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Basic research

Edited by Jacobus Eloff, Victor Kuete and Insop Shim

This section covers pre-clinical, in vitro and in vivo studies related to interventions or resources in the complementary medicine field, including the isolation and purification of herbal remedies, toxicological studies and research into the biological mechanisms of action of the intervention or resource.

Page 1 of 36

  1. Content type: Research article

    The modified Si-Jun-Zi Decoction (SJZ), a Chinese medicine formula, is clinically used against multiple malignancies including colorectal cancer (CRC). This study aims to evaluate the effect of modified SJZ on...

    Authors: Jin-Yong Zhou, Min Chen, Cun-En Wu, Yu-Wen Zhuang, Yu-Gen Chen and Shen-Lin Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:86

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  2. Content type: Research article

    Cytinus is small genus of endophytic parasitic plants distributed in South Africa, Madagascar, and in the Mediterranean region. In the latter area, two species occur, Cytinus hypocistis and C. ruber, distinguishe...

    Authors: Giuseppantonio Maisetta, Giovanna Batoni, Pierluigi Caboni, Semih Esin, Andrea C. Rinaldi and Paolo Zucca

    Citation: BMC Complementary and Alternative Medicine 2019 19:82

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  3. Content type: Research article

    Organochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities. The antioxidant activity and acute toxicity of an organoselenium c...

    Authors: Mohammad Ibrahim, Niaz Muhammad, Musadiq Ibrahim, Muhammad Idrees Khan, Muhammad Ishaq Ali Shah, Muhammad Said, Waliullah Khan, Jean Paul Kamdem and Joao Batista Teixeira Rocha

    Citation: BMC Complementary and Alternative Medicine 2019 19:80

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  4. Content type: Research article

    Methanol extract (MECN) of Clinacanthus nutans Lindau leaves (family Acanthaceae) demonstrated peripherally and centrally mediated antinociceptive activity via the modulation of opioid/NO-mediated, but cGMP-indep...

    Authors: Zainul Amiruddin Zakaria, Mohammad Hafiz Abdul Rahim, Mohd Hijaz Mohd Sani, Maizatul Hasyima Omar, Siew Mooi Ching, Arifah Abdul Kadir and Qamar Uddin Ahmed

    Citation: BMC Complementary and Alternative Medicine 2019 19:79

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  5. Content type: Research article

    The introduction of imatinib revolutionized the treatment of chronic myeloid leukaemia (CML), substantially extending patient survival. However, imatinib resistance is currently a clinical problem for CML. It ...

    Authors: Huayao Li, Lijuan Liu, Jing Zhuang, Cun Liu, Chao Zhou, Jing Yang, Chundi Gao, Gongxi Liu and Changgang Sun

    Citation: BMC Complementary and Alternative Medicine 2019 19:75

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  6. Content type: Research article

    Different plant parts of Roylea cinerea (D. Don) Baill. (Lamiaceae), Clematis grata Wall. (Ranunculaceae), Cornus capitata Wall. (Cornaceae) are traditionally used in the management of diabetes and various other ...

    Authors: Astha Bhatia, Balbir Singh, Rohit Arora and Saroj Arora

    Citation: BMC Complementary and Alternative Medicine 2019 19:74

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  7. Content type: Research article

    Solidago chilensis (syn. microglossa) is a plant from the Asteraceae family widely distributed in South America and used to treat inflammatory diseases. In 2009, it was listed as one of the native medicinal herba...

    Authors: Elena L. A. Malpezzi-Marinho, Graziela R. Molska, Lyvia I. G. P. Freire, Cristiane I. Silva, Eduardo K. Tamura, Laís F. Berro, Carlos A. Parada and Eduardo Ary Villela Marinho

    Citation: BMC Complementary and Alternative Medicine 2019 19:72

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  8. Content type: Research article

    Ocimum gratissimum L. is a medicinal plant widely grown in tropical and subtropical regions with the leaf decoction usually taken in folk medicine to enhance erectile performance in men although the probable mech...

    Authors: Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Babatunji Emmanuel Oyinloye, Basiru Olaitan Ajiboye, Omosola Olufisayo Anifowose, Ayodeji Akawa, Oluranti Esther Olaiya, Oluwaseun Ruth Olasehinde and Abidemi Paul Kappo

    Citation: BMC Complementary and Alternative Medicine 2019 19:71

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  9. Content type: Research article

    Epithelial-mesenchymal transition (EMT) is a vital process in cancer progression and metastasis. Yanggan Jiedu Sanjie (YGJDSJ) is Traditional Chinese Medicine formulation for liver cancer treatment. In the pre...

    Authors: Bing Hu, Hong-Mei An, Xia Yan, Jia-Lu Zheng, Xiao-Wei Huang and Miao Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:67

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  10. Content type: Research article

    We investigated the effects of a berry mixture formula (modified Ojayeonjonghwan (Wuzi Yanzong Wan, MO formula) on detrusor overactivity (DO).

    Authors: Sangrak Bae, Kyu Won Lee, Hyun Cheol Jeong, Bong Hee Park, Woong Jin Bae, Chang Hee Han and Sae Woong Kim

    Citation: BMC Complementary and Alternative Medicine 2019 19:64

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  11. Content type: Research article

    Prolonged hyperuricemia is associated with kidney disease or gouty arthritis. Whether Yokuininto, a commercially available Kampo medicine that has been used for osteoarthritis or rheumatoid arthritis, can exhi...

    Authors: Seung Hoon Lee, Ho-Sung Lee, Gunhyuk Park, Sung-Man Oh and Dal-Seok Oh

    Citation: BMC Complementary and Alternative Medicine 2019 19:57

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  12. Content type: Research article

    Enantia chlorantha is a plant belonging to Annonaceae Family. The Barks and leaves are used traditionally to treat infectious diseases. Earlier studies highlighted the antibacterial activity of stem barks methano...

    Authors: Rebeca Madeleine Ebelle Etame, Raymond Simplice Mouokeu, Frank Stève Monthe Poundeu, Igor Kenfack Voukeng, Cedric Laurel Pouaha Cidjeu, Alembert Tchinda Tiabou, Abel Joel Gbaweng Yaya, Rosalie Anne Ngono Ngane, Jules Roger Kuiate and François Xavier Etoa

    Citation: BMC Complementary and Alternative Medicine 2019 19:56

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  13. Content type: Research article

    Mulberry is a Korean medicinal herb that shows effective prevention and treatment of obesity and diabetes. Bioconversion is the process of producing active ingredients from natural products using microorganism...

    Authors: Sang-Hyuk Jung, Joo-Hui Han, Hyun-Soo Park, Do-Hyung Lee, Seok Jin Kim, Hyun So Cho, Jong Seong Kang and Chang-Seon Myung

    Citation: BMC Complementary and Alternative Medicine 2019 19:55

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  14. Content type: Research article

    We previously reported that tacrolimus (Tac) does not decrease T helper 17 cells (Th17) response in kidney transplantation. In this study, we evaluated whether Resveratrol (Resv) has immunosuppressive effects ...

    Authors: Kyoung Chan Doh, Bo-Mi Kim, Kyoung Woon Kim, Byung Ha Chung and Chul Woo Yang

    Citation: BMC Complementary and Alternative Medicine 2019 19:54

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  15. Content type: Research article

    Ephedra chilensis K Presl, known locally as pingo–pingo, is a Chilean endemic plant used in traditional medicine as an anti-inflammatory and used in other treatments. However, unlike for the other Ephedra species...

    Authors: Marco Mellado, Mauricio Soto, Alejandro Madrid, Iván Montenegro, Carlos Jara-Gutiérrez, Joan Villena, Enrique Werner, Patricio Godoy and Luis F. Aguilar

    Citation: BMC Complementary and Alternative Medicine 2019 19:53

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  16. Content type: Research article

    Senecio serratuloides DC is used in folk medicine for treating hypertension, skin disorders, internal and external sores, rashes, burns and wounds. This study aimed at investigating the antihypertensive effects o...

    Authors: Charlotte Mungho Tata, Constance Rufaro Sewani-Rusike, Opeoluwa Oyehan Oyedeji, Ephraim Tobela Gwebu, Fikile Mahlakata and Benedicta Ngwenchi Nkeh-Chungag

    Citation: BMC Complementary and Alternative Medicine 2019 19:52

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  17. Content type: Research article

    This study investigated the protective effects of the Danshen (DS) and Sanqi (SQ) herb pair on cell survival in the human cardiovascular endothelial (EA.hy926) cell line exposed to injury.

    Authors: Xian Zhou, Valentina Razmovski-Naumovski, Antony Kam, Dennis Chang, Chun Guang Li, Kelvin Chan and Alan Bensoussan

    Citation: BMC Complementary and Alternative Medicine 2019 19:50

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  18. Content type: Research article

    Hordeum vulgare L (barley) contains numerous phenolic substances with proven anticancer, antioxidant and gastroprotective activities. Saccharification increases the functionality and bioavailability of these comp...

    Authors: Jong-Min Lim, Chang-Hyun Song, Su-Jin Park, Dong-Chan Park, Go-Woon Jung, Hyung-Rae Cho, Khawaja Muhammad Imran Bashir, Sae Kwang Ku and Jae-Suk Choi

    Citation: BMC Complementary and Alternative Medicine 2019 19:49

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  19. Content type: Research article

    Development of safe and effective chemopreventive agents is a winning strategy in reducing the morbidity and mortality of breast cancer. The current study was to investigate the mechanism-based chemopreventive...

    Authors: Jingwei Li, Xiaofei Liu, Hongzhi Chen, Ziyuan Sun, Hanhan Chen, Lei Wang, Xiaohui Sun and Xiangqi Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:48

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  20. Content type: Research article

    Libidibia ferrea (L. ferrea) has been used in folk medicine to treat several conditions and to prevent cancer. This study performed a chromatographic analysis of the crude aqueous extract of Libidibia ferrea (Mar...

    Authors: Tamires Rocha Falcão, Cássio Alexandre Oliveira Rodrigues, Aurigena Antunes de Araújo, Caroline Addison Carvalho Xavier de Medeiros, Luiz Alberto Lira Soares, Magda Rhayanny Assunção Ferreira, Roseane Carvalho Vasconcelos, Raimundo Fernandes de Araújo Júnior, Maria Luiza Diniz de Sousa Lopes and Gerlane Coelho Bernardo Guerra

    Citation: BMC Complementary and Alternative Medicine 2019 19:47

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  21. Content type: Research article

    Quinoa is a food crop native to the Andes. The process of dehulling quinoa can produce approximately 8–12% husk, which is often discarded because it contains bitter saponin. Saponin derived from quinoa has bee...

    Authors: Xiaoyan Sun, Xiushi Yang, Peng Xue, Zhiguo Zhang and Guixing Ren

    Citation: BMC Complementary and Alternative Medicine 2019 19:46

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  22. Content type: Research article

    The root of Baliospermum montanum has been used as an ingredient of traditional Thai medicines for the treatments of several diseases including itching eczema, muscle and joint inflammation, and cancer. Few studi...

    Authors: Weerachai Pipatrattanaseree, Arunporn Itharat, Nichamon Mukkasombut and Ubonwan Saesiw

    Citation: BMC Complementary and Alternative Medicine 2019 19:45

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  23. Content type: Research article

    Carica papaya leaves have been used for traditional treatment of dengue fever and have been reported to exhibit an immunomodulatory activity by affecting the level of cytokine production in vitro and in vivo. Due...

    Authors: Nor Azrina Norahmad, Mohd Ridzuan Mohd Abd Razak, Norazlan Mohmad Misnan, Nur Hana Md Jelas, Umi Rubiah Sastu, Amirrudin Muhammad, Tiffiny Chau Dee Ho, Bazilah Jusoh, Nor Azlina Zolkifli, Ravindran Thayan, Adiratna Mat Ripen, Murizal Zainol and Ami Fazlin Syed Mohamed

    Citation: BMC Complementary and Alternative Medicine 2019 19:44

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  24. Content type: Research article

    Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the ...

    Authors: Ha Na Kim, Gwang Hun Park, Su Bin Park, Jeong Dong Kim, Hyun Ji Eo, Ho-Jun Son, Jeong Ho Song and Jin Boo Jeong

    Citation: BMC Complementary and Alternative Medicine 2019 19:43

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  25. Content type: Research article

    This study aimed to elucidate the effects and mechanisms of Radix Linderae (RL) extracts on a mouse model of diabetic bladder dysfunction (DBD), especially on later decompensated phase.

    Authors: Xufeng Yang, Dawei Lian, Pinglong Fan, Yifei Xu, Jing Wang, Fangjun Chen, Huanling Lai, Weiwen Jiang, Linjie Zhang, Ping Huang and Hongying Cao

    Citation: BMC Complementary and Alternative Medicine 2019 19:41

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  26. Content type: Research article

    Borrelia sp. is a causative pathogen of Lyme disease which has become a worldwide health concern. Non-toxic approaches especially directed toward latent persistent forms of this pathogen are desired. Lipids in th...

    Authors: Anna Goc, Aleksandra Niedzwiecki and Matthias Rath

    Citation: BMC Complementary and Alternative Medicine 2019 19:40

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  27. Content type: Research article

    Alzheimer’s disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy populatio...

    Authors: Mustafa F. Alkhouli, Jun Hung, Michaela Squire, Miranda Anderson, Monica Castro, Jeganathan R. Babu, Layla Al-Nakkash, Tom L. Broderick and Jeffrey H. Plochocki

    Citation: BMC Complementary and Alternative Medicine 2019 19:39

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  28. Content type: Research article

    Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays...

    Authors: Wuguo Li, Qing Zhang, Kaotan Chen, Zhenhua Sima, Jingli Liu, Qiang Yu and Jiawei Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:38

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  29. Content type: Research article

    Listeria monocytogenes is an opportunistic foodborne pathogen that causes human Listeriosis and high mortality particularly in immunocompromised individuals. Pregnant women are more prone to L. monocytogenes infe...

    Authors: Ayesha Riaz, Saleha Noureen, Iram Liqat, Muhammad Arshad and Najma Arshad

    Citation: BMC Complementary and Alternative Medicine 2019 19:37

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  30. Content type: Research article

    Bone damage is a condition that affects the quality of life of patients. Mesenchymal stem cells (MSCs) are important for bone repair. Osteoking is a natural compound in traditional Chinese Medicine used to tre...

    Authors: Congtao Yu, Lifen Dai, Zhaoxia Ma, Hongbin Zhao, Yong Yuan, Yunfeng Zhang, Pengfei Bao, Yanfang Su, Daiping Ma, Change Liu, Xingfei Wu, Jinxue Liu, Yanjiao Li, Bing Wang and Min Hu

    Citation: BMC Complementary and Alternative Medicine 2019 19:36

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  31. Content type: Research article

    Wu-Mei-Wan (WMW) is a traditional Chinese herbal formulation that is clinically prescribed to treat diabetes mellitus in China. WMW has been shown to alleviate damage in pancreatic β cells, but the underlying ...

    Authors: Xueping Yang, Fuer Lu, Lingli Li, Jingbin Li, Jinlong Luo, Siyi Zhang, Xinqiao Liu and Guang Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:35

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  32. Content type: Research article

    Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a major cause of disease in pregnant women and new born babies where it causes early and late onset disease characterised by sepsis, pneumonia...

    Authors: Munyaradzi Mukesi, Benson C. Iweriebor, Larry C. Obi, Uchechukwu U. Nwodo, Sylvester R. Moyo and Anthony I. Okoh

    Citation: BMC Complementary and Alternative Medicine 2019 19:34

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  33. Content type: Research article

    Royal jelly (RJ) has been used traditionally for dietary, cosmetic and health purposes for a long time in different parts of the world. Scientific studies have also shown its numerous health-promoting properti...

    Authors: Prakash Raj Pandeya, Ramakanta Lamichhane, Kyung-Hee Lee, Se-Gun Kim, Dae-Ho Lee, Hyeong-Kyu Lee and Hyun-Ju Jung

    Citation: BMC Complementary and Alternative Medicine 2019 19:33

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  34. Content type: Research article

    Colorectal malignant neoplasms is one of the leading causes of death in both men and women in the developed world and the incidence has recently increased markedly in South Africa. Studies have highlighted the...

    Authors: Wagheda Cassiem and Maryna de Kock

    Citation: BMC Complementary and Alternative Medicine 2019 19:32

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  35. Content type: Research article

    Opuntia ficus-indica var. saboten (OFIS) is used widely in Korea to treat constipation due to its diuretic effects and its enhancement of bowel function and appetite. However, its safety has not yet been establis...

    Authors: Eun Hye Han, Mi Kyung Lim, Sang Ho Lee, Md. Mahbubur Rahman and Young-Hee Lim

    Citation: BMC Complementary and Alternative Medicine 2019 19:31

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  36. Content type: Research article

    Exposure of skin to urban air pollutants is closely related to skin aging and inflammatory responses such as wrinkles formation, pigmentation spot, atopic dermatitis, and acne. Thus, a great deal of interest h...

    Authors: Minkyung Kim, Dahee Son, Seoungwoo Shin, Deokhoon Park, Sangyo Byun and Eunsun Jung

    Citation: BMC Complementary and Alternative Medicine 2019 19:30

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  37. Content type: Research article

    In-depth information of potential drug-herb interactions between warfarin and herbal compounds with suspected anticoagulant blood thinning effects is needed to raise caution of concomitant administration. The ...

    Authors: Maisa Alnaqeeb, Kenza A. Mansor, Eyad M. Mallah, Bayan Y. Ghanim, Nasir Idkaidek and Nidal A. Qinna

    Citation: BMC Complementary and Alternative Medicine 2019 19:29

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  38. Content type: Research article

    A combination of parts of Cornus officinalis, Rosa multiflora, Lespedeza bicolor, Platycladus orientalis, and Castanea crenata is commonly used for alleviating inflammatory skin disorders. Therefore, this study w...

    Authors: Abraham Fikru Mechesso, Seung-Jin Lee, Na-Hye Park, Jin-Yoon Kim, Zi-Eum Im, Joo-Won Suh and Seung-Chun Park

    Citation: BMC Complementary and Alternative Medicine 2019 19:25

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  39. Content type: Research article

    An alarm increase the rate of emerging and re-emerging of multidrug resistant bacteria have been caused great public health concern in the worldwide. They have been resisting for most or majority of currently ...

    Authors: Eshetu Gadisa, Gebru Weldearegay, Kassu Desta, Getahun Tsegaye, Sityehu Hailu, Kefiyelewu Jote and Abera Takele

    Citation: BMC Complementary and Alternative Medicine 2019 19:24

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  40. Content type: Research article

    Women diagnosed with breast cancer frequently seek complementary and alternative (CAM) treatment options that can help to cope with their disease and the side effects of conventional cancer therapy. Especially...

    Authors: U. Weissenstein, M. Kunz, M. Oufir, J. T. Wang, M. Hamburger, K. Urech, U. Regueiro and S. Baumgartner

    Citation: BMC Complementary and Alternative Medicine 2019 19:23

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  41. Content type: Research article

    Impaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. The risk of developing diabetic foot ulcers for diabetic patients is 15% over th...

    Authors: Woan Sean Tan, Palanisamy Arulselvan, Shiow-Fern Ng, Che Norma Mat Taib, Murni Nazira Sarian and Sharida Fakurazi

    Citation: BMC Complementary and Alternative Medicine 2019 19:20

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  42. Content type: Research article

    A Panchvalkal formulation (Pentaphyte P-5®) mentioned in ancient texts of Indian traditional medicine was investigated for its anti-infective potential against Pseudomonas aeruginosa.

    Authors: Chinmayi Joshi, Pooja Patel, Hanmanthrao Palep and Vijay Kothari

    Citation: BMC Complementary and Alternative Medicine 2019 19:19

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  43. Content type: Research article

    The present study was carried out to prepare multi-herbal combination via comparing antioxidant activity and polyphenolic composition of five medicinal plant extracts of Punica granatum L., Putranjiva roxburghii ...

    Authors: Pardeep Kaur, Robin, Rajendra G. Mehta, Balbir Singh and Saroj Arora

    Citation: BMC Complementary and Alternative Medicine 2019 19:18

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  44. Content type: Research article

    Asian traditional herbal remedies are typically a concoction of a major and several complementary herbs. While balancing out any adverse effect of the major herb, the complementary herbs could dilute the effic...

    Authors: Jin-Woo Han, Kyun Ha Kim, Min-Jung Kwun, Jun-Yong Choi, Sang-Jun Kim, Seung-Il Jeong, Beom-Joon Lee, Kwan-Il Kim, Ran Won, Ji Hoon Jung, Hee Jae Jung and Myungsoo Joo

    Citation: BMC Complementary and Alternative Medicine 2019 19:15

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  45. Content type: Research article

    Coreopsis tinctoria Nutt is an ethnomedicine widely used in Xinjiang, China. It is consumed as a herbal tea by local Uyghur people to treat high blood pressure and diarrhea. Our previous study confirmed that the ...

    Authors: Lan Yao, Jie Li, Linlin Li, Xinxia Li, Rui Zhang, Yujie Zhang and Xinmin Mao

    Citation: BMC Complementary and Alternative Medicine 2019 19:14

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  46. Content type: Research article

    Post-traumatic stress disorder (PTSD) is a disease associated with that the experience of traumatic stress. The traumatic experience results in the development of a prolonged stress response that causes impair...

    Authors: Bombi Lee, Riwon Hong, Pooreum Lim, Daeun Cho, Mijung Yeom, Sanghyun Lee, Ki Sung Kang, Sang Cheon Lee, Insop Shim, Hyejung Lee and Dae-Hyun Hahm

    Citation: BMC Complementary and Alternative Medicine 2019 19:11

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  47. Content type: Research article

    ChondroT, a new herbal medication, consists of the water extracts of Osterici Radix, Lonicerae Folium, Angelicae Gigantis Radix, Clematidis Radix, and Phellodendri Cortex (6:4:4:4:3). We previously reported that

    Authors: Dool-Ri Oh, Jong Ro Kim, Chul Yung Choi, Chan-hun Choi, Chang-su Na, Bok Yun Kang, Seon-Jong Kim and Young Ran Kim

    Citation: BMC Complementary and Alternative Medicine 2019 19:10

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  48. Content type: Research article

    Danggui Buxue Tang (DBT) is a historical Chinese herbal decoction, and which has more than 800 years of applications. This herbal decoction solely contains two materials: Astragali Radix (AR) and Angelicae Sinens...

    Authors: Guowei Gong, Baohui Qi, Yan T. Liang, Tina T. X. Dong, Huai Y. Wang, Karl W. K. Tsim and Yuzhong Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:9

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  49. Content type: Research article

    Ling-gui-zhu-gan decoction (LGZG), a classic traditional Chinese medicine formula, has been confirmed to be effective in improving steatosis in non-alcoholic fatty liver disease (NAFLD). However, the mechanism...

    Authors: Yanqi Dang, Shijun Hao, Wenjun Zhou, Li Zhang and Guang Ji

    Citation: BMC Complementary and Alternative Medicine 2019 19:8

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