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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Page 1 of 38

  1. Content type: Research article

    Hyperglycemia and dyslipidemia are classic features of patients with diabetes mellitus (DM). Cordyceps taii, a folk medicinal fungus native to southern China, possesses various pharmacological activities. This st...

    Authors: Ru-Ming Liu, Rong Dai, Yi Luo and Jian-Hui Xiao

    Citation: BMC Complementary and Alternative Medicine 2019 19:230

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  2. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) may increase the sensitivity to liver injury caused by stimulants such as drugs and poisons. The traditional Chinese medicine (TCM) Jiang-Zhi Granule (JZG) has been prove...

    Authors: Lili Yang, Yan Zhou, Haiyan Song and Peiyong Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:228

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  3. Content type: Research article

    Oxidative stress is an imbalance between the levels of reactive oxygen species (ROS), reactive nitrogen species (RNS) and endogenous antioxidants. The aetiology and pathogenesis of several oral diseases are at...

    Authors: Ignacio Peralta, Carla Marrassini, María Laura Barreiro Arcos, Graciela Cremaschi, María Rosario Alonso and Claudia Anesini

    Citation: BMC Complementary and Alternative Medicine 2019 19:227

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  4. Content type: Research article

    Commercial herbal medicines (CHMs) marketed as immune boosters are gaining wide popularity in South Africa, in the absence of control and regulatory guidelines. These commercially packaged and labelled herbal ...

    Authors: Mmamosheledi E. Mothibe, Christina P. Kahler-Venter and Elzbieta Osuch

    Citation: BMC Complementary and Alternative Medicine 2019 19:224

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  5. Content type: Research article

    Chronic hepatic diseases are serious problems worldwide, which may lead to the development of fibrosis and eventually cirrhosis. Despite the significant number of people affected by hepatic fibrosis, no effect...

    Authors: Caio Mateus da Silva, Flávio Henrique Caetano, Franco Dani Campos Pereira, Maria Aparecida Marin Morales, Kumiko Koibuchi Sakane and Karen C. M. Moraes

    Citation: BMC Complementary and Alternative Medicine 2019 19:222

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  6. Content type: Research article

    Lichens produce a huge diversity of bioactive compounds with several biological effects. Gyrophoric acid (GA) is found in high concentrations in the common lichen Umbilicaria hirsuta, however evidence for biologi...

    Authors: Michal Goga, Martin Kello, Maria Vilkova, Klaudia Petrova, Martin Backor, Wolfram Adlassnig and Ingeborg Lang

    Citation: BMC Complementary and Alternative Medicine 2019 19:221

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  7. Content type: Research article

    Baeckea frutescens (B. frutescens) of the family Myrtaceae is a plant that has been used in traditional medicine. It is known to have antibacterial, antipyretic and cytoprotective properties. The objective of thi...

    Authors: S. H. Shahruzaman, M. F. Mustafa, S. Ramli, S. Maniam, S. Fakurazi and S. Maniam

    Citation: BMC Complementary and Alternative Medicine 2019 19:220

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  8. Content type: Research article

    Methicillin-resistant Staphylococcus aureus (MRSA) causes serious infections in hospitals. Penthorum chinense Pursh (PCP), employed by the Miao ethnic minority in China, presents antibacterial activities. In this...

    Authors: Bin Ding, Qinchao Ding, Shun Zhang, Zhuo Jin, Zhaolei Wang, Songtao Li and Xiaobing Dou

    Citation: BMC Complementary and Alternative Medicine 2019 19:219

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  9. Content type: Research article

    Staphylococcal aureus (S. aureus) has become the leading causative pathogen of Prosthetic Joint Infection (PJI), which is the most devastating complication after arthroplasty surgeries. Due to the biofilm formati...

    Authors: Jiaqi Tan, Jin Wang, Chuang Yang, Chongzun Zhu, Geyong Guo, Jin Tang and Hao Shen

    Citation: BMC Complementary and Alternative Medicine 2019 19:218

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  10. Content type: Research article

    Systemic inflammation driven neuroinflammation is an event which correlates with pathogenesis of several neurodegenerative diseases. Therefore, targeting peripheral and central inflammation simultaneously coul...

    Authors: Muskan Gupta and Gurcharan Kaur

    Citation: BMC Complementary and Alternative Medicine 2019 19:217

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  11. Content type: Research article

    Breast cancer is still the most common malignant tumor that threatens the female’s life in the world, especially triple-negative breast cancer (TNBC), one of the most difficult subtypes. Lack of targeted thera...

    Authors: Mingjiang Yao, Xiaodi Fan, Bo Yuan, Norio Takagi, Sai Liu, Xiao Han, Junguo Ren and Jianxun Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:216

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  12. Content type: Research article

    Mounting evidence indicates that the cerebral cortex is an important physiological system of emotional activity, and its dysfunction may be the main cause of stress. Glutamate is the primary excitatory neurotr...

    Authors: Yan Liu, Xiu-fang Ding, Xin-xing Wang, Xiao-juan Zou, Xiao-juan Li, Yue-yun Liu, Jie Li, Xiu-yun Qian and Jia-xu Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:215

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  13. Content type: Research article

    The present study evaluated the antinociceptive effect of the bark of Artocarpus lacucha, which is used for the treatment of stomachache, headache and boils in the traditional system of medicine.

    Authors: Shanta Islam, Md. Shafiullah Shajib, Ridwan Bin Rashid, Mohammad Firoz Khan, Md. Abdullah Al-Mansur, Bidyut Kanti Datta and Mohammad Abdur Rashid

    Citation: BMC Complementary and Alternative Medicine 2019 19:214

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  14. Content type: Research article

    Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attem...

    Authors: Afnan Sh. Ahmed, Muhammad Taher, Uttam Kumar Mandal, Juliana Md Jaffri, Deny Susanti, Syed Mahmood and Zainul Amiruddin Zakaria

    Citation: BMC Complementary and Alternative Medicine 2019 19:213

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  15. Content type: Database

    Recently, there has been an increasing tendency to go back to nature in search of new medicines. To facilitate this, a great deal of effort has been made to compile information on natural products worldwide, a...

    Authors: Lemessa Etana Bultum, Assefa Mussa Woyessa and Doheon Lee

    Citation: BMC Complementary and Alternative Medicine 2019 19:212

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  16. Content type: Research article

    Breast cancer is the leading cause of cancer-related death in women worldwide. Although traditional Chinese medicine (TCM) is commonly used by patients with breast cancer, little is known about TCM prescriptio...

    Authors: Yu-Te Liu, Chao-Hsiang Hsiao, Bor-Show Tzang and Tsai-Ching Hsu

    Citation: BMC Complementary and Alternative Medicine 2019 19:211

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  17. Content type: Research article

    The imbalance between the generation of free radicals and natural cellular antioxidant defenses, known as oxidative stress, can cause oxidation of biomolecules and further contribute to aging-associated diseas...

    Authors: Palika Wetchakul, Jo Aan Goon, Ademola Ezekiel Adekoya, Opeyemi Joshua Olatunji, Sutticha Ruangchuay, Patcharawalai Jaisamut, Acharaporn Issuriya, Nongluk Kunworarath, Surasak Limsuwan and Sasitorn Chusri

    Citation: BMC Complementary and Alternative Medicine 2019 19:209

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  18. Content type: Research article

    Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms o...

    Authors: Ka-Yeon Lee, Jae-Hyun Kim, Eun-Young Kim, Mijung Yeom, Hyuk-Sang Jung and Youngjoo Sohn

    Citation: BMC Complementary and Alternative Medicine 2019 19:207

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  19. Content type: Research article

    About 425 million adults had diabetes mellitus globally in 2017. Type 2 diabetes accounts for the enormous majority of diabetes cases and it is gradually growing which is predicted to increase by 48% in 2045. ...

    Authors: Gebretsadkan Hintsa Tekulu, Ephrem Mebrahtu Araya and Hayelom Gebrekirstos Mengesha

    Citation: BMC Complementary and Alternative Medicine 2019 19:206

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  20. Content type: Research article

    Gastric ulcer is one of the most prevalent diseases worldwide. In Iranian folk medicine, Achillea wilhelmsii (AW) is used as a treatment for gastric ulcer. Previous reports also mentioned Antiulcerogenic properti...

    Authors: Mehdi Koushki, Reyhaneh Farrokhi Yekta, Nasrin Amiri-Dashatan, Masoumeh Dadpay and Fatemeh Goshadrou

    Citation: BMC Complementary and Alternative Medicine 2019 19:205

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  21. Content type: Research article

    Metastasis is the main cause of lung cancer death. As a seed of metastasis, circulating tumor cells are an important target for metastasis intervention. The traditional Chinese medicine, Jinfukang, has been cl...

    Authors: Zujun Que, Zhiyi Zhou, Bin Luo, Changsheng Dong, Yi Jiang, Hegen Li and Jianhui Tian

    Citation: BMC Complementary and Alternative Medicine 2019 19:204

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  22. Content type: Research article

    5-Florouracil (5-FU) is a commonly used chemotherapeutic drug for cholangiocarcinoma, whereas it has unsatisfactory effect, and patients often have chemo-resistance to it. The combination of chemotherapeutic a...

    Authors: Zhaoyu Fu, Kexin Ma, Bing Dong, Chongyu Zhao, Chi Che, Chengyong Dong, Rixin Zhang, Haibo Wang, Xiang Wang and Rui Liang

    Citation: BMC Complementary and Alternative Medicine 2019 19:203

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  23. Content type: Research article

    Astilbe rivularis L. is an indigenous medicinal plant growing in high altitude of Darjeeling Himalayan region of India and Nepal. The plant rhizome has been used traditionally as medicine by local tribes to treat...

    Authors: Vijeta Rai, Anoop Kumar, Vaskar Das and Shilpi Ghosh

    Citation: BMC Complementary and Alternative Medicine 2019 19:200

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  24. Content type: Research article

    Triphala is an indigenous medical product used for a variety of diseases. This study was conducted to determine the effect of Triphala on antibiotic properties of gentamicin and oxacillin against multi-drug re...

    Authors: Amirthasingam Manoraj, Vasanthi Thevanesam, B. M. R. Bandara, Asela Ekanayake and Veranja Liyanapathirana

    Citation: BMC Complementary and Alternative Medicine 2019 19:199

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  25. Content type: Research article

    Endothelial cell inflammation is a central event in the pathogenesis of numerous cardiovascular diseases, including sepsis and atherosclerosis. Triptolide, a principal bioactive ingredient of Traditional Chine...

    Authors: Chundong Song, Youping Wang, Lin Cui, Fengna Yan and Si Shen

    Citation: BMC Complementary and Alternative Medicine 2019 19:198

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  26. Content type: Research article

    The present study was aimed to evaluate the molecular level anticaries effect of different medicinal plants against Streptococcus mutans (S.mutans) glucosyltransferases (gtf).

    Authors: Kiranmai Mandava, Uma Rajeswari Batchu, Shravya Kakulavaram, Shulamithi Repally, Ishwarya Chennuri, Srinivas Bedarakota and Namratha Sunkara

    Citation: BMC Complementary and Alternative Medicine 2019 19:197

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  27. Content type: Research article

    Probiotics have been reported to be the active component used in the treatment of many functional gastrointestinal symptoms and syndromes. Lactobacillus and yeast culture are extensively used in probiotic supplem...

    Authors: Ki-Bae Hong, Hyeyoung Seo, Joong-su Lee and Yooheon Park

    Citation: BMC Complementary and Alternative Medicine 2019 19:195

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  28. Content type: Research article

    Wenshen Jianpi recipe (WSJPR), a blended traditional Chinese medicine, is considered to have the possible beneficial effect on the progression of diabetic nephropathy (DN). This present study was designed to e...

    Authors: Xiaodan Cao, Renxiong Wei, Jun Zhou, Xiaoxia Zhang, Wenbo Gong, Tinglong Jin and Xiabo Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:193

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  29. Content type: Research article

    Wnt/β-catenin signaling pathway is closely related to osteoarthritis. In our preliminary study, β-catenin conditional activation (cAct) mice that specifically over-express β-catenin gene in cartilage chondrocy...

    Authors: Wan-qing Xie, Yong-jian Zhao, Feng Li, Bing Shu, Shu-ru Lin, Li Sun, Yong-jun Wang and Hong-xin Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:191

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  30. Content type: Research article

    The Atlantic Forest biome extends along the entire Brazilian coast and is home to approximately 20,000 plant species, many of which are endemic; it is considered one of the hotspot regions of the planet. Sever...

    Authors: Ayla das Chagas Almeida, Lais Azevedo Rodrigues, Graziela dos Santos Paulino, Ananda Pereira Aguilar, Alisson Andrade Almeida, Sukarno Olavo Ferreira, Geraldo Célio Brandão, João Paulo Viana Leite and Andréa de Oliveira Barros Ribon

    Citation: BMC Complementary and Alternative Medicine 2019 19:189

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  31. Content type: Research article

    Apiole was isolated from the leaves of various plants and vegetables and has been demonstrated to inhibit human colon cancer cell (COLO 205 cells) growth through induction of G0/G1 cell cycle arrest and apopto...

    Authors: Kuan-Hsun Wu, Wen-Jui Lee, Tzu-Chun Cheng, Hui-Wen Chang, Li-Ching Chen, Chia-Chang Chen, Hsiu-Man Lien, Teng-Nan Lin and Yuan-Soon Ho

    Citation: BMC Complementary and Alternative Medicine 2019 19:188

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  32. Content type: Research article

    One of the most important ways to cure hydatid cysts is surgery. Today, available chemical drugs have shown severe complications during hydatid cyst surgery. Here we investigated theefficacy and safety of Curcuma...

    Authors: Hossein Mahmoudvand, Mahbobeh Pakravanan, Mohammad Reza Aflatoonian, Amal Khudair Khalaf, Massumeh Niazi, Seyyed Reza Mirbadie, Amir Tavakoli Kareshk and Mehrdad Khatami

    Citation: BMC Complementary and Alternative Medicine 2019 19:187

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  33. Content type: Research article

    Oxidative stress and the inflammatory process are involved in ischemia–reperfusion (I/R) injury. Juglans mollis has been reported as having antioxidant activity, which could attenuate the damage caused by I/R. We...

    Authors: Jonathan Perez-Meseguer, Liliana Torres-González, Jorge Aurelio Gutiérrez-González, Gabriela Alarcón-Galván, Homero Zapata-Chavira, Noemi Waksman-de Torres, Diana Patricia Moreno-Peña, Linda Elsa Muñoz-Espinosa and Paula Cordero-Pérez

    Citation: BMC Complementary and Alternative Medicine 2019 19:186

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  34. Content type: Research article

    Honey has been increasingly recognized as a potential therapeutic agent for treatment of wound infections. There is an urgent need for assessment and evaluation of the antibacterial properties against wound pa...

    Authors: Muhammad Barkaat Hussain, Yasser Mahmoud Kamel, Zia Ullah, Asif Ahmad Mohamad Jiman-Fatani and Ansar Shafiq Ahmad

    Citation: BMC Complementary and Alternative Medicine 2019 19:185

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  35. Content type: Research article

    Bitter gourd (Momordica charantia) has attracted the focus of researchers owing to its excellent anti-diabetic action. The beneficial effect of Momordica charantia on heart has been reported by in vitro and in vi...

    Authors: Muhammad Farooq Khan, Nael Abutaha, Fahd A. Nasr, Ali S. Alqahtani, Omar M. Noman and Mohammad A. M. Wadaan

    Citation: BMC Complementary and Alternative Medicine 2019 19:184

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  36. Content type: Research article

    Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts sho...

    Authors: Omar Aldulaimi, Falko Drijfhout, Fidelia I. Uche, Paul Horrocks and Wen-Wu Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:183

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  37. Content type: Research article

    Increase oxidative trauma is the main cause behind Cisplatin (CP) induced cardiotoxicity which restricts its clinical application as anti-neoplastic prescription. Acacia hydaspica is a natural shrub with diverse ...

    Authors: Tayyaba Afsar, Suhail Razak, Ali Almajwal, Maria Shabbir and Muhammad Rashid Khan

    Citation: BMC Complementary and Alternative Medicine 2019 19:182

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  38. Content type: Research article

    Study of phytochemicals and pharmacological properties of bryophytes has been neglected for a long time because of the three main reasons i.e. (i) difficulty in collection in large amount for analysis; (ii) th...

    Authors: Sumira Mukhia, Palash Mandal, D. K. Singh and Devendra Singh

    Citation: BMC Complementary and Alternative Medicine 2019 19:181

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  39. Content type: Research article

    Fruit, bark and leaves of Zanthoxylum armatum DC are popular remedies for gastrointestinal, cardiovascular and respiratory disorders in the subcontinent traditional practices. The aim of the study was to individu...

    Authors: Fiaz Alam and Abdul Jabbar Shah

    Citation: BMC Complementary and Alternative Medicine 2019 19:180

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  40. Content type: Research article

    To evaluate the effectiveness and safety of HuoXueHuaYu (HXHY) therapy in treating nonalcoholic fatty liver disease (NAFLD) through a systematic review and meta-analysis.

    Authors: Yunfei Cai, Qiuer Liang, Weihao Chen, Minghao Chen, Ruixue Chen, Yun Zhang, Ya Xiao and Liguo Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:178

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  41. Content type: Research article

    Quercus gall extracts’ ability to kill pathogens in vitro and even removal of chronic drug-resistant infections has been reported by several studies. The current investigation is focused on the action of extracts...

    Authors: Akhter Ahmed Ahmed and Fraidoon Abdulqadir Salih

    Citation: BMC Complementary and Alternative Medicine 2019 19:177

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  42. Content type: Research article

    Snake venoms contain various bioactive constituents which possess potential therapeutic effects. The aim of this work was to investigate the effect of the extract from Agkistrodon halys venom on lipopolysaccharid...

    Authors: Quan-Hai Wang, Wei Li, Yu-Xin Jiang, Xiao-Hua Lu and Guo-Guang Wang

    Citation: BMC Complementary and Alternative Medicine 2019 19:176

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  43. Content type: Research article

    Skin injury is inevitable in daily life. In recent years, with the increasing morbidity of diseases such as diabetes and metabolic disorders, chronic wounds have become a considerable challenge in clinical pra...

    Authors: Yan Lin, Qiqi Shao, Meng Zhang, Chenyue Lu, Joy Fleming and Songkun Su

    Citation: BMC Complementary and Alternative Medicine 2019 19:175

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  44. Content type: Research article

    Drug resistance poses a challenge to malaria control measures. This calls for discovery & development of new chemotherapeutic agents. This study therefore was initiated to investigate the antimalarial activity...

    Authors: Desye Misganaw, Ephrem Engidawork and Teshome Nedi

    Citation: BMC Complementary and Alternative Medicine 2019 19:171

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  45. Content type: Research article

    Garcinia species contain bioactive compounds such as flavonoids, xanthones, triterpernoids, and benzophenones with antibacterial, antifungal, anti-inflammatory, and antioxidant activities. In addition, many of th...

    Authors: Aziera Adnan, Zeenathul Nazariah Allaudin, Homayoun Hani, Hwei-San Loh, Teng-Jin Khoo, Kang Nee Ting and Rasedee Abdullah

    Citation: BMC Complementary and Alternative Medicine 2019 19:169

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  46. Content type: Research article

    Several immunological pathways, particularly skin inflammation via various pro-inflammatory cytokines have been reported to be involved in the pathogenesis and clinical manifestations of psoriasis. The aim of ...

    Authors: Raksawan Deenonpoe, Pokpong Prayong, Nattakarn Thippamom, Jitlada Meephansan and Kesara Na-Bangchang

    Citation: BMC Complementary and Alternative Medicine 2019 19:168

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  47. Content type: Research article

    Centella asiatica (L.) Urban, known as Indian Pennywort, is a tropical medicinal plant from Apiaceae family native to Southeast Asian countries. It has been widely used as a nerve tonic in Ayuverdic medicine sinc...

    Authors: Norazzila Omar, Yogeswaran Lokanathan, Zainul Rashid Mohd Razi and Ruszymah Bt Haji Idrus

    Citation: BMC Complementary and Alternative Medicine 2019 19:167

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  48. Content type: Research article

    To evaluate the pharmaceutical safety of Myelophil, an ethanol extract of a mixture of Astragali Radix and Salviae Miltiorrhizae Radix, using both acute and repeated toxicological studies.

    Authors: Jin-Yong Joung, Jin-Seok Lee, Jung-Hyo Cho, Dong-Soo Lee and Chang-Gue Son

    Citation: BMC Complementary and Alternative Medicine 2019 19:166

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  49. Content type: Research article

    Caesalpinia mimosoides, a vegetable consumed in Thailand, has been reported to exhibit in vitro antioxidant properties. The in vivo antioxidant and anti-aging activities have not been investigated. The aim of thi...

    Authors: Panthakarn Rangsinth, Anchalee Prasansuklab, Chatrawee Duangjan, Xiaojie Gu, Krai Meemon, Michael Wink and Tewin Tencomnao

    Citation: BMC Complementary and Alternative Medicine 2019 19:164

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