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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Content type: Research article

    Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in the treatment of the delayed diabetic wound. However, elucidating the related molecular biological mechanism of how...

    Authors: Le Kuai, Jing-ting Zhang, Yu Deng, Shun Xu, Xun-zhe Xu, Min-feng Wu, Dong-jie Guo, Yu Chen, Ren-jie Wu, Xing-qiang Zhao, Hua Nian, Bin Li and Fu-lun Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:32

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  2. Content type: Research article

    Natural products obtained from plants can be potent sources for developing a variety of pharmaceutical products. Allium species have been widely studied for their anti-cancer effects and presented promising resul...

    Authors: Ovgu Isbilen, Nahit Rizaner and Ender Volkan

    Citation: BMC Complementary and Alternative Medicine 2018 18:30

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  3. Content type: Research article

    Oxidative stress as well as bacterial and fungal infections are common source of diseases while plants are source of medication for curative or protective purposes. Hence, aim of study was to compare the pharm...

    Authors: Iram Fatima, Sobia Kanwal and Tariq Mahmood

    Citation: BMC Complementary and Alternative Medicine 2018 18:27

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  4. Content type: Research article

    Cupressus macrocarpa Hartw and Corymbia citriodora (Hook.) K.D. Hill & L.A.S. Johnson, widely grown in many subtropical areas, are used for commercial purposes, such as in perfumery, cosmetics, and room freshener...

    Authors: Mohamed Z. M. Salem, Hosam O. Elansary, Hayssam M. Ali, Ahmed A. El-Settawy, Mohamed S. Elshikh, Eslam M. Abdel-Salam and Krystyna Skalicka-Woźniak

    Citation: BMC Complementary and Alternative Medicine 2018 18:23

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  5. Content type: Research article

    Pelargonium sidoides (PS) and Coptis chinensis root (CR) have traditionally been used to treat various diseases, including respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders. The pre...

    Authors: Sang Mi Park, Byung-Gu Min, Ji Yun Jung, Kyung Hwan Jegal, Chul Won Lee, Kwang Youn Kim, Young Woo Kim, Youn-Woong Choi, Il Je Cho, Sae Kwang Ku and Sang Chan Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:20

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  6. Content type: Research article

    Based on clinical medications and related studies, we established a Yang-Gan Jie-Du Sang-Jie (YGJDSJ) herbal formula for hepatocarcinoma treatment. In present study, we evaluated the anti-cancer potential of Y...

    Authors: Bing Hu, Tong Zhang, Hong-Mei An, Jia-Lu Zheng, Xia Yan and Xiao-Wei Huang

    Citation: BMC Complementary and Alternative Medicine 2018 18:17

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  7. Content type: Research article

    Nutmeg is the seed kernel inside the fruit of Myristica fragrans Houtt. (Myristicaceae). It possesses various pharmacological activities but is used in Cameroon only for its flavor in making cakes. The present st...

    Authors: Joachim K. Dzotam, Ingrid Konga Simo, Gabin Bitchagno, Ilhami Celik, Louis P. Sandjo, Pierre Tane and Victor Kuete

    Citation: BMC Complementary and Alternative Medicine 2018 18:15

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  8. Content type: Research article

    Fructose-mediated protein glycation (fructation) has been linked to an increase in diabetic and cardiovascular complications due to over consumption of high-fructose containing diets in recent times. The objec...

    Authors: Hardik Ghelani, Valentina Razmovski-Naumovski, Rajeswara Rao Pragada and Srinivas Nammi

    Citation: BMC Complementary and Alternative Medicine 2018 18:13

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  9. Content type: Research article

    Inflammation has been implicated in many disorders, including cancer and available therapies elicit adverse effects. Plants of the family Rubiaceae have shown potency against inflammation. The anti-inflammator...

    Authors: Oluwayinka Olufunmilayo Owolabi, Dorcas Bolanle James, Ibrahim Sani, Binda T. Andongma, Opeoluwa O. Fasanya and Barnabas Kure

    Citation: BMC Complementary and Alternative Medicine 2018 18:12

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  10. Content type: Research article

    The highbush blueberry (Vaccinium corymbosum) has a beneficial effect on several aspects of human health. The present study investigated the effects of highbush blueberry proanthocyanidins (PACs) on the virulence...

    Authors: Amel Ben Lagha, Geneviève LeBel and Daniel Grenier

    Citation: BMC Complementary and Alternative Medicine 2018 18:10

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  11. Content type: Research article

    Costus speciosus, Cymbopogon citratus, and Tabernaemontana coronaria are herbal plants traditionally used as remedies for symptoms of tuberculosis (TB) including cough. The aims of the present study were to evalu...

    Authors: Suriyati Mohamad, Nur Najihah Ismail, Thaigarajan Parumasivam, Pazilah Ibrahim, Hasnah Osman and Habibah A. Wahab

    Citation: BMC Complementary and Alternative Medicine 2018 18:5

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  12. Content type: Research article

    An impaired leukocytes function is the factor causing the susceptibility of patients with diabetes mellitus to infections. The outmost importance for the understanding of the immunological processes involved i...

    Authors: Mariia Nagalievska, Mariya Sabadashka, Halyna Hachkova and Nataliia Sybirna

    Citation: BMC Complementary and Alternative Medicine 2018 18:4

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  13. Content type: Research article

    The medicinal importance of a novel plant Olax nana Wall. ex Benth. (family: Olacaceae) was revealed for the first time via HPLC-DAD finger printing, qualitative phytochemical analysis, antioxidant, cholinesteras...

    Authors: Muhammad Ovais, Muhammad Ayaz, Ali Talha Khalil, Sayed Afzal Shah, Muhammad Saeed Jan, Abida Raza, Muhammad Shahid and Zabta Khan Shinwari

    Citation: BMC Complementary and Alternative Medicine 2018 18:1

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  14. Content type: Research article

    Basophilic granulocytes (BGs) not only initiate the induction of Th2 cell differentiation, but also amplify the ongoing Th2 response. Shuang-Huang-Lian (SHL) is clinically used for relieving type I hypersensit...

    Authors: Qiaoling Fei, Yixin Han, Ruijuan Qi, Yuan Gao, Lei Fang, Rui Hou, Runlan Cai and Yun Qi

    Citation: BMC Complementary and Alternative Medicine 2018 18:2

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  15. Content type: Research article

    The use of doxorubicin (DOX) an anthracycline antineoplastic agent is withdrawn due to its cardio-toxic side effects. Oxidative stress has been recognized as the primary cause of DOX induced cardiotoxicity. We...

    Authors: Tayyaba Afsar, Suhail Razak, Khalid Mujasam Batoo and Muhammad Rashid Khan

    Citation: BMC Complementary and Alternative Medicine 2017 17:554

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  16. Content type: Research article

    The conversion of the epithelial phenotype of cancer cells into cells with a mesenchymal phenotype-so-called epithelial–mesenchymal transition (EMT)-has been shown to enhance the capacity of the cells to disse...

    Authors: Nareerat Petpiroon, Boonchoo Sritularak and Pithi Chanvorachote

    Citation: BMC Complementary and Alternative Medicine 2017 17:553

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  17. Content type: Research article

    Danshen is a common traditional Chinese medicine used to treat neoplastic and chronic inflammatory diseases in China. However, the effects of Danshen on human oral cancer cells remain relatively unknown. This ...

    Authors: Cheng-Yu Yang, Cheng-Chih Hsieh, Chih-Kung Lin, Chun-Shu Lin, Bo Peng, Gu-Jiun Lin, Huey-Kang Sytwu, Wen-Liang Chang and Yuan-Wu Chen

    Citation: BMC Complementary and Alternative Medicine 2017 17:555

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  18. Content type: Research article

    Although such local herb as Streblus asper (family Moraceae) has long been recognized for traditional folk medicines and important ingredient of traditional longevity formula, its anti-neurodegeneration or anti-a...

    Authors: Anchalee Prasansuklab, Krai Meemon, Prasert Sobhon and Tewin Tencomnao

    Citation: BMC Complementary and Alternative Medicine 2017 17:551

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  19. Content type: Research article

    Mood disorder accounts for 13 % of global disease burden. And while therapeutic agents are available, usually orally administered, most have unwanted side effects, and thus making the inhalation of essential o...

    Authors: Myra O. Villareal, Ayumi Ikeya, Kazunori Sasaki, Abdelkarim Ben Arfa, Mohamed Neffati and Hiroko Isoda

    Citation: BMC Complementary and Alternative Medicine 2017 17:549

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  20. Content type: Research article

    Extracts from Salvia miltiorrhiza Bunge have been used in traditional Asian medicine to treat coronary heart disease, chronic renal failure, atherosclerosis, myocardial infraction, angina pectoris, myocardial isc...

    Authors: Bongkyun Park, Hae Seong Song, Jeong Eun Kwon, Se Min Cho, Seon-A Jang, Mi Yeon Kim and Se Chan Kang

    Citation: BMC Complementary and Alternative Medicine 2017 17:545

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  21. Content type: Research article

    Bamboo (Phyllostachys pubescens) leaves and Japanese apricot (Mume fructus) fruit are traditionally recognized to be safe herbs broadly used for food and medicinal purposes in Southeast Asia. Our group previously...

    Authors: Eunjung Son, Seung-Hyung Kim, Won-Kyung Yang, Dong-Seon Kim and Jimin Cha

    Citation: BMC Complementary and Alternative Medicine 2017 17:541

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  22. Content type: Research article

    “Horchata” is an herbal mixture infusion consumed in Southern Ecuador; 66% of its plants are anti-inflammatory medicinal plant, and 51% are analgesics. Anti-inflammatory substances can prevent carcinogenesis m...

    Authors: Natalia Bailon-Moscoso, Fani Tinitana, Ruth Martínez-Espinosa, Andrea Jaramillo-Velez, Alejandra Palacio-Arpi, Jessica Aguilar-Hernandez and Juan Carlos Romero-Benavides

    Citation: BMC Complementary and Alternative Medicine 2017 17:539

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  23. Content type: Research article

    Excess dietary fructose intake associated with metabolic syndrome and insulin resistance and increased risk of developing type 2 diabetes. Previous animal studies have reported that diabetic animals have signi...

    Authors: V. A. Chavushyan, K. V. Simonyan, R. M. Simonyan, A. S. Isoyan, G. M. Simonyan, M. A. Babakhanyan, L. E. Hovhannisyian, Kh. H. Nahapetyan, L. G. Avetisyan and M. A. Simonyan

    Citation: BMC Complementary and Alternative Medicine 2017 17:540

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  24. Content type: Research article

    Blood stasis syndrome (BSS) is a general pattern identification and refers to pathological stagnation of blood circulation, dysfunction of endothelial cells or metabolic disorder in traditional Korean medicine...

    Authors: Eun Hyoung Shim, Hoyoung Lee, Myeong Soo Lee and Sooseong You

    Citation: BMC Complementary and Alternative Medicine 2017 17:542

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  25. Content type: Research article

    Acute kidney injury (AKI) is an initial factor in many kidney disorders. Pre- and intra-renal AKI biomarkers have recently been reported. Recovery from AKI by herbal medicine has rarely been reported. Thus, th...

    Authors: Sung-Man Oh, Gunhyuk Park, Seung Hoon Lee, Chang-Seob Seo, Hyeun-Kyoo Shin and Dal-Seok Oh

    Citation: BMC Complementary and Alternative Medicine 2017 17:544

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  26. Content type: Research article

    Various plant extracts have been suggested to be used as auxiliary agents in chemotherapy considering their anti-proliferative effect on cancer cells. However, recent reports reveal that plant extracts may fun...

    Authors: Hai Li and Chen Chen

    Citation: BMC Complementary and Alternative Medicine 2017 17:538

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    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2018 18:72

  27. Content type: Research article

    Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovitis, cartilage degradation and bone deformities. Synovitis is the term for inflammation of the synovial membrane, an early stage of ...

    Authors: Manatsanan Khansai, Thanyaluck Phitak, Jeerawan Klangjorhor, Sasimol Udomrak, Kanda Fanhchaksai, Peraphan Pothacharoen and Prachya Kongtawelert

    Citation: BMC Complementary and Alternative Medicine 2017 17:532

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  28. Content type: Research article

    Quercetin (QCT) is a flavonol present in many vegetables, it is proved to show chemo preventive effect against lung, cervical, prostate, breast and colon cancer due to its anti-inflammatory, anti-tumor and ant...

    Authors: Haojie Liu and Ming Zhou

    Citation: BMC Complementary and Alternative Medicine 2017 17:531

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  29. Content type: Research article

    Acupuncture has been used as a common therapeutic tool in many disorders including anxiety and depression. Serotonin transporter (SERT) plays an important role in the pathology of anxiety and other mood disord...

    Authors: Tae Young Yang, Eun Young Jang, Yeonhee Ryu, Gyu Won Lee, Eun Byeol Lee, Suchan Chang, Jong Han Lee, Jin Suk Koo, Chae Ha Yang and Hee Young Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:528

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  30. Content type: Research article

    Ethnobatanical survey associates Sapium ellipticum (SE) with antidiabetic usage among other medicinal functions in different parts of Africa. More importantly, previous studies on the plant extract in our laborat...

    Authors: Osasenaga Macdonald Ighodaro and Oluseyi Adeboye Akinloye

    Citation: BMC Complementary and Alternative Medicine 2017 17:525

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  31. Content type: Research article

    N-butylidenephthalide (BP) isolated from Radix Angelica Sinensis (Danggui) exhibits anti-tumorigenic effect in various cancer cells both in vivo and in vitro. The effect of BP in bladder cancer treatment is still...

    Authors: Sheng-Chun Chiu, Tsung-Lang Chiu, Sung-Ying Huang, Shu-Fang Chang, Shee-Ping Chen, Cheng-Yoong Pang and Teng-Fu Hsieh

    Citation: BMC Complementary and Alternative Medicine 2017 17:523

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  32. Content type: Research article

    According to only a handful of historical sources, Osmunda regalis, the royal fern, has been used already in the middle age as an anti-cancer remedy. To examine this ancient cancer cure, an ethanolic extract of t...

    Authors: Marianne Schmidt, Josef Skaf, Georgiana Gavril, Christine Polednik, Jeanette Roller, Michael Kessler and Ulrike Holzgrabe

    Citation: BMC Complementary and Alternative Medicine 2017 17:518

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  33. Content type: Research article

    European mistletoe (Viscum album) products used in cancer therapy are frequently combined with other anti-cancer-drugs. Hence, potential herb-drug interactions have become a major safety concern in mistletoe ther...

    Authors: Michael Schink and Oliver Dehus

    Citation: BMC Complementary and Alternative Medicine 2017 17:521

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  34. Content type: Research article

    Salmonella enterica serovar Typhimurium is a foodborne pathogen that triggers inflammatory responses in the intestines of humans and livestock. Colla corii asini is a traditional medic...

    Authors: Kwang-il Park, Mi-ra Lee, Tae-woo Oh, Kwang-Youn Kim and Jin-yeul Ma

    Citation: BMC Complementary and Alternative Medicine 2017 17:520

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  35. Content type: Research article

    Compound Muniziqi granule (MNZQ) is a multi-component herbal preparation and a popular traditional Uighur medicine used in China for treating endocrine...

    Authors: Nan Zou, Yue Wei, Fenghua Li, Yang Yang, Xuemei Cheng and Changhong Wang

    Citation: BMC Complementary and Alternative Medicine 2017 17:517

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  36. Content type: Research article

    Galetin 3,6-dimethyl ether (FGAL) is a flavonoid isolated from aerial parts of Piptadenia stipulacea. Previously, FGAL was shown to inhibit both carbachol- and oxytocin-induced phasic contractions in the rat uter...

    Authors: Juliana da Nóbrega Carreiro, Iara Leão Luna de Souza, Joedna Cavalcante Pereira, Luiz Henrique César Vasconcelos, Rafael de Almeida Travassos, Barbara Viviana de Oliveira Santos and Bagnólia Araújo da Silva

    Citation: BMC Complementary and Alternative Medicine 2017 17:514

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  37. Content type: Research article

    Conventional scientific studies had supported the use of polysaccharides and β-glucans from a number of fungi, including Ganoderma lucidum for the treatment of recurrent oral ulceration (ROU). Our aim of the p...

    Authors: Ling Xie, Xiaohong Zhong, Dongbo Liu, Lin Liu and Zhilan Xia

    Citation: BMC Complementary and Alternative Medicine 2017 17:511

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  38. Content type: Research article

    Jia-Wei-Jiao-Tai-Wan (JWJTW), composed of Jiao-Tai-Wan (Cinnamomum cassia and Rhizoma coptidis) and other antidiabetic herbs, including Astragalus membranaceus, Herba Gynostemmatis, Radix Puerariae Lobatae, Foliu...

    Authors: Guang Chen, Xueping Yang, Xiaoyu Yang, Lingli Li, Jinlong Luo, Hui Dong, Lijun Xu, Ping Yi, Kaifu Wang, Xin Zou and Fuer Lu

    Citation: BMC Complementary and Alternative Medicine 2017 17:507

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  39. Content type: Research article

    Atherosclerosis is a chronic vascular inflammatory disease. Since even low-level endotoxemia constitutes a powerful and independent risk factor for the development of atherosclerosis, it is important to find t...

    Authors: Daun Jeon, Seok Joong Kim and Hong Seok Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:508

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  40. Content type: Research article

    Paclitaxel (taxol) is a potent anticancer drug that is used in the treatment of a wide variety of cancerous. In the present study, we identified a taxol derivative named 7-epi-10-deacetyltaxol (EDT) from the cult...

    Authors: Kamalraj Subban, Satpal Singh, Ramesh Subramani, Muthumary Johnpaul and Jayabaskaran Chelliah

    Citation: BMC Complementary and Alternative Medicine 2017 17:504

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  41. Content type: Research article

    In vitro and in vivo studies have shown that Zuo Jin Wan (ZJW), a herbal formula of traditional Chinese medicine (TCM), possessed anticancer properties. However, the underlying mechanism for the action of ZJW ...

    Authors: Jielu Pan, Yangxian Xu, Haiyan Song, Xiqiu Zhou, Zemin Yao and Guang Ji

    Citation: BMC Complementary and Alternative Medicine 2017 17:506

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  42. Content type: Research article

    Stress, regardless of its nature is nowadays recognized as one of the major risk factors for neuropsychiatric diseases, such as mood and anxiety disorders. The brain compared with other organs is more vulnerab...

    Authors: Harquin Simplice Foyet, Serge Tchinda Deffo, Pascaline Koagne Yewo, Iulia Antioch, Stéphane Zingue, Emmanuel Acha Asongalem, Pierre Kamtchouing and Alin Ciobica

    Citation: BMC Complementary and Alternative Medicine 2017 17:502

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    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2017 17:552

  43. Content type: Research article

    Nonea micrantha Boiss. & Reut . being an unexplored member of Boraginaceae was investigated for GC/MS analysis, acetylcholinesterase (AChE), butyrylcholinest...

    Authors: Muhammad Imran, Farhat Ullah, Muhammad Ayaz, Abdul Sadiq, Muhammad Raza Shah, Muhammad Saeed Jan and Farman Ullah

    Citation: BMC Complementary and Alternative Medicine 2017 17:499

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  44. Content type: Research article

    Recently, we reported high in vitro antibacterial efficacy of Althaea officinalis, Ziziphus jujuba, Cordia latifolia and Thymus vulgaris out of a total 21 plants against wide range of bacteria including MRSA. Thi...

    Authors: Najma Arshad, Arifa Mehreen, Iram Liaqat, Muhammad Arshad and Humera Afrasiab

    Citation: BMC Complementary and Alternative Medicine 2017 17:498

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  45. Content type: Research article

    Aster koraiensis extract (AKE) is a standard dietary herbal supplement. The aim of this study is to investigate the inhibitory effects of AKE on diabetes-induced retinal vascular dysfu...

    Authors: Junghyun Kim, Kyuhyung Jo, Chan-Sik Kim and Jin Sook Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:497

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  46. Content type: Research article

    The current study was conducted to evaluate the antioxidant, analgesic, antihyperglycemic, neuropharmacological and antidiarrheal activities of ethanolic extract of Lepisanthes rubiginosa L. leaves in different e...

    Authors: Md. Mahedi Hasan, Amir Hossain, Abdullah Shamim and Md. Mustafizur Rahman

    Citation: BMC Complementary and Alternative Medicine 2017 17:496

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  47. Content type: Research article

    Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in ra...

    Authors: Nora M. Aborehab, Mahitab H. El Bishbishy, Abeer Refaiy and Nermien E. Waly

    Citation: BMC Complementary and Alternative Medicine 2017 17:495

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  48. Content type: Research article

    We previously reported that a methanol extract of Glycyrrhizae radix (MEGR) blocked methamphetamine-induced locomotor sensitization and conditioned place preference in rats. In the present study, the effects of M...

    Authors: Zheng Lin Zhao, Sang Chan Kim, Hong Feng Liu, Yi Yan Wu, Li Bo Li, Yu Hua Wang, Yu Jiao, Yu Fan, Chul Won Lee, Bong Hyeo Lee, Il Je Cho, Chae Ha Yang and Rong Jie Zhao

    Citation: BMC Complementary and Alternative Medicine 2017 17:493

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  49. Content type: Research article

    Research of natural products from traditionally used medicinal plants to fight against the human ailments is fetching attention of researchers worldwide. Bidens pilosa Linn. var. Radiata (Asteraceae) is well know...

    Authors: Garima Singh, Ajit Kumar Passsari, Pratibha Singh, Vincent Vineeth Leo, Sarathbabu Subbarayan, Brijesh Kumar, Bhim Pratap Singh, Hauzel lalhlenmawia and Nachimuthu Senthil Kumar

    Citation: BMC Complementary and Alternative Medicine 2017 17:492

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  50. Content type: Research article

    Volatile oils from Artemisiae argyi folium (VOAAF) is reported with hepatotoxicity, but the underlying mechanism is still unclear.

    Authors: Hongjie Liu, Sha Zhan, Yan Zhang, Yan Ma, Liang Chen, Lingxiu Chen, Hanqiu Dong, Min Ma and Zhe Zhang

    Citation: BMC Complementary and Alternative Medicine 2017 17:491

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