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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Page 1 of 39

  1. Content type: Research article

    Long-term use of most immunosuppressants to treat allergic contact dermatitis (ACD) generates unavoidable severe side effects, warranting discovery or development of new immunosuppressants with good efficacy a...

    Authors: Premrutai Thitilertdecha, Panwadee Pluangnooch, Sunita Timalsena and Kitipong Soontrapa

    Citation: BMC Complementary and Alternative Medicine 2019 19:268

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  2. Content type: Research article

    Cancer cachexia is a cancer-induced multifactorial debilitating syndrome directly accounting for 20% of cancer deaths without effective therapeutic approaches. It is extremely urgent to explore effective anti-...

    Authors: Huiquan Liu, Lu Li, Jun Zou, Ting Zhou, Bangyan Wang, Huihui Sun and Shiying Yu

    Citation: BMC Complementary and Alternative Medicine 2019 19:267

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  3. Content type: Research article

    Propolis is a natural bee product with a wide range of biological activities that are related to its chemical composition. The present study investigated the quantification of quercetin (Q) in Ardabil ethanol ...

    Authors: Fariba Asgharpour, Ali Akbar Moghadamnia, Ebrahim Zabihi, Sohrab Kazemi, Amirmorteza Ebrahimzadeh Namvar, Hemmat Gholinia, Mina Motallebnejad and Hamid Reza Nouri

    Citation: BMC Complementary and Alternative Medicine 2019 19:266

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  4. Content type: Research article

    Osteoarthritis (OA) is a common degenerative disease of synovial joints caused by inflammation. Acteoside (ACT), a major component and lipase inhibitor from the Chinese tea Ligustrum purpurascens kudingcha, has b...

    Authors: Zhiguang Qiao, Jiaxin Tang, Wen Wu, Jian Tang and Ming Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:264

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  5. Content type: Research article

    Inflammation is a symptom associated with many diseases. This symptom is treated with steroidal and non-steroidal anti-inflammatory drugs, which can cause severe side effects when used as long-term treatments....

    Authors: Axel Villagómez-Rodríguez, Julia Pérez-Ramos, Ana Laura Esquivel-Campos, Cuauhtémoc Pérez-González, Claudia Angélica Soto-Peredo and Salud Pérez-Gutiérrez

    Citation: BMC Complementary and Alternative Medicine 2019 19:263

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  6. Content type: Research article

    Natural products play a significant role in human health in relation to the prevention and treatment of inflammatory conditions. One of the plants with great medicinal potentials is Diospyros kaki which is mainly...

    Authors: Jieun Choi, Mi Jeong Kim, Richard Komakech, Haiyoung Jung and Youngmin Kang

    Citation: BMC Complementary and Alternative Medicine 2019 19:262

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  7. Content type: Research article

    Our previous study exhibited free radicals scavenging and antioxidant activities of ethanolic and aqueous extracts of Tamarindus indica L. leaves in chronic sodium fluoride poisoning in rats. Tamarindus indica L....

    Authors: Bishnu Prasad Sinha, Souvick Chatterjee, Rinku Buragohain, Indranil Samanta, Siddhartha Narayan Joardar, Prasenjit Mukherjee, Asit Kumar Maji, Partha Das, Tapan Kumar Mandal and Tapas Kumar Sar

    Citation: BMC Complementary and Alternative Medicine 2019 19:261

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  8. Content type: Research article

    Dengue is a mosquito-borne viral infection that has become a major public health concern worldwide. Presently, there is no specific vaccine or treatment available for dengue viral infection.

    Authors: Kavithambigai Ellan, Ravindran Thayan, Jegadeesh Raman, Kazuya I. P. J. Hidari, Norizah Ismail and Vikineswary Sabaratnam

    Citation: BMC Complementary and Alternative Medicine 2019 19:260

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  9. Content type: Research article

    Clinacanthus nutans extracts have been consumed by the cancer patients with the hope that the extracts can kill cancers more effectively than conventional chemotherapies. Our previous study reported its anti-infl...

    Authors: Ling-Wei Hii, Swee-Hua Erin Lim, Chee-Onn Leong, Swee-Yee Chin, Ngai-Paing Tan, Kok-Song Lai and Chun-Wai Mai

    Citation: BMC Complementary and Alternative Medicine 2019 19:257

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  10. Content type: Research article

    Arisaema jacquemontii is traditionally used in treatment of different diseases. In this study, phytochemical, in vitro biological and chemo-preventive screening of A. jacquemontii was carried out to explore its p...

    Authors: Saira Tabassum, Muhammad Zia, Esperanza J. Carcahe de Blanco, Riffat Batool, Roohi Aslam, Sajid Hussain, Qamar Wali and Muhammad Mudassar Gulzar

    Citation: BMC Complementary and Alternative Medicine 2019 19:256

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  11. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is characterized by excessive hepatic lipid accumulation. Many studies have suggested that lipid overload is the key initi...

    Authors: Ke Fang, Fan Wu, Guang Chen, Hui Dong, Jingbin Li, Yan Zhao, Lijun Xu, Xin Zou and Fuer Lu

    Citation: BMC Complementary and Alternative Medicine 2019 19:255

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  12. Content type: Research article

    Fumaria species (Fumariacea) has traditionally been used in wound healing in Iranian folk medicine. However, with the discovery of newer agents, its use has faded off into total obscurity. This study explored the...

    Authors: Fatemeh Davoodi-Roodbordeii, Minoo Afshar, Fatemeh Haji Abas Tabrizi, Samira Choopani, Giti Torkaman, Fariborz Moayer and Mona Salimi

    Citation: BMC Complementary and Alternative Medicine 2019 19:254

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  13. Content type: Research article

    General antiviral agents such as oseltamivir are associated with certain adverse effects and the emergence of resistance. This study investigated the phytochemical properties, antiviral activities, and safety ...

    Authors: Won-Young Bae, Hyeong-Yeop Kim, Kyoung-Sook Choi, Kyung Hoon Chang, Young-Ho Hong, Jongsu Eun, Na-Kyoung Lee and Hyun-Dong Paik

    Citation: BMC Complementary and Alternative Medicine 2019 19:253

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  14. Content type: Research article

    Turmeric is commonly used as a dietary treatment for inflammation, but few studies have evaluated the direct effect of turmeric on cartilage. The purpose of this study was to characterize cartilage explants’ i...

    Authors: Wendy Pearson and Laima S. Kott

    Citation: BMC Complementary and Alternative Medicine 2019 19:252

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  15. Content type: Research article

    Bacteria have developed resistance to most of the current antibiotics. There is evidence suggesting that plant-derived compounds have a potential for interacting with biological processes. One of the plants co...

    Authors: Winnie Mozirandi, Dexter Tagwireyi and Stanley Mukanganyama

    Citation: BMC Complementary and Alternative Medicine 2019 19:249

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  16. Content type: Research article

    With the current concern caused by drug resistant microorganisms, alternatives to traditional antimicrobials are increasingly necessary. Historical holistic treatments involving natural approaches are now of i...

    Authors: Rhegan C. McGregor, Kory A. Parker, Jacob M. Hornby and Leigh C. Latta IV

    Citation: BMC Complementary and Alternative Medicine 2019 19:247

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  17. Content type: Research article

    Cosmos caudatus is an annual plant known for its medicinal value in treating several health conditions, such as high blood pressure, arthritis, and diabetes mellitus. The α-glucosidase inhibitory activity and tot...

    Authors: Wan Ahmad Wan-Nadilah, Muhammad Tayyab Akhtar, Khozirah Shaari, Alfi Khatib, Azizah Abdul Hamid and Muhajir Hamid

    Citation: BMC Complementary and Alternative Medicine 2019 19:245

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  18. Content type: Research article

    Catalpol, a natural iridoid glycoside in Rehmannia glutinosa, can alleviate proteinuria associated with diabetic nephropathy (DN), however, whether catalpol has a protective effect against podocyte injury in DN r...

    Authors: Yan Chen, Qingpu Liu, Zengfu Shan, Yingying Zhao, Meng Li, Baiyan Wang, Xiaoke Zheng and Weisheng Feng

    Citation: BMC Complementary and Alternative Medicine 2019 19:244

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  19. Content type: Research article

    Brown adipocytes are known to promote energy expenditure and limit weight gain to combat obesity. Averrhoa bilimbi, locally called belimbing buluh (DBB), is mainly used as an ethnomedicine in the treatment of met...

    Authors: Wai Kwan Lau, Nur Adelina Ahmad Noruddin, Abdul Hadi Ariffin, Muhd Zulkarnain Mahmud, Mohd Hasnan Mohd Noor, Azimah Amanah, Mohamad Faiz Hamzah and Zainuddin Zafarina

    Citation: BMC Complementary and Alternative Medicine 2019 19:243

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  20. Content type: Research article

    Cyanidin-3-rutinoside (C3R), a naturally occurring anthocyanin, possesses anti-oxidant, anti-hyperglycemic, anti-glycation and cardioprotective properties. However, its mechanisms responsible for anti-hyperlip...

    Authors: Thavaree Thilavech and Sirichai Adisakwattana

    Citation: BMC Complementary and Alternative Medicine 2019 19:242

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  21. Content type: Research article

    Mulberry silkworm larvae (Bombyx mori) are known as the oldest resource of food and traditional medicine. Although silkworm larvae have been reported to treat various chronic diseases, the effect of fermentation ...

    Authors: Hyun-Dong Cho, Hye-Ji Min, Yeong-Seon Won, Hee-Young Ahn, Young-Su Cho and Kwon-Il Seo

    Citation: BMC Complementary and Alternative Medicine 2019 19:241

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  22. Content type: Research article

    Major depression is an important complication in patients with breast cancer, but is an underrecognized and undertreated condition in this population. The Baihe Zhimu Tang (BZ formula) is a traditional Chinese...

    Authors: Hailong Li, Chunyu Wu, Yu Liu, Shuo Zhang and Xiufei Gao

    Citation: BMC Complementary and Alternative Medicine 2019 19:240

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  23. Content type: Research article

    Annonacin, an annonaceous acetogenin isolated from Annona muricata has been reported to be strongly cytotoxic against various cell lines, in vitro. Nevertheless, its effect against in vivo tumor promoting activit...

    Authors: Mohd Rohaizad Md Roduan, Roslida Abd Hamid and Norhafizah Mohtarrudin

    Citation: BMC Complementary and Alternative Medicine 2019 19:238

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  24. Content type: Research article

    Rice husk, a waste material produced during milling, contains numerous phytochemicals that may be sources of cancer chemopreventive agents. Various biological activities of white and colored rice husk have bee...

    Authors: Arpamas Chariyakornkul, Charatda Punvittayagul, Sirinya Taya and Rawiwan Wongpoomchai

    Citation: BMC Complementary and Alternative Medicine 2019 19:237

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  25. Content type: Research article

    Syzygium cumini (L.) Skeels. is one of the very popular traditionally used medicinal plants with numerous pharmacological activities including antioxidant, hypoglycemic and anti-inflammatory. However, actions of

    Authors: Ahad Abdul Rehman, Azra Riaz, Muhammad Arif Asghar, Muhammad Liaquat Raza, Shadab Ahmed and Kamran Khan

    Citation: BMC Complementary and Alternative Medicine 2019 19:236

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  26. Content type: Research article

    Oxyresveratrol is a major bioactive component derived from the heartwood of Artocarpus lacucha. This compound exerts several biological activities, including neuroprotective effects in vitro and in vivo. However,...

    Authors: Dhirarin Junsaeng, Tosapol Anukunwithaya, Phanit Songvut, Boonchoo Sritularak, Kittisak Likhitwitayawuid and Phisit Khemawoot

    Citation: BMC Complementary and Alternative Medicine 2019 19:235

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  27. Content type: Research article

    Resveratrol is reported to inhibit the growth of prostate, which is characteristic of benign prostatic hyperplasia (BPH) condition. However, the mechanism remains unclear. This study aimed to identify the effe...

    Authors: Chao Li, Wan-Li Hu, Meng-Xin Lu and Guan-Fa Xiao

    Citation: BMC Complementary and Alternative Medicine 2019 19:233

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  28. Content type: Research article

    Metabolic syndrome is a non-communicable disease inclusive of risk factors such as central obesity, hypertension, hyperglycaemia and dyslipidaemia. In this present study, we investigated the ability of Pandanus a...

    Authors: Nur Hidayah Reshidan, Suhaila Abd Muid and Norshalizah Mamikutty

    Citation: BMC Complementary and Alternative Medicine 2019 19:232

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  29. Content type: Research article

    In Korea and China, asiasari radix (AR) is widely used as a traditional anti-inflammatory and analgesic agent. After its skin-regenerating and hair loss-preventing activities were identified, several types of ...

    Authors: Kwang-Ha Park, Jeong-Hae Choi, Yeon-Suk Song, Gyoo-Cheon Kim and Jin-Woo Hong

    Citation: BMC Complementary and Alternative Medicine 2019 19:231

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  30. Content type: Research article

    Hyperglycemia and dyslipidemia are classic features of patients with diabetes mellitus (DM). Cordyceps taii, a folk medicinal fungus native to southern China, possesses various pharmacological activities. This st...

    Authors: Ru-Ming Liu, Rong Dai, Yi Luo and Jian-Hui Xiao

    Citation: BMC Complementary and Alternative Medicine 2019 19:230

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  31. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) may increase the sensitivity to liver injury caused by stimulants such as drugs and poisons. The traditional Chinese medicine (TCM) Jiang-Zhi Granule (JZG) has been prove...

    Authors: Lili Yang, Yan Zhou, Haiyan Song and Peiyong Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:228

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  32. Content type: Research article

    Oxidative stress is an imbalance between the levels of reactive oxygen species (ROS), reactive nitrogen species (RNS) and endogenous antioxidants. The aetiology and pathogenesis of several oral diseases are at...

    Authors: Ignacio Peralta, Carla Marrassini, María Laura Barreiro Arcos, Graciela Cremaschi, María Rosario Alonso and Claudia Anesini

    Citation: BMC Complementary and Alternative Medicine 2019 19:227

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  33. Content type: Research article

    Commercial herbal medicines (CHMs) marketed as immune boosters are gaining wide popularity in South Africa, in the absence of control and regulatory guidelines. These commercially packaged and labelled herbal ...

    Authors: Mmamosheledi E. Mothibe, Christina P. Kahler-Venter and Elzbieta Osuch

    Citation: BMC Complementary and Alternative Medicine 2019 19:224

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  34. Content type: Research article

    Chronic hepatic diseases are serious problems worldwide, which may lead to the development of fibrosis and eventually cirrhosis. Despite the significant number of people affected by hepatic fibrosis, no effect...

    Authors: Caio Mateus da Silva, Flávio Henrique Caetano, Franco Dani Campos Pereira, Maria Aparecida Marin Morales, Kumiko Koibuchi Sakane and Karen C. M. Moraes

    Citation: BMC Complementary and Alternative Medicine 2019 19:222

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  35. Content type: Research article

    Lichens produce a huge diversity of bioactive compounds with several biological effects. Gyrophoric acid (GA) is found in high concentrations in the common lichen Umbilicaria hirsuta, however evidence for biologi...

    Authors: Michal Goga, Martin Kello, Maria Vilkova, Klaudia Petrova, Martin Backor, Wolfram Adlassnig and Ingeborg Lang

    Citation: BMC Complementary and Alternative Medicine 2019 19:221

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  36. Content type: Research article

    Baeckea frutescens (B. frutescens) of the family Myrtaceae is a plant that has been used in traditional medicine. It is known to have antibacterial, antipyretic and cytoprotective properties. The objective of thi...

    Authors: S. H. Shahruzaman, M. F. Mustafa, S. Ramli, S. Maniam, S. Fakurazi and S. Maniam

    Citation: BMC Complementary and Alternative Medicine 2019 19:220

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  37. Content type: Research article

    Methicillin-resistant Staphylococcus aureus (MRSA) causes serious infections in hospitals. Penthorum chinense Pursh (PCP), employed by the Miao ethnic minority in China, presents antibacterial activities. In this...

    Authors: Bin Ding, Qinchao Ding, Shun Zhang, Zhuo Jin, Zhaolei Wang, Songtao Li and Xiaobing Dou

    Citation: BMC Complementary and Alternative Medicine 2019 19:219

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  38. Content type: Research article

    Staphylococcal aureus (S. aureus) has become the leading causative pathogen of Prosthetic Joint Infection (PJI), which is the most devastating complication after arthroplasty surgeries. Due to the biofilm formati...

    Authors: Jiaqi Tan, Jin Wang, Chuang Yang, Chongzun Zhu, Geyong Guo, Jin Tang and Hao Shen

    Citation: BMC Complementary and Alternative Medicine 2019 19:218

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  39. Content type: Research article

    Systemic inflammation driven neuroinflammation is an event which correlates with pathogenesis of several neurodegenerative diseases. Therefore, targeting peripheral and central inflammation simultaneously coul...

    Authors: Muskan Gupta and Gurcharan Kaur

    Citation: BMC Complementary and Alternative Medicine 2019 19:217

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  40. Content type: Research article

    Breast cancer is still the most common malignant tumor that threatens the female’s life in the world, especially triple-negative breast cancer (TNBC), one of the most difficult subtypes. Lack of targeted thera...

    Authors: Mingjiang Yao, Xiaodi Fan, Bo Yuan, Norio Takagi, Sai Liu, Xiao Han, Junguo Ren and Jianxun Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:216

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  41. Content type: Research article

    Mounting evidence indicates that the cerebral cortex is an important physiological system of emotional activity, and its dysfunction may be the main cause of stress. Glutamate is the primary excitatory neurotr...

    Authors: Yan Liu, Xiu-fang Ding, Xin-xing Wang, Xiao-juan Zou, Xiao-juan Li, Yue-yun Liu, Jie Li, Xiu-yun Qian and Jia-xu Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:215

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  42. Content type: Research article

    The present study evaluated the antinociceptive effect of the bark of Artocarpus lacucha, which is used for the treatment of stomachache, headache and boils in the traditional system of medicine.

    Authors: Shanta Islam, Md. Shafiullah Shajib, Ridwan Bin Rashid, Mohammad Firoz Khan, Md. Abdullah Al-Mansur, Bidyut Kanti Datta and Mohammad Abdur Rashid

    Citation: BMC Complementary and Alternative Medicine 2019 19:214

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  43. Content type: Research article

    Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attem...

    Authors: Afnan Sh. Ahmed, Muhammad Taher, Uttam Kumar Mandal, Juliana Md Jaffri, Deny Susanti, Syed Mahmood and Zainul Amiruddin Zakaria

    Citation: BMC Complementary and Alternative Medicine 2019 19:213

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  44. Content type: Database

    Recently, there has been an increasing tendency to go back to nature in search of new medicines. To facilitate this, a great deal of effort has been made to compile information on natural products worldwide, a...

    Authors: Lemessa Etana Bultum, Assefa Mussa Woyessa and Doheon Lee

    Citation: BMC Complementary and Alternative Medicine 2019 19:212

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  45. Content type: Research article

    Breast cancer is the leading cause of cancer-related death in women worldwide. Although traditional Chinese medicine (TCM) is commonly used by patients with breast cancer, little is known about TCM prescriptio...

    Authors: Yu-Te Liu, Chao-Hsiang Hsiao, Bor-Show Tzang and Tsai-Ching Hsu

    Citation: BMC Complementary and Alternative Medicine 2019 19:211

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  46. Content type: Research article

    The imbalance between the generation of free radicals and natural cellular antioxidant defenses, known as oxidative stress, can cause oxidation of biomolecules and further contribute to aging-associated diseas...

    Authors: Palika Wetchakul, Jo Aan Goon, Ademola Ezekiel Adekoya, Opeyemi Joshua Olatunji, Sutticha Ruangchuay, Patcharawalai Jaisamut, Acharaporn Issuriya, Nongluk Kunworarath, Surasak Limsuwan and Sasitorn Chusri

    Citation: BMC Complementary and Alternative Medicine 2019 19:209

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  47. Content type: Research article

    Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms o...

    Authors: Ka-Yeon Lee, Jae-Hyun Kim, Eun-Young Kim, Mijung Yeom, Hyuk-Sang Jung and Youngjoo Sohn

    Citation: BMC Complementary and Alternative Medicine 2019 19:207

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  48. Content type: Research article

    About 425 million adults had diabetes mellitus globally in 2017. Type 2 diabetes accounts for the enormous majority of diabetes cases and it is gradually growing which is predicted to increase by 48% in 2045. ...

    Authors: Gebretsadkan Hintsa Tekulu, Ephrem Mebrahtu Araya and Hayelom Gebrekirstos Mengesha

    Citation: BMC Complementary and Alternative Medicine 2019 19:206

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  49. Content type: Research article

    Metastasis is the main cause of lung cancer death. As a seed of metastasis, circulating tumor cells are an important target for metastasis intervention. The traditional Chinese medicine, Jinfukang, has been cl...

    Authors: Zujun Que, Zhiyi Zhou, Bin Luo, Changsheng Dong, Yi Jiang, Hegen Li and Jianhui Tian

    Citation: BMC Complementary and Alternative Medicine 2019 19:204

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