Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Research article

    Protective effects of chebulic acid on alveolar epithelial damage induced by urban particulate matter

    Chebulic acid (CA) isolated from T. chebula, which has been reported for treating asthma, as a potent anti-oxidant resources. Exposure to ambient urban particulate matter (UPM) considered as a risk for cardiopulm...

    Kyung-Won Lee, Mi-Hyun Nam, Hee-Ra Lee, Chung-Oui Hong and Kwang-Won Lee

    BMC Complementary and Alternative Medicine 2017 17:373

    Published on: 19 July 2017

  2. Research article

    In vitro antioxidant and antimalarial activities of leaves, pods and bark extracts of Acacia nilotica (L.) Del.

    The emergence of drug resistant malaria is threatening our ability to treat and control malaria in the Southeast Asian region. There is an urgent need to develop novel and chemically diverse antimalarial drugs...

    Muhammad Bilal Sadiq, Pattamon Tharaphan, Kesinee Chotivanich, Joel Tarning and Anil Kumar Anal

    BMC Complementary and Alternative Medicine 2017 17:372

    Published on: 18 July 2017

  3. Research article

    Solanum nigrum Unripe fruit fraction attenuates Adriamycin resistance by down-regulating multi-drug resistance protein (Mdr)-1 through Jak-STAT pathway

    Solanum nigrum, herbal plant that commonly grows in temperate climate zone, has been used as a traditional folk medicine whose ripen fruits were proven to exhibit anti-tumor properties...

    Sankar Jagadeeshan, Diana David, S. Jisha, S. Manjula and S. Asha Nair

    BMC Complementary and Alternative Medicine 2017 17:370

    Published on: 18 July 2017

  4. Research article

    The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice

    Curcuma longa L. is a well-known medicinal plant that has been used for its anti-cancer, neuroprotective, and hepatoprotective effects. However, the neuroprotective effect of fermented...

    Cheong-Su Eun, Jong-Soon Lim, Jihye Lee, Sam-Pin Lee and Seun-Ah Yang

    BMC Complementary and Alternative Medicine 2017 17:367

    Published on: 17 July 2017

  5. Research article

    Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

    In this study, Aloe vera samples were collected from different climatic regions of India. Quantitative HPTLC (high performance thin layer chromatography) analysis of important anthraquinones aloin and aloe-emodin...

    Sandeep Kumar, Manila Yadav, Amita Yadav, Pooja Rohilla and Jaya Parkash Yadav

    BMC Complementary and Alternative Medicine 2017 17:369

    Published on: 17 July 2017

  6. Research article

    Beta-mangostin demonstrates apoptogenesis in murine leukaemia (WEHI-3) cells in vitro and in vivo

    Beta-mangostin (BM) is a xanthone-type of natural compound isolated from Cratoxylum arborescens. This study aimed to examine the apoptosis mechanisms induced by BM in a murine monomyelocytic cell line (WEHI-3) in...

    Fatima Abdelmutaal Ahmed Omer, Najihah Mohd Hashim, Mohamed Yousif Ibrahim, Abdulmannan F. Aldoubi, Pouya Hassandarvish, Firouzeh Dehghan, Noraziah Nordin, Hamed Karimian, Landa Zeenelabdin Ali Salim, Mahmood Ameen Abdulla, Karim Al-Jashamy and Syam Mohan

    BMC Complementary and Alternative Medicine 2017 17:366

    Published on: 17 July 2017

  7. Research article

    Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2

    Retinal ischemia-related eye diseases result in visual dysfunction. This study investigates the protective effects and mechanisms of Xue-Fu-Zhu-Yu decoction (XFZYD) with respect to retinal ischemia.

    Shu-Qiu Tan, Xue Geng, Jorn-Hon Liu, Wynn Hwai-Tzong Pan, Li-Xiang Wang, Hui-Kang Liu, Lei Hu and Hsiao-Ming Chao

    BMC Complementary and Alternative Medicine 2017 17:365

    Published on: 14 July 2017

  8. Research article

    Moringa isothiocyanate complexed with α-cyclodextrin: a new perspective in neuroblastoma treatment

    Several lines of evidence suggest the consume of natural products for cancer prevention or treatment. In particular, isothiocyanates (ITCs) exerting anti-cancer properties, have received great interest as pote...

    Sabrina Giacoppo, Renato Iori, Patrick Rollin, Placido Bramanti and Emanuela Mazzon

    BMC Complementary and Alternative Medicine 2017 17:362

    Published on: 14 July 2017

  9. Research article

    Biochemical characterization and 1H NMR based metabolomics revealed Melicope lunu-ankenda leaf extract a potent anti-diabetic agent in rats

    Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by continuous hyperglycemia associated with insulin resistance and /or reduced insulin secretion. There is an emerging trend regarding the ...

    Mizher Hezam AL-Zuaidy, Muhammad Waseem Mumtaz, Azizah Abdul Hamid, Amin Ismail, Suhaila Mohamed and Ahmad Faizal Abdul Razis

    BMC Complementary and Alternative Medicine 2017 17:359

    Published on: 10 July 2017

  10. Research article

    Anti-diabetic activity of aerial parts of Sarcopoterium spinosum

    Sarcopoterium spinosum (S. spinosum) is used by Bedouin medicinal practitioners for the treatment of diabetes. While the anti-diabetic activity of S. spinosum root extract was validate...

    Uriel Elyasiyan, Adi Nudel, Nir Skalka, Konstantin Rozenberg, Elyashiv Drori, Rachela Oppenheimer, Zohar Kerem and Tovit Rosenzweig

    BMC Complementary and Alternative Medicine 2017 17:356

    Published on: 6 July 2017

  11. Research article

    Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice

    Colitis is a well-known subtype of inflammatory bowel disease and is caused by diverse factors. Previous research has shown that KIOM-MA elicits anti-inflammatory and anti-allergic effects on various diseases....

    Dong-Gun Kim, Mi-Ra Lee, Jae-Myung Yoo, Kwang-Il Park and Jin-Yeul Ma

    BMC Complementary and Alternative Medicine 2017 17:354

    Published on: 5 July 2017

  12. Research article

    Chemical constituents, antibacterial and antioxidant properties of the essential oil flower of Tagetes minuta grown in Cala community Eastern Cape, South Africa

    Tagetes minuta has a long record of human use for the treatment of stomach and intestinal diseases. Most drugs used for diseases treatment are less efficacious with side effects and th...

    Aboi Igwaran, Benson Chucks Iweriebor, Sunday Ofuzim Okoh, Uchechukwu Uchechukwu Nwodo, Larry Chikwelu Obi and Anthony Ifeanyi Okoh

    BMC Complementary and Alternative Medicine 2017 17:351

    Published on: 5 July 2017

  13. Research article

    A novel botanical formula prevents diabetes by improving insulin resistance

    Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease, and the prevalence has increased significantly in recent decades to epidemic proportions in China. Individually, fenugreek (Trigo...

    Juntao Kan, Rodney A. Velliquette, Kerry Grann, Charlie R. Burns, Jeff Scholten, Feng Tian, Qi Zhang and Min Gui

    BMC Complementary and Alternative Medicine 2017 17:352

    Published on: 5 July 2017

  14. Research article

    Antibacterial activities and toxicological study of the aqueous extract from leaves of Alchornea cordifolia (Euphorbiaceae)

    A. cordifolia is a plant widely used in Africa to solve many health problems. In Cameroon, it is used in the treatment of urogenital infections. As a continuation of our search for pha...

    Merline Namekong Djimeli, Siméon Pierre Chegaing Fodouop, Guy Sedar Singor Njateng, Charles Fokunang, Donald Sedric Tala, Fabrice Kengni and Donatien Gatsing

    BMC Complementary and Alternative Medicine 2017 17:349

    Published on: 4 July 2017

  15. Research article

    Chenopodium ambrosioides as a bone graft substitute in rabbits radius fracture

    Bone defects caused by trauma, infection or tumor resection are common in orthopedic clinic and depending on the extent of the fracture; the vast majority require treatment with bone substitutes. Among the bon...

    Vicente F. Pinheiro Neto, Rachel M. Ribeiro, Camila S. Morais, Matheus B. Campos, Denilson A. Vieira, Porfírio C. Guerra, Ana L. Abreu-Silva, José R. Silva Junior, Flavia Raquel F. Nascimento, Marilene O. R. Borges and Antonio C.R. Borges

    BMC Complementary and Alternative Medicine 2017 17:350

    Published on: 4 July 2017

  16. Research article

    Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis

    Axon growth inhibitory factors NogoA/Nogo receptor (NgR) and its signaling pathways RhoA/Rho kinase (ROCK) play a critical role in the repair of nerve damage in multiple sclerosis (MS). Bu Shen Yi Sui Capsule ...

    Ling Fang, Yongqiang Wang, Qi Zheng, Tao Yang, Peiyuan Zhao, Hui Zhao, Qiuxia Zhang, Yuanyuan Zhao, Fang Qi, Kangning Li, Zhenzhen Chen, Junling Li, Nan Zhang, Yongping Fan and Lei Wang

    BMC Complementary and Alternative Medicine 2017 17:346

    Published on: 1 July 2017

  17. Research article

    In vitro characterization and in vivo toxicity, antioxidant and immunomodulatory effect of fermented foods; Xeniji™

    Xeniji, produced by fermenting various types of foods with lactic acid bacteria and yeast, has been commonly consumed as functional food. However, nutrition value, bioactivities and safety of different ferment...

    Noraisyah Zulkawi, Kam Heng Ng, Rizi Zamberi, Swee Keong Yeap, Dilan Satharasinghe, Indu Bala Jaganath, Anisah Binti Jamaluddin, Sheau Wei Tan, Wan Yong Ho, Noorjahan Banu Alitheen and Kamariah Long

    BMC Complementary and Alternative Medicine 2017 17:344

    Published on: 30 June 2017

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