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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Content type: Research article

    Ocimum micranthum Willd is a plant used in traditional medicine practiced in the region of the Yucatan peninsula. In particular, it is used for the treatment of cutaneous infections and wound healing, however the...

    Authors: Isabel O. Caamal-Herrera, Leydi M. Carrillo-Cocom, Diana Y. Escalante-Réndiz, Diana Aráiz-Hernández and José A. Azamar-Barrios

    Citation: BMC Complementary and Alternative Medicine 2018 18:55

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  2. Content type: Research article

    Degradation of components of the extracellular matrix such as elastin and collagen by elastase and collagenase accelerates skin aging. Phytochemicals that inhibit the activity of these enzymes can be developed...

    Authors: Tinotenda Shoko, Vinesh J. Maharaj, Dashnie Naidoo, Malefa Tselanyane, Rudzani Nthambeleni, Eric Khorombi and Zeno Apostolides

    Citation: BMC Complementary and Alternative Medicine 2018 18:54

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  3. Content type: Research article

    Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon’s blood, the Twobrother’s Blood or Dam...

    Authors: Nashwan Abdullah Al-Afifi, Aied Mohammed Alabsi, Marina Mohd Bakri and Anand Ramanathan

    Citation: BMC Complementary and Alternative Medicine 2018 18:50

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  4. Content type: Research article

    In China, Panax notoginseng has been used to treat oxidative stress-related diseases for a long time. Panax notoginseng saponins is an extract from Panax notoginseng Ledeb. Its therapeutic potential is related to...

    Authors: Ming-wei Liu, Rui Wei, Mei-xian Su, Hui Li, Tian-wen Fang and Wei Zhang

    Citation: BMC Complementary and Alternative Medicine 2018 18:51

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  5. Content type: Research article

    This study was to evaluate the effects of herbal compound 861 (Cpd861) on ski-related novel protein N (SnoN) and transforming growth factor-β1 (TGF-β1) /Smad signaling in rats with bile duct ligation (BDL)-ind...

    Authors: Cheng Chi, Xiao-ya Liu, Fei Hou, Xiao-zheng Yu, Chun-yun Li, Li-jian Cui, Rui-xia Liu and Cheng-hong Yin

    Citation: BMC Complementary and Alternative Medicine 2018 18:52

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  6. Content type: Research article

    Cisplatin (CP) drug is platinum compounds used for the treatment of various human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia hydaspica is a natural shrub with various pharmac...

    Authors: Tayyaba Afsar, Suhail Razak, Ali Almajwal and Muhammad Rashid Khan

    Citation: BMC Complementary and Alternative Medicine 2018 18:49

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  7. Content type: Research article

    So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batterie...

    Authors: Mi Young Lee, Yang-Chun Park, Mirim Jin, Eunseok Kim, Jeong June Choi and In Chul Jung

    Citation: BMC Complementary and Alternative Medicine 2018 18:47

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  8. Content type: Research article

    Guang-Pheretima, which is originated from Pheretima aspergillum, has been documented in academic Chinese herbal studies for nearly 2000 years for its prominent treating effects of various inflammatory diseases su...

    Authors: Chuanqi Huang, Wei Li, Qiufeng Zhang, Lihong Chen, Weiming Chen, Hongchao Zhang and Yuxin Ni

    Citation: BMC Complementary and Alternative Medicine 2018 18:46

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  9. Content type: Research article

    Most of herbal medicines are used without any standard safety and toxicological trials although common assumption is that these products are nontoxic. However, this assumption is incorrect and dangerous, so to...

    Authors: Wubayehu Kahaliw, Bjorn Hellman and Ephrem Engidawork

    Citation: BMC Complementary and Alternative Medicine 2018 18:45

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  10. Content type: Research article

    Parrotiopsis jacquemontiana (Decne) Rehder. is locally used for skin infections and in wound healing. In this study we have evaluated methanol extract of its leaves and derived fractions against the clinical mult...

    Authors: Saima Ali, Muhammad Rashid Khan, Irfanullah, Moniba Sajid and Zartash Zahra

    Citation: BMC Complementary and Alternative Medicine 2018 18:43

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  11. Content type: Research article

    Cold hypersensitivity in the hands and feet (CHHF) is a common symptom in Korea and patients with CHHF complain of coldness in the hands and feet in an environment that is not considered cold by unaffected peo...

    Authors: Kwang-Ho Bae, Ho-Yeon Go, Ki-Hyun Park, Ilkoo Ahn, Youngheum Yoon and Siwoo Lee

    Citation: BMC Complementary and Alternative Medicine 2018 18:40

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  12. Content type: Research article

    Our team has identified 17 Boreal forest species from the traditional pharmacopeia of the Eastern James Bay Cree that presented promising in vitro and in vivo biological activities in the context of type 2 dia...

    Authors: Shilin Li, Sarah Pasquin, Hoda M. Eid, Jean-François Gauchat, Ammar Saleem and Pierre S. Haddad

    Citation: BMC Complementary and Alternative Medicine 2018 18:37

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  13. Content type: Research article

    Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective...

    Authors: Victor Kuete, Dominique Ngnintedo, Ghislain W. Fotso, Oğuzhan Karaosmanoğlu, Bonaventure T. Ngadjui, Felix Keumedjio, Samuel O. Yeboah, Kerstin Andrae-Marobela and Hülya Sivas

    Citation: BMC Complementary and Alternative Medicine 2018 18:36

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  14. Content type: Research article

    It has been observed that the various part of Baccaurea ramiflora plant is used in rheumatoid arthritis, cellulitis, abscesses, constipation and injuries. This plant also has anticholinergic, hypolipidemic, hypog...

    Authors: Mst. Luthfun Nesa, S. M. Sajedul Karim, Khairunasa Api, Md. Moklesur Rahman Sarker, Md. Monirul Islam, Asma Kabir, Mithun Kumar Sarker, Kamrun Nahar, Mohammad Asadujjaman and Mohammad Sirajum Munir

    Citation: BMC Complementary and Alternative Medicine 2018 18:35

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  15. Content type: Research article

    Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in the treatment of the delayed diabetic wound. However, elucidating the related molecular biological mechanism of how...

    Authors: Le Kuai, Jing-ting Zhang, Yu Deng, Shun Xu, Xun-zhe Xu, Min-feng Wu, Dong-jie Guo, Yu Chen, Ren-jie Wu, Xing-qiang Zhao, Hua Nian, Bin Li and Fu-lun Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:32

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  16. Content type: Research article

    Icariin (ICA), a major ingredient of Epimediumbrevicornum, has various pharmacological activities including central nervous system protective functions such as the improvement of learning and memory function in m...

    Authors: Xiaolong Fu, Shujun Li, Shaoyu Zhou, Qin Wu, Feng Jin and Jingshan Shi

    Citation: BMC Complementary and Alternative Medicine 2018 18:34

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  17. Content type: Research article

    Natural products obtained from plants can be potent sources for developing a variety of pharmaceutical products. Allium species have been widely studied for their anti-cancer effects and presented promising resul...

    Authors: Ovgu Isbilen, Nahit Rizaner and Ender Volkan

    Citation: BMC Complementary and Alternative Medicine 2018 18:30

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  18. Content type: Research article

    Oxidative stress as well as bacterial and fungal infections are common source of diseases while plants are source of medication for curative or protective purposes. Hence, aim of study was to compare the pharm...

    Authors: Iram Fatima, Sobia Kanwal and Tariq Mahmood

    Citation: BMC Complementary and Alternative Medicine 2018 18:27

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  19. Content type: Research article

    Cupressus macrocarpa Hartw and Corymbia citriodora (Hook.) K.D. Hill & L.A.S. Johnson, widely grown in many subtropical areas, are used for commercial purposes, such as in perfumery, cosmetics, and room freshener...

    Authors: Mohamed Z. M. Salem, Hosam O. Elansary, Hayssam M. Ali, Ahmed A. El-Settawy, Mohamed S. Elshikh, Eslam M. Abdel-Salam and Krystyna Skalicka-Woźniak

    Citation: BMC Complementary and Alternative Medicine 2018 18:23

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  20. Content type: Research article

    Pelargonium sidoides (PS) and Coptis chinensis root (CR) have traditionally been used to treat various diseases, including respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders. The pre...

    Authors: Sang Mi Park, Byung-Gu Min, Ji Yun Jung, Kyung Hwan Jegal, Chul Won Lee, Kwang Youn Kim, Young Woo Kim, Youn-Woong Choi, Il Je Cho, Sae Kwang Ku and Sang Chan Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:20

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  21. Content type: Research article

    Based on clinical medications and related studies, we established a Yang-Gan Jie-Du Sang-Jie (YGJDSJ) herbal formula for hepatocarcinoma treatment. In present study, we evaluated the anti-cancer potential of Y...

    Authors: Bing Hu, Tong Zhang, Hong-Mei An, Jia-Lu Zheng, Xia Yan and Xiao-Wei Huang

    Citation: BMC Complementary and Alternative Medicine 2018 18:17

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  22. Content type: Research article

    Nutmeg is the seed kernel inside the fruit of Myristica fragrans Houtt. (Myristicaceae). It possesses various pharmacological activities but is used in Cameroon only for its flavor in making cakes. The present st...

    Authors: Joachim K. Dzotam, Ingrid Konga Simo, Gabin Bitchagno, Ilhami Celik, Louis P. Sandjo, Pierre Tane and Victor Kuete

    Citation: BMC Complementary and Alternative Medicine 2018 18:15

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  23. Content type: Research article

    Fructose-mediated protein glycation (fructation) has been linked to an increase in diabetic and cardiovascular complications due to over consumption of high-fructose containing diets in recent times. The objec...

    Authors: Hardik Ghelani, Valentina Razmovski-Naumovski, Rajeswara Rao Pragada and Srinivas Nammi

    Citation: BMC Complementary and Alternative Medicine 2018 18:13

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  24. Content type: Research article

    Inflammation has been implicated in many disorders, including cancer and available therapies elicit adverse effects. Plants of the family Rubiaceae have shown potency against inflammation. The anti-inflammator...

    Authors: Oluwayinka Olufunmilayo Owolabi, Dorcas Bolanle James, Ibrahim Sani, Binda T. Andongma, Opeoluwa O. Fasanya and Barnabas Kure

    Citation: BMC Complementary and Alternative Medicine 2018 18:12

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  25. Content type: Research article

    The highbush blueberry (Vaccinium corymbosum) has a beneficial effect on several aspects of human health. The present study investigated the effects of highbush blueberry proanthocyanidins (PACs) on the virulence...

    Authors: Amel Ben Lagha, Geneviève LeBel and Daniel Grenier

    Citation: BMC Complementary and Alternative Medicine 2018 18:10

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  26. Content type: Research article

    Costus speciosus, Cymbopogon citratus, and Tabernaemontana coronaria are herbal plants traditionally used as remedies for symptoms of tuberculosis (TB) including cough. The aims of the present study were to evalu...

    Authors: Suriyati Mohamad, Nur Najihah Ismail, Thaigarajan Parumasivam, Pazilah Ibrahim, Hasnah Osman and Habibah A. Wahab

    Citation: BMC Complementary and Alternative Medicine 2018 18:5

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  27. Content type: Research article

    An impaired leukocytes function is the factor causing the susceptibility of patients with diabetes mellitus to infections. The outmost importance for the understanding of the immunological processes involved i...

    Authors: Mariia Nagalievska, Mariya Sabadashka, Halyna Hachkova and Nataliia Sybirna

    Citation: BMC Complementary and Alternative Medicine 2018 18:4

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  28. Content type: Research article

    The medicinal importance of a novel plant Olax nana Wall. ex Benth. (family: Olacaceae) was revealed for the first time via HPLC-DAD finger printing, qualitative phytochemical analysis, antioxidant, cholinesteras...

    Authors: Muhammad Ovais, Muhammad Ayaz, Ali Talha Khalil, Sayed Afzal Shah, Muhammad Saeed Jan, Abida Raza, Muhammad Shahid and Zabta Khan Shinwari

    Citation: BMC Complementary and Alternative Medicine 2018 18:1

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  29. Content type: Research article

    Basophilic granulocytes (BGs) not only initiate the induction of Th2 cell differentiation, but also amplify the ongoing Th2 response. Shuang-Huang-Lian (SHL) is clinically used for relieving type I hypersensit...

    Authors: Qiaoling Fei, Yixin Han, Ruijuan Qi, Yuan Gao, Lei Fang, Rui Hou, Runlan Cai and Yun Qi

    Citation: BMC Complementary and Alternative Medicine 2018 18:2

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  30. Content type: Research article

    The use of doxorubicin (DOX) an anthracycline antineoplastic agent is withdrawn due to its cardio-toxic side effects. Oxidative stress has been recognized as the primary cause of DOX induced cardiotoxicity. We...

    Authors: Tayyaba Afsar, Suhail Razak, Khalid Mujasam Batoo and Muhammad Rashid Khan

    Citation: BMC Complementary and Alternative Medicine 2017 17:554

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  31. Content type: Research article

    The conversion of the epithelial phenotype of cancer cells into cells with a mesenchymal phenotype-so-called epithelial–mesenchymal transition (EMT)-has been shown to enhance the capacity of the cells to disse...

    Authors: Nareerat Petpiroon, Boonchoo Sritularak and Pithi Chanvorachote

    Citation: BMC Complementary and Alternative Medicine 2017 17:553

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  32. Content type: Research article

    Danshen is a common traditional Chinese medicine used to treat neoplastic and chronic inflammatory diseases in China. However, the effects of Danshen on human oral cancer cells remain relatively unknown. This ...

    Authors: Cheng-Yu Yang, Cheng-Chih Hsieh, Chih-Kung Lin, Chun-Shu Lin, Bo Peng, Gu-Jiun Lin, Huey-Kang Sytwu, Wen-Liang Chang and Yuan-Wu Chen

    Citation: BMC Complementary and Alternative Medicine 2017 17:555

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  33. Content type: Research article

    Although such local herb as Streblus asper (family Moraceae) has long been recognized for traditional folk medicines and important ingredient of traditional longevity formula, its anti-neurodegeneration or anti-a...

    Authors: Anchalee Prasansuklab, Krai Meemon, Prasert Sobhon and Tewin Tencomnao

    Citation: BMC Complementary and Alternative Medicine 2017 17:551

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  34. Content type: Research article

    Mood disorder accounts for 13 % of global disease burden. And while therapeutic agents are available, usually orally administered, most have unwanted side effects, and thus making the inhalation of essential o...

    Authors: Myra O. Villareal, Ayumi Ikeya, Kazunori Sasaki, Abdelkarim Ben Arfa, Mohamed Neffati and Hiroko Isoda

    Citation: BMC Complementary and Alternative Medicine 2017 17:549

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  35. Content type: Research article

    Extracts from Salvia miltiorrhiza Bunge have been used in traditional Asian medicine to treat coronary heart disease, chronic renal failure, atherosclerosis, myocardial infraction, angina pectoris, myocardial isc...

    Authors: Bongkyun Park, Hae Seong Song, Jeong Eun Kwon, Se Min Cho, Seon-A Jang, Mi Yeon Kim and Se Chan Kang

    Citation: BMC Complementary and Alternative Medicine 2017 17:545

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  36. Content type: Research article

    Bamboo (Phyllostachys pubescens) leaves and Japanese apricot (Mume fructus) fruit are traditionally recognized to be safe herbs broadly used for food and medicinal purposes in Southeast Asia. Our group previously...

    Authors: Eunjung Son, Seung-Hyung Kim, Won-Kyung Yang, Dong-Seon Kim and Jimin Cha

    Citation: BMC Complementary and Alternative Medicine 2017 17:541

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  37. Content type: Research article

    “Horchata” is an herbal mixture infusion consumed in Southern Ecuador; 66% of its plants are anti-inflammatory medicinal plant, and 51% are analgesics. Anti-inflammatory substances can prevent carcinogenesis m...

    Authors: Natalia Bailon-Moscoso, Fani Tinitana, Ruth Martínez-Espinosa, Andrea Jaramillo-Velez, Alejandra Palacio-Arpi, Jessica Aguilar-Hernandez and Juan Carlos Romero-Benavides

    Citation: BMC Complementary and Alternative Medicine 2017 17:539

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  38. Content type: Research article

    Excess dietary fructose intake associated with metabolic syndrome and insulin resistance and increased risk of developing type 2 diabetes. Previous animal studies have reported that diabetic animals have signi...

    Authors: V. A. Chavushyan, K. V. Simonyan, R. M. Simonyan, A. S. Isoyan, G. M. Simonyan, M. A. Babakhanyan, L. E. Hovhannisyian, Kh. H. Nahapetyan, L. G. Avetisyan and M. A. Simonyan

    Citation: BMC Complementary and Alternative Medicine 2017 17:540

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  39. Content type: Research article

    Blood stasis syndrome (BSS) is a general pattern identification and refers to pathological stagnation of blood circulation, dysfunction of endothelial cells or metabolic disorder in traditional Korean medicine...

    Authors: Eun Hyoung Shim, Hoyoung Lee, Myeong Soo Lee and Sooseong You

    Citation: BMC Complementary and Alternative Medicine 2017 17:542

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  40. Content type: Research article

    Acute kidney injury (AKI) is an initial factor in many kidney disorders. Pre- and intra-renal AKI biomarkers have recently been reported. Recovery from AKI by herbal medicine has rarely been reported. Thus, th...

    Authors: Sung-Man Oh, Gunhyuk Park, Seung Hoon Lee, Chang-Seob Seo, Hyeun-Kyoo Shin and Dal-Seok Oh

    Citation: BMC Complementary and Alternative Medicine 2017 17:544

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  41. Content type: Research article

    Various plant extracts have been suggested to be used as auxiliary agents in chemotherapy considering their anti-proliferative effect on cancer cells. However, recent reports reveal that plant extracts may fun...

    Authors: Hai Li and Chen Chen

    Citation: BMC Complementary and Alternative Medicine 2017 17:538

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    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2018 18:72

  42. Content type: Research article

    Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovitis, cartilage degradation and bone deformities. Synovitis is the term for inflammation of the synovial membrane, an early stage of ...

    Authors: Manatsanan Khansai, Thanyaluck Phitak, Jeerawan Klangjorhor, Sasimol Udomrak, Kanda Fanhchaksai, Peraphan Pothacharoen and Prachya Kongtawelert

    Citation: BMC Complementary and Alternative Medicine 2017 17:532

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  43. Content type: Research article

    Quercetin (QCT) is a flavonol present in many vegetables, it is proved to show chemo preventive effect against lung, cervical, prostate, breast and colon cancer due to its anti-inflammatory, anti-tumor and ant...

    Authors: Haojie Liu and Ming Zhou

    Citation: BMC Complementary and Alternative Medicine 2017 17:531

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  44. Content type: Research article

    Acupuncture has been used as a common therapeutic tool in many disorders including anxiety and depression. Serotonin transporter (SERT) plays an important role in the pathology of anxiety and other mood disord...

    Authors: Tae Young Yang, Eun Young Jang, Yeonhee Ryu, Gyu Won Lee, Eun Byeol Lee, Suchan Chang, Jong Han Lee, Jin Suk Koo, Chae Ha Yang and Hee Young Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:528

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  45. Content type: Research article

    Ethnobatanical survey associates Sapium ellipticum (SE) with antidiabetic usage among other medicinal functions in different parts of Africa. More importantly, previous studies on the plant extract in our laborat...

    Authors: Osasenaga Macdonald Ighodaro and Oluseyi Adeboye Akinloye

    Citation: BMC Complementary and Alternative Medicine 2017 17:525

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  46. Content type: Research article

    N-butylidenephthalide (BP) isolated from Radix Angelica Sinensis (Danggui) exhibits anti-tumorigenic effect in various cancer cells both in vivo and in vitro. The effect of BP in bladder cancer treatment is still...

    Authors: Sheng-Chun Chiu, Tsung-Lang Chiu, Sung-Ying Huang, Shu-Fang Chang, Shee-Ping Chen, Cheng-Yoong Pang and Teng-Fu Hsieh

    Citation: BMC Complementary and Alternative Medicine 2017 17:523

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  47. Content type: Research article

    According to only a handful of historical sources, Osmunda regalis, the royal fern, has been used already in the middle age as an anti-cancer remedy. To examine this ancient cancer cure, an ethanolic extract of t...

    Authors: Marianne Schmidt, Josef Skaf, Georgiana Gavril, Christine Polednik, Jeanette Roller, Michael Kessler and Ulrike Holzgrabe

    Citation: BMC Complementary and Alternative Medicine 2017 17:518

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  48. Content type: Research article

    European mistletoe (Viscum album) products used in cancer therapy are frequently combined with other anti-cancer-drugs. Hence, potential herb-drug interactions have become a major safety concern in mistletoe ther...

    Authors: Michael Schink and Oliver Dehus

    Citation: BMC Complementary and Alternative Medicine 2017 17:521

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  49. Content type: Research article

    Salmonella enterica serovar Typhimurium is a foodborne pathogen that triggers inflammatory responses in the intestines of humans and livestock. Colla corii asini is a traditional medic...

    Authors: Kwang-il Park, Mi-ra Lee, Tae-woo Oh, Kwang-Youn Kim and Jin-yeul Ma

    Citation: BMC Complementary and Alternative Medicine 2017 17:520

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