Skip to content

Advertisement

Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

Page 5 of 6

  1. Content type: Research article

    Plantago ovata husk therapy could be used in patients with Parkinson disease to reduce the symptoms of gastrointestinal disorders, but it is important to know whether this compound modifies levodopa pharmacoki...

    Authors: M Nelida Fernandez-Martinez, Luis Hernandez-Echevarria, Matilde Sierra-Vega, M Jose Diez-Liebana, Angela Calle-Pardo, Demetrio Carriedo-Ule, Ana M Sahagún-Prieto, Anna Anguera-Vila and Juan Jose Garcia-Vieitez

    Citation: BMC Complementary and Alternative Medicine 2014 14:296

    Published on:

  2. Content type: Study protocol

    Low back pain (LBP) is a major health issue due to its high prevalence rate and socioeconomic cost. While spinal manipulation (SM) is recommended for LBP treatment by recently published clinical guidelines, th...

    Authors: Ting Xia, David G Wilder, Maruti R Gudavalli, James W DeVocht, Robert D Vining, Katherine A Pohlman, Gregory N Kawchuk, Cynthia R Long and Christine M Goertz

    Citation: BMC Complementary and Alternative Medicine 2014 14:292

    Published on:

  3. Content type: Research article

    Oral mucositis is one of the common complications of cancer chemotherapy and about 40% of the patients who take chemotherapy protocols, experience this irritating problem. The purpose of this study was to draw...

    Authors: Mohammad Ali Raeessi, Neda Raeessi, Yunes Panahi, Homa Gharaie, Seyyed Masoud Davoudi, Alireza Saadat, Ali Akbar Karimi Zarchi, Fereshteh Raeessi, Seyyed Mostafa Ahmadi and Hamidreza Jalalian

    Citation: BMC Complementary and Alternative Medicine 2014 14:293

    Published on:

  4. Content type: Study protocol

    Stroke is one of the most common causes of cognitive impairment. Up to 75% of stroke survivors may be considered to have cognitive impairment, which severely limit individual autonomy for successful reintegrat...

    Authors: Shanli Yang, Haicheng Ye, Jia Huang, Jing Tao, Cai Jiang, Zhicheng Lin, Guohua Zheng and Lidian Chen

    Citation: BMC Complementary and Alternative Medicine 2014 14:290

    Published on:

  5. Content type: Research article

    Many Chinese patent medicines (CPMs) have been authorized by the Chinese State of Food and Drug Administration for the treatment of the common cold. A number of clinical trials have been conducted and publishe...

    Authors: Wei Chen, Bo Liu, Li-qiong Wang, Jun Ren and Jian-ping Liu

    Citation: BMC Complementary and Alternative Medicine 2014 14:273

    Published on:

  6. Content type: Research article

    Korean red ginseng (KRG) is a processed ginseng from raw ginseng to enhance safety, preservation and efficacy, known having beneficial effects on women’s health due to its estrogen like function. While estroge...

    Authors: Mihi Yang, Ho-Sun Lee, Min-Woo Hwang and Mirim Jin

    Citation: BMC Complementary and Alternative Medicine 2014 14:265

    Published on:

  7. Content type: Study protocol

    Acupuncture is safe and may be effective for severe chronic constipation. The World Gastroenterology Organisation recommends prucalopride for patients for whom previous laxative use failed to provide satisfact...

    Authors: Baoyan Liu, Yang Wang, Jiani Wu, Qian Mo, Weiming Wang, Liyun He, Shiyan Yan and Zhishun Liu

    Citation: BMC Complementary and Alternative Medicine 2014 14:260

    Published on:

  8. Content type: Research article

    Our previous studies have demonstrated the treatment benefits of dense cranial electroacupuncture stimulation (DCEAS), a novel brain stimulation therapy in patients with major depression, postpartum depression...

    Authors: Sui-Cheung Man, Ben H B Hung, Roger M K Ng, Xiao-Chun Yu, Hobby Cheung, Mandy P M Fung, Leonard S W Li, Kwok-Pui Leung, Kei-Pui Leung, Kevin W Y Tsang, Eric Ziea, Vivian T Wong and Zhang-Jin Zhang

    Citation: BMC Complementary and Alternative Medicine 2014 14:255

    Published on:

  9. Content type: Research article

    Visceral obesity is associated with facial characteristics and chronic disease, but no studies on the best predictor of visceral obesity based on facial characteristics have been reported. The aims of the pres...

    Authors: Bum Ju Lee and Jong Yeol Kim

    Citation: BMC Complementary and Alternative Medicine 2014 14:248

    Published on:

  10. Content type: Research article

    Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common cause of morbidity and mortality. Traditional Chinese medicine (TCM) is used to treat AECOPD as adjunctive therapy. This study a...

    Authors: Miao Liu, Xianggen Zhong, Yuhang Li, Fengjie Zheng, Ruohan Wu, Yan Sun and Jinchao Zhang

    Citation: BMC Complementary and Alternative Medicine 2014 14:239

    Published on:

  11. Content type: Research article

    Red ginseng is prepared by steaming raw ginseng, a process believed to increase the pharmacological efficacy. Further bioconversion of red ginseng through fermentation is known to increase its intestinal absor...

    Authors: Mi-Ra Oh, Soo-Hyun Park, Sun-Young Kim, Hyang-Im Back, Min-Gul Kim, Ji-Young Jeon, Ki-Chan Ha, Won-Taek Na, Youn-Soo Cha, Byung-Hyun Park, Tae-sun Park and Soo-Wan Chae

    Citation: BMC Complementary and Alternative Medicine 2014 14:237

    Published on:

  12. Content type: Research article

    Endometriosis affects fertility negatively. The study aims to evaluate whether laparoscopic surgery combined with oral contraceptive or herbs were more effective than laparoscopic alone in improving fecundity ...

    Authors: Shaomi Zhu, Dong Liu, Wei Huang, Qiushi Wang, Qiuyi Wang, Lu Zhou and Guimei Feng

    Citation: BMC Complementary and Alternative Medicine 2014 14:222

    Published on:

  13. Content type: Research article

    Secondary arm lymphoedema continues to affect at least 20% of women after treatment for breast cancer requiring lifelong professional treatment and self-management. The holistic practice of yoga may offer bene...

    Authors: Annette Loudon, Tony Barnett, Neil Piller, Maarten A Immink and Andrew D Williams

    Citation: BMC Complementary and Alternative Medicine 2014 14:214

    Published on:

  14. Content type: Research article

    Type 2 diabetes is a major health problem in many countries including India. Yoga may be an effective type 2 diabetes prevention strategy in India, particularly given its cultural familiarity.

    Authors: Kelly A McDermott, Mohan Raghavendra Rao, Raghuram Nagarathna, Elizabeth J Murphy, Adam Burke, Ramarao Hongasandra Nagendra and Frederick M Hecht

    Citation: BMC Complementary and Alternative Medicine 2014 14:212

    Published on:

  15. Content type: Research article

    To evaluate and compare 6-month effects of 8 weeks of an integrative treatment (IT), therapeutic acupuncture (TA), and conventional treatment (CT) in reducing symptoms of anxiety, depression and in improving h...

    Authors: Tina Arvidsdotter, Bertil Marklund and Charles Taft

    Citation: BMC Complementary and Alternative Medicine 2014 14:210

    Published on:

  16. Content type: Research article

    Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance, increased risk of type II diabetes, and cardiovascular pathology. Recently, investigators h...

    Authors: Feng Huang, Jianxun Dong, Jian Kong, Hongcai Wang, Hong Meng, Rosa B Spaeth, Stephanie Camhi, Xing Liao, Xia Li, Xu Zhai, Shaoyuan Li, Bing Zhu and Peijing Rong

    Citation: BMC Complementary and Alternative Medicine 2014 14:203

    Published on:

    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2016 16:218

  17. Content type: Research article

    Acupuncture is commonly used to reduce pain during labour despite contradictory results. The aim of this study is to evaluate the effectiveness of acupuncture with manual stimulation and acupuncture with combi...

    Authors: Linda Vixner, Erica Schytt, Elisabet Stener-Victorin, Ulla Waldenström, Hans Pettersson and Lena B Mårtensson

    Citation: BMC Complementary and Alternative Medicine 2014 14:187

    Published on:

  18. Content type: Research article

    Gastrointestinal (GI) discomfort, e.g. bloating or rumbling, is a common symptom in otherwise healthy adults. Approximately 20% of the population, particularly women suffer from gastrointestinal discomfort and...

    Authors: Sybille Buchwald-Werner, Hajime Fujii, Claudia Reule and Christiane Schoen

    Citation: BMC Complementary and Alternative Medicine 2014 14:173

    Published on:

  19. Content type: Research article

    The management of osteoarthritis (OA) remains a challenge. There is a need not only for safe and efficient treatments but also for accurate and reliable biomarkers that would help diagnosis and monitoring both...

    Authors: Yves Henrotin, Myriam Gharbi, Yvan Dierckxsens, Fabian Priem, Marc Marty, Laurence Seidel, Adelin Albert, Elisabeth Heuse, Valérie Bonnet and Caroline Castermans

    Citation: BMC Complementary and Alternative Medicine 2014 14:159

    Published on:

  20. Content type: Research article

    Acupuncture and moxibustion have widely been used to treat lateral elbow pain (LEP). A comprehensive systematic review of randomized controlled trials (RCTs) including both English and Chinese databases was co...

    Authors: Marcus Gadau, Wing-Fai Yeung, Hua Liu, Chris Zaslawski, Yuan-Sheng Tan, Fu-Chun Wang, Sergio Bangrazi, Ka-Fai Chung, Zhao-Xiang Bian and Shi-Ping Zhang

    Citation: BMC Complementary and Alternative Medicine 2014 14:136

    Published on:

  21. Content type: Study protocol

    Preliminary research shows ginger may be an effective adjuvant treatment for chemotherapy-induced nausea and vomiting but significant limitations need to be addressed before recommendations for clinical practi...

    Authors: Wolfgang Marx, Alexandra L McCarthy, Karin Ried, Luis Vitetta, Daniel McKavanagh, Damien Thomson, Avni Sali and Liz Isenring

    Citation: BMC Complementary and Alternative Medicine 2014 14:134

    Published on:

  22. Content type: Research article

    In a large randomised trial in patients with seasonal allergic rhinitis (SAR), acupuncture was superior compared to sham acupuncture and rescue medication. The aim of this paper is to describe the characterist...

    Authors: Miriam Ortiz, Claudia M Witt, Sylvia Binting, Cornelia Helmreich, Josef Hummelsberger, Florian Pfab, Michael Wullinger, Dominik Irnich, Klaus Linde, Bodo Niggemann, Stefan N Willich and Benno Brinkhaus

    Citation: BMC Complementary and Alternative Medicine 2014 14:128

    Published on:

  23. Content type: Case report

    Complementary and alternative medicine is often used by patients with malignant glioma. Although several interactions of various alternative agents with chemotherapy are known, none has been described for temo...

    Authors: Thomas Melchardt, Teresa Magnes, Lukas Weiss, Michael Grundbichler, Michael Strasser, Clemens Hufnagl, Martin Moik, Richard Greil and Alexander Egle

    Citation: BMC Complementary and Alternative Medicine 2014 14:115

    Published on:

  24. Content type: Research article

    Deqi is a central concept in traditional Chinese acupuncture. We performed a secondary analysis on data from a larger randomized controlled trial (RCT) in order to assess the effect of acupuncture on deqi traits...

    Authors: Guang-Xia Shi, Qian-Qian Li, Cun-Zhi Liu, Jiang Zhu, Lin-Peng Wang, Jing Wang, Li-Li Han, Li-Ping Guan and Meng-Meng Wu

    Citation: BMC Complementary and Alternative Medicine 2014 14:69

    Published on:

  25. Content type: Research article

    Moringa oleifera is a plant found in many tropical and subtropical countries. Many different uses and properties have been attributed to this plant, mainly as a nutritional supplement and as a water purifier. It...

    Authors: Belen Torondel, David Opare, Bjorn Brandberg, Emma Cobb and Sandy Cairncross

    Citation: BMC Complementary and Alternative Medicine 2014 14:57

    Published on:

  26. Content type: Research article

    Declining cognitive function is relatively common and increasingly prevalent. Studies have shown that different nutrients (e.g., Ginkgo biloba and vitamin E) appear to be effective at improving memory and conc...

    Authors: John E Lewis, Angelica B Melillo, Eduard Tiozzo, Lawrence Chen, Susanna Leonard, Mark Howell, Janelle Diaz, Kathy Gonzalez, Judi M Woolger, Janet Konefal, Elaine Paterson and David Barnes

    Citation: BMC Complementary and Alternative Medicine 2014 14:43

    Published on:

    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2014 14:332

  27. Content type: Research article

    There is an urgent need for innovative and developmentally appropriate lifestyle interventions to promote healthy lifestyle behaviors and to prevent the early onset of type 2 diabetes and cardiovascular diseas...

    Authors: Marc J Weigensberg, Christianne J Lane, Quintilia Ávila, Kati Konersman, Emily Ventura, Tanja Adam, Zohreh Shoar, Michael I Goran and Donna Spruijt-Metz

    Citation: BMC Complementary and Alternative Medicine 2014 14:28

    Published on:

  28. Content type: Research article

    Human skin properties have been used as an important diagnostic component in traditional medicine as they change with health conditions. Sasang constitutional medicine (SCM) puts emphasis on the recognition of...

    Authors: Young-Min Kim, Boncho Ku, Chang Jin Jung, Jaeuk U Kim, Young Ju Jeon, Keun Ho Kim and Jong Yeol Kim

    Citation: BMC Complementary and Alternative Medicine 2014 14:24

    Published on:

  29. Content type: Research article

    Increasing numbers of reports show the beneficial effects of listening to Mozart music in decreasing epileptiform discharges as well as seizure frequency in epileptic children. There has been no effective meth...

    Authors: Lung-Chang Lin, Mei-Wen Lee, Ruey-Chang Wei, Hin-Kiu Mok and Rei-Cheng Yang

    Citation: BMC Complementary and Alternative Medicine 2014 14:17

    Published on:

  30. Content type: Research article

    During their reproductive years about 10% of women experience some kind of symptoms before menstruation (PMS) in a degree that affects their quality of life (QOL). Acupuncture and herbal medicine has been a re...

    Authors: Su Hee Jang, Dong Il Kim and Min-Sun Choi

    Citation: BMC Complementary and Alternative Medicine 2014 14:11

    Published on:

  31. Content type: Research article

    An increasing number of studies have documented the effectiveness of qigong exercise in helping people reduce psychological stress and anxiety, but there is a scarcity of systematic reviews evaluating evidence...

    Authors: Chong-Wen Wang, Celia HY Chan, Rainbow TH Ho, Jessie SM Chan, Siu-Man Ng and Cecilia LW Chan

    Citation: BMC Complementary and Alternative Medicine 2014 14:8

    Published on:

  32. Content type: Research article

    Guizhi Fuling Formula is widely applied for uterine fibroids in China. Many clinical trials are reported. This study assessed the efficacy and safety of Guizhi Fuling Formula for the treatment of uterine fibro...

    Authors: Ni-Ni Chen, Mei Han, Hong Yang, Guo-Yan Yang, Yu-Yi Wang, Xiao-Ke Wu and Jian-Ping Liu

    Citation: BMC Complementary and Alternative Medicine 2014 14:2

    Published on:

  33. Content type: Research article

    Lung cancer is the leading cause of death in cancer patients. Clinical studies showed that a variety of acupoint stimulations have been extensively used for lung cancer patients, including needle insertion, in...

    Authors: Hai-Yong Chen, Shi-Guang Li, William CS Cho and Zhang-Jin Zhang

    Citation: BMC Complementary and Alternative Medicine 2013 13:362

    Published on:

  34. Content type: Research article

    Parkinson’s disease (PD) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal (HPA) axis. ...

    Authors: Carl-Johan Törnhage, Örjan Skogar, Astrid Borg, Birgitta Larsson, Laila Robertsson, Lena Andersson, Lena Andersson, Paulina Backström, Per-Arne Fall, Gunnar Hallgren, Birgitta Bringer, Miriam Carlsson, Ulla Birgitta Lennartsson, Håkan Sandbjörk and Johan Lökk

    Citation: BMC Complementary and Alternative Medicine 2013 13:357

    Published on:

  35. Content type: Research article

    Cranberry is one of the most commonly used herbs during pregnancy. The herb has been used traditionally against urinary tract infections. No studies are found that specifically address the risk of malformation...

    Authors: Kristine Heitmann, Hedvig Nordeng and Lone Holst

    Citation: BMC Complementary and Alternative Medicine 2013 13:345

    Published on:

  36. Content type: Research article

    There have been numerous studies assessing the association of diet and blood pressure but little is known about the association between less commonly used nutritional supplements and blood pressured. The purpo...

    Authors: Catherine A McCarty, Richard L Berg, Carla M Rottscheit and Richard A Dart

    Citation: BMC Complementary and Alternative Medicine 2013 13:339

    Published on:

  37. Content type: Study protocol

    Atopic dermatitis is a chronic inflammatory skin disease with a high prevalence rate and a large socioeconomic cost. There are many treatments for atopic dermatitis, such as antihistamine, tacrolimus and corti...

    Authors: Chunhoo Cheon, Sunju Park, Jeong-Su Park, So-Mi Oh, Soobin Jang, Ho-Yeon Go, Bo-Hyoung Jang, Yong-Cheol Shin and Seong-Gyu Ko

    Citation: BMC Complementary and Alternative Medicine 2013 13:335

    Published on:

  38. Content type: Study protocol

    Moisturisers prevent and treat dry skin. They can also protect sensitive skin, improve skin tone and texture, and mask imperfections. Herbal medicines or their extracts have been available as topical formulati...

    Authors: Dong-Hyo Lee, Eun-Sung Seo, Jin-Tae Hong, Gang-Tai Lee, Young-Kyoung You, Kun-Kook Lee, Ga-Won Jo and Nam-Kwen Kim

    Citation: BMC Complementary and Alternative Medicine 2013 13:330

    Published on:

  39. Content type: Research article

    Many studies have explored the relationship between skin microcirculation and meridian activation. However, few studies have examined blood perfusion coherence along the meridians, and other studies have sugge...

    Authors: Guangjun Wang, Yuying Tian, Shuyong Jia, Wenting Zhou and Weibo Zhang

    Citation: BMC Complementary and Alternative Medicine 2013 13:327

    Published on:

  40. Content type: Research article

    Traditional Chinese medicine has been widely used for the treatment of recurrent miscarriage in China and other Asian countries for long time. We conducted this review to systematically summarize the evidences...

    Authors: Guo-Yan Yang, Hui Luo, Xing Liao and Jian-Ping Liu

    Citation: BMC Complementary and Alternative Medicine 2013 13:320

    Published on:

  41. Content type: Research article

    Lavender essential oil shows evidence of sedative properties in neurophysiological and animal studies but clinical trials of its effectiveness as a treatment of agitation in people with dementia have shown mix...

    Authors: Daniel W O’Connor, Barbara Eppingstall, John Taffe and Eva S van der Ploeg

    Citation: BMC Complementary and Alternative Medicine 2013 13:315

    Published on:

  42. Content type: Research article

    Acupuncture is widely used to treat diabetic patients with dyspeptic symptoms suggestive of gastroparesis in China. We conducted this systematic review of randomized controlled trials (RCTs) to evaluate the ef...

    Authors: Mingxing Yang, Xiumin Li, Suhuan Liu, Zhipeng Li, Mei Xue, Dehong Gao, Xuejun Li and Shuyu Yang

    Citation: BMC Complementary and Alternative Medicine 2013 13:311

    Published on:

  43. Content type: Research article

    Sasang constitutional medicine (SCM) is a type of tailored medicine that divides human beings into four Sasang constitutional (SC) types. Diagnosis of SC types is crucial to proper treatment in SCM. Voice char...

    Authors: Jun-Su Jang, Boncho Ku, Young-Su Kim, Jiho Nam, Keun Ho Kim and Jong Yeol Kim

    Citation: BMC Complementary and Alternative Medicine 2013 13:307

    Published on:

  44. Content type: Research article

    To evaluate and compare effects of an integrative treatment (IT), therapeutic acupuncture (TA), and conventional treatment (CT) in alleviating symptoms of anxiety and depression in psychologically distressed p...

    Authors: Tina Arvidsdotter, Bertil Marklund and Charles Taft

    Citation: BMC Complementary and Alternative Medicine 2013 13:308

    Published on:

  45. Content type: Research article

    Traditional Chinese eye exercises of acupoints involve acupoint self-massage. These have been advocated as a compulsory measure to reduce ocular fatigue, as well as to retard the development of myopia, among C...

    Authors: Zhong Lin, Balamurali Vasudevan, Vishal Jhanji, Tie Ying Gao, Ning Li Wang, Qi Wang, Ji Wang, Kenneth J Ciuffreda and Yuan Bo Liang

    Citation: BMC Complementary and Alternative Medicine 2013 13:306

    Published on:

  46. Content type: Research article

    There have been many attempts to find an objective phenotype by Sasang constitutional types (SCTs) on an anatomical, physiological, and psychological basis, but there has been no research on total nasal resist...

    Authors: Dae Wui Yoon, Seung Ku Lee, Hyeryeon Yi, Jeong Hwa Hong, Miyazaki Soichiro, Si Woo Lee, Jong Yeol Kim and Chol Shin

    Citation: BMC Complementary and Alternative Medicine 2013 13:302

    Published on:

  47. Content type: Research article

    Rhodiola crenulata (R. crenulata) is widely used to prevent acute mountain sickness in the Himalayan areas and in Tibet, but no scientific studies have previously examined its effectiveness. We conducted a rando...

    Authors: Te-Fa Chiu, Lisa Li-Chuan Chen, Deng-Huang Su, Hsiang-Yun Lo, Chung-Hsien Chen, Shih-Hao Wang and Wei-Lung Chen

    Citation: BMC Complementary and Alternative Medicine 2013 13:298

    Published on:

  48. Content type: Study protocol

    Metabolic syndrome is a set of disorders that increases the risk of developing cardiovascular disease. The primary target of treatment of patients with metabolic syndrome is therapeutic lifestyle change. Numer...

    Authors: Hyang-Im Back, Ki-Chan Ha, Hye-Mi Kim, Min-Gul Kim, Ok-Kyeong Yu, Moon-Sun Byun, Do-Youn Jeong, Seong-Yeop Jeong, Youn-Soo Cha and Tae-Sun Park

    Citation: BMC Complementary and Alternative Medicine 2013 13:297

    Published on:

  49. Content type: Study protocol

    The stress of a breast cancer diagnosis and its treatment can produce a variety of psychosocial sequelae including impaired immune responses. Mindfulness Based Stress Reduction (MBSR) is a structured complemen...

    Authors: Elisabeth Kenne Sarenmalm, Lena B Mårtensson, Stig B Holmberg, Bengt A Andersson, Anders Odén and Ingrid Bergh

    Citation: BMC Complementary and Alternative Medicine 2013 13:248

    Published on:

  50. Content type: Research article

    Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Many patients suffer from IBS that can be difficult to treat, thus complementary therapies which may be effective and have a low...

    Authors: Jae-Woo Park, Byung-Hee Lee and Hyangsook Lee

    Citation: BMC Complementary and Alternative Medicine 2013 13:247

    Published on: