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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Page 1 of 35

  1. Content type: Research article

    Development of safe and effective chemopreventive agents is a winning strategy in reducing the morbidity and mortality of breast cancer. The current study was to investigate the mechanism-based chemopreventive...

    Authors: Jingwei Li, Xiaofei Liu, Hongzhi Chen, Ziyuan Sun, Hanhan Chen, Lei Wang, Xiaohui Sun and Xiangqi Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:48

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  2. Content type: Research article

    The root of Baliospermum montanum has been used as an ingredient of traditional Thai medicines for the treatments of several diseases including itching eczema, muscle and joint inflammation, and cancer. Few studi...

    Authors: Weerachai Pipatrattanaseree, Arunporn Itharat, Nichamon Mukkasombut and Ubonwan Saesiw

    Citation: BMC Complementary and Alternative Medicine 2019 19:45

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  3. Content type: Research article

    Quinoa is a food crop native to the Andes. The process of dehulling quinoa can produce approximately 8–12% husk, which is often discarded because it contains bitter saponin. Saponin derived from quinoa has bee...

    Authors: Xiaoyan Sun, Xiushi Yang, Peng Xue, Zhiguo Zhang and Guixing Ren

    Citation: BMC Complementary and Alternative Medicine 2019 19:46

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  4. Content type: Research article

    Libidibia ferrea (L. ferrea) has been used in folk medicine to treat several conditions and to prevent cancer. This study performed a chromatographic analysis of the crude aqueous extract of Libidibia ferrea (Mar...

    Authors: Tamires Rocha Falcão, Cássio Alexandre Oliveira Rodrigues, Aurigena Antunes de Araújo, Caroline Addison Carvalho Xavier de Medeiros, Luiz Alberto Lira Soares, Magda Rhayanny Assunção Ferreira, Roseane Carvalho Vasconcelos, Raimundo Fernandes de Araújo Júnior, Maria Luiza Diniz de Sousa Lopes and Gerlane Coelho Bernardo Guerra

    Citation: BMC Complementary and Alternative Medicine 2019 19:47

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  5. Content type: Research article

    Carica papaya leaves have been used for traditional treatment of dengue fever and have been reported to exhibit an immunomodulatory activity by affecting the level of cytokine production in vitro and in vivo. Due...

    Authors: Nor Azrina Norahmad, Mohd Ridzuan Mohd Abd Razak, Norazlan Mohmad Misnan, Nur Hana Md Jelas, Umi Rubiah Sastu, Amirrudin Muhammad, Tiffiny Chau Dee Ho, Bazilah Jusoh, Nor Azlina Zolkifli, Ravindran Thayan, Adiratna Mat Ripen, Murizal Zainol and Ami Fazlin Syed Mohamed

    Citation: BMC Complementary and Alternative Medicine 2019 19:44

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  6. Content type: Research article

    Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the ...

    Authors: Ha Na Kim, Gwang Hun Park, Su Bin Park, Jeong Dong Kim, Hyun Ji Eo, Ho-Jun Son, Jeong Ho Song and Jin Boo Jeong

    Citation: BMC Complementary and Alternative Medicine 2019 19:43

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  7. Content type: Research article

    Borrelia sp. is a causative pathogen of Lyme disease which has become a worldwide health concern. Non-toxic approaches especially directed toward latent persistent forms of this pathogen are desired. Lipids in th...

    Authors: Anna Goc, Aleksandra Niedzwiecki and Matthias Rath

    Citation: BMC Complementary and Alternative Medicine 2019 19:40

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  8. Content type: Research article

    This study aimed to elucidate the effects and mechanisms of Radix Linderae (RL) extracts on a mouse model of diabetic bladder dysfunction (DBD), especially on later decompensated phase.

    Authors: Xufeng Yang, Dawei Lian, Pinglong Fan, Yifei Xu, Jing Wang, Fangjun Chen, Huanling Lai, Weiwen Jiang, Linjie Zhang, Ping Huang and Hongying Cao

    Citation: BMC Complementary and Alternative Medicine 2019 19:41

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  9. Content type: Research article

    Alzheimer’s disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy populatio...

    Authors: Mustafa F. Alkhouli, Jun Hung, Michaela Squire, Miranda Anderson, Monica Castro, Jeganathan R. Babu, Layla Al-Nakkash, Tom L. Broderick and Jeffrey H. Plochocki

    Citation: BMC Complementary and Alternative Medicine 2019 19:39

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  10. Content type: Research article

    Listeria monocytogenes is an opportunistic foodborne pathogen that causes human Listeriosis and high mortality particularly in immunocompromised individuals. Pregnant women are more prone to L. monocytogenes infe...

    Authors: Ayesha Riaz, Saleha Noureen, Iram Liqat, Muhammad Arshad and Najma Arshad

    Citation: BMC Complementary and Alternative Medicine 2019 19:37

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  11. Content type: Research article

    Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays...

    Authors: Wuguo Li, Qing Zhang, Kaotan Chen, Zhenhua Sima, Jingli Liu, Qiang Yu and Jiawei Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:38

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  12. Content type: Research article

    Wu-Mei-Wan (WMW) is a traditional Chinese herbal formulation that is clinically prescribed to treat diabetes mellitus in China. WMW has been shown to alleviate damage in pancreatic β cells, but the underlying ...

    Authors: Xueping Yang, Fuer Lu, Lingli Li, Jingbin Li, Jinlong Luo, Siyi Zhang, Xinqiao Liu and Guang Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:35

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  13. Content type: Research article

    Bone damage is a condition that affects the quality of life of patients. Mesenchymal stem cells (MSCs) are important for bone repair. Osteoking is a natural compound in traditional Chinese Medicine used to tre...

    Authors: Congtao Yu, Lifen Dai, Zhaoxia Ma, Hongbin Zhao, Yong Yuan, Yunfeng Zhang, Pengfei Bao, Yanfang Su, Daiping Ma, Change Liu, Xingfei Wu, Jinxue Liu, Yanjiao Li, Bing Wang and Min Hu

    Citation: BMC Complementary and Alternative Medicine 2019 19:36

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  14. Content type: Research article

    Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a major cause of disease in pregnant women and new born babies where it causes early and late onset disease characterised by sepsis, pneumonia...

    Authors: Munyaradzi Mukesi, Benson C. Iweriebor, Larry C. Obi, Uchechukwu U. Nwodo, Sylvester R. Moyo and Anthony I. Okoh

    Citation: BMC Complementary and Alternative Medicine 2019 19:34

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  15. Content type: Research article

    Colorectal malignant neoplasms is one of the leading causes of death in both men and women in the developed world and the incidence has recently increased markedly in South Africa. Studies have highlighted the...

    Authors: Wagheda Cassiem and Maryna de Kock

    Citation: BMC Complementary and Alternative Medicine 2019 19:32

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  16. Content type: Research article

    Royal jelly (RJ) has been used traditionally for dietary, cosmetic and health purposes for a long time in different parts of the world. Scientific studies have also shown its numerous health-promoting properti...

    Authors: Prakash Raj Pandeya, Ramakanta Lamichhane, Kyung-Hee Lee, Se-Gun Kim, Dae-Ho Lee, Hyeong-Kyu Lee and Hyun-Ju Jung

    Citation: BMC Complementary and Alternative Medicine 2019 19:33

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  17. Content type: Research article

    Opuntia ficus-indica var. saboten (OFIS) is used widely in Korea to treat constipation due to its diuretic effects and its enhancement of bowel function and appetite. However, its safety has not yet been establis...

    Authors: Eun Hye Han, Mi Kyung Lim, Sang Ho Lee, Md. Mahbubur Rahman and Young-Hee Lim

    Citation: BMC Complementary and Alternative Medicine 2019 19:31

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  18. Content type: Research article

    Exposure of skin to urban air pollutants is closely related to skin aging and inflammatory responses such as wrinkles formation, pigmentation spot, atopic dermatitis, and acne. Thus, a great deal of interest h...

    Authors: Minkyung Kim, Dahee Son, Seoungwoo Shin, Deokhoon Park, Sangyo Byun and Eunsun Jung

    Citation: BMC Complementary and Alternative Medicine 2019 19:30

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  19. Content type: Research article

    In-depth information of potential drug-herb interactions between warfarin and herbal compounds with suspected anticoagulant blood thinning effects is needed to raise caution of concomitant administration. The ...

    Authors: Maisa Alnaqeeb, Kenza A. Mansor, Eyad M. Mallah, Bayan Y. Ghanim, Nasir Idkaidek and Nidal A. Qinna

    Citation: BMC Complementary and Alternative Medicine 2019 19:29

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  20. Content type: Research article

    A combination of parts of Cornus officinalis, Rosa multiflora, Lespedeza bicolor, Platycladus orientalis, and Castanea crenata is commonly used for alleviating inflammatory skin disorders. Therefore, this study w...

    Authors: Abraham Fikru Mechesso, Seung-Jin Lee, Na-Hye Park, Jin-Yoon Kim, Zi-Eum Im, Joo-Won Suh and Seung-Chun Park

    Citation: BMC Complementary and Alternative Medicine 2019 19:25

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  21. Content type: Research article

    Women diagnosed with breast cancer frequently seek complementary and alternative (CAM) treatment options that can help to cope with their disease and the side effects of conventional cancer therapy. Especially...

    Authors: U. Weissenstein, M. Kunz, M. Oufir, J. T. Wang, M. Hamburger, K. Urech, U. Regueiro and S. Baumgartner

    Citation: BMC Complementary and Alternative Medicine 2019 19:23

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  22. Content type: Research article

    An alarm increase the rate of emerging and re-emerging of multidrug resistant bacteria have been caused great public health concern in the worldwide. They have been resisting for most or majority of currently ...

    Authors: Eshetu Gadisa, Gebru Weldearegay, Kassu Desta, Getahun Tsegaye, Sityehu Hailu, Kefiyelewu Jote and Abera Takele

    Citation: BMC Complementary and Alternative Medicine 2019 19:24

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  23. Content type: Research article

    Impaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. The risk of developing diabetic foot ulcers for diabetic patients is 15% over th...

    Authors: Woan Sean Tan, Palanisamy Arulselvan, Shiow-Fern Ng, Che Norma Mat Taib, Murni Nazira Sarian and Sharida Fakurazi

    Citation: BMC Complementary and Alternative Medicine 2019 19:20

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  24. Content type: Research article

    A Panchvalkal formulation (Pentaphyte P-5®) mentioned in ancient texts of Indian traditional medicine was investigated for its anti-infective potential against Pseudomonas aeruginosa.

    Authors: Chinmayi Joshi, Pooja Patel, Hanmanthrao Palep and Vijay Kothari

    Citation: BMC Complementary and Alternative Medicine 2019 19:19

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  25. Content type: Research article

    The present study was carried out to prepare multi-herbal combination via comparing antioxidant activity and polyphenolic composition of five medicinal plant extracts of Punica granatum L., Putranjiva roxburghii ...

    Authors: Pardeep Kaur, Robin, Rajendra G. Mehta, Balbir Singh and Saroj Arora

    Citation: BMC Complementary and Alternative Medicine 2019 19:18

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  26. Content type: Research article

    Coreopsis tinctoria Nutt is an ethnomedicine widely used in Xinjiang, China. It is consumed as a herbal tea by local Uyghur people to treat high blood pressure and diarrhea. Our previous study confirmed that the ...

    Authors: Lan Yao, Jie Li, Linlin Li, Xinxia Li, Rui Zhang, Yujie Zhang and Xinmin Mao

    Citation: BMC Complementary and Alternative Medicine 2019 19:14

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  27. Content type: Research article

    Asian traditional herbal remedies are typically a concoction of a major and several complementary herbs. While balancing out any adverse effect of the major herb, the complementary herbs could dilute the effic...

    Authors: Jin-Woo Han, Kyun Ha Kim, Min-Jung Kwun, Jun-Yong Choi, Sang-Jun Kim, Seung-Il Jeong, Beom-Joon Lee, Kwan-Il Kim, Ran Won, Ji Hoon Jung, Hee Jae Jung and Myungsoo Joo

    Citation: BMC Complementary and Alternative Medicine 2019 19:15

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  28. Content type: Research article

    Post-traumatic stress disorder (PTSD) is a disease associated with that the experience of traumatic stress. The traumatic experience results in the development of a prolonged stress response that causes impair...

    Authors: Bombi Lee, Riwon Hong, Pooreum Lim, Daeun Cho, Mijung Yeom, Sanghyun Lee, Ki Sung Kang, Sang Cheon Lee, Insop Shim, Hyejung Lee and Dae-Hyun Hahm

    Citation: BMC Complementary and Alternative Medicine 2019 19:11

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  29. Content type: Research article

    Danggui Buxue Tang (DBT) is a historical Chinese herbal decoction, and which has more than 800 years of applications. This herbal decoction solely contains two materials: Astragali Radix (AR) and Angelicae Sinens...

    Authors: Guowei Gong, Baohui Qi, Yan T. Liang, Tina T. X. Dong, Huai Y. Wang, Karl W. K. Tsim and Yuzhong Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:9

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  30. Content type: Research article

    ChondroT, a new herbal medication, consists of the water extracts of Osterici Radix, Lonicerae Folium, Angelicae Gigantis Radix, Clematidis Radix, and Phellodendri Cortex (6:4:4:4:3). We previously reported that

    Authors: Dool-Ri Oh, Jong Ro Kim, Chul Yung Choi, Chan-hun Choi, Chang-su Na, Bok Yun Kang, Seon-Jong Kim and Young Ran Kim

    Citation: BMC Complementary and Alternative Medicine 2019 19:10

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  31. Content type: Research article

    Neptunia oleracea is a plant cultivated as vegetable in Southeast Asia. Previous works have revealed the potential of this plant as a source of natural antioxidants and α-glucosidase inhibitors. Continuing our in...

    Authors: Soo Yee Lee, Ahmed Mediani, Intan Safinar Ismail, Maulidiani and Faridah Abas

    Citation: BMC Complementary and Alternative Medicine 2019 19:7

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  32. Content type: Research article

    Candida sp. represent the most common cause of fungal infections worldwide. In the present work, we have evaluated the activity of an essential oil extracted from pistachio hulls against a number of standard and ...

    Authors: Manuela D’Arrigo, Carlo Bisignano, Pierangela Irrera, Antonella Smeriglio, Roberto Zagami, Domenico Trombetta, Orazio Romeo and Giuseppina Mandalari

    Citation: BMC Complementary and Alternative Medicine 2019 19:6

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  33. Content type: Research article

    Ling-gui-zhu-gan decoction (LGZG), a classic traditional Chinese medicine formula, has been confirmed to be effective in improving steatosis in non-alcoholic fatty liver disease (NAFLD). However, the mechanism...

    Authors: Yanqi Dang, Shijun Hao, Wenjun Zhou, Li Zhang and Guang Ji

    Citation: BMC Complementary and Alternative Medicine 2019 19:8

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  34. Content type: Research article

    Plants represent an intricate and innovative source for the discovery of novel therapeutic remedies for the management of various ailments. The current study has been aimed to validate the therapeutic potentia...

    Authors: Tanzeel Zohra, Muhammad Ovais, Ali Talha Khalil, Muhammad Qasim, Muhammad Ayaz, Zabta Khan Shinwari, Sajjad Ahmad and Mohammad Zahoor

    Citation: BMC Complementary and Alternative Medicine 2019 19:4

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  35. Content type: Research article

    Recently, it has been noted that natural herbal medications may be effective in treating obesity. Tongbi-san (TBS) is a traditional medicine usually used for dysuria (i.e., painful urination), containing three...

    Authors: Yea-Jin Park, Gui-Sun Lee, Se-Yun Cheon, Yun-Yeop Cha and Hyo-Jin An

    Citation: BMC Complementary and Alternative Medicine 2019 19:1

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  36. Content type: Research article

    Saururus chinensis leaves have been used as traditional medicine in Korea for pain, intoxication, edema, and furuncle. According to previous reports, these leaves exert renoprotective, neuroprotective, and antiox...

    Authors: Jong-Hyun Nho, Hyeun-Joo Lee, Ho-Kyung Jung, Ji-Hun Jang, Ki-Ho Lee, A-Hyeon Kim, Tae-Kyoung Sung and Hyun-Woo Cho

    Citation: BMC Complementary and Alternative Medicine 2019 19:2

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  37. Content type: Research article

    Considerable morbidity, mortality, and economic loss result from schistosomiasis infection. Deposition of Schistosoma eggs in the hepatic portal vein is considered as the main causative agent for the development ...

    Authors: Manal F. El-Khadragy, Ebtesam M. Al-Olayan, Mohammed I. Y. Elmallah, Afra M. Alharbi, Hany M. Yehia and Ahmed E. Abdel Moneim

    Citation: BMC Complementary and Alternative Medicine 2019 19:3

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  38. Content type: Research article

    Chinese herbal formula Shaoyao Gancao decoction (SGD) is often used as an adjuvant with chemotherapeutic agents to treat cancer. Due to the herb-drug interactions, the alternations of drug metabolic enzyme and...

    Authors: Dandan Feng, Tao Tang, Rong Fan, Jiekun Luo, Hanjin Cui, Yang Wang and Pingping Gan

    Citation: BMC Complementary and Alternative Medicine 2018 18:345

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  39. Content type: Research article

    Erectile dysfunction (ED) is a common complication of diabetes. This study aimed to explore the beneficial effect of Danshen injection on ED in a streptozotocin (STZ)-induced diabetic rat model and the underly...

    Authors: Yong Zhang, Jian Chen, Hua Ji, Zhang-Gang Xiao, Peiqiang Shen and Lin-Hao Xu

    Citation: BMC Complementary and Alternative Medicine 2018 18:343

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  40. Content type: Research article

    Chronic fat-rich diets consumption is increased risk associated with cardiovascular diseases (CVD). Prevention or reduction the progression of cardiac tissue deterioration could benefit in CVD. This study aime...

    Authors: Arunwan Udomkasemsab, Chattraya Ngamlerst, Poom Adisakwattana, Amornrat Aroonnual, Rungsunn Tungtrongchitr and Pattaneeya Prangthip

    Citation: BMC Complementary and Alternative Medicine 2018 18:344

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  41. Content type: Research article

    Triphala is an Ayurvedic rasayana formulation reputed for its antitumour activities, and chebulinic acid and chebulagic acid, along with other phenolic acids, have been proposed to be responsible for its effects.

    Authors: Min Wang, Yanru Li and Xianda Hu

    Citation: BMC Complementary and Alternative Medicine 2018 18:342

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  42. Content type: Research article

    Jian-Pi-Yi-Shen Formula (JPYSF), a Chinese herbal decoction with the efficacies of ‘fortify the spleen and tonify the kidney’ and ‘activate blood and resolve stasis’, is effective for the treatment of chronic ...

    Authors: Xinhui Liu, Jianping Chen, Xiaoyan Liu, Dongtao Wang, Ping Zheng, Airong Qi, Tiegang Yi and Shunmin Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:340

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  43. Content type: Research article

    Rheumatoid arthritis (RA) being an incapacitating disease requires early effective intervention. Considering Methotrexate (MTX)- the first line of treatment for RA- intoxicates the liver; therefore, alternativ...

    Authors: Hiba Hasan, Hanan Ismail, Youmna El-Orfali and Ghada Khawaja

    Citation: BMC Complementary and Alternative Medicine 2018 18:337

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  44. Content type: Research article

    The fruit of Elaeagnus umbellata has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antioxidant, enzyme inhibitory and antidiabetic potential of Elaeagnus...

    Authors: Nausheen Nazir, Muhammad Zahoor, Mohammad Nisar, Imran Khan, Nasiara Karim, Heba Abdel-Halim and Akhtar Ali

    Citation: BMC Complementary and Alternative Medicine 2018 18:332

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  45. Content type: Research article

    The placenta is a reservoir enriched with growth factors, hormones, cytokines and minerals. While several beneficial effects of placenta extracts on wound healing, anti-aging and anti-inflammatory responses ha...

    Authors: Jae Hyeok Heo, Yoonki Heo, Hee Jung Lee, Minjee Kim and Ha Youn Shin

    Citation: BMC Complementary and Alternative Medicine 2018 18:331

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  46. Content type: Research article

    Identification of novel sources for developing new antibiotics is imperative with the emergence of antibiotic resistant bacteria. The fruits of Terminalia bellirica (Gaertn) Roxb., widely used in traditional medi...

    Authors: M. Priyanga Jayamal Dharmaratne, Amirthasingam Manoraj, Vasanthi Thevanesam, Asela Ekanayake, Nimal Savitri Kumar, Veranja Liyanapathirana, Eranga Abeyratne and B. M. Ratnayake Bandara

    Citation: BMC Complementary and Alternative Medicine 2018 18:325

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  47. Content type: Research article

    Cordyceps sinensis has been used for centuries in China as one of the most valued herbal medicine and tonic food. Paecilomyces hepiali, a fungal strain isolated from natural C. sinensis, has been used widely as a...

    Authors: Mei Ge, Rui Guo, Hai-xia Lou and Wen Zhang

    Citation: BMC Complementary and Alternative Medicine 2018 18:326

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  48. Content type: Research article

    Celastrus orbiculatus (Celastraceae) are used as traditional Chinese medicine to treat inflammation and cancer. This study aims to evaluate the effect of Celastrus orbiculatus extract (COE) on the apoptosis in hu...

    Authors: Yayun Qian, Ting Yang, Xueyu Zhao, Yan Yan, Wenyuan Li, Chuanci Fang, Jingjing Hou, Li Tao and Yanqing Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:328

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  49. Content type: Research article

    This study assessed the effects of propolis alone or combined with insulin on maternal status, pregnancy outcomes and placental oxidative stress in streptozotocin-induced diabetic rats.

    Authors: Umar Zayyanu Usman, Ainul Bahiyah Abu Bakar and Mahaneem Mohamed

    Citation: BMC Complementary and Alternative Medicine 2018 18:324

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  50. Content type: Research article

    Weight reduction frequently occurs in patients receiving vagus nerve stimulation (VNS) therapy. Therefore, we hypothesized that during dietary intervention for weight loss, auricular electric stimulation (AES)...

    Authors: Szu-Han Chen, Hsiao-Chien Chen, Ching-Liang Hsieh and Pei-Min Chao

    Citation: BMC Complementary and Alternative Medicine 2018 18:323

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