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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification or herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

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  1. Content type: Research article

    Homoharringtonine (HHT) is a natural alkaloid with potent antitumor activity, but its precise mechanism of action is still poorly understood.

    Authors: Qi Sun, Shiyue Li, Junjun Li, Qiuxia Fu, Zhongyuan Wang, Bo Li, Shan-Shan Liu, Zijie Su, Jiaxing Song and Desheng Lu

    Citation: BMC Complementary and Alternative Medicine 2018 18:164

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  2. Content type: Research article

    There are increasing interests in natural compounds for cancer chemoprevention. Blocking agents represent an important class of chemopreventive compounds. They prevent carcinogens from undergoing metabolic act...

    Authors: Ali M. El-Halawany, Hossam M. Abdallah, Ahmed R. Hamed, Hany Ezzat Khalil and Ameen M. Almohammadi

    Citation: BMC Complementary and Alternative Medicine 2018 18:163

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  3. Content type: Research article

    Diabetes mellitus is one of the major global health disorders increasing at an alarming rate in both developed and developing countries. The objective of this study was to assess the effect of aqueous extract of

    Authors: Gulzar Ahmad Bhat, Haseeb A. Khan, Abdullah S. Alhomida, Poonam Sharma, Rambir Singh and Bilal Ahmad Paray

    Citation: BMC Complementary and Alternative Medicine 2018 18:162

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  4. Content type: Research article

    Ficus vasta Forssk. (Moraceae) is traditionally used for the treatment of various ailments; nonetheless, this species has been poorly studied to date. This work aimed to characterize the phenolic profile and to e...

    Authors: Maria Fernanda Taviano, Khaled Rashed, Angela Filocamo, Francesco Cacciola, Paola Dugo, Luigi Mondello, Carlo Bisignano, Rosaria Acquaviva, Manuela D’Arrigo and Natalizia Miceli

    Citation: BMC Complementary and Alternative Medicine 2018 18:161

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  5. Content type: Research article

    This present study sought to assess the modulatory effects of five Nigerian traditional polyherbal in high fructose-fed, streptozotocin-induced (HF-STZ) Type 2 diabetes (T2D) in rats. T2D was achieved via fruc...

    Authors: O. E. Kale, O. B. Akinpelu, A. A. Bakare, F. O. Yusuf, R. Gomba, D. C. Araka, T. O. Ogundare, A. C. Okolie, O. Adebawo and O. Odutola

    Citation: BMC Complementary and Alternative Medicine 2018 18:160

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  6. Content type: Research article

    Antimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and...

    Authors: Raissa Tioyem Nzogong, Fabrice Sterling Tchantchou Ndjateu, Steve Endeguele Ekom, Jules-Arnaud Mboutchom Fosso, Maurice Ducret Awouafack, Mathieu Tene, Pierre Tane, Hiroyuki Morita, Muhammad Iqbal Choudhary and Jean-de-Dieu Tamokou

    Citation: BMC Complementary and Alternative Medicine 2018 18:159

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  7. Content type: Research article

    Oxidative stress and renal apoptosis play a significant role in the progression of diabetic nephropathy. The tubers of Pueraria tuberosa (Roxb. ex Willd.) DC. has been traditionally used as anti-ageing and health...

    Authors: Rashmi Shukla, Somanshu Banerjee and Yamini B. Tripathi

    Citation: BMC Complementary and Alternative Medicine 2018 18:156

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  8. Content type: Research article

    Since oxidative stress and inflammation are two linked factors in the pathogenesis of several human diseases. Thus identification of effective treatment is of great importance. Edible mushroom and microalgae a...

    Authors: Marwa M. Abu-Serie, Noha H. Habashy and Wafaa E. Attia

    Citation: BMC Complementary and Alternative Medicine 2018 18:154

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  9. Content type: Research article

    Breast cancer is the most common cancer in women and affects 1.38 million women worldwide per year. Antiestrogens such as tamoxifen, a selective estrogen receptor (ER) modulator, are widely used in clinics to ...

    Authors: Yu-Shih Lin, Yin-Yin Lin, Yao-Hsu Yang, Chun-Liang Lin, Feng-Che Kuan, Cheng-Nan Lu, Geng-He Chang, Ming-Shao Tsai, Cheng-Ming Hsu, Reming-Albert Yeh, Pei-Rung Yang, I-Yun Lee, Li-Hsin Shu, Yu-Ching Cheng, Hung-Te Liu, Kuan-Der Lee…

    Citation: BMC Complementary and Alternative Medicine 2018 18:152

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  10. Content type: Research article

    Dental caries remains a serious problem due to its detrimental effects on individual health and quality of life. The bulbs of Myrmecodia pendans (Merr & Perry), native plants of Papua, have been used as natural r...

    Authors: Meirina Gartika, Hening T. Pramesti, Dikdik Kurnia and Mieke H. Satari

    Citation: BMC Complementary and Alternative Medicine 2018 18:151

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  11. Content type: Research article

    Sheng Jiang San (SJS), a multi-herb formulation, is used in treating high fever, thirsty and anxiety in ancient China and it is sometimes used to treat seasonal influenza nowadays. However, there is no evidenc...

    Authors: Tianbo Zhang, Mengjie Xiao, Chun-Kwok Wong, Ka-Pun Chris Mok, Xin Zhao, Huihui Ti and Pang-Chui Shaw

    Citation: BMC Complementary and Alternative Medicine 2018 18:150

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  12. Content type: Research article

    The potential toxicity of Chinese herbal medicine has attracted more attention in recent years. Jueyin granules (JYG), a polyherbal formula, have been proven to be an effective agent for treating psoriasis in bot...

    Authors: Yu Chen, Dong-jie Guo, Hui Deng, Min-feng Wu, Ya-Nan Zhang, Su Li, Rong Xu, Jie Chen, Xing-xiu Jin, Bin Li, Qi Xu and Fu-lun Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:148

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  13. Content type: Research article

    Natural product is one of the most important sources of drugs used in pharmaceutical therapeutics. Artemisia capillaris has been traditionally used as a hepatoprotective and anti-inflammatory agent. In this study...

    Authors: Juyoung Kim, Kyung Hee Jung, Hong Hua Yan, Min Ji Cheon, Sunmi Kang, Xing Jin, Sunghyouk Park, Myung Sook Oh and Soon-Sun Hong

    Citation: BMC Complementary and Alternative Medicine 2018 18:147

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  14. Content type: Research article

    Human placenta hydrolysate (hPH) has been utilized to improve menopausal, fatigue, liver function. Its high concentration of bioactive substances is known to produce including antioxidant, anti-inflammatory an...

    Authors: Hyun-Jung Park, Hyun Soo Shim, Sunyoung Lee, Dae Hyun Hahm, Hyejung Lee, Chang Taek Oh, Hae Jung Han, Hyi Jeong Ji and Insop Shim

    Citation: BMC Complementary and Alternative Medicine 2018 18:149

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  15. Content type: Research article

    Fine particulate matter (PM2.5) is a major risk factor for the development and progression of atherosclerosis. Proliferation and infiltration of vascular smooth muscle cells (VSMCs) from the blood vessel media...

    Authors: Qiang Wan, Zhongyong Liu and Yuping Yang

    Citation: BMC Complementary and Alternative Medicine 2018 18:146

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  16. Content type: Research article

    Cryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients. In addition, the lower susceptibility of this yeast to azoles is ...

    Authors: Daniela Scalas, Narcisa Mandras, Janira Roana, Roberta Tardugno, Anna Maria Cuffini, Valeria Ghisetti, Stefania Benvenuti and Vivian Tullio

    Citation: BMC Complementary and Alternative Medicine 2018 18:143

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  17. Content type: Research article

    Propolis, a polyphenol-rich natural product, has been used as a functional food in anti-inflammation. However, its bioactive components and mechanisms have not been fully elucidated.

    Authors: Huasong Chang, Wenwen Yuan, Haizhu Wu, Xusheng Yin and Hongzhuan Xuan

    Citation: BMC Complementary and Alternative Medicine 2018 18:142

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  18. Content type: Research article

    The current treatment for human brucellosis requires a combination of antibiotics for long periods of time, and the reported incidence and prevalence of the disease vary widely in nomadic livestock of Mongolia...

    Authors: Tsevelmaa N, Narangerel B, Odgerel O, Dariimaa D and Batkhuu J

    Citation: BMC Complementary and Alternative Medicine 2018 18:144

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  19. Content type: Research article

    Herba Siegesbeckiae (HS, Xixiancao in Chinese) is a commonly used traditional Chinese medicinal herb for soothing joints. In ancient materia medica books, HS is recorded to be the aerial part of Siegesbeckia pube...

    Authors: Hui Guo, Yi Zhang, Brian Chi-Yan Cheng, Mei-Yuk Lau, Xiu-Qiong Fu, Ting Li, Tao Su, Pei-Li Zhu, Yuen-Cheung Chan, Anfernee Kai-Wing Tse, Tao Yi, Hu-Biao Chen and Zhi-Ling Yu

    Citation: BMC Complementary and Alternative Medicine 2018 18:141

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  20. Content type: Research article

    Medicinal plants have been founded as traditional herbal medicine worldwide. Most of the plant’s therapeutic properties are due to the presence of secondary metabolites such as alkaloids, glycosides, tannins a...

    Authors: Hazir Rahman, Ilyas Khan, Anwar Hussain, Abdelaaty Abdelaziz Shahat, Abdul Tawab, Muhammad Qasim, Muhammad Adnan, Mansour S. Al-Said, Riaz Ullah and Shahid Niaz Khan

    Citation: BMC Complementary and Alternative Medicine 2018 18:140

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