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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Content type: Research article

    MicroRNAs(miRNAs)are involved in the initiation and progression of hepatocellular carcinoma. ESC, an extract of Stellerachamaejasme L, had been confirmed as a potential anti-tumor extract of Traditional Chinese M...

    Authors: Xiaoni Liu, Shuang Wang, Jianji Xu, Buxin Kou, Dexi Chen, Yajie Wang and Xiaoxin Zhu

    Citation: BMC Complementary and Alternative Medicine 2018 18:99

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  2. Content type: Research article

    Allium fistulosum (Welsh onion) is a traditional medicinal plant used for the treatment of colds, influenza, abdominal pain, headache, and heart disease. This study evaluated the effects of A. fistulosum ethanoli...

    Authors: Yoon-Young Sung, Dong-Seon Kim, Seung-Hyung Kim and Ho Kyoung Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:105

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  3. Content type: Research article

    Neuraminidase (NA) is one of the key surface protein of the influenza virus, and has been established as a primary drug target for anti-influenza therapies. This study aimed to screen bioactive herbal extracts...

    Authors: Jiawei Liu, Mian Zu, Kaotan Chen, Li Gao, Huan Min, Weiling Zhuo, Weiwen Chen and Ailin Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:102

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  4. Content type: Research article

    Apium graveolens L. is a traditional Chinese medicine prescribed as a treatment for hypertension, gout, and diabetes. This study aimed to determine the neuroprotective effects of A. graveolens extract against a P...

    Authors: Pennapa Chonpathompikunlert, Phetcharat Boonruamkaew, Wanida Sukketsiri, Pilaiwanwadee Hutamekalin and Morakot Sroyraya

    Citation: BMC Complementary and Alternative Medicine 2018 18:103

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  5. Content type: Research article

    Sutherlandia frutescens (L.) R. Br is endemic to Southern Africa where it has been traditionally used for cancer and diabetes. In recent times it has been marketed for its reputed (but not proven) anticancer, ant...

    Authors: Siyabulela S. B. N. Ntuli, Wentzel C. A. Gelderblom and David R. Katerere

    Citation: BMC Complementary and Alternative Medicine 2018 18:93

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  6. Content type: Research article

    Khaya grandifoliola (C.D.C.) stem bark, Cymbopogon citratus (Stapf) and Cryptolepis sanguinolenta (Lindl.) Schltr leaves are used in Cameroonian traditional medicine for the treatment of inflammatory diseases. Se...

    Authors: Francine Kengne Mediesse, Thaddée Boudjeko, Anantharaju Hasitha, Matharasala Gangadhar, Wilfred Fon Mbacham and Perumal Yogeeswari

    Citation: BMC Complementary and Alternative Medicine 2018 18:86

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  7. Content type: Research article

    This study showed phytochemical composition and evaluates the anti-inflammatory, and analgesic activities of crude extract (CE) and fractions from E. uniflora Linn leaves.

    Authors: Tamires Rocha Falcão, Aurigena Antunes de Araújo, Luiz Alberto Lira Soares, Rhayanne Thaís de Moraes Ramos, Isabelle Cristinne Ferraz Bezerra, Magda Rhayanny Assunção Ferreira, Manoel André de Souza Neto, Maria Celeste Nunes Melo, Raimundo Fernandes de Araújo Jr, Andreza Conceição Véras de Aguiar Guerra, Juliana Silva de Medeiros and Gerlane Coelho Bernardo Guerra

    Citation: BMC Complementary and Alternative Medicine 2018 18:84

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  8. Content type: Research article

    Astragalus membranaceus (AM) is a commonly used herb in traditional Chinese medicine (TCM), which has been used as an essential tonic to treat various diseases for more than 2000 years. In this study, we aimed to...

    Authors: Ruijuan Zhou, Hongjiu Chen, Junpeng Chen, Xuemei Chen, Yu Wen and Leqin Xu

    Citation: BMC Complementary and Alternative Medicine 2018 18:83

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  9. Content type: Research article

    Salix aegyptiaca is known for its medicinal properties mainly due to the presence of salicylate compounds. However, it also contains other beneficial phytochemicals such as gallic acid, quercetin, rutin and vanil...

    Authors: Mohd Nauman, R. K. Kale and Rana P. Singh

    Citation: BMC Complementary and Alternative Medicine 2018 18:81

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  10. Content type: Research article

    α-glucosidase is a therapeutic target for diabetes mellitus (DM) and α-glucosidase inhibitors play a vital role in the treatments for the disease. Furthermore, xanthine oxidase (XO) is a key enzyme that cataly...

    Authors: Habib Mosbah, Hassiba Chahdoura, Jannet Kammoun, Malek Besbes Hlila, Hanen Louati, Saoussen Hammami, Guido Flamini, Lotfi Achour and Boulbaba Selmi

    Citation: BMC Complementary and Alternative Medicine 2018 18:79

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  11. Content type: Research article

    Semecarpus parvifolia Thw is used as an ingredient of poly herbal decoctions to treat cancer in traditional medicine. The present study aims to investigate the antiproliferative activity on HEp 2 cells by the wat...

    Authors: Preethi Soysa, Panchima Jayarthne and Imali Ranathunga

    Citation: BMC Complementary and Alternative Medicine 2018 18:78

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  12. Content type: Research article

    Extensive epidemiological and clinical studies revealed that Alzheimer’s Disease (AD) and Type 2 Diabetes Mellitus (T2D) are most likely to appear simultaneously in aged people as T2D is a major risk factor fo...

    Authors: Mohan Penumala, Raveendra Babu Zinka, Jeelan Basha Shaik, Suresh Kumar Reddy Mallepalli, Ramakrishna Vadde and Damu Gangaiah Amooru

    Citation: BMC Complementary and Alternative Medicine 2018 18:77

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  13. Content type: Research article

    Cordyceps militaris (C. militaris) is reported to exert various immune-activities. To enhance its activity, we fermented C.militaris with Pediococcus pentosaceus ON89A (GRC-ON89A). In this study, we investigated ...

    Authors: Ha-Kyoung Kwon, Woo-Ri Jo and Hye-Jin Park

    Citation: BMC Complementary and Alternative Medicine 2018 18:75

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  14. Content type: Research article

    Uses of polyherbal formulations have played a major role in traditional medicine. The present study is focused on the formulations used in traditional Thai folkloric medicine as tonics or bracers. Twenty docum...

    Authors: Wipawee Chanthasri, Nuntitporn Puangkeaw, Nongluk Kunworarath, Patcharawalai Jaisamut, Surasak Limsuwan, Katesarin Maneenoon, Piyapong Choochana and Sasitorn Chusri

    Citation: BMC Complementary and Alternative Medicine 2018 18:73

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  15. Content type: Research article

    Cumulated evidence reveals that glial cells in the spinal cord play an important role in the development of chronic neuropathic pain and are also complicated in the analgesic effect of EA intervention. But the...

    Authors: Jun-ying Wang, Yong-hui Gao, Li-na Qiao, Jian-liang Zhang, Cheng-Lin Duan-mu, Ya-xia Yan, Shu-ping Chen and Jun-ling Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:74

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  16. Content type: Research article

    Pancreatic cancer is one of the leading causes of cancer related death and its incidence has risen steadily. Although anticancer drugs have been developed based on the new molecular findings, the drugs have pr...

    Authors: Maiyon Park, Danielle Upton, Melodie Blackmon, Valerie Dixon, Scott Craver, Dawn Neal and Derek Perkins

    Citation: BMC Complementary and Alternative Medicine 2018 18:71

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  17. Content type: Research article

    Spinacia oleracea is an important dietary vegetable in India and throughout the world and has many beneficial effects. It is cultivated globally. However, its effect on osteoarthritis that mainly targets the cart...

    Authors: Dharmendra Choudhary, Priyanka Kothari, Ashish Kumar Tripathi, Sonu Singh, Sulekha Adhikary, Naseer Ahmad, Sudhir Kumar, Kapil Dev, Vijay Kumar Mishra, Shubha Shukla, Rakesh Maurya, Prabhat R. Mishra and Ritu Trivedi

    Citation: BMC Complementary and Alternative Medicine 2018 18:69

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  18. Content type: Research article

    Zanthoxylum armatum DC is an important medicinal plant of south East Asia, and has been used to treat various ailments in traditional medicine including diabetes. This study investigated the in vitro and in vivo ...

    Authors: Fiaz Alam, Qazi Najam us Saqib and Mohammad Ashraf

    Citation: BMC Complementary and Alternative Medicine 2018 18:68

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  19. Content type: Research article

    Traditional healing practice is an important and integral part of healthcare systems in almost all countries of the world. Very few studies have addressed the holistic scenario of traditional healing practices...

    Authors: Md. Imdadul Haque, A. B. M. Alauddin Chowdhury, Md. Shahjahan and Md. Golam Dostogir Harun

    Citation: BMC Complementary and Alternative Medicine 2018 18:62

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  20. Content type: Research article

    Parkinson’s disease (PD) is a progressive neurodegenerative disorder of the central nervous system. Although the causes of PD pathogenesis remain incomplete, some evidences has suggested that oxidative stress ...

    Authors: Joana Silva, Celso Alves, Susete Pinteus, Susana Mendes and Rui Pedrosa

    Citation: BMC Complementary and Alternative Medicine 2018 18:58

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