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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Content type: Research article

    In Traditional Chinese Medicine (TCM), tongue diagnosis has been an important diagnostic method for the last 3000 years. Tongue diagnosis is a non-invasive, simple and valuable diagnostic tool. TCM treats the ...

    Authors: Zhu-Mei Sun, Jie Zhao, Peng Qian, Yi-Qin Wang, Wei-Fei Zhang, Chun-Rong Guo, Xiao-Yan Pang, Shun-Chun Wang, Fu-Feng Li and Qi Li

    Citation: BMC Complementary and Alternative Medicine 2013 13:227

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  2. Content type: Research article

    We report results of a pilot study designed to test a novel smoking cessation intervention, Mindfulness Training for Smokers (MTS), in smokers age 18-29 years with regular episodes of binge drinking. Mindfulne...

    Authors: James M Davis, David M Mills, Kristin A Stankevitz, Alison R Manley, Matthew R Majeskie and Stevens S Smith

    Citation: BMC Complementary and Alternative Medicine 2013 13:215

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  3. Content type: Case report

    Rhabdomyolysis is an uncommon side effect of trabectedin which is used for the second line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. This side effect may be due to pharmacokinet...

    Authors: Sabino Strippoli, Vito Lorusso, Anna Albano and Michele Guida

    Citation: BMC Complementary and Alternative Medicine 2013 13:199

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  4. Content type: Research article

    In recent years, red yeast rice (RYR) supplements have been marketed aggressively as a natural way to lower cholesterol; however, the large majority of commercially available products have not been studied accord...

    Authors: Veronique Verhoeven, Maja Lopez Hartmann, Roy Remmen, Johan Wens, Sandra Apers and Paul Van Royen

    Citation: BMC Complementary and Alternative Medicine 2013 13:178

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  5. Content type: Research article

    Our aim was to evaluate the recovery effects of hydrotherapy after aerobic exercise in cardiovascular, performance and perceived fatigue.

    Authors: Antonio I Cuesta-Vargas, Alvaro Travé-Mesa, Alberto Vera-Cabrera, Dario Cruz-Terrón, Adelaida M Castro-Sánchez, Cesar Fernández-de-las-Peñas and Manuel Arroyo-Morales

    Citation: BMC Complementary and Alternative Medicine 2013 13:180

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  6. Content type: Research article

    Aromatherapy and hand massage therapies have been reported to have some benefit for people with dementia who display behavioural symptoms; however there are a number of limitations of reported studies. The aim...

    Authors: Chieh-Yu Fu, Wendy Moyle and Marie Cooke

    Citation: BMC Complementary and Alternative Medicine 2013 13:165

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  7. Content type: Research article

    Chronic pain affects nearly 116 million American adults at an estimated cost of up to $635 billion annually and is the No. 1 condition for which patients seek care at integrative medicine clinics. In our Study...

    Authors: Donald I Abrams, Rowena Dolor, Rhonda Roberts, Constance Pechura, Jeffery Dusek, Sandi Amoils, Steven Amoils, Kevin Barrows, Joel S Edman, Joyce Frye, Erminia Guarneri, Ben Kligler, Daniel Monti, Myles Spar and Ruth Q Wolever

    Citation: BMC Complementary and Alternative Medicine 2013 13:146

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  8. Content type: Research article

    Women with polycystic ovary syndrome (PCOS) have symptoms of depression and anxiety and impaired health related quality of life (HRQoL). Here we test the post-hoc hypothesis that acupuncture and exercise impro...

    Authors: Elisabet Stener-Victorin, Göran Holm, Per Olof Janson, Deborah Gustafson and Margda Waern

    Citation: BMC Complementary and Alternative Medicine 2013 13:131

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  9. Content type: Research article

    Distressed individuals in Korea may benefit from the practice of mind–body exercises such as Qigong. However, the effectiveness of such techniques needs to be investigated.

    Authors: Eun-Young Hwang, Sun-Yong Chung, Jae-Heung Cho, Mi-Yeon Song, Sehyun Kim and Jong-Woo Kim

    Citation: BMC Complementary and Alternative Medicine 2013 13:113

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  10. Content type: Research article

    Diabetes remains a major health problem worldwide. Low-risk low-cost alternatives to pharmaceutical interventions are needed where lifestyle modifications have failed. We conducted a double-blind randomised pl...

    Authors: Suzanne J Grant, Dennis Hsu-Tung Chang, Jianxun Liu, Vincent Wong, Hosen Kiat and Alan Bensoussan

    Citation: BMC Complementary and Alternative Medicine 2013 13:104

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  11. Content type: Research article

    Tai Chi training enhances physical function and may reduce falls in older adults with and without balance disorders, yet its effect on postural control as quantified by the magnitude or speed of center-of-pres...

    Authors: Brad Manor, Lewis A Lipsitz, Peter M Wayne, C-K Peng and Li Li

    Citation: BMC Complementary and Alternative Medicine 2013 13:87

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  12. Content type: Research article

    Flight simulators have been used to train pilots to experience and recognize spatial disorientation, a condition in which pilots incorrectly perceive the position, location, and movement of their aircrafts. Ho...

    Authors: Hsin Chu, Min-Hui Li, Yu-Cheng Huang and Shih-Yu Lee

    Citation: BMC Complementary and Alternative Medicine 2013 13:84

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  13. Content type: Research article

    Chronic work-related stress is an independent risk factor for cardiometabolic diseases and associated mortality, particularly when compounded by a sedentary work environment. The purpose of this study was to d...

    Authors: Birinder S Cheema, Angelique Houridis, Lisa Busch, Verena Raschke-Cheema, Geoff W Melville, Paul W Marshall, Dennis Chang, Bianca Machliss, Chris Lonsdale, Julia Bowman and Ben Colagiuri

    Citation: BMC Complementary and Alternative Medicine 2013 13:82

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  14. Content type: Research article

    The effect of massage therapy on bone metabolism in adults has only scarcely been explored. In a randomized crossover trial, we investigated the skeletal effect of Thai traditional massage by examining the cha...

    Authors: Sunee Saetung, La-or Chailurkit and Boonsong Ongphiphadhanakul

    Citation: BMC Complementary and Alternative Medicine 2013 13:69

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  15. Content type: Research article

    Treatment of cardiac syndrome X with unknown pathological mechanism remains a big challenge for clinicians. Complementary and alternative medicine may bring a new choice for its management. The aim of this stu...

    Authors: Jia-ying Wang, Lu Xiao, Jing Chen, Jing-bo Zhai, Wei Mu, Jing-yuan Mao and Hongcai Shang

    Citation: BMC Complementary and Alternative Medicine 2013 13:62

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  16. Content type: Study protocol

    The treatment of knee osteoarthritis, which is a major cause of disability among the elderly, is typically selected from multidisciplinary options, including complementary and alternative medicine. Moxibustion...

    Authors: Seunghoon Lee, Kun Hyung Kim, Tae-Hun Kim, Jung-Eun Kim, Joo-Hee Kim, Jung Won Kang, Kyung-Won Kang, So-Young Jung, Ae-Ran Kim, Hyo-Ju Park, Mi-Suk Shin, Kwon-Eui Hong, Ho-Sueb Song, Jin-Bong Choi, Hyung-Jun Kim and Sun-Mi Choi

    Citation: BMC Complementary and Alternative Medicine 2013 13:59

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  17. Content type: Research article

    Previous animal studies have shown that Curcuma longa (turmeric) improves liver function. Turmeric may thus be a promising ingredient in functional foods aimed at improving liver function. The purpose of the stud...

    Authors: Sang-Wook Kim, Ki-Chan Ha, Eun-Kyung Choi, Su-Young Jung, Min-Gul Kim, Dae-Young Kwon, Hye-Jung Yang, Min-Jung Kim, Hee-Joo Kang, Hyang-Im Back, Sun-Young Kim, Soo-Hyun Park, Hum-Young Baek, Yong-Jae Kim, Joon-Yeol Lee and Soo-Wan Chae

    Citation: BMC Complementary and Alternative Medicine 2013 13:58

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  18. Content type: Research article

    Ankle sprain is one of the most frequently encountered musculoskeletal injuries; however, the efficacy of acupuncture in treating ankle sprains remains uncertain. We therefore performed a systematic review to ...

    Authors: Jimin Park, Seokyung Hahn, Ji-Yeun Park, Hi-Joon Park and Hyangsook Lee

    Citation: BMC Complementary and Alternative Medicine 2013 13:55

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  19. Content type: Research article

    Chinese herbal medicine (CHM) has been used in China and some other countries for the treatment of patients with functional dyspepsia (FD). However, controlled studies supporting the efficacy of such treatment...

    Authors: Shengsheng Zhang, Luqing Zhao, Hongbing Wang, Chuijie Wang, Suiping Huang, Hong Shen, Wei Wei, Lin Tao and Tao Zhou

    Citation: BMC Complementary and Alternative Medicine 2013 13:54

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  20. Content type: Study protocol

    Elevated stress can exacerbate cancer symptom severity, and after completion of primary cancer treatments, many individuals continue to have significant distress. Mindfulness-Based Cancer Recovery (MBCR) is an...

    Authors: Kristin A Zernicke, Tavis S Campbell, Michael Speca, Kelley McCabe-Ruff, Steven Flowers, Dale A Dirkse and Linda E Carlson

    Citation: BMC Complementary and Alternative Medicine 2013 13:34

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  21. Content type: Research article

    Insomnia is a widespread human health problem, but there currently are the limitations of conventional therapies available. Suanzaoren decoction (SZRD) is a well known classic Chinese herbal prescription for i...

    Authors: Cheng-long Xie, Yong Gu, Wen-Wen Wang, Lin Lu, Deng-lei Fu, Ai-ju Liu, Hui-qin Li, Ji-huang Li, Yan Lin, Wen-jie Tang and Guo-qing Zheng

    Citation: BMC Complementary and Alternative Medicine 2013 13:18

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  22. Content type: Research article

    The number of older adults participating in yoga has increased dramatically in recent years; yet, the physical demands associated with yoga performance have not been reported. The primary aim of the Yoga Empow...

    Authors: Man-Ying Wang, Sean S-Y Yu, Rami Hashish, Sachithra D Samarawickrame, Leslie Kazadi, Gail A Greendale and George Salem

    Citation: BMC Complementary and Alternative Medicine 2013 13:8

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  23. Content type: Study protocol

    Depressive disorders are the most common form of mental disorders in community and health care settings. Unfortunately, the treatment of Major Depressive Disorder (MDD) is far from satisfactory. Vagus nerve st...

    Authors: Pei-Jing Rong, Ji-Liang Fang, Li-Ping Wang, Hong Meng, Jun Liu, Ying-ge Ma, Hui Ben, Liang Li, Ru-Peng Liu, Zhan-Xia Huang, Yu-Feng Zhao, Xia Li, Bing Zhu and Jian Kong

    Citation: BMC Complementary and Alternative Medicine 2012 12:255

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  24. Content type: Research article

    Tinnitus, the perception of sound in absence of an external acoustic source, impairs the quality of life in 2% of the population. Since in most cases causal treatment is not possible, the majority of therapeut...

    Authors: Peter M Kreuzer, Monika Goetz, Maria Holl, Martin Schecklmann, Michael Landgrebe, Susanne Staudinger and Berthold Langguth

    Citation: BMC Complementary and Alternative Medicine 2012 12:235

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  25. Content type: Research article

    Shivering during regional anesthesia is a common complication and is related to a decrease in the patient’s core body temperature. Previous studies have shown that acupuncture on specific acupoints can preserv...

    Authors: Bo-Yan Yeh, Yi-Chun Hsu, Jyun-Yan Huang, I-Ting Shih, Wei-Jia Zhuo, Yung-Fong Tsai, Chee-Jen Chang and Huang-Ping Yu

    Citation: BMC Complementary and Alternative Medicine 2012 12:233

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  26. Content type: Study protocol

    Stroke is one of the leading causes of death and disability in China. Current treatments for stroke are limited and achieve no optimal effect. Acupuncture is widely used in the treatment of stroke and in impro...

    Authors: Huilin Liu, Dangsheng Zhang, Xiuge Tan, Daqing Yang, Guiling Wang, Yin Zhao, Yali Wen, Guangxia Shi and Linpeng Wang

    Citation: BMC Complementary and Alternative Medicine 2012 12:216

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  27. Content type: Study protocol

    Irritable bowel syndrome is a chronic condition with no known cure. Many sufferers seek complementary and alternative medicine including homeopathic treatment. However there is much controversy as to the effec...

    Authors: Emily J Peckham, Clare Relton, Jackie Raw, Clare Walters, Kate Thomas and Christine Smith

    Citation: BMC Complementary and Alternative Medicine 2012 12:212

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  28. Content type: Research article

    Multiple sclerosis (MS) is a complex autoimmune disease mediated by an immune response to central nervous system antigens. Modern immunomodulatory therapies, however, do not ameliorate many of the symptoms, su...

    Authors: Juan G Quispe-Cabanillas, Alfredo Damasceno, Felipe von Glehn, Carlos O Brandão, Benito P Damasceno, Wanderley D Silveira and Leonilda MB Santos

    Citation: BMC Complementary and Alternative Medicine 2012 12:209

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  29. Content type: Research article

    Traditional Chinese medicine (TCM) has been used to treat chronic obstructive pulmonary disease (COPD) for many years. This study aimed to evaluate the efficacy and safety of the comprehensive therapy based on...

    Authors: Su-yun Li, Jian-sheng Li, Ming-hang Wang, Yang Xie, Xue-qing Yu, Zi-kai Sun, Li-jun Ma, Wei Zhang, Hai-long Zhang, Fan Cao and Ying-chao Pan

    Citation: BMC Complementary and Alternative Medicine 2012 12:197

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  30. Content type: Research article

    Cupping is used in various traditional medicine forms to relieve pain in musculoskeletal diseases. The aim of this study was to investigate the effectiveness of cupping in relieving the symptoms of knee osteoa...

    Authors: Michael Teut, Stefan Kaiser, Miriam Ortiz, Stephanie Roll, Sylvia Binting, Stefan N Willich and Benno Brinkhaus

    Citation: BMC Complementary and Alternative Medicine 2012 12:184

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  31. Content type: Research article

    Mistletoe (Viscum album L.) extracts are widely used in complementary cancer therapy. Aim of this study was to evaluate safety and efficacy of a standardized mistletoe extract (abnobaVISCUM® Quercus, aVQ) in p...

    Authors: Kab-Choong Kim, Jeong-Hwan Yook, Jürgen Eisenbraun, Byung-Sik Kim and Roman Huber

    Citation: BMC Complementary and Alternative Medicine 2012 12:172

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  32. Content type: Research article

    Difficulty in controlling attention can lead to mental fatigue in the healthy population. We identified one trial reporting a benefit in patients’ attention using a homeopathic formula preparation. One compone...

    Authors: Michael Emmans Dean, Raj Karsandas, J Martin Bland, Debbie Gooch and Hugh MacPherson

    Citation: BMC Complementary and Alternative Medicine 2012 12:167

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  33. Content type: Research article

    Mindfulness-based stress reduction (MBSR) is frequently used for pain conditions. While systematic reviews on MBSR for chronic pain have been conducted, there are no reviews for specific pain conditions. There...

    Authors: Holger Cramer, Heidemarie Haller, Romy Lauche and Gustav Dobos

    Citation: BMC Complementary and Alternative Medicine 2012 12:162

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  34. Content type: Study protocol

    Despite the growing popularity of massage, its effectiveness for treating neck pain remains unclear, largely because of the poor quality of research. A major deficiency of previous studies has been their use o...

    Authors: Karen J Sherman, Andrea J Cook, Janet R Kahn, Rene J Hawkes, Robert D Wellman and Daniel C Cherkin

    Citation: BMC Complementary and Alternative Medicine 2012 12:158

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  35. Content type: Research article

    Common cold is caused by a variety of respiratory viruses. The prevalence in children is high, and it potentially contributes to significant morbidity. Iota-carragenan, a polymer derived from red seaweed, has ...

    Authors: Tamas Fazekas, Philipp Eickhoff, Nathalie Pruckner, Georg Vollnhofer, Gustav Fischmeister, Christopher Diakos, Margit Rauch, Maria Verdianz, Andreas Zoubek, Helmut Gadner and Thomas Lion

    Citation: BMC Complementary and Alternative Medicine 2012 12:147

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  36. Content type: Study protocol

    Despite high levels of clinically significant persistent cancer related fatigue in breast cancer survivors few treatments are currently available and most pose a significant burden on the part of the woman. Ac...

    Authors: Suzanna Maria Zick, Gwen Karilyn Wyatt, Susan Lynn Murphy, J Todd Arnedt, Ananda Sen and Richard Edmund Harris

    Citation: BMC Complementary and Alternative Medicine 2012 12:132

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  37. Content type: Research article

    In the field of acupuncture research, the topic of acupoint specificity has received increasing attention, but no unified conclusion has been reached on whether or not acupoint specificity exists. Furthermore,...

    Authors: Jie Yang, Fang Zeng, Yue Feng, Li Fang, Wei Qin, Xuguang Liu, Wenzhong Song, Hongjun Xie, Ji Chen and Fanrong Liang

    Citation: BMC Complementary and Alternative Medicine 2012 12:123

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  38. Content type: Research article

    Complementary and alternative medicine (CAM) has frequently been used to treat tinnitus, and acupuncture is a particularly popular option. The objective of this review was to assess the evidence concerning the...

    Authors: Jong-In Kim, Jun-Yong Choi, Dong-Hyo Lee, Tae-Young Choi, Myeong Soo Lee and Edzard Ernst

    Citation: BMC Complementary and Alternative Medicine 2012 12:97

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  39. Content type: Research article

    Infection with HIV-1 results in marked immunologic insults and structural damage to the intestinal mucosa, including compromised barrier function. While the development of highly active antiretroviral therapy ...

    Authors: Marco Schunter, Hiutung Chu, Timothy L Hayes, Delandy McConnell, Sean S Crawford, Paul A Luciw, Stig Bengmark, David M Asmuth, Jennifer Brown, Charles L Bevins, Barbara L Shacklett and J William Critchfield

    Citation: BMC Complementary and Alternative Medicine 2012 12:84

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