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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Content type: Research article

    Among the processes involved in the breast tumor microenvironment, angiogenesis and inflammation play a central role, and the main factors of these processes are the vascular endothelial growth factor (VEGF), ...

    Authors: Jéssica Alessandra-Perini, Jamila Alessandra Perini, Karina Cristina Rodrigues-Baptista, Roberto Soares de Moura, Antonio Palumbo Junior, Thiago Alves dos Santos, Pergentino José Cunha Souza, Luiz Eurico Nasciutti and Daniel Escorsim Machado

    Citation: BMC Complementary and Alternative Medicine 2018 18:116

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  2. Content type: Research article

    Bupleurum yinchowense Shan et Y. Li is widely used to treat depressive and anxiety disorders for hundreds of years in China. Total saikosaponins (TSS) is the major ingredient of Bupleurum yinchowense. A-amino-3-h...

    Authors: Xiuping Sun, Xianglei Li, Ruile Pan, Yanfeng Xu, Qiong Wang and Mingjing Song

    Citation: BMC Complementary and Alternative Medicine 2018 18:117

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  3. Content type: Research article

    Type 2 Diabetes (T2D) is a polygenic disease requiring a multipronged therapeutic approach. In the current scenario, the use of polyherbals is increasing among the diabetics. MD-1, a poly herbal formulation is...

    Authors: Srivani Telapolu, Mangathayaru Kalachavedu, Alan Mathew Punnoose and Dwarakanath Bilikere

    Citation: BMC Complementary and Alternative Medicine 2018 18:113

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  4. Content type: Research article

    Accumulating evidence suggests that Fructus Ligustri Lucidi (FLL) plays a beneficial role in preventing the development of osteoporosis. However, the effects of FLL on estrogen receptor (ER) α and ERβ expressions...

    Authors: Yu-qing Tang, Cheng Li, Xue-jiao Sun, Yi Liu, Xi-ting Wang, Yu-bo Guo, Li-li Wang, Ru-feng Ma, Jian-zhao Niu, Min Fu, Dong-wei Zhang and Yu Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:118

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  5. Content type: Research article

    Influenza infection remains a major health threat for animals and humans which crucially requires effective antiviral remedies. The usage of herbal medications as readily available alternatives for their compa...

    Authors: Parvaneh Mehrbod, Muna A. Abdalla, Emmanuel M. Njoya, Aroke S. Ahmed, Fatemeh Fotouhi, Behrokh Farahmand, Dorcas A. Gado, Mansoureh Tabatabaian, Olubunmi G. Fasanmi, Jacobus N. Eloff, Lyndy J. McGaw and Folorunso O. Fasina

    Citation: BMC Complementary and Alternative Medicine 2018 18:112

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  6. Content type: Research article

    Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the germ layer and bran of Brown rice (BR) help maintain good health an...

    Authors: Michiaki Okuda, Yuki Fujita, Takuya Katsube, Hiromasa Tabata, Katsumi Yoshino, Michio Hashimoto and Hachiro Sugimoto

    Citation: BMC Complementary and Alternative Medicine 2018 18:110

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  7. Content type: Research article

    Antrodia cinnamomea is an indigenous medicinal mushroom in Taiwan, commonly used for the treatment of cancers and inflammatory disorders. 4-acetylantroquinonol B (4AAQB) is one of the active component isolated fr...

    Authors: Chien-Hsin Chang, Chun-Chieh Hsu, An-Sheng Lee, Shih-Wei Wang, Kung-Tin Lin, Wei-Luen Chang, Hui-Chin Peng, Wen-Chiung Huang and Ching-Hu Chung

    Citation: BMC Complementary and Alternative Medicine 2018 18:108

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  8. Content type: Research article

    Dependence on antipsycotic drugs like aripriprazole (ARI) is increasing at alarming rate, hence, this study was undertaken to support the hypothesis that supplementation of Citrus paradisi (Grapefruit) juice havi...

    Authors: Seema Zargar, Abdul-Rahman A. Al-Majed and Tanveer A. Wani

    Citation: BMC Complementary and Alternative Medicine 2018 18:106

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  9. Content type: Research article

    MicroRNAs(miRNAs)are involved in the initiation and progression of hepatocellular carcinoma. ESC, an extract of Stellerachamaejasme L, had been confirmed as a potential anti-tumor extract of Traditional Chinese M...

    Authors: Xiaoni Liu, Shuang Wang, Jianji Xu, Buxin Kou, Dexi Chen, Yajie Wang and Xiaoxin Zhu

    Citation: BMC Complementary and Alternative Medicine 2018 18:99

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  10. Content type: Research article

    Allium fistulosum (Welsh onion) is a traditional medicinal plant used for the treatment of colds, influenza, abdominal pain, headache, and heart disease. This study evaluated the effects of A. fistulosum ethanoli...

    Authors: Yoon-Young Sung, Dong-Seon Kim, Seung-Hyung Kim and Ho Kyoung Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:105

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  11. Content type: Research article

    Neuraminidase (NA) is one of the key surface protein of the influenza virus, and has been established as a primary drug target for anti-influenza therapies. This study aimed to screen bioactive herbal extracts...

    Authors: Jiawei Liu, Mian Zu, Kaotan Chen, Li Gao, Huan Min, Weiling Zhuo, Weiwen Chen and Ailin Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:102

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  12. Content type: Research article

    Apium graveolens L. is a traditional Chinese medicine prescribed as a treatment for hypertension, gout, and diabetes. This study aimed to determine the neuroprotective effects of A. graveolens extract against a P...

    Authors: Pennapa Chonpathompikunlert, Phetcharat Boonruamkaew, Wanida Sukketsiri, Pilaiwanwadee Hutamekalin and Morakot Sroyraya

    Citation: BMC Complementary and Alternative Medicine 2018 18:103

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  13. Content type: Research article

    No animal model studies have been conducted in which the efficacy of herbal compounds has been tested against multidrug-resistant Acinetobacter baumannii infections. Very few antibiotics are available for the tre...

    Authors: Chin-Chuan Tsai, Chi-Shiuan Lin, Chun-Ru Hsu, Chiu-Ming Chang, I-Wei Chang, Li-Wei Lin, Chih-Hsin Hung and Jiun-Ling Wang

    Citation: BMC Complementary and Alternative Medicine 2018 18:96

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  14. Content type: Research article

    Lung adenocarcinoma is the most common subtype of Non small cell lung cancer in which the PI3K/Akt cascade is frequently deregulated. The ubiquitous expression of the PI3K and the frequent inactivation of PTEN...

    Authors: Fazeela Mahaboob Begum S.M., Kalai Chitra, Benin Joseph, Raji Sundararajan and Hemalatha S.

    Citation: BMC Complementary and Alternative Medicine 2018 18:104

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  15. Content type: Research article

    Laminaria japonica has frequently been used as a food supplement and drug in traditional oriental medicine. Among the major active constituents responsible for the bioactivities of L. japonica, fucoxanthin (FX) h...

    Authors: Eun Jeong Jang, Sang Chan Kim, Ju-Hee Lee, Jong Rok Lee, Il Kon Kim, Su Youn Baek and Young Woo Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:97

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  16. Content type: Research article

    Zingiber zerumbet (L.) Smith belongs to the Zingiberaceae family that is widely distributed throughout the tropics, particularly in Southeast Asia. It is locally known as ‘Lempoyang’ and traditionally used to tre...

    Authors: Asmah Hamid, Farah Wahida Ibrahim, Teoh Hooi Ming, Mohd Nazir Nasrom, Norelina Eusoff, Khairana Husain and Mazlyzam Abdul Latif

    Citation: BMC Complementary and Alternative Medicine 2018 18:101

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  17. Content type: Research article

    Sutherlandia frutescens (L.) R. Br is endemic to Southern Africa where it has been traditionally used for cancer and diabetes. In recent times it has been marketed for its reputed (but not proven) anticancer, ant...

    Authors: Siyabulela S. B. N. Ntuli, Wentzel C. A. Gelderblom and David R. Katerere

    Citation: BMC Complementary and Alternative Medicine 2018 18:93

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  18. Content type: Research article

    Khaya grandifoliola (C.D.C.) stem bark, Cymbopogon citratus (Stapf) and Cryptolepis sanguinolenta (Lindl.) Schltr leaves are used in Cameroonian traditional medicine for the treatment of inflammatory diseases. Se...

    Authors: Francine Kengne Mediesse, Thaddée Boudjeko, Anantharaju Hasitha, Matharasala Gangadhar, Wilfred Fon Mbacham and Perumal Yogeeswari

    Citation: BMC Complementary and Alternative Medicine 2018 18:86

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  19. Content type: Research article

    This study showed phytochemical composition and evaluates the anti-inflammatory, and analgesic activities of crude extract (CE) and fractions from E. uniflora Linn leaves.

    Authors: Tamires Rocha Falcão, Aurigena Antunes de Araújo, Luiz Alberto Lira Soares, Rhayanne Thaís de Moraes Ramos, Isabelle Cristinne Ferraz Bezerra, Magda Rhayanny Assunção Ferreira, Manoel André de Souza Neto, Maria Celeste Nunes Melo, Raimundo Fernandes de Araújo Jr, Andreza Conceição Véras de Aguiar Guerra, Juliana Silva de Medeiros and Gerlane Coelho Bernardo Guerra

    Citation: BMC Complementary and Alternative Medicine 2018 18:84

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  20. Content type: Research article

    Astragalus membranaceus (AM) is a commonly used herb in traditional Chinese medicine (TCM), which has been used as an essential tonic to treat various diseases for more than 2000 years. In this study, we aimed to...

    Authors: Ruijuan Zhou, Hongjiu Chen, Junpeng Chen, Xuemei Chen, Yu Wen and Leqin Xu

    Citation: BMC Complementary and Alternative Medicine 2018 18:83

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  21. Content type: Research article

    Salix aegyptiaca is known for its medicinal properties mainly due to the presence of salicylate compounds. However, it also contains other beneficial phytochemicals such as gallic acid, quercetin, rutin and vanil...

    Authors: Mohd Nauman, R. K. Kale and Rana P. Singh

    Citation: BMC Complementary and Alternative Medicine 2018 18:81

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  22. Content type: Research article

    α-glucosidase is a therapeutic target for diabetes mellitus (DM) and α-glucosidase inhibitors play a vital role in the treatments for the disease. Furthermore, xanthine oxidase (XO) is a key enzyme that cataly...

    Authors: Habib Mosbah, Hassiba Chahdoura, Jannet Kammoun, Malek Besbes Hlila, Hanen Louati, Saoussen Hammami, Guido Flamini, Lotfi Achour and Boulbaba Selmi

    Citation: BMC Complementary and Alternative Medicine 2018 18:79

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  23. Content type: Research article

    Semecarpus parvifolia Thw is used as an ingredient of poly herbal decoctions to treat cancer in traditional medicine. The present study aims to investigate the antiproliferative activity on HEp 2 cells by the wat...

    Authors: Preethi Soysa, Panchima Jayarthne and Imali Ranathunga

    Citation: BMC Complementary and Alternative Medicine 2018 18:78

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  24. Content type: Research article

    Extensive epidemiological and clinical studies revealed that Alzheimer’s Disease (AD) and Type 2 Diabetes Mellitus (T2D) are most likely to appear simultaneously in aged people as T2D is a major risk factor fo...

    Authors: Mohan Penumala, Raveendra Babu Zinka, Jeelan Basha Shaik, Suresh Kumar Reddy Mallepalli, Ramakrishna Vadde and Damu Gangaiah Amooru

    Citation: BMC Complementary and Alternative Medicine 2018 18:77

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  25. Content type: Research article

    Cordyceps militaris (C. militaris) is reported to exert various immune-activities. To enhance its activity, we fermented C.militaris with Pediococcus pentosaceus ON89A (GRC-ON89A). In this study, we investigated ...

    Authors: Ha-Kyoung Kwon, Woo-Ri Jo and Hye-Jin Park

    Citation: BMC Complementary and Alternative Medicine 2018 18:75

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  26. Content type: Research article

    Uses of polyherbal formulations have played a major role in traditional medicine. The present study is focused on the formulations used in traditional Thai folkloric medicine as tonics or bracers. Twenty docum...

    Authors: Wipawee Chanthasri, Nuntitporn Puangkeaw, Nongluk Kunworarath, Patcharawalai Jaisamut, Surasak Limsuwan, Katesarin Maneenoon, Piyapong Choochana and Sasitorn Chusri

    Citation: BMC Complementary and Alternative Medicine 2018 18:73

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  27. Content type: Research article

    Cumulated evidence reveals that glial cells in the spinal cord play an important role in the development of chronic neuropathic pain and are also complicated in the analgesic effect of EA intervention. But the...

    Authors: Jun-ying Wang, Yong-hui Gao, Li-na Qiao, Jian-liang Zhang, Cheng-Lin Duan-mu, Ya-xia Yan, Shu-ping Chen and Jun-ling Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:74

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  28. Content type: Research article

    Pancreatic cancer is one of the leading causes of cancer related death and its incidence has risen steadily. Although anticancer drugs have been developed based on the new molecular findings, the drugs have pr...

    Authors: Maiyon Park, Danielle Upton, Melodie Blackmon, Valerie Dixon, Scott Craver, Dawn Neal and Derek Perkins

    Citation: BMC Complementary and Alternative Medicine 2018 18:71

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  29. Content type: Research article

    Spinacia oleracea is an important dietary vegetable in India and throughout the world and has many beneficial effects. It is cultivated globally. However, its effect on osteoarthritis that mainly targets the cart...

    Authors: Dharmendra Choudhary, Priyanka Kothari, Ashish Kumar Tripathi, Sonu Singh, Sulekha Adhikary, Naseer Ahmad, Sudhir Kumar, Kapil Dev, Vijay Kumar Mishra, Shubha Shukla, Rakesh Maurya, Prabhat R. Mishra and Ritu Trivedi

    Citation: BMC Complementary and Alternative Medicine 2018 18:69

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  30. Content type: Research article

    Zanthoxylum armatum DC is an important medicinal plant of south East Asia, and has been used to treat various ailments in traditional medicine including diabetes. This study investigated the in vitro and in vivo ...

    Authors: Fiaz Alam, Qazi Najam us Saqib and Mohammad Ashraf

    Citation: BMC Complementary and Alternative Medicine 2018 18:68

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  31. Content type: Research article

    Traditional healing practice is an important and integral part of healthcare systems in almost all countries of the world. Very few studies have addressed the holistic scenario of traditional healing practices...

    Authors: Md. Imdadul Haque, A. B. M. Alauddin Chowdhury, Md. Shahjahan and Md. Golam Dostogir Harun

    Citation: BMC Complementary and Alternative Medicine 2018 18:62

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  32. Content type: Research article

    Dental caries is considered a multifactorial disease, in which microorganisms play an important role. The diet is decisive in the biofilm formation because it provides the necessary resources for cellular grow...

    Authors: Guilherme Roncari Rocha, Elkin Jahir Florez Salamanca, Ana Letícia de Barros, Carmélia Isabel Vitorino Lobo and Marlise Inêz Klein

    Citation: BMC Complementary and Alternative Medicine 2018 18:61

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  33. Content type: Research article

    Parkinson’s disease (PD) is a progressive neurodegenerative disorder of the central nervous system. Although the causes of PD pathogenesis remain incomplete, some evidences has suggested that oxidative stress ...

    Authors: Joana Silva, Celso Alves, Susete Pinteus, Susana Mendes and Rui Pedrosa

    Citation: BMC Complementary and Alternative Medicine 2018 18:58

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  34. Content type: Research article

    Breast cancer remains a leading cause of death in women worldwide. Although breast cancer therapies have greatly advanced in recent years, many patients still develop tumour recurrence and metastasis, and even...

    Authors: Siyamak Ebrahimi Nigjeh, Swee Keong Yeap, Norshariza Nordin, Behnam Kamalideghan, Huynh Ky and Rozita Rosli

    Citation: BMC Complementary and Alternative Medicine 2018 18:56

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  35. Content type: Research article

    Ocimum micranthum Willd is a plant used in traditional medicine practiced in the region of the Yucatan peninsula. In particular, it is used for the treatment of cutaneous infections and wound healing, however the...

    Authors: Isabel O. Caamal-Herrera, Leydi M. Carrillo-Cocom, Diana Y. Escalante-Réndiz, Diana Aráiz-Hernández and José A. Azamar-Barrios

    Citation: BMC Complementary and Alternative Medicine 2018 18:55

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  36. Content type: Research article

    Degradation of components of the extracellular matrix such as elastin and collagen by elastase and collagenase accelerates skin aging. Phytochemicals that inhibit the activity of these enzymes can be developed...

    Authors: Tinotenda Shoko, Vinesh J. Maharaj, Dashnie Naidoo, Malefa Tselanyane, Rudzani Nthambeleni, Eric Khorombi and Zeno Apostolides

    Citation: BMC Complementary and Alternative Medicine 2018 18:54

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  37. Content type: Research article

    Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon’s blood, the Twobrother’s Blood or Dam...

    Authors: Nashwan Abdullah Al-Afifi, Aied Mohammed Alabsi, Marina Mohd Bakri and Anand Ramanathan

    Citation: BMC Complementary and Alternative Medicine 2018 18:50

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  38. Content type: Research article

    In China, Panax notoginseng has been used to treat oxidative stress-related diseases for a long time. Panax notoginseng saponins is an extract from Panax notoginseng Ledeb. Its therapeutic potential is related to...

    Authors: Ming-wei Liu, Rui Wei, Mei-xian Su, Hui Li, Tian-wen Fang and Wei Zhang

    Citation: BMC Complementary and Alternative Medicine 2018 18:51

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  39. Content type: Research article

    This study was to evaluate the effects of herbal compound 861 (Cpd861) on ski-related novel protein N (SnoN) and transforming growth factor-β1 (TGF-β1) /Smad signaling in rats with bile duct ligation (BDL)-ind...

    Authors: Cheng Chi, Xiao-ya Liu, Fei Hou, Xiao-zheng Yu, Chun-yun Li, Li-jian Cui, Rui-xia Liu and Cheng-hong Yin

    Citation: BMC Complementary and Alternative Medicine 2018 18:52

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  40. Content type: Research article

    Cisplatin (CP) drug is platinum compounds used for the treatment of various human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia hydaspica is a natural shrub with various pharmac...

    Authors: Tayyaba Afsar, Suhail Razak, Ali Almajwal and Muhammad Rashid Khan

    Citation: BMC Complementary and Alternative Medicine 2018 18:49

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  41. Content type: Research article

    So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batterie...

    Authors: Mi Young Lee, Yang-Chun Park, Mirim Jin, Eunseok Kim, Jeong June Choi and In Chul Jung

    Citation: BMC Complementary and Alternative Medicine 2018 18:47

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  42. Content type: Research article

    Guang-Pheretima, which is originated from Pheretima aspergillum, has been documented in academic Chinese herbal studies for nearly 2000 years for its prominent treating effects of various inflammatory diseases su...

    Authors: Chuanqi Huang, Wei Li, Qiufeng Zhang, Lihong Chen, Weiming Chen, Hongchao Zhang and Yuxin Ni

    Citation: BMC Complementary and Alternative Medicine 2018 18:46

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  43. Content type: Research article

    Most of herbal medicines are used without any standard safety and toxicological trials although common assumption is that these products are nontoxic. However, this assumption is incorrect and dangerous, so to...

    Authors: Wubayehu Kahaliw, Bjorn Hellman and Ephrem Engidawork

    Citation: BMC Complementary and Alternative Medicine 2018 18:45

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  44. Content type: Research article

    Parrotiopsis jacquemontiana (Decne) Rehder. is locally used for skin infections and in wound healing. In this study we have evaluated methanol extract of its leaves and derived fractions against the clinical mult...

    Authors: Saima Ali, Muhammad Rashid Khan, Irfanullah, Moniba Sajid and Zartash Zahra

    Citation: BMC Complementary and Alternative Medicine 2018 18:43

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  45. Content type: Research article

    Cold hypersensitivity in the hands and feet (CHHF) is a common symptom in Korea and patients with CHHF complain of coldness in the hands and feet in an environment that is not considered cold by unaffected peo...

    Authors: Kwang-Ho Bae, Ho-Yeon Go, Ki-Hyun Park, Ilkoo Ahn, Youngheum Yoon and Siwoo Lee

    Citation: BMC Complementary and Alternative Medicine 2018 18:40

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  46. Content type: Research article

    Our team has identified 17 Boreal forest species from the traditional pharmacopeia of the Eastern James Bay Cree that presented promising in vitro and in vivo biological activities in the context of type 2 dia...

    Authors: Shilin Li, Sarah Pasquin, Hoda M. Eid, Jean-François Gauchat, Ammar Saleem and Pierre S. Haddad

    Citation: BMC Complementary and Alternative Medicine 2018 18:37

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  47. Content type: Research article

    Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective...

    Authors: Victor Kuete, Dominique Ngnintedo, Ghislain W. Fotso, Oğuzhan Karaosmanoğlu, Bonaventure T. Ngadjui, Felix Keumedjio, Samuel O. Yeboah, Kerstin Andrae-Marobela and Hülya Sivas

    Citation: BMC Complementary and Alternative Medicine 2018 18:36

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  48. Content type: Research article

    It has been observed that the various part of Baccaurea ramiflora plant is used in rheumatoid arthritis, cellulitis, abscesses, constipation and injuries. This plant also has anticholinergic, hypolipidemic, hypog...

    Authors: Mst. Luthfun Nesa, S. M. Sajedul Karim, Khairunasa Api, Md. Moklesur Rahman Sarker, Md. Monirul Islam, Asma Kabir, Mithun Kumar Sarker, Kamrun Nahar, Mohammad Asadujjaman and Mohammad Sirajum Munir

    Citation: BMC Complementary and Alternative Medicine 2018 18:35

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  49. Content type: Research article

    Icariin (ICA), a major ingredient of Epimediumbrevicornum, has various pharmacological activities including central nervous system protective functions such as the improvement of learning and memory function in m...

    Authors: Xiaolong Fu, Shujun Li, Shaoyu Zhou, Qin Wu, Feng Jin and Jingshan Shi

    Citation: BMC Complementary and Alternative Medicine 2018 18:34

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