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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Content type: Research article

    Royal jelly (RJ), the exclusive food for the larva of queen honeybee, is regarded as the novel supplement to promote human health. The function of RJ may be attributed to its major and unique fatty acid, 10-hy...

    Authors: Yuan-Chang Yang, Wing-Ming Chou, Debora Arny Widowati, I-Ping Lin and Chi-Chung Peng

    Citation: BMC Complementary and Alternative Medicine 2018 18:202

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  2. Content type: Research article

    Cancer is one of the most frequently occurring diseases and is the second leading cause of death worldwide. In this study, anthraquinone derivatives (Compounds 1–5) were evaluated for their anti-cancer potenti...

    Authors: Vivek K. Bajpai, Md Badrul Alam, Khong Trong Quan, Hee-Jeong Choi, Hongyan An, Mi-Kyoung Ju, Sang-Han Lee, Yun Suk Huh, Young-Kyu Han and MinKyun Na

    Citation: BMC Complementary and Alternative Medicine 2018 18:200

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  3. Content type: Research article

    One of the molecular mechanisms involved in upper airway-related diseases is epithelial-to-mesenchymal transition (EMT). Olea europaea (OE) has anti-inflammatory properties and thus, great potential to prevent EM...

    Authors: Rabiatul Adawiyah Razali, Nik Ahmad Hafiz Nik Ahmad Eid, Turkambigai Jayaraman, Muhammad Asyrafi Amir Hassan, Nabilah Qistina Azlan, Nur Farhana Ismail, Nur Qisya Afifah Veronica Sainik, Muhammad Dain Yazid, Yogeswaran Lokanathan, Aminuddin Bin Saim and Ruszymah Bt Hj Idrus

    Citation: BMC Complementary and Alternative Medicine 2018 18:197

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  4. Content type: Research article

    Agastache rugosa (Fisch. & C.A.Mey.) Kuntze (Korean mint) is used to treat diverse types of human disorders in traditional medicine. In recent years, its non-fermented leaf extract (ARE) has been shown to possess...

    Authors: Daehyun Shin, Yoonjin Lee, Yu-Hua Huang, Hye-Won Lim, Kyounghee Jang, Dae-Duk Kim and Chang-Jin Lim

    Citation: BMC Complementary and Alternative Medicine 2018 18:196

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  5. Content type: Research article

    Coconut water has been commonly consumed as a beverage for its multiple health benefits while vinegar has been used as common seasoning and a traditional Chinese medicine. The present study investigates the po...

    Authors: Nurul Elyani Mohamad, Swee Keong Yeap, Boon-Kee Beh, Huynh Ky, Kian Lam Lim, Wan Yong Ho, Shaiful Adzni Sharifuddin, Kamariah Long and Noorjahan Banu Alitheen

    Citation: BMC Complementary and Alternative Medicine 2018 18:195

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  6. Content type: Research article

    It is widely accepted the key role of endothelium in the onset of many chronic and acute vascular and cardiovascular diseases.

    Authors: Chiara Bernardini, Augusta Zannoni, Martina Bertocchi, Irvin Tubon, Mercedes Fernandez and Monica Forni

    Citation: BMC Complementary and Alternative Medicine 2018 18:194

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  7. Content type: Research article

    Presumably, progression of developmental retinal vascular disorders is mainly driven by persistent ischemia/hypoxia. An investigation into vision-threatening retinal ischemia remains important. Our aim was to ...

    Authors: Wen-Haur Chao, Ming-Yi Lai, Hwai-Tzong Pan, Huei-Wen Shiu, Mi-Mi Chen and Hsiao-Ming Chao

    Citation: BMC Complementary and Alternative Medicine 2018 18:193

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  8. Content type: Research article

    The Nucleotide binding and oligomerization domain-like receptorfamily pyrin domain-containing 3 (NLRP3)-inflammasome plays an important role in various diseases, including a variety of kidney diseases. Naringi...

    Authors: Fenqin Chen, Guozhu Wei, Jiao Xu, Xiaoyu Ma and Qiuyue Wang

    Citation: BMC Complementary and Alternative Medicine 2018 18:192

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  9. Content type: Research article

    Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied. Thus, we elucidated the potentia...

    Authors: Su Bin Park, Gwang Hun Park, Ha Na Kim, Hun Min Song, Ho-Jun Son, Ji Ae Park, Hyun-Seok Kim and Jin Boo Jeong

    Citation: BMC Complementary and Alternative Medicine 2018 18:189

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  10. Content type: Research article

    Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by 5′-adenosine monophosphate-activated protein kinase (...

    Authors: Amber F. MacDonald, Ahmed Bettaieb, Dallas R. Donohoe, Dina S. Alani, Anna Han, Yi Zhao and Jay Whelan

    Citation: BMC Complementary and Alternative Medicine 2018 18:188

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  11. Content type: Research article

    The outbreak of MDR and XDR strains of Pseudomonas aeruginosa and increased resistance to infection in burn patients recommend the issue of infection control. In this research, we study ZOUSH herbal ointment for ...

    Authors: Maryam Meskini and Davoud Esmaeili

    Citation: BMC Complementary and Alternative Medicine 2018 18:185

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  12. Content type: Research article

    Influenza infection is a major public health threat. The role of influenza A virus-induced inflammatory response in severe cases of this disease is widely recognized. Drug resistance and side effects of chemic...

    Authors: Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O. Aro, Jacobus N. Eloff, Lyndy J. McGaw and Folorunso O. Fasina

    Citation: BMC Complementary and Alternative Medicine 2018 18:184

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  13. Content type: Research article

    Anacardium occidentale L phenolic lipid (LDT11) is used in traditional medicine as anti-inflammatory, astringent, antidiarrheal, anti-asthmatic and depurative. Phenolic derivatives, such as anacardic acid, extrac...

    Authors: Marilen Queiroz de Souza, Isabella Márcia Soares Nogueira Teotônio, Fernanda Coutinho de Almeida, Gabriella Simões Heyn, Priscilla Souza Alves, Luiz Antônio Soares Romeiro, Riccardo Pratesi, Yanna Karla de Medeiros Nóbrega and Claudia B. Pratesi

    Citation: BMC Complementary and Alternative Medicine 2018 18:181

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  14. Content type: Research article

    Kaempferia parviflora (KP) is an herb found in the north of Thailand and used as a folk medicine for improving vitality. Current reports have shown the anti-cancer activities of KP. However, the anti-cancer effec...

    Authors: Suthasinee Paramee, Siriwoot Sookkhee, Choompone Sakonwasun, Mingkwan Na Takuathung, Pitchaya Mungkornasawakul, Wutigri Nimlamool and Saranyapin Potikanond

    Citation: BMC Complementary and Alternative Medicine 2018 18:178

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  15. Content type: Research article

    Stevia (Stevia rebaudiana) natural, non-caloric sugar substitute is rich source of pharmacologically important glycoside stevioside that is linked to the pathology and complications of diabetes.

    Authors: Uswa Ahmad and Rabia Shabir Ahmad

    Citation: BMC Complementary and Alternative Medicine 2018 18:179

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  16. Content type: Research article

    Oroxylum indicum (L.) Kurz (O. indicum) is found in Thailand. It has been used for the treatment of obesity. This study aimed to investigate the effects of an O. indicum extract (OIE) on the adipogenic and biomol...

    Authors: Tanaporn Hengpratom, Gordon M. Lowe, Kanjana Thumanu, Siriporn Suknasang, Kanokwan Tiamyom and Griangsak Eumkeb

    Citation: BMC Complementary and Alternative Medicine 2018 18:177

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  17. Content type: Research article

    In the view of endemic avian influenza H9N2 infection in poultry, its zoonotic potential and emergence of antiviral resistance, two herbal plants, Ocimum sanctum and Acacia arabica, which are easily available thr...

    Authors: S. S. Ghoke, R. Sood, N. Kumar, A. K. Pateriya, S. Bhatia, A. Mishra, R. Dixit, V. K. Singh, D. N. Desai, D. D. Kulkarni, U. Dimri and V. P. Singh

    Citation: BMC Complementary and Alternative Medicine 2018 18:174

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  18. Content type: Research article

    Trichilia catigua A. Juss. (Meliaceae) is a species known as catuaba and used in folk medicine for the treatment of fatigue, stress, impotence and memory deficit. The main phytochemical compounds identified in th...

    Authors: Nadini Oliveira Martins, Isabella Modelli de Brito, Sandra Syomara O. Araújo, Giuseppina Negri, Elisaldo de Araújo Carlini and Fúlvio Rieli Mendes

    Citation: BMC Complementary and Alternative Medicine 2018 18:172

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  19. Content type: Research article

    Bidens pilosa and Dichrostachys cinerea extracts were investigated for the antibacterial properties against waterborne diarrhoeagenic bacteria.

    Authors: Pfarelo Daphney Shandukani, Shonisani Cathphonia Tshidino, Peter Masoko and Kgabo Maureen Moganedi

    Citation: BMC Complementary and Alternative Medicine 2018 18:171

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  20. Content type: Research article

    The collapse of mitochondrial membrane potential (ΔΨm) resulted in the cell apoptosis and heart failure. Xinshuitong Capsule (XST) could ameliorate left ventricular ejection fraction (LVEF), New York Heart Ass...

    Authors: Chunjiang Tan, Jianwei Zeng, Yanbin Wu, Jiahui Zhang and Wenlie Chen

    Citation: BMC Complementary and Alternative Medicine 2018 18:170

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  21. Content type: Research article

    Biofilms have great significance in healthcare-associated infections owing to their inherent tolerance and resistance to antimicrobial therapies. New approaches to prevent and treat unwanted biofilms are urgen...

    Authors: Luca De Vincenti, Yvana Glasenapp, Cristina Cattò, Federica Villa, Francesca Cappitelli and Jutta Papenbrock

    Citation: BMC Complementary and Alternative Medicine 2018 18:168

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  22. Content type: Research article

    Combining conventional drugs and traditional medicine may represent a useful approach to combating antibiotic resistance, which has become a serious threat to global public health. This study aimed to evaluate...

    Authors: Weifeng Yang, Jueling Liu, Biljana Blažeković, Yanan Sun, Shuhua Ma, Chuanyun Ren, Sanda Vladimir-Knežević, Chaohua Li, Yajun Xing, Guijie Tian and Yi Wang

    Citation: BMC Complementary and Alternative Medicine 2018 18:169

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  23. Content type: Research article

    It is well known that Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition and synaptic dysfunction play importa...

    Authors: Jing-Hua Zhang, Lin-Jie Yu, Hui Yang, Zhen Hui, Su Jiang, Ling Chen, Yang Zhao, Su-Lei Wang, Yi Liu and Yun Xu

    Citation: BMC Complementary and Alternative Medicine 2018 18:167

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  24. Content type: Research article

    Propolis is multicomponent substance collected by honeybees from various plants. It is known for numerous biological effects and is commonly used as ethanolic extract because most of active substances of propo...

    Authors: Loreta Kubiliene, Aiste Jekabsone, Modestas Zilius, Sonata Trumbeckaite, Daiva Simanaviciute, Rima Gerbutaviciene and Daiva Majiene

    Citation: BMC Complementary and Alternative Medicine 2018 18:165

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  25. Content type: Research article

    Homoharringtonine (HHT) is a natural alkaloid with potent antitumor activity, but its precise mechanism of action is still poorly understood.

    Authors: Qi Sun, Shiyue Li, Junjun Li, Qiuxia Fu, Zhongyuan Wang, Bo Li, Shan-Shan Liu, Zijie Su, Jiaxing Song and Desheng Lu

    Citation: BMC Complementary and Alternative Medicine 2018 18:164

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  26. Content type: Research article

    There are increasing interests in natural compounds for cancer chemoprevention. Blocking agents represent an important class of chemopreventive compounds. They prevent carcinogens from undergoing metabolic act...

    Authors: Ali M. El-Halawany, Hossam M. Abdallah, Ahmed R. Hamed, Hany Ezzat Khalil and Ameen M. Almohammadi

    Citation: BMC Complementary and Alternative Medicine 2018 18:163

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  27. Content type: Research article

    Diabetes mellitus is one of the major global health disorders increasing at an alarming rate in both developed and developing countries. The objective of this study was to assess the effect of aqueous extract of

    Authors: Gulzar Ahmad Bhat, Haseeb A. Khan, Abdullah S. Alhomida, Poonam Sharma, Rambir Singh and Bilal Ahmad Paray

    Citation: BMC Complementary and Alternative Medicine 2018 18:162

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    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2018 18:182

    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2018 18:175

  28. Content type: Research article

    Ficus vasta Forssk. (Moraceae) is traditionally used for the treatment of various ailments; nonetheless, this species has been poorly studied to date. This work aimed to characterize the phenolic profile and to e...

    Authors: Maria Fernanda Taviano, Khaled Rashed, Angela Filocamo, Francesco Cacciola, Paola Dugo, Luigi Mondello, Carlo Bisignano, Rosaria Acquaviva, Manuela D’Arrigo and Natalizia Miceli

    Citation: BMC Complementary and Alternative Medicine 2018 18:161

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  29. Content type: Research article

    This present study sought to assess the modulatory effects of five Nigerian traditional polyherbal in high fructose-fed, streptozotocin-induced (HF-STZ) Type 2 diabetes (T2D) in rats. T2D was achieved via fruc...

    Authors: O. E. Kale, O. B. Akinpelu, A. A. Bakare, F. O. Yusuf, R. Gomba, D. C. Araka, T. O. Ogundare, A. C. Okolie, O. Adebawo and O. Odutola

    Citation: BMC Complementary and Alternative Medicine 2018 18:160

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  30. Content type: Research article

    Antimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and...

    Authors: Raissa Tioyem Nzogong, Fabrice Sterling Tchantchou Ndjateu, Steve Endeguele Ekom, Jules-Arnaud Mboutchom Fosso, Maurice Ducret Awouafack, Mathieu Tene, Pierre Tane, Hiroyuki Morita, Muhammad Iqbal Choudhary and Jean-de-Dieu Tamokou

    Citation: BMC Complementary and Alternative Medicine 2018 18:159

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  31. Content type: Research article

    Oxidative stress and renal apoptosis play a significant role in the progression of diabetic nephropathy. The tubers of Pueraria tuberosa (Roxb. ex Willd.) DC. has been traditionally used as anti-ageing and health...

    Authors: Rashmi Shukla, Somanshu Banerjee and Yamini B. Tripathi

    Citation: BMC Complementary and Alternative Medicine 2018 18:156

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  32. Content type: Research article

    Since oxidative stress and inflammation are two linked factors in the pathogenesis of several human diseases. Thus identification of effective treatment is of great importance. Edible mushroom and microalgae a...

    Authors: Marwa M. Abu-Serie, Noha H. Habashy and Wafaa E. Attia

    Citation: BMC Complementary and Alternative Medicine 2018 18:154

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  33. Content type: Research article

    Breast cancer is the most common cancer in women and affects 1.38 million women worldwide per year. Antiestrogens such as tamoxifen, a selective estrogen receptor (ER) modulator, are widely used in clinics to ...

    Authors: Yu-Shih Lin, Yin-Yin Lin, Yao-Hsu Yang, Chun-Liang Lin, Feng-Che Kuan, Cheng-Nan Lu, Geng-He Chang, Ming-Shao Tsai, Cheng-Ming Hsu, Reming-Albert Yeh, Pei-Rung Yang, I-Yun Lee, Li-Hsin Shu, Yu-Ching Cheng, Hung-Te Liu, Kuan-Der Lee…

    Citation: BMC Complementary and Alternative Medicine 2018 18:152

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  34. Content type: Research article

    Dental caries remains a serious problem due to its detrimental effects on individual health and quality of life. The bulbs of Myrmecodia pendans (Merr & Perry), native plants of Papua, have been used as natural r...

    Authors: Meirina Gartika, Hening T. Pramesti, Dikdik Kurnia and Mieke H. Satari

    Citation: BMC Complementary and Alternative Medicine 2018 18:151

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  35. Content type: Research article

    Sheng Jiang San (SJS), a multi-herb formulation, is used in treating high fever, thirsty and anxiety in ancient China and it is sometimes used to treat seasonal influenza nowadays. However, there is no evidenc...

    Authors: Tianbo Zhang, Mengjie Xiao, Chun-Kwok Wong, Ka-Pun Chris Mok, Xin Zhao, Huihui Ti and Pang-Chui Shaw

    Citation: BMC Complementary and Alternative Medicine 2018 18:150

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  36. Content type: Research article

    The potential toxicity of Chinese herbal medicine has attracted more attention in recent years. Jueyin granules (JYG), a polyherbal formula, have been proven to be an effective agent for treating psoriasis in bot...

    Authors: Yu Chen, Dong-jie Guo, Hui Deng, Min-feng Wu, Ya-Nan Zhang, Su Li, Rong Xu, Jie Chen, Xing-xiu Jin, Bin Li, Qi Xu and Fu-lun Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:148

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  37. Content type: Research article

    Natural product is one of the most important sources of drugs used in pharmaceutical therapeutics. Artemisia capillaris has been traditionally used as a hepatoprotective and anti-inflammatory agent. In this study...

    Authors: Juyoung Kim, Kyung Hee Jung, Hong Hua Yan, Min Ji Cheon, Sunmi Kang, Xing Jin, Sunghyouk Park, Myung Sook Oh and Soon-Sun Hong

    Citation: BMC Complementary and Alternative Medicine 2018 18:147

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  38. Content type: Research article

    Human placenta hydrolysate (hPH) has been utilized to improve menopausal, fatigue, liver function. Its high concentration of bioactive substances is known to produce including antioxidant, anti-inflammatory an...

    Authors: Hyun-Jung Park, Hyun Soo Shim, Sunyoung Lee, Dae Hyun Hahm, Hyejung Lee, Chang Taek Oh, Hae Jung Han, Hyi Jeong Ji and Insop Shim

    Citation: BMC Complementary and Alternative Medicine 2018 18:149

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  39. Content type: Research article

    Fine particulate matter (PM2.5) is a major risk factor for the development and progression of atherosclerosis. Proliferation and infiltration of vascular smooth muscle cells (VSMCs) from the blood vessel media...

    Authors: Qiang Wan, Zhongyong Liu and Yuping Yang

    Citation: BMC Complementary and Alternative Medicine 2018 18:146

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  40. Content type: Research article

    Cryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients. In addition, the lower susceptibility of this yeast to azoles is ...

    Authors: Daniela Scalas, Narcisa Mandras, Janira Roana, Roberta Tardugno, Anna Maria Cuffini, Valeria Ghisetti, Stefania Benvenuti and Vivian Tullio

    Citation: BMC Complementary and Alternative Medicine 2018 18:143

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  41. Content type: Research article

    Propolis, a polyphenol-rich natural product, has been used as a functional food in anti-inflammation. However, its bioactive components and mechanisms have not been fully elucidated.

    Authors: Huasong Chang, Wenwen Yuan, Haizhu Wu, Xusheng Yin and Hongzhuan Xuan

    Citation: BMC Complementary and Alternative Medicine 2018 18:142

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  42. Content type: Research article

    The current treatment for human brucellosis requires a combination of antibiotics for long periods of time, and the reported incidence and prevalence of the disease vary widely in nomadic livestock of Mongolia...

    Authors: Tsevelmaa N, Narangerel B, Odgerel O, Dariimaa D and Batkhuu J

    Citation: BMC Complementary and Alternative Medicine 2018 18:144

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  43. Content type: Research article

    Terminalia chebula Retz. (Combretaceae) is a traditional herbal medicine that is widely used in the treatment of diabetes, immunodeficiency diseases, and stomach ulcer in Asia. However, the anti-amnesic effect of...

    Authors: Min-Soo Kim, Dong Young Lee, Jun Lee, Hyun Woo Kim, Sang Hyun Sung, Jung-Soo Han and Won Kyung Jeon

    Citation: BMC Complementary and Alternative Medicine 2018 18:136

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  44. Content type: Research article

    Brazilian green propolis is produced by mixing secretions from Africanized honey bees with exudate, mainly from Baccharis dracunculifolia. Brazilian propolis is especially rich in flavonoids and cinammic acid der...

    Authors: Hiroshi Kitamura, Natsuko Saito, Junpei Fujimoto, Ken-ichi Nakashima and Daisuke Fujikura

    Citation: BMC Complementary and Alternative Medicine 2018 18:138

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  45. Content type: Research article

    Solanum aculeastrum fruits are used by some cancer sufferers as a form of alternative treatment. Scientific literature is scarce concerning its anticancer activity, and thus the aim of the study was to assess the...

    Authors: Trevor Burger, Tsholofelo Mokoka, Gerda Fouché, Paul Steenkamp, Vanessa Steenkamp and Werner Cordier

    Citation: BMC Complementary and Alternative Medicine 2018 18:137

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  46. Content type: Research article

    Herba Siegesbeckiae (HS, Xixiancao in Chinese) is a commonly used traditional Chinese medicinal herb for soothing joints. In ancient materia medica books, HS is recorded to be the aerial part of Siegesbeckia pube...

    Authors: Hui Guo, Yi Zhang, Brian Chi-Yan Cheng, Mei-Yuk Lau, Xiu-Qiong Fu, Ting Li, Tao Su, Pei-Li Zhu, Yuen-Cheung Chan, Anfernee Kai-Wing Tse, Tao Yi, Hu-Biao Chen and Zhi-Ling Yu

    Citation: BMC Complementary and Alternative Medicine 2018 18:141

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  47. Content type: Research article

    Medicinal plants have been founded as traditional herbal medicine worldwide. Most of the plant’s therapeutic properties are due to the presence of secondary metabolites such as alkaloids, glycosides, tannins a...

    Authors: Hazir Rahman, Ilyas Khan, Anwar Hussain, Abdelaaty Abdelaziz Shahat, Abdul Tawab, Muhammad Qasim, Muhammad Adnan, Mansour S. Al-Said, Riaz Ullah and Shahid Niaz Khan

    Citation: BMC Complementary and Alternative Medicine 2018 18:140

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  48. Content type: Research article

    Schistosomiasis is an acute and chronic zoonotic parasitic disease caused by trematode worms. The host inflammatory response to schistosome eggs leads to perioval granulomata formation, mainly in the liver and...

    Authors: Dina M. Metwally, Ebtesam M. Al-Olayan, Mohammad Alanazi, Sanaa B. Alzahrany and Abdelhabib Semlali

    Citation: BMC Complementary and Alternative Medicine 2018 18:135

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  49. Content type: Research article

    The medicinal orchid Dendrobium moniliforme contains water-soluble polysaccharides, phenanthrenes, bibenzyl derivatives, and polyphenol compounds. This study explored the antioxidant and cytotoxic activities of D...

    Authors: Mukti Ram Paudel, Mukesh Babu Chand, Basant Pant and Bijaya Pant

    Citation: BMC Complementary and Alternative Medicine 2018 18:134

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