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2017 17:552

  11. Content type: Research article

    Nonea micrantha Boiss. & Reut . being an unexplored member of Boraginaceae was investigated for GC/MS analysis, acetylcholinesterase (AChE), butyrylcholinest...

    Authors: Muhammad Imran, Farhat Ullah, Muhammad Ayaz, Abdul Sadiq, Muhammad Raza Shah, Muhammad Saeed Jan and Farman Ullah

    Citation: BMC Complementary and Alternative Medicine 2017 17:499

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  12. Content type: Research article

    Recently, we reported high in vitro antibacterial efficacy of Althaea officinalis, Ziziphus jujuba, Cordia latifolia and Thymus vulgaris out of a total 21 plants against wide range of bacteria including MRSA. Thi...

    Authors: Najma Arshad, Arifa Mehreen, Iram Liaqat, Muhammad Arshad and Humera Afrasiab

    Citation: BMC Complementary and Alternative Medicine 2017 17:498

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  13. Content type: Research article

    Aster koraiensis extract (AKE) is a standard dietary herbal supplement. The aim of this study is to investigate the inhibitory effects of AKE on diabetes-induced retinal vascular dysfu...

    Authors: Junghyun Kim, Kyuhyung Jo, Chan-Sik Kim and Jin Sook Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:497

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  14. Content type: Research article

    The current study was conducted to evaluate the antioxidant, analgesic, antihyperglycemic, neuropharmacological and antidiarrheal activities of ethanolic extract of Lepisanthes rubiginosa L. leaves in different e...

    Authors: Md. Mahedi Hasan, Amir Hossain, Abdullah Shamim and Md. Mustafizur Rahman

    Citation: BMC Complementary and Alternative Medicine 2017 17:496

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  15. Content type: Research article

    Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in ra...

    Authors: Nora M. Aborehab, Mahitab H. El Bishbishy, Abeer Refaiy and Nermien E. Waly

    Citation: BMC Complementary and Alternative Medicine 2017 17:495

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  16. Content type: Research article

    We previously reported that a methanol extract of Glycyrrhizae radix (MEGR) blocked methamphetamine-induced locomotor sensitization and conditioned place preference in rats. In the present study, the effects of M...

    Authors: Zheng Lin Zhao, Sang Chan Kim, Hong Feng Liu, Yi Yan Wu, Li Bo Li, Yu Hua Wang, Yu Jiao, Yu Fan, Chul Won Lee, Bong Hyeo Lee, Il Je Cho, Chae Ha Yang and Rong Jie Zhao

    Citation: BMC Complementary and Alternative Medicine 2017 17:493

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  17. Content type: Research article

    Research of natural products from traditionally used medicinal plants to fight against the human ailments is fetching attention of researchers worldwide. Bidens pilosa Linn. var. Radiata (Asteraceae) is well know...

    Authors: Garima Singh, Ajit Kumar Passsari, Pratibha Singh, Vincent Vineeth Leo, Sarathbabu Subbarayan, Brijesh Kumar, Bhim Pratap Singh, Hauzel lalhlenmawia and Nachimuthu Senthil Kumar

    Citation: BMC Complementary and Alternative Medicine 2017 17:492

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  18. Content type: Research article

    Volatile oils from Artemisiae argyi folium (VOAAF) is reported with hepatotoxicity, but the underlying mechanism is still unclear.

    Authors: Hongjie Liu, Sha Zhan, Yan Zhang, Yan Ma, Liang Chen, Lingxiu Chen, Hanqiu Dong, Min Ma and Zhe Zhang

    Citation: BMC Complementary and Alternative Medicine 2017 17:491

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  19. Content type: Research article

    Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. In an at...

    Authors: Siti Zawanah Halim, Zainul Amiruddin Zakaria, Maizatul Hasyima Omar, Norhafizah Mohtarrudin, Ikarastika Rahayu Abdul Wahab and Muhammad Nazrul Hakim Abdullah

    Citation: BMC Complementary and Alternative Medicine 2017 17:488

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  20. Content type: Research article

    Coix lacryma-jobi var. ma-yuen (Rom.Caill.) Stapf has been used in China as an herbal medicine. Many studies of this plant have reported anti-proliferative and apoptotic activities on ...

    Authors: Eun Suk Son, Young Ock Kim, Chun Geon Park, Kyung Hun Park, Sung Hwan Jeong, Jeong-Woong Park and Se-Hee Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:486

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  21. Content type: Research article

    During ischemic stroke (IS), adenosine 5′-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors si...

    Authors: Jia Huang, Xiaofang You, Weilin Liu, Changming Song, Xiaomin Lin, Xiufeng Zhang, Jing Tao and Lidian Chen

    Citation: BMC Complementary and Alternative Medicine 2017 17:480

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  22. Content type: Research article

    Essential hypertension is mainly caused by endothelial dysfunction which results from nitric oxide (NO) deficiency. The present study was design to evaluate the protective effect of Bidens pilosa ethylene acetate...

    Authors: Danielle Claude Bilanda, Paul Désiré D. Dzeufiet, Léontine Kouakep, Bibi Farouck O. Aboubakar, Léonard Tedong, Pierre Kamtchouing and Théophile Dimo

    Citation: BMC Complementary and Alternative Medicine 2017 17:479

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  23. Content type: Research article

    Oxidative stress has a pivotal role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complications of diabetes mellitus. There is accumulating evide...

    Authors: Davood Nasiry, Ali Reza khalatbary, Hassan Ahmadvand, Fereshteh Talebpour Amiri and Esmaeil Akbari

    Citation: BMC Complementary and Alternative Medicine 2017 17:476

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  24. Content type: Research article

    Hypertension is one of the most important risk factors for cardiovascular disease (CVD) and a worldwide problem. Despite increases in the development of synthetic drugs for hypertension treatment, the rate of ...

    Authors: Bumjung Kim, Youngki Kwon, Somin Lee, Kyungjin Lee, Inhye Ham and Ho-Young Choi

    Citation: BMC Complementary and Alternative Medicine 2017 17:474

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  25. Content type: Research article

    Many people still experience pain and inflammation regardless of the available drugs for treatments. In addition, the available drugs have many side effects, which necessitated a quest for new drugs from sever...

    Authors: Yohannes Tamrat, Teshome Nedi, Solomon Assefa, Tilahun Teklehaymanot and Workineh Shibeshi

    Citation: BMC Complementary and Alternative Medicine 2017 17:473

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  26. Content type: Research article

    Cisplatin is widely used chemotherapeutic agent for cancer treatment with limited uses due to its neurotoxic side effect. The aim of this study was to determine the potential preventive effects of rutin on the...

    Authors: Mashal M. Almutairi, Wael A. Alanazi, Musaad A. Alshammari, Moureq Rashed Alotaibi, Ali R. Alhoshani, Salim Salah Al-Rejaie, Mohamed M. Hafez and Othman A. Al-Shabanah

    Citation: BMC Complementary and Alternative Medicine 2017 17:472

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  27. Content type: Research article

    Cerebral edema, erupting simultaneously with severe ischemic stroke, might lead to increased intracranial pressure, cerebral herniation, and ultimately death. Studies conducted previously by our team have demo...

    Authors: Nannan Yu, Zhenguo Wang, Yucen Chen, Juntao Yang, Xuan Lu, Yi Guo, Zelin Chen and Zhifang Xu

    Citation: BMC Complementary and Alternative Medicine 2017 17:470

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  28. Content type: Research article

    Propolis and its major constituent – caffeic acid phenethyl ester (CAPE) have good abilities on antitumor and anti-inflammation. However, little is known about the actions of propolis and CAPE on tumor in infl...

    Authors: Huasong Chang, Yuehua Wang, Xusheng Yin, Xinying Liu and Hongzhuan Xuan

    Citation: BMC Complementary and Alternative Medicine 2017 17:471

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  29. Content type: Research article

    Mango mistletoes Dendrophthoe pentandra (MMDP) extract has attracted interest due to its pharmacological properties, including gastro protective effects. The aim of this study was to investigate whether MMDP extr...

    Authors: Agustina Tri Endharti and Sofy Permana

    Citation: BMC Complementary and Alternative Medicine 2017 17:468

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  30. Content type: Research article

    Extracts of plants have been considered as sources of natural antioxidant agents. In this study, we aimed to explore the antioxidant capacity of the aqueous root extract of Asparagus cochinchinensis (Lour.) Merr.

    Authors: Linghua Lei, Yanhua Chen, Lijun Ou, Yinglong Xu and Xiaoying Yu

    Citation: BMC Complementary and Alternative Medicine 2017 17:469

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  31. Content type: Research article

    The emergence of multidrug-resistant bacteria is a worldwide concern and in order to find an alternative to this problem, the occurrence of antimicrobial compounds in Plectranthus amboinicus essential oil was inv...

    Authors: Sara Edwirgens Costa Benício Vasconcelos, Hider Machado Melo, Theodora Thays Arruda Cavalcante, Francisco Eduardo Aragão Catunda Júnior, Mário Geraldo de Carvalho, Francisca Gleire Rodrigues Menezes, Oscarina Viana de Sousa and Renata Albuquerque Costa

    Citation: BMC Complementary and Alternative Medicine 2017 17:462

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  32. Content type: Research article

    Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were act...

    Authors: Sabrina M. Noritake, Jenny Liu, Sierra Kanetake, Carol E. Levin, Christina Tam, Luisa W. Cheng, Kirkwood M. Land and Mendel Friedman

    Citation: BMC Complementary and Alternative Medicine 2017 17:461

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  33. Content type: Research article

    Alkaloids have been considered as the most promising bioactive ingredients in plant species from the genus Zanthoxylum. This study reports on the compositions and contents of the Zanthoxylum alkaloids (ZAs) from ...

    Authors: Yongqiang Tian, Chunyun Zhang and Mingquan Guo

    Citation: BMC Complementary and Alternative Medicine 2017 17:460

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  34. Content type: Research article

    Tinospora cordifolia (Guduchi or Amrita) is an important drug of Ayurvedic System of Medicine and found mention in various classical texts for the treatment of diseases such as jaundic...

    Authors: Picheswara Rao Polu, Udupa Nayanbhirama, Saleemulla Khan and Rajlexmi Maheswari

    Citation: BMC Complementary and Alternative Medicine 2017 17:457

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  35. Content type: Research article

    So-ochim-tang-gamibang (SOCG) is a decoction formula which has been used to improve mental activity in traditional Korean medicine. The present study was performed to evaluate whether ...

    Authors: Hwa Chul Shin, Jae Ho Lee, Ki Joong Kim, Hyun Jin Shin, Jeong June Choi, Chan Yong Lee, Uk Namgung and In Chul Jung

    Citation: BMC Complementary and Alternative Medicine 2017 17:456

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  36. Content type: Research article

    Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of tau...

    Authors: Wenhua Zhu, Siwen Chen, Ronggui Chen, Zhiqing Peng, Jun Wan and Benyan Wu

    Citation: BMC Complementary and Alternative Medicine 2017 17:455

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  37. Content type: Research article

    Radix puerariae (RP) is a herbal medicines for diabetes, mainly because of anti-oxidative, insulin resistance and hypoglycemic effect. Fructus crataegi (FC) also possesses strong antioxidant activity in vitro....

    Authors: Zhengyue Chen, Yanyan Yuan, Xinrong Zou, Mengqi Hong, Ming Zhao, Yu Zhao, Yuanping Liu, Guofu Li, Yabin Zhu, Lin Luo, Beiyan Bao and Shizhong Bu

    Citation: BMC Complementary and Alternative Medicine 2017 17:454

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  38. Content type: Research article

    Foodstuffs of both plant and animal origin contain a wide range of bioactive compounds. Although human intervention studies are mandatory to assess the health effects of bioactives, the in vitro approach is of...

    Authors: Mattia Di Nunzio, Veronica Valli, Lidia Tomás-Cobos, Teresa Tomás-Chisbert, Lucía Murgui-Bosch, Francesca Danesi and Alessandra Bordoni

    Citation: BMC Complementary and Alternative Medicine 2017 17:453

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  39. Content type: Research article

    Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders that are mediated by pathogenic Th1 and Th17 cells. Previous studies have demonstrated that taheebo water extract (TWE) derived from Tabebuia ...

    Authors: Hyun Jung Park, Sung Won Lee, Dong-Joo Kwon, Seong-Il Heo, Se-Ho Park, Sun Young Kim and Seokmann Hong

    Citation: BMC Complementary and Alternative Medicine 2017 17:448

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  40. Content type: Research article

    Previous studies have revealed that gypenosides (GPS) improve the symptoms of anxiety disorders in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned rat model of Parkinson’s disease (PD). The pres...

    Authors: Ting Ting Zhao, Kyung Sook Kim, Keon Sung Shin, Hyun Jin Park, Hyun Jeong Kim, Kyung Eun Lee and Myung Koo Lee

    Citation: BMC Complementary and Alternative Medicine 2017 17:449

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  41. Content type: Research article

    Mutations play a major role in the pathogenesis and development of several chronic degenerative diseases including cancer. It follows, therefore that antimutagenic compound may inhibit the pathological process...

    Authors: Tshepiso Jan Makhafola, Esameldin Elzein Elgorashi, Lyndy Joy McGaw, Maurice Ducret Awouafack, Luc Verschaeve and Jacobus Nicolaas Eloff

    Citation: BMC Complementary and Alternative Medicine 2017 17:446

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  42. Content type: Research article

    “Jiedu Huayu” (JDHY) granules are traditional Chinese herbal compounds that have been used to treat severe liver injury for many years. The purpose of the current study is to evaluate the safety of JDHY granules.

    Authors: Minggang Wang, Hua Qiu, Rongzhen Zhang, Fuli Long and Dewen Mao

    Citation: BMC Complementary and Alternative Medicine 2017 17:450

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  43. Content type: Research article

    The concept of botanical therapeutics has revitalized due to wide importance of plant derived pharmaceuticals. Therefore, the ameliorative characteristics of Ajuga bracteosa were studied.

    Authors: Syeda Saniya Zahra, Madiha Ahmed, Muhammad Qasim, Bilquees Gul, Muhammad Zia, Bushra Mirza and Ihsan-ul Haq

    Citation: BMC Complementary and Alternative Medicine 2017 17:443

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  44. Content type: Research article

    Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail. In this study, we elucidated anti-cancer activ...

    Authors: Su Bin Park, Gwang Hun Park, Hun Min Song, Ho-Jun Son, Yurry Um, Hyun-Seok Kim and Jin Boo Jeong

    Citation: BMC Complementary and Alternative Medicine 2017 17:445

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  45. Content type: Research article

    Agrimonia pilosa Ledeb. is a medicinal plant with physiological activities such as anti-cancer, antioxidant, anti-inflammatory activities and in vitro anti-diabetic activity. However, ...

    Authors: Hwan Hee Jang, Song Yee Nam, Mi Ju Kim, Jung Bong Kim, Jeong Sook Choi, Haeng Ran Kim and Young Min Lee

    Citation: BMC Complementary and Alternative Medicine 2017 17:442

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  46. Content type: Research article

    A variety of plants in Acanthaceae have long been used in traditional Thai ailment and commercialised with significant economic value. Nowadays medicinal plants are sold in processed forms and thus morphologic...

    Authors: Tanakorn Suesatpanit, Kitisak Osathanunkul, Panagiotis Madesis and Maslin Osathanunkul

    Citation: BMC Complementary and Alternative Medicine 2017 17:437

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  47. Content type: Research article

    Tetracera indica Merr. (Family: Dilleniaceae), known to the Malay as ‘Mempelas paya’, is one of the medicinal plants used in the treatment of diabetes in Malaysia. However, no proper s...

    Authors: Md. Mahmudul Hasan, Qamar Uddin Ahmed, Siti Zaiton Mat Soad, Jalifah Latip, Muhammad Taher, Tengku Muhamad Faris Syafiq, Murni Nazira Sarian, Alhassan Muhammad Alhassan and Zainul Amiruddin Zakaria

    Citation: BMC Complementary and Alternative Medicine 2017 17:431

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  48. Content type: Research article

    Recent reports have demonstrated that impaired barrier function and local microinflammation in the duodenal mucosa contribute to the pathogeneses of functional dyspepsia (FD). Thus, restoring normal barrier in...

    Authors: Xiongfei Chang, Luqing Zhao, Jiajia Wang, Xiaofang Lu and Shengsheng Zhang

    Citation: BMC Complementary and Alternative Medicine 2017 17:432

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