Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Previous Page Page 1 of 75 Next Page
  1. Research article

    Electroacupuncture ameliorating post-stroke cognitive impairments via inhibition of peri-infarct astroglial and microglial/macrophage P2 purinoceptors-mediated neuroinflammation and hyperplasia

    During ischemic stroke (IS), adenosine 5′-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors si...

    Jia Huang, Xiaofang You, Weilin Liu, Changming Song, Xiaomin Lin, Xiufeng Zhang, Jing Tao and Lidian Chen

    BMC Complementary and Alternative Medicine 2017 17:480

    Published on: 10 October 2017

  2. Research article

    Bidens pilosa Ethylene acetate extract can protect against L-NAME-induced hypertension on rats

    Essential hypertension is mainly caused by endothelial dysfunction which results from nitric oxide (NO) deficiency. The present study was design to evaluate the protective effect of Bidens pilosa ethylene acetate...

    Danielle Claude Bilanda, Paul Désiré D. Dzeufiet, Léontine Kouakep, Bibi Farouck O. Aboubakar, Léonard Tedong, Pierre Kamtchouing and Théophile Dimo

    BMC Complementary and Alternative Medicine 2017 17:479

    Published on: 10 October 2017

  3. Research article

    Protective effects of methanolic extract of Juglans regia L. leaf on streptozotocin-induced diabetic peripheral neuropathy in rats

    Oxidative stress has a pivotal role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complications of diabetes mellitus. There is accumulating evide...

    Davood Nasiry, Ali Reza khalatbary, Hassan Ahmadvand, Fereshteh Talebpour Amiri and Esmaeil Akbari

    BMC Complementary and Alternative Medicine 2017 17:476

    Published on: 2 October 2017

  4. Research article

    Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings

    Hypertension is one of the most important risk factors for cardiovascular disease (CVD) and a worldwide problem. Despite increases in the development of synthetic drugs for hypertension treatment, the rate of ...

    Bumjung Kim, Youngki Kwon, Somin Lee, Kyungjin Lee, Inhye Ham and Ho-Young Choi

    BMC Complementary and Alternative Medicine 2017 17:474

    Published on: 2 October 2017

  5. Research article

    Anti-inflammatory and analgesic activities of solvent fractions of the leaves of Moringa stenopetala Bak. (Moringaceae) in mice models

    Many people still experience pain and inflammation regardless of the available drugs for treatments. In addition, the available drugs have many side effects, which necessitated a quest for new drugs from sever...

    Yohannes Tamrat, Teshome Nedi, Solomon Assefa, Tilahun Teklehaymanot and Workineh Shibeshi

    BMC Complementary and Alternative Medicine 2017 17:473

    Published on: 29 September 2017

  6. Research article

    Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model

    Cisplatin is widely used chemotherapeutic agent for cancer treatment with limited uses due to its neurotoxic side effect. The aim of this study was to determine the potential preventive effects of rutin on the...

    Mashal M. Almutairi, Wael A. Alanazi, Musaad A. Alshammari, Moureq Rashed Alotaibi, Ali R. Alhoshani, Salim Salah Al-Rejaie, Mohamed M. Hafez and Othman A. Al-Shabanah

    BMC Complementary and Alternative Medicine 2017 17:472

    Published on: 29 September 2017

  7. Research article

    The ameliorative effect of bloodletting puncture at hand twelve Jing-well points on cerebral edema induced by permanent middle cerebral ischemia via protecting the tight junctions of the blood-brain barrier

    Cerebral edema, erupting simultaneously with severe ischemic stroke, might lead to increased intracranial pressure, cerebral herniation, and ultimately death. Studies conducted previously by our team have demo...

    Nannan Yu, Zhenguo Wang, Yucen Chen, Juntao Yang, Xuan Lu, Yi Guo, Zelin Chen and Zhifang Xu

    BMC Complementary and Alternative Medicine 2017 17:470

    Published on: 26 September 2017

  8. Research article

    Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy

    Propolis and its major constituent – caffeic acid phenethyl ester (CAPE) have good abilities on antitumor and anti-inflammation. However, little is known about the actions of propolis and CAPE on tumor in infl...

    Huasong Chang, Yuehua Wang, Xusheng Yin, Xinying Liu and Hongzhuan Xuan

    BMC Complementary and Alternative Medicine 2017 17:471

    Published on: 26 September 2017

  9. Research article

    Extract from mango mistletoes Dendrophthoe pentandra ameliorates TNBS-induced colitis by regulating CD4+ T cells in mesenteric lymph nodes

    Mango mistletoes Dendrophthoe pentandra (MMDP) extract has attracted interest due to its pharmacological properties, including gastro protective effects. The aim of this study was to investigate whether MMDP extr...

    Agustina Tri Endharti and Sofy Permana

    BMC Complementary and Alternative Medicine 2017 17:468

    Published on: 25 September 2017

  10. Research article

    Aqueous root extract of Asparagus cochinchinensis (Lour.) Merr. Has antioxidant activity in D-galactose-induced aging mice

    Extracts of plants have been considered as sources of natural antioxidant agents. In this study, we aimed to explore the antioxidant capacity of the aqueous root extract of Asparagus cochinchinensis (Lour.) Merr.

    Linghua Lei, Yanhua Chen, Lijun Ou, Yinglong Xu and Xiaoying Yu

    BMC Complementary and Alternative Medicine 2017 17:469

    Published on: 25 September 2017

  11. Research article

    Plectranthus amboinicus essential oil and carvacrol bioactive against planktonic and biofilm of oxacillin- and vancomycin-resistant Staphylococcus aureus

    The emergence of multidrug-resistant bacteria is a worldwide concern and in order to find an alternative to this problem, the occurrence of antimicrobial compounds in Plectranthus amboinicus essential oil was inv...

    Sara Edwirgens Costa Benício Vasconcelos, Hider Machado Melo, Theodora Thays Arruda Cavalcante, Francisco Eduardo Aragão Catunda Júnior, Mário Geraldo de Carvalho, Francisca Gleire Rodrigues Menezes, Oscarina Viana de Sousa and Renata Albuquerque Costa

    BMC Complementary and Alternative Medicine 2017 17:462

    Published on: 16 September 2017

  12. Research article

    Phytochemical-rich foods inhibit the growth of pathogenic trichomonads

    Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were act...

    Sabrina M. Noritake, Jenny Liu, Sierra Kanetake, Carol E. Levin, Christina Tam, Luisa W. Cheng, Kirkwood M. Land and Mendel Friedman

    BMC Complementary and Alternative Medicine 2017 17:461

    Published on: 13 September 2017

  13. Research article

    Modulation of hippocampal neuronal activity by So-ochim-tang-gamibang in mice subjected to chronic restraint stress

    So-ochim-tang-gamibang (SOCG) is a decoction formula which has been used to improve mental activity in traditional Korean medicine. The present study was performed to evaluate whether ...

    Hwa Chul Shin, Jae Ho Lee, Ki Joong Kim, Hyun Jin Shin, Jeong June Choi, Chan Yong Lee, Uk Namgung and In Chul Jung

    BMC Complementary and Alternative Medicine 2017 17:456

    Published on: 9 September 2017

  14. Research article

    Radix Puerariae and Fructus Crataegi mixture inhibits renal injury in type 2 diabetes via decreasing of AKT/PI3K

    Radix puerariae (RP) is a herbal medicines for diabetes, mainly because of anti-oxidative, insulin resistance and hypoglycemic effect. Fructus crataegi (FC) also possesses strong antioxidant activity in vitro....

    Zhengyue Chen, Yanyan Yuan, Xinrong Zou, Mengqi Hong, Ming Zhao, Yu Zhao, Yuanping Liu, Guofu Li, Yabin Zhu, Lin Luo, Beiyan Bao and Shizhong Bu

    BMC Complementary and Alternative Medicine 2017 17:454

    Published on: 8 September 2017

  15. Research article

    Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives?

    Foodstuffs of both plant and animal origin contain a wide range of bioactive compounds. Although human intervention studies are mandatory to assess the health effects of bioactives, the in vitro approach is of...

    Mattia Di Nunzio, Veronica Valli, Lidia Tomás-Cobos, Teresa Tomás-Chisbert, Lucía Murgui-Bosch, Francesca Danesi and Alessandra Bordoni

    BMC Complementary and Alternative Medicine 2017 17:453

    Published on: 7 September 2017

  16. Research article

    Subchronic toxicity of herbal compound “Jiedu Huayu” granules in rats

    “Jiedu Huayu” (JDHY) granules are traditional Chinese herbal compounds that have been used to treat severe liver injury for many years. The purpose of the current study is to evaluate the safety of JDHY granules.

    Minggang Wang, Hua Qiu, Rongzhen Zhang, Fuli Long and Dewen Mao

    BMC Complementary and Alternative Medicine 2017 17:450

    Published on: 6 September 2017

Previous Page Page 1 of 75 Next Page