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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Content type: Research article

    The collapse of mitochondrial membrane potential (ΔΨm) resulted in the cell apoptosis and heart failure. Xinshuitong Capsule (XST) could ameliorate left ventricular ejection fraction (LVEF), New York Heart Ass...

    Authors: Chunjiang Tan, Jianwei Zeng, Yanbin Wu, Jiahui Zhang and Wenlie Chen

    Citation: BMC Complementary and Alternative Medicine 2018 18:170

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  2. Content type: Research article

    Biofilms have great significance in healthcare-associated infections owing to their inherent tolerance and resistance to antimicrobial therapies. New approaches to prevent and treat unwanted biofilms are urgen...

    Authors: Luca De Vincenti, Yvana Glasenapp, Cristina Cattò, Federica Villa, Francesca Cappitelli and Jutta Papenbrock

    Citation: BMC Complementary and Alternative Medicine 2018 18:168

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  3. Content type: Research article

    Combining conventional drugs and traditional medicine may represent a useful approach to combating antibiotic resistance, which has become a serious threat to global public health. This study aimed to evaluate...

    Authors: Weifeng Yang, Jueling Liu, Biljana Blažeković, Yanan Sun, Shuhua Ma, Chuanyun Ren, Sanda Vladimir-Knežević, Chaohua Li, Yajun Xing, Guijie Tian and Yi Wang

    Citation: BMC Complementary and Alternative Medicine 2018 18:169

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  4. Content type: Research article

    It is well known that Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition and synaptic dysfunction play importa...

    Authors: Jing-Hua Zhang, Lin-Jie Yu, Hui Yang, Zhen Hui, Su Jiang, Ling Chen, Yang Zhao, Su-Lei Wang, Yi Liu and Yun Xu

    Citation: BMC Complementary and Alternative Medicine 2018 18:167

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  5. Content type: Research article

    Propolis is multicomponent substance collected by honeybees from various plants. It is known for numerous biological effects and is commonly used as ethanolic extract because most of active substances of propo...

    Authors: Loreta Kubiliene, Aiste Jekabsone, Modestas Zilius, Sonata Trumbeckaite, Daiva Simanaviciute, Rima Gerbutaviciene and Daiva Majiene

    Citation: BMC Complementary and Alternative Medicine 2018 18:165

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  6. Content type: Research article

    Homoharringtonine (HHT) is a natural alkaloid with potent antitumor activity, but its precise mechanism of action is still poorly understood.

    Authors: Qi Sun, Shiyue Li, Junjun Li, Qiuxia Fu, Zhongyuan Wang, Bo Li, Shan-Shan Liu, Zijie Su, Jiaxing Song and Desheng Lu

    Citation: BMC Complementary and Alternative Medicine 2018 18:164

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  7. Content type: Research article

    There are increasing interests in natural compounds for cancer chemoprevention. Blocking agents represent an important class of chemopreventive compounds. They prevent carcinogens from undergoing metabolic act...

    Authors: Ali M. El-Halawany, Hossam M. Abdallah, Ahmed R. Hamed, Hany Ezzat Khalil and Ameen M. Almohammadi

    Citation: BMC Complementary and Alternative Medicine 2018 18:163

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  8. Content type: Research article

    Diabetes mellitus is one of the major global health disorders increasing at an alarming rate in both developed and developing countries. The objective of this study was to assess the effect of aqueous extract of

    Authors: Gulzar Ahmad Bhat, Haseeb A. Khan, Abdullah S. Alhomida, Poonam Sharma, Rambir Singh and Bilal Ahmad Paray

    Citation: BMC Complementary and Alternative Medicine 2018 18:162

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    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2018 18:182

    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2018 18:175

  9. Content type: Research article

    Ficus vasta Forssk. (Moraceae) is traditionally used for the treatment of various ailments; nonetheless, this species has been poorly studied to date. This work aimed to characterize the phenolic profile and to e...

    Authors: Maria Fernanda Taviano, Khaled Rashed, Angela Filocamo, Francesco Cacciola, Paola Dugo, Luigi Mondello, Carlo Bisignano, Rosaria Acquaviva, Manuela D’Arrigo and Natalizia Miceli

    Citation: BMC Complementary and Alternative Medicine 2018 18:161

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  10. Content type: Research article

    This present study sought to assess the modulatory effects of five Nigerian traditional polyherbal in high fructose-fed, streptozotocin-induced (HF-STZ) Type 2 diabetes (T2D) in rats. T2D was achieved via fruc...

    Authors: O. E. Kale, O. B. Akinpelu, A. A. Bakare, F. O. Yusuf, R. Gomba, D. C. Araka, T. O. Ogundare, A. C. Okolie, O. Adebawo and O. Odutola

    Citation: BMC Complementary and Alternative Medicine 2018 18:160

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  11. Content type: Research article

    Antimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and...

    Authors: Raissa Tioyem Nzogong, Fabrice Sterling Tchantchou Ndjateu, Steve Endeguele Ekom, Jules-Arnaud Mboutchom Fosso, Maurice Ducret Awouafack, Mathieu Tene, Pierre Tane, Hiroyuki Morita, Muhammad Iqbal Choudhary and Jean-de-Dieu Tamokou

    Citation: BMC Complementary and Alternative Medicine 2018 18:159

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  12. Content type: Research article

    Oxidative stress and renal apoptosis play a significant role in the progression of diabetic nephropathy. The tubers of Pueraria tuberosa (Roxb. ex Willd.) DC. has been traditionally used as anti-ageing and health...

    Authors: Rashmi Shukla, Somanshu Banerjee and Yamini B. Tripathi

    Citation: BMC Complementary and Alternative Medicine 2018 18:156

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  13. Content type: Research article

    Since oxidative stress and inflammation are two linked factors in the pathogenesis of several human diseases. Thus identification of effective treatment is of great importance. Edible mushroom and microalgae a...

    Authors: Marwa M. Abu-Serie, Noha H. Habashy and Wafaa E. Attia

    Citation: BMC Complementary and Alternative Medicine 2018 18:154

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  14. Content type: Research article

    Breast cancer is the most common cancer in women and affects 1.38 million women worldwide per year. Antiestrogens such as tamoxifen, a selective estrogen receptor (ER) modulator, are widely used in clinics to ...

    Authors: Yu-Shih Lin, Yin-Yin Lin, Yao-Hsu Yang, Chun-Liang Lin, Feng-Che Kuan, Cheng-Nan Lu, Geng-He Chang, Ming-Shao Tsai, Cheng-Ming Hsu, Reming-Albert Yeh, Pei-Rung Yang, I-Yun Lee, Li-Hsin Shu, Yu-Ching Cheng, Hung-Te Liu, Kuan-Der Lee…

    Citation: BMC Complementary and Alternative Medicine 2018 18:152

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  15. Content type: Research article

    Dental caries remains a serious problem due to its detrimental effects on individual health and quality of life. The bulbs of Myrmecodia pendans (Merr & Perry), native plants of Papua, have been used as natural r...

    Authors: Meirina Gartika, Hening T. Pramesti, Dikdik Kurnia and Mieke H. Satari

    Citation: BMC Complementary and Alternative Medicine 2018 18:151

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  16. Content type: Research article

    Sheng Jiang San (SJS), a multi-herb formulation, is used in treating high fever, thirsty and anxiety in ancient China and it is sometimes used to treat seasonal influenza nowadays. However, there is no evidenc...

    Authors: Tianbo Zhang, Mengjie Xiao, Chun-Kwok Wong, Ka-Pun Chris Mok, Xin Zhao, Huihui Ti and Pang-Chui Shaw

    Citation: BMC Complementary and Alternative Medicine 2018 18:150

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  17. Content type: Research article

    The potential toxicity of Chinese herbal medicine has attracted more attention in recent years. Jueyin granules (JYG), a polyherbal formula, have been proven to be an effective agent for treating psoriasis in bot...

    Authors: Yu Chen, Dong-jie Guo, Hui Deng, Min-feng Wu, Ya-Nan Zhang, Su Li, Rong Xu, Jie Chen, Xing-xiu Jin, Bin Li, Qi Xu and Fu-lun Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:148

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  18. Content type: Research article

    Natural product is one of the most important sources of drugs used in pharmaceutical therapeutics. Artemisia capillaris has been traditionally used as a hepatoprotective and anti-inflammatory agent. In this study...

    Authors: Juyoung Kim, Kyung Hee Jung, Hong Hua Yan, Min Ji Cheon, Sunmi Kang, Xing Jin, Sunghyouk Park, Myung Sook Oh and Soon-Sun Hong

    Citation: BMC Complementary and Alternative Medicine 2018 18:147

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  19. Content type: Research article

    Human placenta hydrolysate (hPH) has been utilized to improve menopausal, fatigue, liver function. Its high concentration of bioactive substances is known to produce including antioxidant, anti-inflammatory an...

    Authors: Hyun-Jung Park, Hyun Soo Shim, Sunyoung Lee, Dae Hyun Hahm, Hyejung Lee, Chang Taek Oh, Hae Jung Han, Hyi Jeong Ji and Insop Shim

    Citation: BMC Complementary and Alternative Medicine 2018 18:149

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  20. Content type: Research article

    Fine particulate matter (PM2.5) is a major risk factor for the development and progression of atherosclerosis. Proliferation and infiltration of vascular smooth muscle cells (VSMCs) from the blood vessel media...

    Authors: Qiang Wan, Zhongyong Liu and Yuping Yang

    Citation: BMC Complementary and Alternative Medicine 2018 18:146

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  21. Content type: Research article

    Cryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients. In addition, the lower susceptibility of this yeast to azoles is ...

    Authors: Daniela Scalas, Narcisa Mandras, Janira Roana, Roberta Tardugno, Anna Maria Cuffini, Valeria Ghisetti, Stefania Benvenuti and Vivian Tullio

    Citation: BMC Complementary and Alternative Medicine 2018 18:143

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  22. Content type: Research article

    Propolis, a polyphenol-rich natural product, has been used as a functional food in anti-inflammation. However, its bioactive components and mechanisms have not been fully elucidated.

    Authors: Huasong Chang, Wenwen Yuan, Haizhu Wu, Xusheng Yin and Hongzhuan Xuan

    Citation: BMC Complementary and Alternative Medicine 2018 18:142

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  23. Content type: Research article

    The current treatment for human brucellosis requires a combination of antibiotics for long periods of time, and the reported incidence and prevalence of the disease vary widely in nomadic livestock of Mongolia...

    Authors: Tsevelmaa N, Narangerel B, Odgerel O, Dariimaa D and Batkhuu J

    Citation: BMC Complementary and Alternative Medicine 2018 18:144

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  24. Content type: Research article

    Terminalia chebula Retz. (Combretaceae) is a traditional herbal medicine that is widely used in the treatment of diabetes, immunodeficiency diseases, and stomach ulcer in Asia. However, the anti-amnesic effect of...

    Authors: Min-Soo Kim, Dong Young Lee, Jun Lee, Hyun Woo Kim, Sang Hyun Sung, Jung-Soo Han and Won Kyung Jeon

    Citation: BMC Complementary and Alternative Medicine 2018 18:136

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  25. Content type: Research article

    Brazilian green propolis is produced by mixing secretions from Africanized honey bees with exudate, mainly from Baccharis dracunculifolia. Brazilian propolis is especially rich in flavonoids and cinammic acid der...

    Authors: Hiroshi Kitamura, Natsuko Saito, Junpei Fujimoto, Ken-ichi Nakashima and Daisuke Fujikura

    Citation: BMC Complementary and Alternative Medicine 2018 18:138

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  26. Content type: Research article

    Solanum aculeastrum fruits are used by some cancer sufferers as a form of alternative treatment. Scientific literature is scarce concerning its anticancer activity, and thus the aim of the study was to assess the...

    Authors: Trevor Burger, Tsholofelo Mokoka, Gerda Fouché, Paul Steenkamp, Vanessa Steenkamp and Werner Cordier

    Citation: BMC Complementary and Alternative Medicine 2018 18:137

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  27. Content type: Research article

    Herba Siegesbeckiae (HS, Xixiancao in Chinese) is a commonly used traditional Chinese medicinal herb for soothing joints. In ancient materia medica books, HS is recorded to be the aerial part of Siegesbeckia pube...

    Authors: Hui Guo, Yi Zhang, Brian Chi-Yan Cheng, Mei-Yuk Lau, Xiu-Qiong Fu, Ting Li, Tao Su, Pei-Li Zhu, Yuen-Cheung Chan, Anfernee Kai-Wing Tse, Tao Yi, Hu-Biao Chen and Zhi-Ling Yu

    Citation: BMC Complementary and Alternative Medicine 2018 18:141

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  28. Content type: Research article

    Medicinal plants have been founded as traditional herbal medicine worldwide. Most of the plant’s therapeutic properties are due to the presence of secondary metabolites such as alkaloids, glycosides, tannins a...

    Authors: Hazir Rahman, Ilyas Khan, Anwar Hussain, Abdelaaty Abdelaziz Shahat, Abdul Tawab, Muhammad Qasim, Muhammad Adnan, Mansour S. Al-Said, Riaz Ullah and Shahid Niaz Khan

    Citation: BMC Complementary and Alternative Medicine 2018 18:140

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  29. Content type: Research article

    Schistosomiasis is an acute and chronic zoonotic parasitic disease caused by trematode worms. The host inflammatory response to schistosome eggs leads to perioval granulomata formation, mainly in the liver and...

    Authors: Dina M. Metwally, Ebtesam M. Al-Olayan, Mohammad Alanazi, Sanaa B. Alzahrany and Abdelhabib Semlali

    Citation: BMC Complementary and Alternative Medicine 2018 18:135

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  30. Content type: Research article

    Radix Paeoniae Rubra (RPR), a traditional Chinese herb, has anti-inflammatory and immuno-regulatory properties. This study explored the effects of RPR on stimulation of osteoclast differentiation in RAW264.7 c...

    Authors: Huey-En Tzeng, Chun-Hao Tsai, Tin-Yun Ho, Chin-Tung Hsieh, Shen-Chieh Chou, Yi-Ju Lee, Gregory J. Tsay, Po-Hao Huang and Yi-Ying Wu

    Citation: BMC Complementary and Alternative Medicine 2018 18:132

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  31. Content type: Research article

    The medicinal orchid Dendrobium moniliforme contains water-soluble polysaccharides, phenanthrenes, bibenzyl derivatives, and polyphenol compounds. This study explored the antioxidant and cytotoxic activities of D...

    Authors: Mukti Ram Paudel, Mukesh Babu Chand, Basant Pant and Bijaya Pant

    Citation: BMC Complementary and Alternative Medicine 2018 18:134

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  32. Content type: Research article

    Previously, we reported that ChondorT showed significant anti-arthritis and anti-inflammatory effects. ChondroT, a new herbal medication, consists of the water extracts of Osterici Radix, Lonicerae Folium, Angeli...

    Authors: Jiwon Jeong, Kiljoon Bae, Sun-Gil Kim, Dongwook Kwak, Young-Joo Moon, Chan-Hun Choi, Young-Ran Kim, Chang-Su Na and Seon-Jong Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:131

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  33. Content type: Research article

    Houttuynia cordata Thunb. and Phyllanthus emblica Linn. are native plants with medicinal and nutritive significance in Asia. The present study was aimed at evaluating antiproliferative effects on human cancer cel...

    Authors: Piyawan Kumnerdkhonkaen, Somprasong Saenglee, Md. Ali Asgar, Gulsiri Senawong, Kanoknan Khongsukwiwat and Thanaset Senawong

    Citation: BMC Complementary and Alternative Medicine 2018 18:130

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  34. Content type: Research article

    Crocin (CRO), chlorogenic acid (CGA), geniposide (GEN), and quercetin (QUE) are all natural compounds with anti-obesity properties, in particular, hypolipidemic effects, which have been widely used for the tre...

    Authors: Ennian Leng, Yuan Xiao, Zhentao Mo, Yiqi Li, Yueyue Zhang, Xiaosi Deng, Min Zhou, Chaochao Zhou, Zengxuan He, Jingyi He, Lu Xiao, Junming Li and Wenna Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:122

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  35. Content type: Research article

    Cucumis sativus L. (cucumber), from the family Cucurbitaceae, is a therapeutic plant with various pharmacological benefits, broadly utilized as a part of complementary medicine (e.g., Unani, Ayurveda, Siddha, and...

    Authors: Raid Al Akeel, Ayesha Mateen, Khalid K. Alharbi, Abdullah A. Alyousef, Hazem M. Al-Mandeel and Rabbani Syed

    Citation: BMC Complementary and Alternative Medicine 2018 18:121

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  36. Content type: Research article

    A Chinese herbal formula, namely Jian-Pi-Yi-Shen (JPYS), has been clinically prescribed for patients with chronic kidney disease associated-anemia, and which can improve the patient’s immunological system. How...

    Authors: Jianping Chen, Amy G. W. Gong, Xiaoyan Liu, Zhonggui Li, Airong Qi, Tina T. X. Dong, Tiegang Yi, Karl W. K. Tsim and Shunmin Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:119

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  37. Content type: Research article

    Among the processes involved in the breast tumor microenvironment, angiogenesis and inflammation play a central role, and the main factors of these processes are the vascular endothelial growth factor (VEGF), ...

    Authors: Jéssica Alessandra-Perini, Jamila Alessandra Perini, Karina Cristina Rodrigues-Baptista, Roberto Soares de Moura, Antonio Palumbo Junior, Thiago Alves dos Santos, Pergentino José Cunha Souza, Luiz Eurico Nasciutti and Daniel Escorsim Machado

    Citation: BMC Complementary and Alternative Medicine 2018 18:116

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  38. Content type: Research article

    Bupleurum yinchowense Shan et Y. Li is widely used to treat depressive and anxiety disorders for hundreds of years in China. Total saikosaponins (TSS) is the major ingredient of Bupleurum yinchowense. A-amino-3-h...

    Authors: Xiuping Sun, Xianglei Li, Ruile Pan, Yanfeng Xu, Qiong Wang and Mingjing Song

    Citation: BMC Complementary and Alternative Medicine 2018 18:117

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  39. Content type: Research article

    Type 2 Diabetes (T2D) is a polygenic disease requiring a multipronged therapeutic approach. In the current scenario, the use of polyherbals is increasing among the diabetics. MD-1, a poly herbal formulation is...

    Authors: Srivani Telapolu, Mangathayaru Kalachavedu, Alan Mathew Punnoose and Dwarakanath Bilikere

    Citation: BMC Complementary and Alternative Medicine 2018 18:113

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  40. Content type: Research article

    Accumulating evidence suggests that Fructus Ligustri Lucidi (FLL) plays a beneficial role in preventing the development of osteoporosis. However, the effects of FLL on estrogen receptor (ER) α and ERβ expressions...

    Authors: Yu-qing Tang, Cheng Li, Xue-jiao Sun, Yi Liu, Xi-ting Wang, Yu-bo Guo, Li-li Wang, Ru-feng Ma, Jian-zhao Niu, Min Fu, Dong-wei Zhang and Yu Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:118

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  41. Content type: Research article

    Influenza infection remains a major health threat for animals and humans which crucially requires effective antiviral remedies. The usage of herbal medications as readily available alternatives for their compa...

    Authors: Parvaneh Mehrbod, Muna A. Abdalla, Emmanuel M. Njoya, Aroke S. Ahmed, Fatemeh Fotouhi, Behrokh Farahmand, Dorcas A. Gado, Mansoureh Tabatabaian, Olubunmi G. Fasanmi, Jacobus N. Eloff, Lyndy J. McGaw and Folorunso O. Fasina

    Citation: BMC Complementary and Alternative Medicine 2018 18:112

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  42. Content type: Research article

    Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the germ layer and bran of Brown rice (BR) help maintain good health an...

    Authors: Michiaki Okuda, Yuki Fujita, Takuya Katsube, Hiromasa Tabata, Katsumi Yoshino, Michio Hashimoto and Hachiro Sugimoto

    Citation: BMC Complementary and Alternative Medicine 2018 18:110

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  43. Content type: Research article

    Antrodia cinnamomea is an indigenous medicinal mushroom in Taiwan, commonly used for the treatment of cancers and inflammatory disorders. 4-acetylantroquinonol B (4AAQB) is one of the active component isolated fr...

    Authors: Chien-Hsin Chang, Chun-Chieh Hsu, An-Sheng Lee, Shih-Wei Wang, Kung-Tin Lin, Wei-Luen Chang, Hui-Chin Peng, Wen-Chiung Huang and Ching-Hu Chung

    Citation: BMC Complementary and Alternative Medicine 2018 18:108

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  44. Content type: Research article

    Dependence on antipsycotic drugs like aripriprazole (ARI) is increasing at alarming rate, hence, this study was undertaken to support the hypothesis that supplementation of Citrus paradisi (Grapefruit) juice havi...

    Authors: Seema Zargar, Abdul-Rahman A. Al-Majed and Tanveer A. Wani

    Citation: BMC Complementary and Alternative Medicine 2018 18:106

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  45. Content type: Research article

    Neuraminidase (NA) is one of the key surface protein of the influenza virus, and has been established as a primary drug target for anti-influenza therapies. This study aimed to screen bioactive herbal extracts...

    Authors: Jiawei Liu, Mian Zu, Kaotan Chen, Li Gao, Huan Min, Weiling Zhuo, Weiwen Chen and Ailin Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:102

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  46. Content type: Research article

    Apium graveolens L. is a traditional Chinese medicine prescribed as a treatment for hypertension, gout, and diabetes. This study aimed to determine the neuroprotective effects of A. graveolens extract against a P...

    Authors: Pennapa Chonpathompikunlert, Phetcharat Boonruamkaew, Wanida Sukketsiri, Pilaiwanwadee Hutamekalin and Morakot Sroyraya

    Citation: BMC Complementary and Alternative Medicine 2018 18:103

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  47. Content type: Research article

    No animal model studies have been conducted in which the efficacy of herbal compounds has been tested against multidrug-resistant Acinetobacter baumannii infections. Very few antibiotics are available for the tre...

    Authors: Chin-Chuan Tsai, Chi-Shiuan Lin, Chun-Ru Hsu, Chiu-Ming Chang, I-Wei Chang, Li-Wei Lin, Chih-Hsin Hung and Jiun-Ling Wang

    Citation: BMC Complementary and Alternative Medicine 2018 18:96

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  48. Content type: Research article

    Lung adenocarcinoma is the most common subtype of Non small cell lung cancer in which the PI3K/Akt cascade is frequently deregulated. The ubiquitous expression of the PI3K and the frequent inactivation of PTEN...

    Authors: Fazeela Mahaboob Begum S.M., Kalai Chitra, Benin Joseph, Raji Sundararajan and Hemalatha S.

    Citation: BMC Complementary and Alternative Medicine 2018 18:104

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  49. Content type: Research article

    Laminaria japonica has frequently been used as a food supplement and drug in traditional oriental medicine. Among the major active constituents responsible for the bioactivities of L. japonica, fucoxanthin (FX) h...

    Authors: Eun Jeong Jang, Sang Chan Kim, Ju-Hee Lee, Jong Rok Lee, Il Kon Kim, Su Youn Baek and Young Woo Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:97

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  50. Content type: Research article

    Zingiber zerumbet (L.) Smith belongs to the Zingiberaceae family that is widely distributed throughout the tropics, particularly in Southeast Asia. It is locally known as ‘Lempoyang’ and traditionally used to tre...

    Authors: Asmah Hamid, Farah Wahida Ibrahim, Teoh Hooi Ming, Mohd Nazir Nasrom, Norelina Eusoff, Khairana Husain and Mazlyzam Abdul Latif

    Citation: BMC Complementary and Alternative Medicine 2018 18:101

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